KEGG   ENZYME: 1.13.11.8
Entry
EC 1.13.11.8                Enzyme                                 

Name
protocatechuate 4,5-dioxygenase;
protocatechuate 4,5-oxygenase;
protocatechuic 4,5-dioxygenase;
protocatechuic 4,5-oxygenase;
protocatechuate:oxygen 4,5-oxidoreductase (decyclizing);
protocatechuate:oxygen 4,5-oxidoreductase (ring-opening)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
3,4-dihydroxybenzoate:oxygen 4,5-oxidoreductase (ring-opening)
Reaction(IUBMB)
3,4-dihydroxybenzoate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde [RN:R01632]
Reaction(KEGG)
R01632;
(other) R03550 R04280 R09272 R09565
Substrate
3,4-dihydroxybenzoate [CPD:C00230];
O2 [CPD:C00007]
Product
4-carboxy-2-hydroxymuconate semialdehyde [CPD:C04484]
Comment
Requires Fe2+.
History
EC 1.13.11.8 created 1965 as EC 1.13.1.8, transferred 1972 to EC 1.13.11.8
Pathway
ec00362  Benzoate degradation
ec00624  Polycyclic aromatic hydrocarbon degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04100  protocatechuate 4,5-dioxygenase, alpha chain
K04101  protocatechuate 4,5-dioxygenase, beta chain
Genes
VNA: PN96_18545 PN96_18550
VEJ: VEJY3_18111 VEJY3_18116
VFL: AL536_10310 AL536_10315
PVR: PverR02_14345
AVN: Avin_42210
AVL: AvCA_42210
AVD: AvCA6_42210
EMO: DM558_04785 DM558_04790(ligA)
PAT: Patl_3885 Patl_3886
PCAR: PC2016_2100 PC2016_2101
RFO: REIFOR_00545(ligA) REIFOR_00546(ligB)
KKI: KKKWG1_0313(ligB)
PPUL: RO07_25060
HYF: DTO96_100892(ligA_1) DTO96_100893(ligB)
AFQ: AFA_05515 AFA_05520(ligA)
LIM: L103DPR2_01497(ligA_1) L103DPR2_01498(ligB_1) L103DPR2_01514(ligA_2) L103DPR2_01515(ligB_2)
LIH: L63ED372_01144(ligA_1) L63ED372_01145(ligB)
HPSE: HPF_08080(ligA1) HPF_08085(ligB1) HPF_08185(ligA2) HPF_08190(ligB2)
DAR: Daro_3248
AZO: azo2522(ligB1) azo2523(ligA1) azo2537(ligB2) azo2538(ligA2)
AVP: AVENP_2164(ligB) AVENP_2165(ligD)
BRA: BRADO2341(ligA) BRADO2342(ligB) BRADO2379 BRADO2380(mhpB)
BBT: BBta_2701(ligA) BBta_2702(ligB) BBta_2733 BBta_2734(mhpB)
BRO: BRAD285_4958(ligB) BRAD285_4959(ligA) BRAD285_4995(ligB) BRAD285_4996(ligA)
RPA: RPA1006 RPA1007(mhpB) RPA4701(ligA) RPA4702(ligB)
MMED: Mame_04593(ligB)
SPHR: BSY17_3446(ligB) BSY17_3447(ligA)
BLAS: BSY18_3523(ligA) BSY18_3524(ligB)
AAY: WYH_01045(ligB_1) WYH_01046(ligA_2) WYH_01908(ligA_3) WYH_01909(ligB_2) WYH_03214(ligB_3) WYH_03215(ligA_4)
ADO: A6F68_01079(ligB) A6F68_01080(ligA_1)
MAGX: XM1_1094 XM1_1095(ligB)
TMO: TMO_b0115(mhpB)
MAGQ: MGMAQ_2661(ligB) MGMAQ_2662(ligA) MGMAQ_2669(ligA) MGMAQ_2670(ligB)
AUW: AURUGA1_00419(ligA_1) AURUGA1_00420(ligB)
NML: Namu_0046
BSD: BLASA_2598(ligA) BLASA_2599(ligB)
MMAR: MODMU_2843(ligB) MODMU_2844(ligA) MODMU_3384
PSEA: WY02_25080
PAUT: Pdca_48140(pcaH_2) Pdca_48150
ACTN: L083_0820
AFS: AFR_03865
PFLA: Pflav_029930 Pflav_029940(pcaH_1)
AFO: Afer_2021
 » show all
Reference
1
  Authors
Trippett, S., Dagley, S. and Stopher, D.A.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
Biochem J 76:9 (1960)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.8
IUBMB Enzyme Nomenclature: 1.13.11.8
ExPASy - ENZYME nomenclature database: 1.13.11.8
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.8
BRENDA, the Enzyme Database: 1.13.11.8
CAS: 9029-56-5
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