KEGG   ENZYME: 1.1.2.5
Entry
EC 1.1.2.5                  Enzyme                                 
Name
D-lactate dehydrogenase (cytochrome c-553)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With a cytochrome as acceptor
Sysname
(R)-lactate:cytochrome-c-553 2-oxidoreductase
Reaction(IUBMB)
(R)-lactate + 2 ferricytochrome c-553 = pyruvate + 2 ferrocytochrome c-553 + 2 H+ [RN:R00198]
Reaction(KEGG)
R00198
Substrate
(R)-lactate [CPD:C00256];
ferricytochrome c-553 [CPD:C01070]
Product
pyruvate [CPD:C00022];
ferrocytochrome c-553 [CPD:C01071];
H+ [CPD:C00080]
Comment
The enzyme from the sulfate-reducing bacterium Desulfovibrio vulgaris can also act on (R)-2-hydroxybutanoate.
History
EC 1.1.2.5 created 1989
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:7275946]
  Authors
Ogata M, Arihara K, Yagi T.
  Title
D-lactate dehydrogenase of Desulfovibrio vulgaris.
  Journal
J Biochem 89:1423-31 (1981)
DOI:10.1093/oxfordjournals.jbchem.a133334
Other DBs
ExplorEnz - The Enzyme Database: 1.1.2.5
IUBMB Enzyme Nomenclature: 1.1.2.5
ExPASy - ENZYME nomenclature database: 1.1.2.5
BRENDA, the Enzyme Database: 1.1.2.5
CAS: 37250-79-6
LinkDB

KEGG   REACTION: R00198
Entry
R00198                      Reaction                               
Name
(R)-Lactate:ferricytochrome-c-553 2-oxidoreductase
Definition
(R)-Lactate + 2 Ferricytochrome c-553 <=> Pyruvate + 2 Ferrocytochrome c-553 + 2 H+
Equation
C00256 + 2 C01070 <=> C00022 + 2 C01071 + 2 C00080
Reaction class
RC00044  C00022_C00256
Enzyme
Pathway
rn00620  Pyruvate metabolism
rn01100  Metabolic pathways
Other DBs
RHEA: 16468
LinkDB

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