Entry
Name
3-carboxyethylcatechol 2,3-dioxygenase;
2,3-dihydroxy-beta-phenylpropionic dioxygenase;
2,3-dihydroxy-beta-phenylpropionate oxygenase;
3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase;
3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (ring-opening)
Reaction(IUBMB)
(1) 3-(2,3-dihydroxyphenyl)propanoate + O2 = (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate [RN:
R04376 ];
(2) (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate [RN:
R06788 ]
Reaction(KEGG)
Substrate
3-(2,3-dihydroxyphenyl)propanoate [CPD:
C04044 ];
O2 [CPD:
C00007 ];
(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate [CPD:
C12623 ]
Product
(2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate [CPD:
C04479 ];
(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate [CPD:
C12624 ]
Comment
An iron protein. This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation.
History
EC 1.13.11.16 created 1972, modified 2011, modified 2012
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K05713 2,3-dihydroxyphenylpropionate 1,2-dioxygenase
Genes
ECOC : C3026_01715(mhpB) C3026_24875(mhpB)
ECOO : ECRM13514_0498(mhpB)
ECOH : ECRM13516_0328(mhpB)
ELR : ECO55CA74_02215(mhpB)
ECW : EcE24377A_0372(mhpB)
ECOA : APECO78_05260(mhpB)
EDJ : ECDH1ME8569_0335(mhpB)
ELP : P12B_c0308(mhpB) P12B_c0366(mhpB)
KPM : KPHS_31030 KPHS_31040
REE : electrica_02136(mhpB)
RTG : NCTC13098_00845(mhpB_2)
SERA : Ser39006_017360(mhpB)
LRI : NCTC12151_03198(mhpB)
VIB : VspSTUT11_14700(mhpB)
MSHE : MAALD49_03490(mhpB)
ATN : FM020_09420 FM020_13935
ACIG : BS636_03555 BS636_11000(mhpB)
AQL : BXU06_16215 BXU06_17035(mhpB)
RPJ : N234_23040(mhpB) N234_34800(mhpB) N234_36990
BPSL : WS57_02985(mhpB) WS57_14600(mhpB)
BGE : BC1002_4116 BC1002_4723 BC1002_5803
PDIO : PDMSB3_0764.1(mhpB)
PANN : PanNE5_01400(mhpB_1) PanNE5_18670(mhpB_2)
BOJ : CBF45_02880(mhpB) CBF45_10070(mhpB) CBF45_12465
AXX : ERS451415_04169(mhpB)
AALN : Q3V95_01600 Q3V95_07630
PIG : EGT29_10730 EGT29_21780
KGY : EHF36_03290 EHF36_10470 EHF36_12695
SMIO : CATMQ487_25910(mhpB)
SPHT : K426_04870(mhpB) K426_12685(mhpB) K426_18710(mhpB)
SPHJ : BSL82_10995 BSL82_11320
NDT : L1999_03360 L1999_23255
MMAN : MMAN_43180(mhpB_1) MMAN_50360(mhpB_2)
MSER : MTY59_17710(mhpB) MTY59_26640(mhpB)
MSA : Mycsm_01986 Mycsm_04568
MMAE : MMARE11_46050(mhpB)
MXE : MYXE_09040(mhpB) MYXE_10040
MBAI : MB901379_04186(mhpB)
MHEK : JMUB5695_00881(mhpB_1) JMUB5695_00957(mhpB_2)
MPHL : MPHLCCUG_03810(mhpB)
MVQ : MYVA_4047(mhpB) MYVA_4677(pydA)
MTHN : 4412656_03104(mhpB)
MHAS : MHAS_02631(mhpB_1) MHAS_03118(mhpB_2)
MDU : MDUV_04260(mhpB_1) MDUV_30350(mhpB_2)
MAUU : NCTC10437_03988(mhpB)
MALV : MALV_21080(mhpB_1) MALV_51960(mhpB_2)
MBOK : MBOE_31240(mhpB_1) MBOE_58440(mhpB_2)
MFLV : NCTC10271_01473(mhpB)
MMON : EWR22_19465 EWR22_20725
NWL : NWFMUON74_27410(mhpB)
ROP : ROP_70940 ROP_pROB02-01950(nimB)
ROA : Pd630_LPD12024 Pd630_LPD12044
RPY : Y013_12695(mhpB) Y013_22370
RRT : 4535765_04590(mhpB_2)
RGO : KYT97_18205 KYT97_21290
ROZ : CBI38_30650(mhpB) CBI38_32800(mhpB)
RHOJ : JVH1_18975 JVH1_35295 JVH1_40475
REQ : REQ_30260 REQ_35200 REQ_43390
PDEF : P9209_05905 P9209_10945
PSOW : ABI214_15965 ABI214_20485
SKY : D0C37_00620 D0C37_31250
SGM : GCM10017557_70860(mhpB)
MCAW : F6J84_03015 F6J84_14895
AMAU : DSM26151_27930(mhpB)
ARX : ARZXY2_3586(mhpB) ARZXY2_4003(mhpB)
ARTQ : CGQ24_01970(mhpB) CGQ24_03850(mhpB)
ARZ : AUT26_01400 AUT26_19825(mhpB)
RAIN : Rai3103_02135 Rai3103_07640
NMAR : HPC71_03300 HPC71_13475
AMAZ : LUW76_33635 LUW76_45510 LUW76_45920
FRE : Franean1_2892 Franean1_4746
FRI : FraEuI1c_4094 FraEuI1c_5339
AMQ : AMETH_1850(mhpB) AMETH_2409(mhpB) AMETH_4604(mhpB)
AACD : LWP59_17050 LWP59_27085
PBRO : HOP40_05265 HOP40_17910 HOP40_22525 HOP40_33105 HOP40_33370
PPEL : H6H00_18710 H6H00_24660 H6H00_25985
MCRA : ID554_06965 ID554_07050
ACTR : Asp14428_11570(mhpB)
PSUU : Psuf_010520(mhpB_1) Psuf_074260(mhpB_2)
» show all
Taxonomy
Reference
Authors
Dagley S, Chapman PJ, Gibson DT.
Title
The metabolism of beta-phenylpropionic acid by an Achromobacter.
Journal
Reference
2
Authors
Lam W W Y, Bugg T D H.
Title
Chemistry of extradiol aromatic ring cleavage: isolation of a stable dienol ring fission intermediate and stereochemistry of its enzymatic hydrolytic clevage.
Journal
J Chem Soc, Chem Commun 10:1163-1164 (1994)
Reference
Authors
Diaz E, Ferrandez A, Garcia JL.
Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
Journal
Sequence
Other DBs
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.16
LinkDB
All DBs