KEGG   ENZYME: 1.13.11.89
Entry
EC 1.13.11.89               Enzyme                                 
Name
(hydroxymethyl)phosphonate dioxygenase;
phnZ1 (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
(hydroxymethyl)phosphonate:oxygen 1-oxidoreductase (formate-forming)
Reaction(IUBMB)
(hydroxymethyl)phosphonate + O2 = formate + phosphate [RN:R12451]
Reaction(KEGG)
R12451
Substrate
hydroxymethylphosphonate [CPD:C06455];
O2 [CPD:C00007]
Product
formate [CPD:C00058];
phosphate [CPD:C00009]
Comment
Requires iron(II). The enzyme, characterized from the marine bacterium Gimesia maris, participates in a methylphosphonate degradation pathway. It also has the activity of EC 1.13.11.78, (2-amino-1-hydroxyethyl)phosphonate dioxygenase (glycine-forming).
History
EC 1.13.11.89 created 2019
Pathway
ec00440  Phosphonate and phosphinate metabolism
Orthology
K05915  (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase
Genes
GMR: GmarT_03180
Reference
1  [PMID:30810303]
  Authors
Gama SR, Vogt M, Kalina T, Hupp K, Hammerschmidt F, Pallitsch K, Zechel DL
  Title
An Oxidative Pathway for Microbial Utilization of Methylphosphonic Acid as a Phosphate Source.
  Journal
ACS Chem Biol 14:735-741 (2019)
DOI:10.1021/acschembio.9b00024
  Sequence
[gmr:GmarT_03180]
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.89
IUBMB Enzyme Nomenclature: 1.13.11.89
ExPASy - ENZYME nomenclature database: 1.13.11.89
BRENDA, the Enzyme Database: 1.13.11.89
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