KEGG   ENZYME: 1.1.2.2
Entry
EC 1.1.2.2                  Enzyme                                 
Name
mannitol dehydrogenase (cytochrome);
polyol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With a cytochrome as acceptor
Sysname
D-mannitol:cytochrome-c 2-oxidoreductase
Reaction(IUBMB)
D-mannitol + a ferricytochrome c = D-fructose + a ferrocytochrome c + 2 H+ [RN:R00865]
Reaction(KEGG)
R00865;
(other) R01892
Substrate
D-mannitol [CPD:C00392];
ferricytochrome c [CPD:C00125]
Product
D-fructose [CPD:C00095];
ferrocytochrome c [CPD:C00126];
H+ [CPD:C00080]
Comment
The enzyme from the bacterium Gluconobacter oxydans acts on polyols with a D-lyxo configuration, such as D-mannitol and D-sorbitol, with preference towards the former.
History
EC 1.1.2.2 created 1961
Pathway
ec00040  Pentose and glucuronate interconversions
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:13373782]
  Authors
ARCUS AC, EDSON NL.
  Title
Polyol dehydrogenases.  2.  The polyol dehydrogenases of Acetobacter suboxydans and Candida utilis.
  Journal
Biochem J 64:385-94 (1956)
DOI:10.1042/bj0640385
Reference
2
  Authors
Cho NC, Kim K, Jhon DY.
  Title
Purification and characterization of polyol dehydrogenase from Gluconobacter melanogenus.
  Journal
Han'guk Saenghwa Hakhaochi 23:172-178 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.2.2
IUBMB Enzyme Nomenclature: 1.1.2.2
ExPASy - ENZYME nomenclature database: 1.1.2.2
BRENDA, the Enzyme Database: 1.1.2.2
CAS: 37250-78-5
LinkDB

KEGG   REACTION: R00865
Entry
R00865                      Reaction                               
Name
D-mannitol:ferricytochrome-c 2-oxidoreductase
Definition
Mannitol + 2 Ferricytochrome c <=> D-Fructose + 2 Ferrocytochrome c + 2 H+
Equation
C00392 + 2 C00125 <=> C00095 + 2 C00126 + 2 C00080
Reaction class
RC00016  C00125_C00126
RC00085  C00095_C00392
Enzyme
1.1.2.2
Pathway
rn00051  Fructose and mannose metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.2  With a cytochrome as acceptor
    1.1.2.2
     R00865  Mannitol + 2 Ferricytochrome c <=> D-Fructose + 2 Ferrocytochrome c + 2 H+
Other DBs
RHEA: 17600
LinkDB

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