KEGG   ENZYME: 1.1.99.2
Entry
EC 1.1.99.2                 Enzyme                                 
Name
L-2-hydroxyglutarate dehydrogenase;
alpha-ketoglutarate reductase;
alpha-hydroxyglutarate dehydrogenase;
L-alpha-hydroxyglutarate dehydrogenase;
hydroxyglutaric dehydrogenase;
alpha-hydroxyglutarate oxidoreductase;
L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase;
alpha-hydroxyglutarate dehydrogenase (NAD+ specific);
(S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
Sysname
(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase
Reaction(IUBMB)
(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor [RN:R00298]
Reaction(KEGG)
R00298 > R03534
Substrate
(S)-2-hydroxyglutarate [CPD:C03196];
acceptor [CPD:C00028]
Product
2-oxoglutarate [CPD:C00026];
reduced acceptor [CPD:C00030]
History
EC 1.1.99.2 created 1961, modified 2013
Pathway
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
Orthology
K00109  2-hydroxyglutarate dehydrogenase
Genes
HSA79944(L2HGDH)
PTR452898(L2HGDH)
PPS100978899(L2HGDH)
GGO101139276(L2HGDH)
PON100172827(L2HGDH)
NLE100600833(L2HGDH)
MCC705721(L2HGDH)
MCF102137911(L2HGDH)
CSAB103228958(L2HGDH)
CATY105586729(L2HGDH)
PANU101004693(L2HGDH)
TGE112629080(L2HGDH)
RRO104682749(L2HGDH)
RBB108513673(L2HGDH)
TFN117069668(L2HGDH)
PTEH111549460(L2HGDH)
CJC100410851(L2HGDH)
SBQ101047482(L2HGDH)
CSYR103276426(L2HGDH)
MMUR105867642(L2HGDH)
OGA100958822(L2HGDH)
MMU217666(L2hgdh)
MCAL110307199(L2hgdh)
MPAH110324754(L2hgdh)
RNO314196(L2hgdh)
MCOC116081051(L2hgdh)
CGE100768751(L2hgdh)
PLEU114684211(L2hgdh) 114699469
NGI103731511(L2hgdh)
HGL101702109(L2hgdh)
CPOC100726948(L2hgdh)
CCAN109686540 109687204
DORD105982574(L2hgdh)
DSP122106558(L2hgdh)
NCAR124978155
OCU100343830 100350193(L2HGDH)
OPI101525748(L2HGDH)
TUP102480205(L2HGDH)
CFA480316(L2HGDH)
VVP112921448(L2HGDH)
VLG121492464(L2HGDH)
UMR103665372(L2HGDH)
UAH113266207(L2HGDH)
UAR123793268(L2HGDH)
ELK111140398
LLV125104045
MPUF101677511(L2HGDH)
ORO101385619(L2HGDH)
EJU114205644(L2HGDH)
ZCA113909058(L2HGDH)
MLX118002663(L2HGDH)
FCA101094353(L2HGDH)
PYU121031739(L2HGDH)
PBG122469067(L2HGDH)
PTG102951061(L2HGDH)
PPAD109268501(L2HGDH)
AJU106981946(L2HGDH)
HHV120220283(L2HGDH)
BTA514230(L2HGDH)
BOM102277294(L2HGDH)
BIU109565017(L2HGDH)
BBUB102414364(L2HGDH)
CHX102190421(L2HGDH)
OAS101121015(L2HGDH)
ODA120853130(L2HGDH)
CCAD122443466(L2HGDH)
SSC100152180(L2HGDH)
CFR102520166(L2HGDH)
CBAI105078435(L2HGDH)
CDK105091405(L2HGDH)
VPC102541170(L2HGDH)
BACU103020579(L2HGDH)
LVE103075209(L2HGDH)
OOR101284995(L2HGDH)
DLE111173173(L2HGDH)
PCAD102974237(L2HGDH)
PSIU116746671(L2HGDH)
ECB100066314(L2HGDH)
EPZ103545570 103559182(L2HGDH)
EAI106839519(L2HGDH)
MYB102238888(L2HGDH)
MYD102773864(L2HGDH)
MMYO118654881(L2HGDH)
MLF102436915(L2HGDH)
MNA107525853(L2HGDH)
PKL118718572(L2HGDH)
HAI109375228(L2HGDH)
DRO112310993(L2HGDH)
SHON118992376(L2HGDH)
AJM119057067(L2HGDH)
PDIC114492353(L2HGDH)
PHAS123808855(L2HGDH)
MMF118641009(L2HGDH)
RFQ117022919(L2HGDH)
PALE102889350(L2HGDH)
PGIG120604449(L2HGDH)
PVP105309524(L2HGDH)
RAY107511438(L2HGDH)
MJV108401304(L2HGDH)
TOD119239072(L2HGDH)
SARA101542023 101552954(L2HGDH)
LAV100657343(L2HGDH)
TMU101347817
DNM101426209(L2HGDH)
MDO100018728(L2HGDH)
GAS123249242(L2HGDH)
SHR100933496(L2HGDH)
PCW110221753(L2HGDH)
OAA100084662(L2HGDH)
GGA423573(L2HGDH)
PCOC116234586(L2HGDH)
MGP100540849(L2HGDH)
CJO107315524(L2HGDH)
NMEL110401965(L2HGDH)
APLA101804444(L2HGDH)
ACYG106049309(L2HGDH)
AFUL116489445(L2HGDH)
TGU100220092(L2HGDH)
LSR110473477(L2HGDH)
SCAN103826825(L2HGDH)
PMOA120497062(L2HGDH)
OTC121338797(L2HGDH)
PRUF121348713(L2HGDH)
GFR102033150(L2HGDH)
FAB101808533(L2HGDH)
PHI102103991(L2HGDH)
PMAJ107206240(L2HGDH)
CCAE111929517(L2HGDH)
CCW104695923(L2HGDH)
ETL114070306(L2HGDH)
ZAB102065921(L2HGDH)
FPG101912902(L2HGDH)
FCH102056594(L2HGDH)
CLV102089678(L2HGDH)
EGZ104135009(L2HGDH)
NNI104019490(L2HGDH)
ACUN113480383(L2HGDH)
TALA104359874(L2HGDH)
PADL103914919(L2HGDH)
ACHC115351825(L2HGDH)
AAM106497441(L2HGDH)
AROW112961190(L2HGDH)
NPD112957761(L2HGDH)
DNE112994129(L2HGDH)
ASN102387436(L2HGDH)
AMJ106737189(L2HGDH)
CPOO109320894(L2HGDH)
GGN109299276(L2HGDH)
PSS102458506(L2HGDH)
CMY102946571(L2HGDH)
CPIC101935892(L2HGDH)
TST117876656(L2HGDH)
CABI116822134(L2HGDH)
MRV120404320(L2HGDH)
ACS100563174(l2hgdh)
PVT110089153(L2HGDH)
SUND121933538(L2HGDH)
PBI103059564(L2HGDH)
PMUR107296219(L2HGDH) 107300310
TSR106545963(L2HGDH)
PGUT117675047(L2HGDH)
VKO123026580(L2HGDH)
ZVI118075482(L2HGDH) 118077556
GJA107122496(L2HGDH) 107122626
STOW125427105(L2HGDH)
XLA108698751(l2hgdh.L)
XTR100145085(l2hgdh)
NPR108795062(L2HGDH)
RTEM120920990(L2HGDH)
BBUF120982398(L2HGDH)
BGAR122922049(L2HGDH)
DRE566872(l2hgdh)
SRX107705441 107736610
SANH107654945 107682613
SGH107553179 107602969(l2hgdh)
CAUA113056798(l2hgdh)
PPRM120467767(l2hgdh)
MAMB125277305(l2hgdh)
IPU108263080(l2hgdh)
PHYP113541918(l2hgdh)
SMEO124394589(l2hgdh)
TFD113656881(l2hgdh)
AMEX103038136(l2hgdh)
EEE113577730(l2hgdh)
TRU101061325(l2hgdh)
TNGGSTEN00035790G001
LCO104935982(l2hgdh)
ELY117267127(l2hgdh)
PLEP121953833(l2hgdh)
SLUC116057421(l2hgdh)
ECRA117935420(l2hgdh)
PFLV114546504(l2hgdh)
GAT120832742(l2hgdh)
PPUG119227550(l2hgdh)
MSAM119910239(l2hgdh)
CUD121526427(l2hgdh)
MZE101471313(l2hgdh)
ONL100693423(l2hgdh)
OAU116318049(l2hgdh)
OLA101160274(l2hgdh)
OML112148407(l2hgdh)
XMA102234259(l2hgdh)
XCO114134501(l2hgdh)
XHE116709345(l2hgdh)
PRET103458314(l2hgdh)
PFOR103144733(l2hgdh)
PLAI106946982(l2hgdh)
PMEI106922077(l2hgdh)
GAF122845944(l2hgdh)
CVG107097184(l2hgdh)
CTUL119783545(l2hgdh)
GMU124855285(l2hgdh)
NFU107391749(l2hgdh)
KMR108237533(l2hgdh)
ALIM106528408(l2hgdh)
NWH119427080(l2hgdh)
AOCE111579386(l2hgdh)
CSEM103380943(l2hgdh)
POV109636312(l2hgdh)
SSEN122782868(l2hgdh)
HHIP117756671(l2hgdh)
LCF108886702(l2hgdh)
SDU111225601(l2hgdh)
SLAL111665849(l2hgdh)
XGL120795133(l2hgdh)
HCQ109517328(l2hgdh)
BPEC110174617(l2hgdh)
MALB109973393(l2hgdh)
SASA106602521(l2hgdh)
OTW112262152(l2hgdh)
OMY110498274(l2hgdh)
OGO124001327(l2hgdh)
ONE115123468(l2hgdh)
SALP112074717(l2hgdh)
SNH120060119(l2hgdh)
ELS105025540(l2hgdh)
SFM108919404(l2hgdh)
PKI111840026(l2hgdh)
AANG118233134(l2hgdh)
LOC102696708(l2hgdh)
PSPA121329827(l2hgdh)
ARUT117415534 117973928
LCM102364974(L2HGDH)
CMK103175273(l2hgdh)
RTP109921716(l2hgdh)
BFO118425660
BBEL109472341
CIN100184325
SCLV120332968
SPU578357
APLC110989722
SKO100376601
DMEDmel_CG10639(L2HGDH)
DER6549344
DSE6614613
DSIDsimw501_GD21794(Dsim_GD21794)
DYADyak_GE12689
DAN6497466
DSR110176882
DPODpse_GA10459
DPE6589400
DMN108162904
DWI6644340
DGR6561783
DMODmoj_GI17168
DAZ108611749
DNV115562394
DHE111595763
DVI6627935
CCAT101459974
BOD106617655
MDE101896371
SCAC106094778
LCQ111679528
AGAAgaP_AGAP007868
ACOZ120957117
AARA120902388
AAG110676307
AALB109408591 109423851 115254254 115270189
CPII120413413
CNS116337955
AME410999
ACER108002286
ALAB122719765
BIM100749758
BBIF117208266
BVK117232015
BVAN117158104
BTER100651400
BPYO122566980
CCAL108633134
OBB114872679
MGEN117220837
NMEA116432498
CGIG122395366
SOC105200020
MPHA105833196
AEC105144701
ACEP105625974
PBAR105427409
VEM105568115
HST105186316
DQU106748629
CFO105249825
FEX115242424
LHU105671500
PGC109855448
OBO105277467
PCF106784231
PFUC122517756
VPS122633701
NVI100115746
CSOL105363875
TPRE106651314 106657515
MDL103571533
CGLO123275144
FAS105269212
DAM107041651
AGIF122848200
CCIN107273133
TCA663434 663451
DPA109532975 109532977
SOY115874125 115880394
ATD109597930 109597948
CSET123310241
AGB108912861 108912863
LDC111511179 111518166
NVL108562516
APLN108738437
PPYR116169477 116175866
OTU111425060
BMOR101745774
BMAN114248641
MSEX115449335
DPLKGM_205781
BANY112045086
PMAC106714825
PPOT106101977
PXU106126058
PRAP110994004
ZCE119834401
HAW110370685
TNL113497247
SLIU111348308
OFU114364277
PXY105383252
API100161579
DNX107173172
AGS114122022
RMD113554561
BTAB109034234
DCI103512203 103524011
HHAL106684302
NLU111048250 111061381
PHUPhum_PHUM349820
FOC113215791
ZNE110839593
CSEC111861901
FCD110842667
DPXDAPPUDRAFT_305386
PJA122258374
PCHN125043203
HAME121876086
PCLA123765477
PTRU123515988
HAZT108668244
EAF111709696
LSM121130696
DSV119457594
RSAN119374770
RMP119167076
VDE111248653
VJA111265096
TUT107368266
DPTE113798662
DFR124495119
CSCU111642015 111642314
PTEP107445392
SDM118195860
CELCELE_Y45G12B.3(Y45G12B.3)
CBRCBG_06643
BMYBM_BM6576(Bm6576)
LOALOAG_00810
NAINECAME_13279
TSPTsp_09673
HROHELRODRAFT_179569
LGILOTGIDRAFT_215736
PCAN112562380
BGT106056896
GAE121371255
HRF124119887
HRJ124289690
CRG105338880
MYI110461468
PMAX117323620
MMER123528892
OBI106870546
OSN115217198
LAK106169805
SMMSmp_050080
SHXMS3_0017444
OVIT265_00030 T265_10884
NVE5506318
EPA110250348
ATEN116302724
ADF107331220
AMIL114956637
PDAM113676926
SPIS111341504
DGT114520068
XEN124442749
HMG101241363
TADTRIADDRAFT_51164
AQU100634553
ATHAT3G56840
ALY9314181
CRB17885421
CSAT104712343 104781577 104791973
EUSEUTSA_v10005964mg
BRP103841581
BNA106368050
BOE106312181
RSZ108856716 108858610
THJ104803249 104803303
CPAP110817154
CIT102609019
CICCICLE_v10011846mg
PVY116129226
MINC123197735
TCC18598621
GRA105786167
GHI107922088 107939016
GAB108460382
DZI111312149
EGR104443589
GMX100798359
GSJ114412325
PVUPHAVU_004G053400g
VRA106772172
VAR108345625
VUN114181963
CCAJ109793634
APRC113867533
MTRMTR_6g026730
CAM101512589
LJALj5g3v0409270.1(Lj5g3v0409270.1)
ADU107472023
AIP107610063 107624200
AHF112716797 112766327 112783200
LANG109336445
FVE101311454
RCN112193613
PPER18771102
PMUM103339099
PAVI110772356
PDUL117635016
MDM103454693
ZJU107423578
MNT21410561
CSV101204963
CMO103495875
BHJ120073869
MCHA111021786
RCU8280365
JCU105637120
HBR110641410
MESC110619054 110624185
POP7495656
PEU105136871
PALZ118052957
JRE109007945
QSU111993190 112025402
QLO115951395
TWL119986884
VVI100255157
VRI117919654
SLY101243839
SPEN107031969
SOT102580963 102595556
CANN107844695
NTA107788841 107819020
NSY104235362
NTO104092698
NAU109238833
INI109162108
ITR116025010
SIND105159876
OEU111370392
EGT105949407
SSPL121795825
HAN110920848
ECAD122578997
LSV111880182
CCAV112517920
DCR108224905
CSIN114290177
BVG104889663 104889666
SOE110799881
CQI110711721 110714898
NNU104593510
MING122065489
TSS122642969
PSOM113313279 113322729
NCOL116260468
OSA4327565
DOSAOs01t0809900-01(Os01g0809900)
OBR102718692
BDI106866221
ATS109731554
TDC119269333 119277332
TAES123062359 123071129 123079492
SBI8055270
ZMA100276389
SITA106804356
SVS117855082
PVIR120673284 120708411
PHAI112893238
PDA103705022
EGU105032055
MUS103971924
DCT110091894
PEQ110024641
AOF109831714
ATR18426140
SMOSELMODRAFT_271760 SELMODRAFT_88360 SELMODRAFT_92593
PPP112289277
ERCEcym_3372
KLAKLLA0_E14763g
KMXKLMA_60011
LTHKLTH0F09526g
ZROZYRO0A07084g
TDLTDEL_0G02630(TDEL0G02630)
TGBHG536_0A02610
ZMKHG535_0D01560
PPAPAS_chr2-2_0452
DHADEHA2G21252g
PICPICST_41267(GPH2)
PGUPGUG_02491
SPAASPAPADRAFT_62681
LELLELG_00601
CALCAALFM_C106720CA(CaO19.6238)
CTPCTRG_04212
COTCORT_0A06390
CDUCD36_06290
CTENCANTEDRAFT_113027
YLIYALI0D04312g
CLUCLUG_01842
CLUSA9F13_21g00242
CAURCJI97_004404
SLBAWJ20_5189
BNNFOA43_002736
BBRXBRETT_002742
OPAHPODL_01730
NCRNCU08048
NTENEUTE1DRAFT121335(NEUTE1DRAFT_121335)
PANPODANSg7269
TTTTHITE_132641
MTMMYCTH_2298784
CTHRCTHT_0033760
PPEIPpBr36_04679
TMNUCRPA7_6836
FGRFGSG_05122
FPUFPSE_06518
FVRFVEG_06111
FOXFOXG_08557
NHENECHADRAFT_32312
CHIGCH63R_07748
SSLSS1G_09974
BFUBCIN_07g04400
MBEMBM_06595
PSCOLY89DRAFT_787317
GLZGLAREA_01990
AFMAFUA_1G04090
ACTACLA_030540
NFINFIA_020640
AORAO090003000940
ANGANI_1_370014(An01g02920)
AFVAFLA_000734
ALUCAKAW2_20460S
ACHEACHE_11581S
PCSPc16g09140
PDPPDIP_20670
TMFPMAA_054710
TRGTRUGW13939_00541
CIMCIMG_04999
CPWCPC735_068870
AJEHCAG_06023
PNOSNOG_05922
PTEPTT_02289
BZECOCCADRAFT_91816
BSCCOCSADRAFT_38383
BORCOCMIDRAFT_101015
AALTCC77DRAFT_1031976
ZTRMYCGRDRAFT_111010
PFJMYCFIDRAFT_29489
FFUCLAFUR5_02954
CNECNA06700
CNBCNBA6520
CNGCNAG_00692
CGICGB_A7510W
TMSTREMEDRAFT_34801
TASAA1Q1_07526
TVSTRAVEDRAFT_115285
DSQDICSQDRAFT_60737
PCOPHACADRAFT_249787
SHSSTEHIDRAFT_158155
HIRHETIRDRAFT_408521
PSQPUNSTDRAFT_100030
ADLAURDEDRAFT_133588
FMEFOMMEDRAFT_135532
GTRGLOTRDRAFT_136462
LBCLACBIDRAFT_158383
MRRMoror_1445
MOREE1B28_004087
CCICC1G_01295
SCMSCHCODRAFT_80512
ABPAGABI1DRAFT127941(AGABI1DRAFT_127941)
ABVAGABI2DRAFT202848(AGABI2DRAFT_202848)
CPUTCONPUDRAFT_123520
SLASERLADRAFT_446497
WSEWALSEDRAFT_60608
UMAUMAG_05061
PFPPFL1_04759
MGLMGL_4098
MRTMRET_3729
MSYMMSY001_3219
PGRPGTG_16481
MLRMELLADRAFT_104896
MBRMONBRDRAFT_14006
SREPTSG_00278
CCURIAR63_02185
 » show all
Reference
1  [PMID:16746551]
  Authors
Weil-Malherbe H
  Title
The oxidation of l(-)alpha-hydroxyglutaric acid in animal tissues.
  Journal
Biochem J 31:2080-94 (1937)
DOI:10.1042/bj0312080
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.2
IUBMB Enzyme Nomenclature: 1.1.99.2
ExPASy - ENZYME nomenclature database: 1.1.99.2
BRENDA, the Enzyme Database: 1.1.99.2
CAS: 9028-80-2
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