KEGG ENZYME: 1.13.11.66

ENZYME: 1.13.11.66

Entry

EC 1.13.11.66               Enzyme

Name

hydroquinone 1,2-dioxygenase;
hydroquinone dioxygenase;
benzene-1,4-diol:oxygen 1,2-oxidoreductase (decyclizing)

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen

Sysname

benzene-1,4-diol:oxygen 1,2-oxidoreductase (ring-opening)

Reaction(IUBMB)

benzene-1,4-diol + O2 = (2Z,4E)-4-hydroxy-6-oxohexa-2,4-dienoate [RN:R05246]

Reaction(KEGG)

R05246

Substrate

benzene-1,4-diol [CPD:C00530];
O2 [CPD:C00007]

Product

(2Z,4E)-4-hydroxy-6-oxohexa-2,4-dienoate

Comment

The enzyme is an extradiol-type dioxygenase, and is a member of the nonheme-iron(II)-dependent dioxygenase family. It catalyses the ring cleavage of a wide range of hydroquinone substrates to produce the corresponding 4-hydroxymuconic semialdehydes.

History

EC 1.13.11.66 created 2012

Pathway

ec00361

Chlorocyclohexane and chlorobenzene degradation

ec01120

Microbial metabolism in diverse environments

Orthology

K15240

hydroquinone 1,2-dioxygenase

Genes

SINA:

KNJ79_19535 KNJ79_19710(linE)

SPHM:

G432_21695

SJP:	SJA_P1-01430(linE)

SINB:

SIDU_18535

SPMI:

K663_19943 K663_22998

SPHT:

K426_30065

Reference

1 [PMID:10542173]

Authors

Miyauchi K, Adachi Y, Nagata Y, Takagi M

Title

Cloning and sequencing of a novel meta-cleavage dioxygenase gene whose product is involved in degradation of gamma-hexachlorocyclohexane in Sphingomonas paucimobilis.

Journal

J Bacteriol 181:6712-9 (1999)
DOI:10.1128/JB.181.21.6712-6719.1999

Sequence

[sjp:SJA_P1-01430]

Reference

2 [PMID:18502867]

Authors

Moonen MJ, Synowsky SA, van den Berg WA, Westphal AH, Heck AJ, van den Heuvel RH, Fraaije MW, van Berkel WJ

Title

Hydroquinone dioxygenase from pseudomonas fluorescens ACB: a novel member of the family of nonheme-iron(II)-dependent dioxygenases.

Journal

J Bacteriol 190:5199-209 (2008)
DOI:10.1128/JB.01945-07