KEGG ENZYME: 1.13.11.58

ENZYME: 1.13.11.58

Entry

EC 1.13.11.58               Enzyme

Name

linoleate 9S-lipoxygenase;
9-lipoxygenase;
9S-lipoxygenase;
linoleate 9-lipoxygenase;
LOX1 (gene name);
9S-LOX

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen

Sysname

linoleate:oxygen 9S-oxidoreductase

Reaction(IUBMB)

linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate [RN:R07057]

Reaction(KEGG)

R07057

Substrate

linoleate [CPD:C01595];
O2 [CPD:C00007]

Product

(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate [CPD:C14827]

Comment

Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C9 position with (S)-configuration. The enzyme plays a physiological role during the early stages of seedling growth. The enzyme from Arabidopsis thaliana shows comparable activity towards linoleate and linolenate [4]. EC 1.13.11.12 (linoleate 13S-lipoxygenase) catalyses a similar reaction at another position of these fatty acids.

History

EC 1.13.11.58 created 2011

Pathway

ec00591

Linoleic acid metabolism

Orthology

K15718

linoleate 9S-lipoxygenase

Genes

ATH:	AT1G55020(LOX1) AT3G22400(LOX5)

ALY:	9319428 9327996

CRB:	17893758 17894417

CSAT:

104701021 104715474 104746689 104746690 104750191 104758943 104766136 104787362 104787405

EUS:	EUTSA_v10020023mg EUTSA_v10023267mg

BRP:	103834572 103844546 103869043

BNA:	106352821 106376623 106388246 106433608 106433973 106453908

BOE:	106295789 106314534 106319746

RSZ:	108807444 108807735 108812350 108863125 130496708

THJ:	104801865 104806939 104820855 104823730 104825976

CPAP:

110814120 110814127 110815297 110817254 110817280 110819775

CIT:	102621545 102621914

CIC:	CICLE_v10000236mg CICLE_v10004281mg

PVY:	116118850 116130512

MINC:

123208387 123211895 123220058 123220698

TCC:	18600365 18600367 18600368 18600369 18600371 18602959

GRA:	105783043 105792522 105792525 105796638 105800512

GHI:	107893644 107894329 107894336 107899106 107919998 107927619 107928543 107944366 121206339

GAB:	108457463 108464242 108468954 108470002 108474786

HSYR:

120123922 120124693 120149585 120151377 120153657 120162137 120164026 120176098 120176099 120213824

DZI:	111277300 111277932 111277933 111280136 111293906 111295420 111307953

EGR:	104414852 104415560 104415561 104415562 104415563 104415564 104429569

GMX:	100101853(VLXB) 100127399(LOX9) 100127400(LOX10) 100782558 100789019 100800451 100802459 100802685 100802887 100803358 100815477 100815550 100816880 547694 547774(LOX2) 547835 547836(LOXB1) 547856(VLXC) 547860(LOX7) 547869(LOX3) 547923(LOX1.1)

GSJ:	114370204 114372569 114375008 114375009 114376278 114376458 114386328 114388361 114388668 114403306 114407603 114417913 114418141 114418142 114419180 114422277 114422278 114422279 114422280 114423939

PVU:

PHAVU_004G168400g PHAVU_005G156700g PHAVU_005G1568001 PHAVU_005G156900g PHAVU_005G157000g PHAVU_006G091400g PHAVU_007G055600g PHAVU_007G055800g PHAVU_007G179600g PHAVU_010G134700g PHAVU_010G134800g PHAVU_010G134900g PHAVU_010G135000g PHAVU_010G135300g PHAVU_010G135400g PHAVU_010G135500g PHAVU_010G135600g PHAVU_010G135700g PHAVU_010G135800g PHAVU_010G135900g

VRA:	106760770 106760780 106761927 106761928 106762003 106772236 106773082 106773083 106773084 106773085 106773086 106773087 106773712 106773713 106775016 106780386 106780387 111242517

VAR:	108320191 108320205 108320206 108320208 108320213 108320214 108323174 108323175 108323176 108323178 108323181 108323182 108324769 108326670 108332293 108334116 108334134 108334142 108334300 108341800 108345752

VUN:	114165654 114165656 114165728 114166339 114166341 114166734 114166735 114166737 114166739 114166740 114183038 114184324 114185546 114185686 114188176 114190244 114191620 114191794

VUM:	124820787 124821152 124823787 124823788 124823789 124823790 124823791 124823792 124823793 124823794 124823795 124823796 124823798 124823799 124834165 124843314 124846678 124847332 124847333

CCAJ:

109795363 109796222 109801924 109801925 109802085 109802609 109805652 109805653 109806359 109806596 109813937

APRC:

113849062 113849063 113850555 113850556 113850558 113854776 113856262 113863959 113873505 113873685

MTR:	11409882 11418914 11420242 11422014 11423969 11423970 11424335 11424336 11424965 11426409 11428618 11428623 11429451 11429452 11431430 11431756 11434044 11435017 11441966 25489617 25500504

TPRA:

123883099 123885375 123885379 123885380 123885383 123885384 123885386 123885387 123885388 123890910 123894106 123894107 123894877 123909569 123911177

CAM:	101490986 101491283 101491298 101491605 101491624 101491931 101495975 101496167 101502002 101502735

PSAT:

127076330 127076331 127076333 127076334 127076335 127076336 127076338 127076339 127076340 127076341 127076345 127080206 127087314 127087315 127092431 127098542 127120011 127132364 127138079

VVO:	131610596 131616237 131616238 131616239 131616240 131616241 131616242 131616244 131618083 131618084 131618085 131621893 131621894 131623268 131623270 131623271 131623362 131623363 131623364 131623365 131623366 131623367 131633907 131643460 131644090 131646723 131653921 131653922

LJA:	130717778 130718065 130731189 130746504 130746506 130746507 130746509 130746510 130746514 130746519 130748239 130749849

ADU:	107461392 107461394 107461395 107464433 107464479 107464749 107464753 107464854 107465391 107466861 107492121

AIP:	107612513 107613293 107617165 107617328 107617419 107617549 107617585 107617884 107617918 107645767 107645896

AHF:	112695520 112706546 112706548 112710190 112710191 112710462 112710463 112710465 112710832 112711806 112758131 112773062 112773063 112775199 112776097 112776420 112777366 112779426 112779892 112780083

LANG:

109329108 109333451 109334172 109342911 109345801 109346208 109346835 109347840 109347870 109347874 109351272 109356561

PCIN:

129287589 129287590 129288077 129288214 129288215 129288413 129289079 129291504 129296670 129299345 129305988 129309062 129318526 129319371

QSA:	O6P43_003382 O6P43_007512 O6P43_010085 O6P43_011110 O6P43_012103

FVE:	101293106 101293406 101301961 101311821

RCN:	112192081 112192269 112193452 112196194 112197257

PPER:

18773359 18774870 18774983 18774987 18775056 18788938

PMUM:

103324270 103344101 103344102 103344618 103344619 103344620 103344621 103344623 103344624

PAVI:

110759643 110759644 110759645 110759647 110759772 110762049

PDUL:

117630134 117631039 117631075 117631076 117631077 117631511 117631853

MDM:	103403905 103411221 103423655 103433945 103433947 103433949 103433950 103450936 103453113

MSYL:

126582618 126593283 126593284 126594423 126596572 126607012 126619021 126619022 126619024 126619025 126619026

PXB:	103935971 103955722 103955797 103956622 103965340 103965341 103965342 103965343 103965358 103965359 103965360 103965361

ZJU:	107411945 107412008 107412009 107423042

MNT:	21384383 21384679 21395587 21410719 21412472

CSAV:

115709296 115718693 115718785 115719336 115719608 115720291 115721132 115721268 115722275 115722276 115723988 115724062

CSV:	101206086 101206327 101207163 101207406 101207901 101208141 101211823 101215030(LOX9) 101222652 105434408 105434554(LOX2)

CMO:	103491403 103494836 103494845 103494856 103494864(LOX2) 103494874 103494895 103494902 103494917 103503184 103504417 127149413

BHJ:	120067292 120069352 120069357 120069359 120070059 120080124 120080250 120080269 120080303

MCHA:

111009757 111018834 111018836 111018837 111018853 111018861 111018866 111018876

CMAX:

111469465 111493488 111493533 111493534 111493535 111493536 111493537 111493538 111494274 111498962

CMOS:

111436857 111450285 111450334 111450335 111450336 111450337 111450392 111450394 111450815 111460083 111464693

CPEP:

111778601 111782626 111804709 111804710 111804711 111804712 111804713 111804714 111804715 111804811 111804812 111805572 111805573 111806989

RCU:	8258686 8261460 8285570

MEAN:

126669411 126673743

JCU:	105631969 105647535 105647755

HBR:	110632826 110644513 110659976 110668153 110673184

MESC:

110601518 110616996 110620937 110623462 110623720

POP:	18098779 18098781 18098782 7473290 7480575 7498088

PEU:	105123587 105125032 105125034 105126930 105134181 105134182

PALZ:

118045050 118045055 118046620 118055808 118060796 118060797

PNZ:	133670007 133670089 133694522 133694524 133695118 133697971 133704413

JRE:	109005853 109008077 109008078 109009742 109009743 109010446

CILL:

122275176 122300549 122314898 122314899 122318427 122318428

CAVE:

132169987 132170277 132170278 132190053 132191407

QSU:	111995669 112037399 112037400 136062412

QLO:	115979595 115979596 115979598 115981619 115981620 115981969 115993804

TWL:	120009577 120013468

VVI:	100232917(LOX) 100251097 100252850

VRI:	117914704 117929787 117929788

SLY:	101244618 101256707 101257007 101263535 101266174 107648852 543818(TomloxE) 543994(LOX1.1) 543997(LOXB)

SPEN:

107007908 107014742 107014961 107025579 107027197 107028818 107031569

SOT:	102577615 102577714(POTLX-3) 102589305 102590288 102590626 102590972 102593728 102594942 102598541(LOX1) 102602192(LOX1) 102602528(LOX) 102603362

SSTN:

125842138 125842153 125842182 125842227 125853100 125853292 125871422 125871423 125876895 125876904 125876920 125876929 125876961

SDUL:

129881808 129882996 129886182 129886183 129888735 129888736 129888963 129900524

CANN:

107839570 107847934 107854880 107854882 107864114 107864538 107865522 107876113 107879335 107879336

LBB:	132603936 132603939 132609097 132609108 132609411 132610720 132645915 132645916 132645917 132645918 132645919 132645920

NTA:	107760301 107761738 107763327 107763616 107770253(LOX) 107784700 107803018 107806322(Lox1) 107806327 107820148 107821968 107822679 107830098 107830099

NSY:	104215707 104224166 104224167 104224294 104228802 104235514 104238212

NTO:	104093558 104104499 104113268 104116625 104116626 104116823 104116824

NAU:	109208420 109211626 109211630 109211631 109214964 109217855 109235566 109240031

INI:	109165994 109181728 109181729 109181753 109182100

ITR:	116005581 116006926 116007679 116016833

SIND:

105168907 105171355 105172350

OEU:	111368968 111386480 111388392 111410046

EGT:	105952561 105953334 105970234

SSPL:

121749206 121774707 121775098 121777182 121777325 121777757 121783783 121792334 121795868 121808600

SMIL:

130991503 130991504 130996920 131008914

SHIS:

125192970 125196667 125197298 125200846 125201156 125201157 125221936 125224437

APAN:

127247809 127249270 127260716 127260905 127262173

HAN:	110885238 110890392 110890395 110890467 110929179 110929318 110937517

ECAD:

122583170 122591252 122594113 122594164 122594977 122596863 122602264

LSV:	111878912 111878925 111884545 111890758 111895776 111895782 111895793

CCAV:

112499841 112500096 112503534 112504390 112505089 112516522

DCR:	108199891 108200212 108203125 108206848 108225558

CSIN:

114258339 114259967 114261869 114287060

RVL:	131310168 131321654 131334424 131334425

AEW:	130764394 130771819 130782963 130783954 130794664 130794665

BVG:	104884450 104890828 104890829 104890831 104890834

SOE:	110791738 110791739 110791741 110791742 110799291

CQI:	110685047 110708631 110708632 110708633 110708634 110713336 110736902 110736903 110736904 110736905

ATRI:

130796711 130796721 130796829 130817661 130825162

MOF:	131152011 131152685 131152686 131152695

NNU:	104596509 104611974

MING:

122071222 122071238 122077795 122079067 122091235

TSS:	122642514 122642515 122642516 122664805 122664813 122668787

PSOM:

113277899 113277907 113278788 113290221 113290293 113303475 113304704 113316453 113345387 113347840 113348965 113350553 113355139

OSA:	4333818(LOX3) 4333821(LOX4) 4333823(LOX5) 4334049(LOX1.1) 4350766

OBR:	102699485 102710961 102722753 102723035

OGL:	127766496 127768470 127768471 127768645

BDI:	100821461 100831787 100833634 100845752

ATS:	109751942 109755494 109765406 109766078 109767522 109774264 109781224 109781225 109787375

TDC:	119286965 119292455 119294745 119294746 119303063 119303065 119303066 119303067 119311742 119311743 119311744 119311745 119311747 119311748 119311749 119322730 119344048 119356912 119366161

TAES:

100313965 100313966 100682480 123047197 123055004 123056064 123056066 123067109 123072903 123090789 123090791 123095797 123095798 123104947 123104949 123104951 123104952 123113250 123113251 123122756 123122758 123123631 123132351 123132353 123136398 123190851

TUA:	125510538 125510543 125510544 125515877 125515882 125516594 125540143 125550427 125553004

LPER:

127292961 127293303 127293305 127308238 127308239 127308240 127308250

LRD:	124691233 124691738 124700529 124700530 124703965 124703966 124703967

SBI:	110431916 8056098 8063420 8064218 8070256 8078665

ZMA:	100037802(lox2) 100037803(lox4) 100037804(lox5) 100037805(lox6) 541856(lox1) 542495(lox3)

MFLO:

136456940 136520060 136520071 136520081 136521433 136521443 136538394 136539321 136549863 136549946

SITA:

101755932 101756871 101757274 101757730 101758142 101779081

SVS:	117836611 117837112 117837920 117838364 117854454 117855018

PVIR:

120650087 120650088 120693127

PHAI:

112873951 112877880 112877881 112893939

PDA:	103697518 103715746 120109566

EGU:	105032459 105054692 105055039

MUS:	103974527 103974528 103989036 103989037 103989775 103989776 103990202 103996519 103998404

ZOF:	121971742 121975911 122002246 122002247 122002248 122002251 122006508 122006509 122006510 122006513 122006514

DCT:	110096882 110107728 110108000 110108011 110111010

PEQ:	110018528 110020829 110024558 110031792

AOF:	109819934 109820941 109822273 109822383 109826305 109834563 109834564 109851469 109851585

MSIN:

131222595 131222597

NCOL:

116246452 116248359 116262776 116263617

ATR:	18428895 18439893

SMO:	SELMODRAFT_109226(LOX9) SELMODRAFT_112468(LOX14) SELMODRAFT_112556(LOX2) SELMODRAFT_170977 SELMODRAFT_178158(LOX1) SELMODRAFT_178856(LOX6) SELMODRAFT_234610 SELMODRAFT_439120(LOX10) SELMODRAFT_439121(LOX11) SELMODRAFT_446634 SELMODRAFT_446635

PPP:	112282145 112288202 112291149 112291557 112294414

CRE:	CHLRE_12g512300v5

VCN:	VOLCADRAFT_105416 VOLCADRAFT_97557 VOLCADRAFT_97558

» show all

Reference

1 [PMID:17369372]

Authors

Vellosillo T, Martinez M, Lopez MA, Vicente J, Cascon T, Dolan L, Hamberg M, Castresana C

Title

Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade.

Journal

Plant Cell 19:831-46 (2007)
DOI:10.1105/tpc.106.046052

Sequence

[ath:AT1G55020 AT3G22400]

Reference

2 [PMID:18795358]

Authors

Boeglin WE, Itoh A, Zheng Y, Coffa G, Howe GA, Brash AR

Title

Investigation of substrate binding and product stereochemistry issues in two linoleate 9-lipoxygenases.

Journal

Lipids 43:979-87 (2008)
DOI:10.1007/s11745-008-3230-1