KEGG ENZYME: 1.1.3.29

ENZYME: 1.1.3.29

Entry

EC 1.1.3.29                 Enzyme

Name

N-acylhexosamine oxidase;
N-acyl-D-hexosamine oxidase;
N-acyl-beta-D-hexosamine:oxygen 1-oxidoreductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor

Sysname

N-acyl-D-hexosamine:oxygen 1-oxidoreductase

Reaction(IUBMB)

(1) N-acetyl-D-glucosamine + O2 + H2O = N-acetyl-D-glucosaminate + H2O2 (overall reaction) [RN:R01203];
(1a) N-acetyl-D-glucosamine + O2 = N-acetyl-D-glucosamino-1,5-lactone + H2O2 [RN:R12973];
(1b) N-acetyl-D-glucosamino-1,5-lactone + H2O = N-acetyl-D-glucosaminate (spontaneous) [RN:R12974];
(2) N-acetyl-D-galactosamine + O2 + H2O = N-acetyl-D-galacotsaminate + H2O2 (overall reaction) [RN:R12975];
(2a) N-acetyl-D-galactosamine + O2 = N-acetyl-D-galactosamino-1,5-lactone + H2O2 [RN:R12976];
(2b) N-acetyl-D-galactosamino-1,5-lactone + H2O = N-acetyl-D-galactosaminate (spontaneous) [RN:R12977]

Reaction(KEGG)

R01203 R12973 R12974 R12975 R12976 R12977

Substrate

N-acetyl-D-glucosamine [CPD:C00140];
O2 [CPD:C00007];
H2O [CPD:C00001];
N-acetyl-D-glucosamino-1,5-lactone [CPD:C22488];
N-acetyl-D-galactosamine [CPD:C01132];
N-acetyl-D-galactosamino-1,5-lactone [CPD:C22489]

Product

N-acetyl-D-glucosaminate [CPD:C01133];
H2O2 [CPD:C00027];
N-acetyl-D-glucosamino-1,5-lactone [CPD:C22488];
N-acetyl-D-galacotsaminate;
N-acetyl-D-galactosamino-1,5-lactone [CPD:C22489];
N-acetyl-D-galactosaminate [CPD:C03408]

Comment

The enzyme, found in bacteria, also acts more slowly on N-acetyl-D-mannosamine.

History

EC 1.1.3.29 created 1992, modified 2022

Orthology

K26080

N-acylhexosamine oxidase

Genes

KLE:	AO703_02750

BSEL:

RHD99_13685

AAPT:

QNH14_02610

YPE:

YPO0308

YPK:

y0566

YPH:

YPC_0697

YPA:

YPA_3976

YPN:

YPN_3361

YPM:	YP_0464(glcD1)

YPP:	YPDSF_3664

YPG:	YpAngola_A0676

YPZ:

YPZ3_0265

YPT:	A1122_03600

YPD:

YPD4_0270

YPX:

YPD8_0271

YPW:

CH59_1556

YPJ:

CH55_3455

YPV:

BZ15_3264

YPL:

CH46_606

YPS:

YPTB0364

YPO:

BZ17_2206

YPI:	YpsIP31758_3776

YPY:

YPK_3866

YPB:

YPTS_0387

YPQ:

DJ40_2045

YPU:

BZ21_3734

YPR:

BZ20_1748

YPC:

BZ23_4004

YPF:

BZ19_3835

YSI:	BF17_09925

LGB:	V8L73_06505

DYE:	EO087_03910

PFL:

PFL_0338

PPRC:

PFLCHA0_c03430

PFC:	PflA506_0033

PFB:

VO64_3080

PTV:	AA957_14265

PVR:	PverR02_00205

POI:	BOP93_00170

PRX:	HRH33_01065

PSOS:

POS17_0335

PANR:

A7J50_1605

PSEP:

C4K39_0350

PTRT:

HU722_0001180

PSAM:

HU731_016245

PPEG:

KUA23_00170

CRZ:	D1345_00310

CHAE:

CH06BL_00600

AMAH:

DLM_1403

RSO:

RSc0050

RSE:

F504_57

RPU:	CDC45_00260

RNC:	GO999_16455

RSC:	RCFBP_21395

RSL:	RPSI07_3328

RSN:	RSPO_c03310

RSM:	CMR15_30852

RSY:	RSUY_31940

RSG:	JK151_02115

RPI:

Rpic_3700

RPF:	Rpic12D_3377

RMN:	TK49_03295

RIN:	ACS15_3846

RWE:	KOL96_24230

BMA:

BMA2895

BMV:	BMASAVP1_A3473

BML:	BMA10229_A1646

BMN:	BMA10247_3077

BMAL:

DM55_933

BMAE:

DM78_788

BMAQ:

DM76_910

BMAI:

DM57_1647

BMAF:

DM51_2511

BMAZ:

BM44_282

BMAB:

BM45_3006

BPS:

BPSL3339

BPM:	BURPS1710b_0113(glcD1)

BPL:	BURPS1106A_3978

BPD:	BURPS668_3897

BPR:	GBP346_A4084

BPSE:

BDL_2035

BPSM:

BBQ_3495

BPSU:

BBN_81

BPSD:

BBX_427

BPZ:	BP1026B_I3577

BPQ:	BPC006_I4016

BPK:

BBK_1524

BPSH:

DR55_1162

BPSA:

BBU_2201

BPSO:

X996_774

BUT:

X994_2793

BTE:

BTH_I3218

BTQ:

BTQ_3158

BTJ:

BTJ_2537

BTZ:

BTL_452

BTD:

BTI_226

BTV:

BTHA_542

BTHE:

BTN_909

BTHM:

BTRA_656

BTHA:

DR62_1102

BTHL:

BG87_665

BOK:

DM82_3036

BOC:

BG90_1680

BUU:	WS70_00895

BSAV:

WS86_01315

BHG:	I6G56_19655

BUD:	AQ610_00950

BUL:

BW21_309

AXO:	NH44784_043681

AXN:	AX27061_2534

AXX:	ERS451415_02524

ADT:	APT56_12480

ASW:	CVS48_23045

ACHR:

C2U31_18540

ACHB:

DVB37_17430

VPE:	Varpa_1307

VAZ:	H7F35_18670

VAV:	IG196_04930

CPRA:

CPter91_0977

ACM:	AciX9_3805

GMA:	AciX8_3480 AciX8_4014

GRW:	FTO74_07490

TSA:	AciPR4_1704 AciPR4_2445

TRS:	Terro_2944

TALB:

FTW19_05120

EDA:	GWR55_05100 GWR55_06340 GWR55_12210

EDG:	H7846_10845 H7846_11285

ADIN:

H7849_15695

TGI:	RBB81_14780

» show all

Reference

Authors

Horiuchi T.

Title

Purification and properties of N-acyl-D-hexosamine oxidase from Pseudomonas sp. 15-1.

Journal

Agric Biol Chem 53:361-368 (1989)

Reference

2 [PMID:34709726]

Authors

Rembeza E, Boverio A, Fraaije MW, Engqvist MKM.

Title

Discovery of Two Novel Oxidases Using a High-Throughput Activity Screen.

Journal

Chembiochem 23:e202100510 (2022)
DOI:10.1002/cbic.202100510

Sequence

[rsy:RSUY_31940]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.3.29

IUBMB Enzyme Nomenclature:

1.1.3.29

ExPASy - ENZYME nomenclature database:

1.1.3.29

BRENDA, the Enzyme Database:

1.1.3.29

CAS:	121479-58-1

LinkDB

DBGET integrated database retrieval system