Entry
Name
D-lactate dehydrogenase (quinone);
dld (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
(R)-lactate:quinone 2-oxidoreductase
Reaction(IUBMB)
(R)-lactate + a quinone = pyruvate + a quinol [RN:
R11591 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme is an FAD-dependent peripheral membrane dehydrogenase that participates in respiration. Electrons derived from D-lactate oxidation are transferred to the membrane soluble quinone pool.
History
EC 1.1.5.12 created 2017
Pathway
Orthology
K03777 D-lactate dehydrogenase (quinone)
Genes
ECOO : ECRM13514_2896(dld)
ECOH : ECRM13516_2837(dld)
EDJ : ECDH1ME8569_2069(dld)
KOM : HR38_23750 HR38_28450
RTG : NCTC13098_02149(dld_1)
REE : electrica_01581(dld)
CWE : CO701_07220 CO701_18785
CLAP : NCTC11466_03166(dld)
PGE : LG71_12610 LG71_17730
KIE : NCTC12125_00523(dld)
METY : MRY16398_17360(dld)
AHN : NCTC12129_01706(dld)
YPI : YpsIP31758_2805(dld)
SFJ : SAMEA4384070_1426(dld)
SOF : NCTC11214_05553(dld)
EAME : GXP68_03200(dld) GXP68_14520(dld)
RBAD : H2866_13925(dld) H2866_19175(dld)
EBI : EbC_04020 EbC_13750(dld)
EPE : CI789_11705 CI789_16845
ERWI : GN242_14155 GN242_19380
ERP : LJN55_06890(dld) LJN55_21350(dld)
PAO : Pat9b_1192 Pat9b_1794
KLN : LH22_13335 LH22_16230
PANS : FCN45_06215 FCN45_09195
TPTY : NCTC11468_01823(dld)
PHEI : NCTC12003_01646(dld)
HPIT : NCTC13334_01776(dld)
HAEG : NCTC8502_01820(dld)
ADP : NCTC12871_00784(dld)
ALIG : NCTC10568_00749(dld)
ASEG : NCTC10977_01616(dld)
RPNE : NCTC8284_01089(dld_1)
PALI : A3K91_1301 A3K91_1984
PSYP : E5677_03480 E5677_06890
AMC : MADE_000001022270 MADE_1016380
AMH : I633_13635 I633_17130
AMAA : amad1_13235 amad1_16575
AMAL : I607_12460 I607_15735
AMAE : I876_12840 I876_16035
AMAO : I634_12700 I634_15980
AMAD : I636_12850 I636_15890
AMAI : I635_13210 I635_16530
AMAG : I533_12450 I533_15585
AMAC : MASE_12275 MASE_15625
AMB : AMBAS45_12825 AMBAS45_16070
AMG : AMEC673_12600 AMEC673_15920
AMK : AMBLS11_12065 AMBLS11_15365
ALR : DS731_01550 DS731_17145
CHJ : NCTC10426_00869(dld)
NMM : NMBM01240149_1091(dld)
NMS : NMBM01240355_1001(dld)
NMQ : NMBM04240196_1166(dld)
NWE : SAMEA3174300_0660(dld)
NZO : SAMEA4504057_1807(dld)
NCI : NCTC10296_01204(dld)
NCZ : NCTC10294_00563(dld)
NANI : NCTC12227_00468(dld)
BUZ : AYM40_22985 AYM40_23200
PACS : FAZ98_15725 FAZ98_30710
AXX : ERS451415_03645(dld)
ATEM : PQV96_17500(dld) PQV96_20335(dld)
MAQU : Maq22A_c17965(glcD)
NPP : PP1Y_AT32830 PP1Y_Mpl8985
NOR : FA702_18365 FA702_21270
NHUM : PQ457_04805(dld) PQ457_18555(dld)
SNOS : K8P63_00650(dld) K8P63_03655(dld)
KRE : GWK63_05710(dld) GWK63_12925(dld)
BCOP : JD108_01815(cas12b)
LLR : llh_13730 llh_14085(dld2)
CVA : CVAR_1383(dld1) CVAR_1388(dld2) CVAR_1899(dld3)
BHH : Bra3105_02045(dld) Bra3105_11575(dld)
» show all
Taxonomy
Reference
Authors
Kohn LD, Kaback HR
Title
Mechanisms of active transport in isolated bacterial membrane vesicles. XV. Purification and properties of the membrane-bound D-lactate dehydrogenase from Escherichia coli.
Journal
J Biol Chem 248:7012-7 (1973)
Reference
Authors
Futai M
Title
Membrane D-lactate dehydrogenase from Escherichia coli. Purification and properties.
Journal
Reference
Authors
Matsushita K, Kaback HR
Title
D-lactate oxidation and generation of the proton electrochemical gradient in membrane vesicles from Escherichia coli GR19N and in proteoliposomes reconstituted with purified D-lactate dehydrogenase and cytochrome o oxidase.
Journal
Reference
Authors
Peersen OB, Pratt EA, Truong HT, Ho C, Rule GS
Title
Site-specific incorporation of 5-fluorotryptophan as a probe of the structure and function of the membrane-bound D-lactate dehydrogenase of Escherichia coli: a 19F nuclear magnetic resonance study.
Journal
Reference
Authors
Dym O, Pratt EA, Ho C, Eisenberg D
Title
The crystal structure of D-lactate dehydrogenase, a peripheral membrane respiratory enzyme.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.5.12
ExPASy - ENZYME nomenclature database: 1.1.5.12
LinkDB
All DBs