KEGG   ENZYME: 1.13.12.2
Entry
EC 1.13.12.2                Enzyme                                 
Name
lysine 2-monooxygenase;
lysine oxygenase;
lysine monooxygenase;
L-lysine-2-monooxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
Sysname
L-lysine:oxygen 2-oxidoreductase (decarboxylating)
Reaction(IUBMB)
L-lysine + O2 = 5-aminopentanamide + CO2 + H2O [RN:R00449]
Reaction(KEGG)
R00449
Substrate
L-lysine [CPD:C00047];
O2 [CPD:C00007]
Product
5-aminopentanamide [CPD:C00990];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). Also acts on other diamino acids.
History
EC 1.13.12.2 created 1972
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00468  lysine 2-monooxygenase
Genes
PAPPSPA7_3191
PREPCA10_04900
PFUWKF707C_4430
PCQPcP3B5_32620(iaaM)
PMUIG4G71_17665
PPUPP_0383(davB)
PPFPput_0407
PPGPputGB1_0411
PPWPputW619_4820
PPTPPS_0377
PPBPPUBIRD1_0418
PPIYSA_05771
PPXT1E_2171
PPUHB479_02390
PPUTL483_01950
PPUNPP4_04120
PPUDDW66_0391
PMONX969_00210
PMOTX970_00210
PMOSO165_025840
PPJRK21_04637
PMOLCLJ08_14860
PSTPSPTO_0518
PSBPsyr_4667
PSYRN018_02455
PSPPSPPH_4701
PSAVPSA3335_02275
PAMGBKM19_027110
PCIPCH70_05900
PAVLBKM03_02885
PVDCFBP1590_0582
PCABJGS08_01800
PCOFPOR16_22965
PFLPFL_5670
PPRCPFLCHA0_c56220(iaaM)
PPROPPC_5615
PFEPSF113_5381
PFNHZ99_15135
PFOPfl01_5154
PFSPFLU_5595 PFLU_5656
PFCPflA506_4896
PPZH045_18360
PFBVO64_2482 VO64_2537
PMANOU5_4020
PTVAA957_17040
PCGAXG94_12810
PVRPverR02_28745 PverR02_29020
PAZOAYR47_04170
POIBOP93_23795
PRXHRH33_10955 HRH33_24550
PFWPF1751_v1c50220
PFFPFLUOLIPICF710880
PFXA7318_24740
PENPSEEN0401 PSEEN2116
PBAPSEBR_a5163
PBCCD58_27095
PPUUPputUW4_04962(iaaM)
PDRH681_11755
PSVPVLB_23330
PSKU771_28955 U771_29220
PKCPKB_2893
PCHEY04_11230 EY04_32245
PCZPCL1606_05880 PCL1606_37330
PCPJM49_03030 JM49_18715
PFZAV641_02090
PLQAA042_07850
PALKPSAKL28_04170
PRHLT40_18260
PSWLK03_07335
PPVNJ69_16690
PSESPSCI_1278
PSEMTO66_12070 TO66_28745
PSECCCOS191_4943
PPSYAOC04_22275
PSOSPOS17_5602
PKRAYO71_27665
PFKPFAS1_13880
PANRA7J50_5326
PSETTHL1_442
PSILPMA3_27685
PYMAK972_0332
PKEDLD99_26305
PUMHGP31_28600
POJPtoMrB4_05620
PGGFX982_01132
PPSHG5J76_05060
PGYAWU82_09110
PLALFXN65_02360
PVKEPZ47_27210
PEZHWQ56_26295
PBZGN234_20975
PATAJWU58_03245
PDWBV82_1886
PZEHU754_027565
PMOEHV782_026615
PSEPC4K39_4005
PVWHU752_029785
PTRTHU722_0026995 HU722_0027275
PXAKSS93_05305
PSAMHU731_013105
PTZHU718_027800
PQIKH389_15910 KH389_24750
PSHHHU773_025540
PXNHU772_002040
PHVHU739_026525
PPRGHU725_001910
PANHHU763_001780
PASGKSS96_26175
PFAKKSS94_02185
PMUYKSS95_01035
PMAMKSS90_02065
PAZEKSS91_26375
PALVKSS97_26550
PORYEJA05_02060
PTKEXN22_25295 EXN22_25680
PTWTUM18999_06990
PZAHU749_027315
PIEHU724_025755
PTAENCTC10697_00440
PGFJ0G10_28150
PALNB0W48_00210
PPISB1L02_22860
PSENPNC201_21920
GAIIMCC3135_25895(iaaM)
BCMBcenmc03_4304
PLGNCTC10937_04967
ACHRC2U31_20870
RHGEXZ61_17005
HYRBSY239_3752
HYBQ5W_21180
HYLLPB072_12110
HYCE5678_15835
HPSEHPF_21750(iaaM)
HYNF9K07_27130
HTNKI616_24530
TTWLCC91_12495
ALKALEK_2246
LNEFZC33_28930
NOHG5V57_10515
RDERD1_1495
RLIRLO149_c032070
KROBVG79_p1000114(iaaM)
CIDP73_2156
CEHCEW89_04465
SUAMBOO69_20305
SPSESULPSESMR1_04820(iaaM)
PAMIJCM7686_2738
PZHCX676_20255
THWBMG03_02595
TECAKL02_019605
HMLHmaOT1_17940
PSEBEOK75_04320
PPRUFDP22_08075
PAEDG5B38_13710
MONG8E03_11995
POZI0K15_15880
NSMJO391_03695
ACRAcry_2670
AMVACMV_29960
APBSAR116_1765
PARHI5S86_26925
MAUBMAUB_03580
MPHUMPHO_09260
MMUCC1S78_013580
MABMAB_0818
MMVMYCMA_0419
MIZBAB75_04605
ASDAS9A_4558
CYZC3B44_10390
RHARHA1_ro03531
RERRER_05790
REYO5Y_02765
REBXU06_03020
RQIC1M55_03275
ROPROP_33250
ROAPd630_LPD07918
RHBNY08_2002
RFAA3L23_00334(iaaM)
RHSA3Q41_03073(iaaM)
RHODAOT96_13615
RKOJWS14_18540
RGOKYT97_22355
GPOGPOL_c37600
GOQACH46_10800
GOCCXX93_12150
GOMD7316_04814(iaaM)
GAMGII34_08380
GPDGII33_07800
GOILK459_15080
TPRTpau_1414
TSMASU32_08035
TOYFO059_17000
SCOSCO1454(SCL6.11c)
SALBXNR_5396
SMASAVERM_6893
SGRSGR_6070
SGBWQO_05045
SCBSCAB_75511
SSXSACTE_0868
SVLStrvi_3092 Strvi_7983
SHYSHJG_2887
SHOSHJGH_2651
SRCM271_10065 M271_31700
SMALSMALA_2699 SMALA_6565
SSOII1A49_17425 I1A49_36625
SCTSCAT_5364
SCYSCATT_53630
SFASfla_5404
SBHSBI_00391 SBI_02339
SVESVEN_1051
SDVBN159_7134
SALSSLNWT_6481
STRPF750_1215
SFISFUL_973
SCIB446_07515
SALUDC74_1908
SALLSAZ_10120
SLVSLIV_30495
SGUSGLAU_05850
SVTSVTN_06660
STREGZL_07240
SCWTU94_06000
SLDT261_6481 T261_6801
SLCSL103_12270
STRMM444_04775 M444_07415
STRCAA958_33330
SAMBSAM23877_1515
SPRISPRI_6108
SCZABE83_30770
SCXAS200_36385
SRWTUE45_01867(iaaM)
STRFASR50_06875
SLEsle_56450(sle_56450)
SRNA4G23_00701(iaaM)
SPAVSpa2297_05485
STRTA8713_04935
SCLFBB341_24500
SGSAVL59_33725
STSIA4E84_07150
SKYD0C37_29005
SALWCP975_05400 CP975_27365
SGMGCM10017557_68710
SCADDN051_31405
SLSSLINC_1640
SNRSNOUR_33165
SPLULK06_003985
STRDNI25_31935
SNWBBN63_29450
SAUOBV401_17055 BV401_36765
SSIAA7J05_29765
SVUB1H20_04230
SPUNBFF78_34345
SGVB1H19_09260 B1H19_30785
SLAUSLA_0954
SALFSMD44_01484 SMD44_07575
SALJSMD11_5570
SLXSLAV_08180(iaaM1) SLAV_30455(iaaM2)
STROSTRMOE7_07825
SFKKY5_1236c
SNZDC008_05320
SGEDWG14_07044(iaaM)
SRJSRO_6028
SLKSLUN_06565
SDXC4B68_33600
SGDELQ87_32500
SQZFQU76_04085
SCYAEJ357_08035
SASTCD934_28455
SNQCP978_06815
STIRDDW44_11275
SKACP970_36610
SGZC0216_20655
SVNCP980_27695
SNKCP967_29140
SHAWCEB94_07595
SRKFGW37_05775
SFICEIZ62_27970
SGALCP966_05645
SSPODDQ41_11325
SPADDVK44_03165 DVK44_35645
SFYGFH48_33265
SAQUEJC51_09830
SGFHEP81_06337
SCAVCVT27_03865
SSEOD0Z67_04190
SBYH7H31_03770 H7H31_05640
SRIMCP984_34420
SSUBCP968_01715 CP968_27340
SPHVF9278_06750
SCINCP977_06250
SFUGCNQ36_05825
SPACB1H29_30325
STSUB7R87_04060
SCHACP983_35925
SGXH4W23_07170
SCOECP976_08235
SBATG4Z16_29730
SSPBCP982_08605 CP982_34935
SNFJYK04_02077(iaaM_1) JYK04_07278(iaaM_2)
SPLACP981_04500 CP981_06945
SBROGQF42_09830
STUIGCM10017668_10290
SATAC5746_07755
SCHFIPT68_06350
SHUNDWB77_00484(iaaM_1) DWB77_06298(iaaM_2)
SCYGS1361_08065(iaaM)
SFEUIM697_15435
SLIAHA039_28955
SDWK7C20_06045
SVDCP969_08230
SCALI6J39_02360 I6J39_04415
SAUHSU9_005005
SFBCP974_03685
SMOBJ7W19_04790
SPRACP972_06305
SROIIAG44_33300
SXNIAG42_29810
SGJIAG43_04625
SHKJ2N69_05330
SANUK7396_29765
STRYEQG64_03855
SDDD9753_29615
SACTDMT42_06215
SGOBtest1122_00480
SINEKI385_09355
SLFJEQ17_38525
KABB7C62_03830
FRPAX769_07645
ARTArth_1110
ARRARUE_c11570(iaaM)
AREAL755_05460
ARWMB46_01795
ARHAHiyo8_18570 AHiyo8_18580
ARZAUT26_05370
ARQBWQ92_04225
ARNCGK93_06470
ARXARZXY2_2790
ACRYAC20117_05745
ARTHC3B78_05455
ARTPE5206_17715
AAUAAur_1221
PUEFV140_06155
PNVJMY29_05780
ACHAchl_1186
APNAsphe3_11460
PSULAU252_04545 AU252_09225 AU252_13885
PSNINIBR502771_19895
PSEYGU243_22225
GARAOZ07_00795
GCRGcLGCM259_0537
KPLKPaMU14_03965
AULDCC27_008990 DCC27_010520
PAEYKUF55_14615
DNIHX89_12990
DAYFV141_12400
NOOFE634_14640
NBEBack2_10550
PSIMKR76_13980
NDANdas_3618
NALB005_0760
NGVCDO52_09335
GOBGobs_1732
BSDBLASA_1708
KRAKrad_1432
AMDAMED_6946
AMNRAM_35635
AMMAMES_6839
AMZB737_6839
AOIAORI_2933 AORI_4877
AJAAJAP_12350 AJAP_15180
AMYCCU254_28105
AMYBBKN51_07110 BKN51_16800
AABA4R43_38290
AMYYYIM_39760(iaaM)
AORISD37_24115 SD37_26610
PSEAWY02_17480
PSEEFRP1_25145
PSEHXF36_24010
PSEQAD006_04325
PECQAD017_12145
PHHAFB00_09870
PAUTPdca_02760
PFLAPflav_056910
PSUUPsuf_016500
CAICaci_8157
RHOZGXP67_00915
 » show all
Reference
1  [PMID:4624115]
  Authors
Nakazawa T, Hori K, Hayaishi O.
  Title
Studies on monooxygenases. V. Manifestation of amino acid oxidase activity by L-lysine monooxygenase.
  Journal
J Biol Chem 247:3439-44 (1972)
Reference
2  [PMID:5911646]
  Authors
Takeda H, Hayaishi O.
  Title
Crystalline L-lysine oxygenase.
  Journal
J Biol Chem 241:2733-6 (1966)
Reference
3  [PMID:5772467]
  Authors
Takeda H, Yamamoto S, Kojima Y, Hayaishi O.
  Title
Studies on monooxygenases. I. General properties of crystalline L-lysine monooxygenase.
  Journal
J Biol Chem 244:2935-41 (1969)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.2
IUBMB Enzyme Nomenclature: 1.13.12.2
ExPASy - ENZYME nomenclature database: 1.13.12.2
BRENDA, the Enzyme Database: 1.13.12.2
CAS: 9031-22-5
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