Entry
Name
7,8-dihydroneopterin oxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
7,8-dihydroneopterin:oxygen oxidoreductase
Reaction(IUBMB)
7,8-dihydroneopterin + O2 = 7,8-dihydroxanthopterin + formate + glycolaldehyde [RN:
R11037 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme from the bacterium Mycobacterium tuberculosis is multifunctional and also catalyses the epimerisation of the 2'-hydroxy group of 7,8-dihydroneopterin (EC
5.1.99.8 , 7,8-dihydroneopterin epimerase) and the reaction of EC
4.1.2.25 (dihydroneopterin aldolase).
History
EC 1.13.11.81 created 2015
Pathway
Orthology
K01633 7,8-dihydroneopterin aldolase/epimerase/oxygenase
Genes
ATH : AT3G11750(FOLB1) AT3G21730(FOLB3) AT5G62980(FOLB2)
ALY : 9302599 9320929 9321529
CSAT : 104740587 104745381 104746607 104762434 104764933 104766075 104775828 104786784
EUS : EUTSA_v10005125mg EUTSA_v10021697mg
BRP : 103846016 103870313 103870314
BNA : 106345503 106351230 106411792 106411793 106450405
RSZ : 108809185 108861666 108862899 130501094
MINC : 123226697 123227225
GHI : 107898920 107918176 107921273 107949127
HSYR : 120113742 120128731 120153847
GMX : 100500602 100526908 100527653 100792326
GSJ : 114399768 114407281 114418415
VRA : 106756013 106757127 106773925 106777055
VAR : 108321590 108327013 108336984
VUM : 124825504 124825505 124841052 124845584
CCAJ : 109802661 109808367
APRC : 113859163 113863130
MTR : 11418039 25499506 25499508
PSAT : 127084958 127125516
LJA : 130724423 130724439 130726950
AIP : 107623191 107626311 107638443
AHF : 112718364 112728720 112740996 112757415 112782908
QSA : O6P43_005739 O6P43_009391
MSYL : 126594400 126600833
MEAN : 126676531 126676532
QSU : 111997472 112012018 112014057 136068729
QLO : 115953550 115962697 115976736
SDUL : 129870616 129877472
CANN : 107843858 107869989
NSY : 104215758 104227093 104235873
INI : 109148703 109181352 109193553
SSPL : 121755797 121759060
APAN : 127255243 127266222
ECAD : 122588472 122597282
CQI : 110683547 110688187 110711108
PSOM : 113304189 113313814 113314003 113344741 113344744 113353313
OSA : 4340171 4346285 4347851
DOSA : Os06g0154600 Os08g0556200 Os09g0560500
OGL : 127778019 127781316 127784362
TDC : 119318347 119331376 119338003 119360796
TAES : 123105831 123152667 123157917 123168132 123180060 542903
MFLO : 136473024 136477015 136501707 136542281 136550132
SITA : 101767252 101773590
PVIR : 120658425 120678392 120687102 120713818
PHAI : 112882041 112897079
PAUA : 133895974 133897913 133899119 133902247
ZOF : 121992192 122000612 122004904 122039019
SMO : SELMODRAFT_234163 SELMODRAFT_84592
EHX : EMIHUDRAFT_351975 EMIHUDRAFT_372344
ECOO : ECRM13514_3953(folB)
ECOH : ECRM13516_3821(folB)
ELR : ECO55CA74_18020(folB)
ECW : EcE24377A_3521(folB)
ECOA : APECO78_19100(folB)
EDJ : ECDH1ME8569_2955(folB)
ECOI : ECOPMV1_03375(folB)
SEM : STMDT12_C32640(folB)
SETC : CFSAN001921_00980(folB)
SEEN : SE451236_22155(folB)
SENH : CFSAN002069_16110(folB)
SEEH : SEEH1578_02175(folB)
SENJ : CFSAN001992_17505(folB)
SEEC : CFSAN002050_23015(folB)
SEEB : SEEB0189_003840(folB)
SENC : SEET0819_23040(folB)
REE : electrica_00623(folB)
RTG : NCTC13098_00877(folB)
RIP : RIEPE_0582(folB1) RIEPE_0592(folB2)
RIG : AOQ88_02205 AOQ88_02245
CLAP : NCTC11466_03969(folB)
KIE : NCTC12125_04556(folB)
BAGE : BADSM9389_35440(folB)
AHN : NCTC12129_00800(folB)
METY : MRY16398_07210(ygiG)
PSHI : SAMEA2665130_0456(folB)
MPHG : MPHASIOC01_003525(folB)
YPG : YpAngola_A0298(folB)
YPI : YpsIP31758_0558(folB)
SMW : SMWW4_v1c42190(folB)
SERS : SERRSCBI_20510(folB)
SFJ : SAMEA4384070_4258(folB)
SOF : NCTC11214_02388(folB)
SSAR : SSARUM_004115(folB)
SERA : Ser39006_007150(folB)
PAQU : DMB82_0004390(folB)
PARL : PEC302110_31760(folB)
DIC : Dpoa569_000764(folB)
EHD : ERCIPSTX3056_303(folB)
TPTY : NCTC11468_00586(folB)
PHEI : NCTC12003_03132(folB)
PRJ : NCTC6933_03235(folB)
LRI : NCTC12151_02792(folB)
HIC : NTHIC486_00728(folB)
HPIT : NCTC13334_00219(folB)
HHZ : NCTC10839_00240(folB)
HAEG : NCTC8502_00960(folB)
PDAG : 4362423_02056(folB)
ADP : NCTC12871_01098(folB)
ALIG : NCTC10568_01665(folB)
ASEG : NCTC10977_00875(folB)
AVT : NCTC3438_00180(folB)
RPNE : NCTC8284_01004(folB)
PAET : NCTC13378_01872(folB)
XFU : XFF4834R_chr37590(folB)
XPH : XppCFBP6546_15045(folB)
XHD : LMG31886_40080(folB)
STEK : AXG53_08325 AXG53_16315
LLZ : LYB30171_00300(folB)
VAU : VANGNB10_cI0430(folB)
VPL : SA104470976_02203(folB)
PAEB : NCGM1900_0597(folB)
PPRC : PFLCHA0_c56110(folB)
PFC : PflA506_4887(folB_2)
PMUD : NCTC8068_04860(folB)
PFW : PF1751_v1c50120(folB)
PFF : PFLUOLIPICF710935(folB)
PPUU : PputUW4_04947(folB)
PTRT : HU722_0026950(folB)
PTAE : NCTC10697_00448(folB)
PSYC : DABAL43B_1616(folB)
MCAT : MC25239_00894(folB)
MCUN : NCTC10297_01607(folB)
SCAA : TUM17387_10820(folB)
PLZ : S4054249_04815(folB)
SALH : HMF8227_00601(folB)
CBS : COXBURSA331_A0116(folB)
LLG : 44548918_00550(folB)
LJR : NCTC11533_00600(folB)
LCJ : NCTC11976_03053(folB)
LWA : SAMEA4504053_2276(folB)
LSS : NCTC12082_02747(folB)
LADL : NCTC12735_01440(folB)
MISZ : MishRS11D_37700(folB)
THIO : AYJ59_03160 AYJ59_04130
TIB : THMIRHAM_18680(folB)
TZO : THMIRHAT_05530(folB)
BLEP : AL038_04830(folB) AL038_15180(folB)
TFRI : Thiofri_02400(folB)
TNI : TVNIR_0431(folB_[H])
GAI : IMCC3135_05315(folB)
THIC : TspCOW1_22970(folB)
HAAH : HALA3H3_680016(folB)
HTT : HZS52_07680 HZS52_11245(folB)
HAXI : HAALTHF_22600n(folB)
COBE : CLAM6_30480(folB-1)
ALCA : ASALC70_03214(folB)
AEL : NCTC12917_03747(folB)
CHJ : NCTC10426_02171(folB)
CDIZ : CEDIAZO_03032(folB)
NMM : NMBM01240149_1053(folB)
NMS : NMBM01240355_1033(folB)
NMQ : NMBM04240196_1100(folB)
NMZ : NMBNZ0533_1086(folB)
NMX : NMA510612_1402(folB)
NWE : SAMEA3174300_0640(folB)
NZO : SAMEA4504057_1865(folB)
NCI : NCTC10296_01928(folB)
NCZ : NCTC10294_00779(folB)
NANI : NCTC12227_00612(folB)
ECOR : SAMEA4412678_1368(folB)
RSO : RSc0157 RSc1105(folB2) RSp0050(folB1)
RPU : CDC45_00795 CDC45_05665 CDC45_17830
RNC : GO999_10950 GO999_15890
RSM : CMR15_20223 CMR15_30754
REU : Reut_A0226 Reut_B4826
COX : E0W60_11865 E0W60_31945
CUK : KB879_01215 KB879_15065
CUPP : CTP10_R01990 CTP10_R72690
BMA : BMA3382(folB) BMAA0894
BMV : BMASAVP1_0487 BMASAVP1_A3055(folB)
BML : BMA10229_0163 BMA10229_A2038(folB)
BMN : BMA10247_2246(folB) BMA10247_A1447
BMAZ : BM44_1004 BM44_4513
BMAE : DM78_2872 DM78_3509
BMAI : DM57_08820 DM57_2142
BMAF : DM51_2971 DM51_4586
BPS : BPSL0315 BPSS1365(folB)
BPM : BURPS1710b_0520(folB) BURPS1710b_A0391
BPL : BURPS1106A_0341(folB) BURPS1106A_A1858(folB)
BPD : BURPS668_0328(folB) BURPS668_A1950(folB)
BPR : GBP346_A0247(folB_1)
BPZ : BP1026B_I3193 BP1026B_II1454(folB)
BPQ : BPC006_I0324 BPC006_II1841
BTE : BTH_I0291 BTH_II1000
BTHA : DR62_1488 DR62_3909
BUU : WS70_15875 WS70_24625
BSAV : WS86_17500 WS86_26095
BHG : I6G56_03025 I6G56_21105
BUD : AQ610_17100 AQ610_23880
BVI : Bcep1808_3067 Bcep1808_3455 Bcep1808_7298
BUR : Bcep18194_A6328 Bcep18194_B0490
BCM : Bcenmc03_2999 Bcenmc03_5132
BCH : Bcen2424_2979 Bcen2424_5147
BCJ : BCAL0614 BCAM2387(folB)
BCEN : DM39_3074 DM39_5460
BCEO : I35_3054 I35_6283(folB)
BAC : BamMC406_2889 BamMC406_5065
BMJ : BMULJ_00259(folB) BMULJ_05009(folB)
BMUL : NP80_3101 NP80_5027
BCED : DM42_2030 DM42_5601
BCEP : APZ15_02805 APZ15_22340
BPYR : ABD05_04930 ABD05_23720
BCON : NL30_00505 NL30_27985
BDF : WI26_14370 WI26_24705
BLAT : WK25_14425 WK25_27830
BTEI : WS51_08900 WS51_25220
BSEM : WJ12_14945 WJ12_31870
BPSL : WS57_02190 WS57_33695
BMEC : WJ16_15120 WJ16_30395
BSTG : WT74_15720 WT74_30745
BSTL : BBJ41_13710 BBJ41_25825
BANN : JFN94_15235 JFN94_29780
BARI : NLX30_17135 NLX30_25270
BAEN : L3V59_17035 L3V59_26655
BSER : R0290_15385 R0290_18545
BGL : bglu_1g32760 bglu_2g05030
BUG : BC1001_3333 BC1001_3953
BGF : BC1003_3294 BC1003_5450
BGD : bgla_1g36690 bgla_2g06690
BYI : BYI23_A025580 BYI23_B012760 BYI23_B014420
BUE : BRPE67_ACDS26030 BRPE67_BCDS01400 BRPE67_BCDS16570
BUQ : AC233_16980 AC233_22050
BGP : BGL_1c34560 BGL_2c06440
BPLA : bpln_1g33520 bpln_2g07120
BUM : AXG89_05025 AXG89_19670
BUI : AX768_14955 AX768_29435
BURK : DM992_04955 DM992_23470
BURT : BTHE68_24090(folB) BTHE68_26740 BTHE68_38480
BURM : GJG85_15785 GJG85_23030
BPH : Bphy_2893 Bphy_3329 Bphy_5943 Bphy_6489
BGE : BC1002_2950 BC1002_3218
BPX : BUPH_00537 BUPH_03688
BCAI : K788_0001559 K788_0007187 K788_0008485 K788_0008562
PSPW : BJG93_13680 BJG93_19420
PARA : BTO02_19645 BTO02_24100
PARB : CJU94_06390 CJU94_31170
PHS : C2L64_17200 C2L64_21800 C2L64_27255 C2L64_38270
PTER : C2L65_15035 C2L65_21235 C2L65_26195 C2L65_34265
PGP : CUJ91_16910 CUJ91_21475
PTS : CUJ90_17085 CUJ90_28045
PMEG : FNZ07_10100 FNZ07_32275
PTRO : G5S35_13715 G5S35_22650
PGIS : I6I06_12425 I6I06_22490
PACP : FAZ97_13450 FAZ97_18300(folB) FAZ97_18750
PEW : KZJ38_02410 KZJ38_25845
PDIO : PDMSB3_0624.1 PDMSB3_4148
PSAA : QEN71_08060 QEN71_28595 QEN71_32795 QEN71_34070
PKF : RW095_18780 RW095_34155
PPAI : E1956_03930 E1956_20470 E1956_31565
PHUN : U0042_02335 U0042_18220
PLAD : PPGU16_30560(folB) PPGU16_34160 PPGU16_69600
PAZZ : PBP221_30910 PBP221_42820 PBP221_72120
POLT : TUM22923_17350(folB)
PLG : NCTC10937_04947(folB)
LMIR : NCTC12852_01447(folB)
CABA : SBC2_34230 SBC2_55150
BUO : BRPE64_ACDS26570 BRPE64_BCDS01540 BRPE64_BCDS13920
CABK : NK8_26630 NK8_29580 NK8_41380
VTR : MYVALT_G_00040(folB)
TVL : FAZ95_20905 FAZ95_30265
TCAR : U0034_11110 U0034_17505
BTRM : SAMEA390648700942(folB)
AXX : ERS451415_00375(folB)
ACHR : C2U31_06790(folB) C2U31_15420
ODH : DHf2319_10610 DHf2319_12570
RAC : RA876_03415 RA876_03420
RMK : RAN89_18105 RAN89_18110
ATEM : PQV96_07045 PQV96_17915
ACIQ : ACDW_06570 ACDW_06580
VAP : Vapar_0975 Vapar_3078
VPD : VAPA_1c10290 VAPA_1c31420(folB)
CTES : O987_22170 O987_25425
CSER : CCO03_18345 CCO03_18350
COF : FOZ74_09185 FOZ74_09190
CTEZ : CT3_37010(folB) CT3_37020
AANT : HUK68_01785 HUK68_01790
CENP : M9799_10140 M9799_10145
ADN : Alide_0592 Alide_0593
ADK : Alide2_0557 Alide2_0558
LIH : L63ED372_00356 L63ED372_00357(folB)
LIMI : LINBF2_02860(folB_1) LINBF2_02870(folB_2)
HYN : F9K07_04645 F9K07_04650
DLS : P4826_10315 P4826_10320
DIA : Dtpsy_0506 Dtpsy_0507
SIMP : C6571_09705 C6571_09710
CBAA : SRAA_1751(folB) SRAA_1752
METP : C1M51_11880 C1M51_15075
RGE : RGE_04840(folB) RGE_40290(folB)
SNN : EWH46_00680 EWH46_16940
SMIO : CATMQ487_07590(folB) CATMQ487_35710
ATER : MW290_07965 MW290_30225
CFU : CFU_0378(folB) CFU_3078(folB2)
CARE : LT85_0370 LT85_1488
CPRA : CPter91_0454 CPter91_1439
GLC : JQN73_09790 JQN73_15275
AON : DEH84_02560 DEH84_18980
TSW : VA613_06575 VA613_12680
NIM : W01_00950(folB) W01_20630
NARC : NTG6680_1467 NTG6680_2937(folB)
SPLB : SFPGR_03140 SFPGR_06580(folB)
URU : DSM104443_03876(folB)
UPL : DSM104440_03438(folB)
APET : ToN1_10600(folB1) ToN1_42550 ToN1_45170(folB2) ToN1_49890
DEY : HYN24_02270 HYN24_05755
DDEN : KI615_09235 KI615_18545
DECH : GBK02_04695 GBK02_12130
QAU : KI612_13480 KI612_17455
FLE : KI610_09215 KI610_17085
AHV : AADV58_05180 AADV58_08155
AZA : AZKH_1265(folB) AZKH_p0180 AZKH_p0269
AZI : AzCIB_1174 AzCIB_2128 AzCIB_3223
AZD : CDA09_03210 CDA09_03700 CDA09_11285 CDA09_11335
THU : AC731_004860 AC731_010660
THAU : C4PIVTH_2212 C4PIVTH_3701
THK : CCZ27_03005 CCZ27_13235
THAG : CKCBHOJB_00443(folB_1) CKCBHOJB_02578(folB_2) CKCBHOJB_02945(folB_3)
AZQ : G3580_05285(folB) G3580_15735
ACOM : CEW83_16680(folB) CEW83_16750(folB) CEW83_20260
DDZ : DSYM_03750 DSYM_25880
ERU : Erum4080(possible_folB)
MAM : Mesau_02871 Mesau_03912
MESU : LHFGNBLO_004162(folB)
KMN : HW532_00140 HW532_17120(folB)
RBS : RHODOSMS8_02028(folB)
SMEL : SM2011_c00463(folB)
SFD : USDA257_c40860(folB)
SAME : SAMCFNEI73_Ch2038(folB)
AGR : AGROH133_05805(folB)
ALF : CFBP5473_08705(folB)
AVF : RvVAR031_19810(folB)
ASAL : CFBP5507_05170(folB)
RPUS : CFBP5875_05655(folB)
ALEG : CFBP4996_05135(folB)
REC : RHECIAT_CH0002433(folB)
REL : REMIM1_CH02346(folB)
REP : IE4803_CH02377(folB)
REI : IE4771_CH02464(folB)
RTR : RTCIAT899_CH10000(folB)
RGA : RGR602_CH02124(folB)
RPHA : AMC79_CH02463(folB)
RLW : RlegWSM1455_11010(folB)
RBW : RLCC275e_11180(folB)
NEN : NCHU2750_17420(folB)
BIO : BR141012304_11634(folB)
BSEP : HAP48_0031205(folB) HAP48_0031830(folB)
BCAN : BcanWSM471_14575(folB)
VGO : GJW-30_1_03836(folB)
MAQU : Maq22A_c05245(folB)
MMES : MMSR116_16600(folB)
MLD : U0023_22430(folB) U0023_25655(folB) U0023_27775(folB)
CMET : K6K41_06050(folB) K6K41_25445(folB)
BSB : Bresu_0919 Bresu_2112
BVY : NCTC9239_00388(folB)
BPON : IFE19_02290 IFE19_02305(folB)
BBUL : U0030_12615(folB) U0030_12630
TSV : DSM104635_03160 DSM104635_03162
RFU : ROLI_008610 ROLI_029950
CEH : CEW89_07745 CEW89_15835(folB)
CBAK : DA792_01640(folB) DA792_11685
PLCG : RVY76_04815 RVY76_07600
MANH : LA6_001532 LA6_005529
CBOT : ATE48_14310 ATE48_14320
NDR : HT578_07795 HT578_11755
SPHD : HY78_00760 HY78_27350
RDI : CMV14_03825 CMV14_11575
STAX : MC45_08675 MC45_11620
SPHI : TS85_11945 TS85_14205
SSAN : NX02_15655 NX02_28615
SNJ : A7E77_00735 A7E77_02065 A7E77_02340
SMY : BJP26_09745 BJP26_11080 BJP26_11345
SPAN : AWL63_16835 AWL63_20860
SKR : BRX40_07535 BRX40_18565
SPLK : AV944_05490 AV944_14225
SPHF : DM480_01415 DM480_13110
SPAU : DRN02_000870(folB) DRN02_017235 DRN02_017605
SPAP : H3Z74_05640 H3Z74_06825
SPAI : FPZ24_07680 FPZ24_10170
SARI : H5J25_11265 H5J25_12380
SSUA : FPZ54_00135 FPZ54_11600
SAER : NEF64_06840 NEF64_14360
SSAG : KV697_05465 KV697_16395 KV697_17885(folB)
SAAP : E2E30_07765 E2E30_11255
SUFL : FIL70_03560 FIL70_20915
SBAR : H5V43_04525 H5V43_17565
SAMI : SAMIE_1005610 SAMIE_1012510
SPAG : sphantq_03656 sphantq_03758
SPCA : GL174_04225 GL174_14735 GL174_14785
SPHJ : BSL82_02660 BSL82_15400
SPZR : G5C33_08990 G5C33_15225
ALTC : P7228_00535 P7228_15370
AZL : AZL_a09600 AZL_c01880 AZL_d02340
ALI : AZOLI_p10708 AZOLI_p10900 AZOLI_p40330
ABS : AZOBR_p110122 AZOBR_p1130124 AZOBR_p270016 AZOBR_p270101
ABQ : ABAZ39_16190 ABAZ39_17030 ABAZ39_22140 ABAZ39_25375
ABF : AMK58_17140 AMK58_19365 AMK58_22425
ATI : AL072_22475 AL072_25095 AL072_26970
AHU : A6A40_18515 A6A40_27015 A6A40_28805
AZT : TSH58p_01110 TSH58p_27970
AZM : DM194_17190 DM194_22610
AOZ : HUE56_04640 HUE56_08965 HUE56_27830
AARE : D3093_18150 D3093_25055
AZS : E6C72_17115 E6C72_18290 E6C72_22350 E6C72_27180
AZP : E6C67_01605 E6C67_07285 E6C67_12630 E6C67_18265 E6C67_20420
NAO : Y958_11145(folB) Y958_28915(folB)
NCB : C0V82_07260 C0V82_10205
ACRU : HHL28_10235 HHL28_12145(folB)
ECOG : FIV45_00355 FIV45_09325(folB)
HPO : HMPREF4655_20107(folB)
HPX : HMPREF0462_1496(folB)
CJV : MTVDSCj20_0328(folB)
CAMP : CFT03427_0248(folB)
CCOC : CCON33237_1527(folB)
CLR : UPTC16701_0185(folB)
CLM : UPTC16712_0183(folB)
CAMR : CAQ16704_0176(folB)
CHV : CHELV3228_1130(folB)
CPIN : CPIN18020_0619(folB)
SBF : JCM31447_24190(folB)
BTHO : Btheta7330_00892(folB)
BCEL : BcellWH2_01614(folB)
BFC : BacF7301_00030(folB)
PCRE : NCTC12858_01606(folB)
PCAG : NCTC12856_00701(folB)
CFAS : Cfast33896_11330(folB)
PMZ : HMPREF0659_A7406(folB)
PDN : HMPREF9137_2496(folB)
POC : NCTC13071_02246(folB)
SMIZ : 4412673_02952(folB)
SDJ : NCTC13534_04201(folB)
STHA : NCTC11429_02541(folB)
PSEZ : HME7025_01625(folB)