KEGG   ENZYME: 1.13.12.22
Entry
EC 1.13.12.22               Enzyme                                 
Name
deoxynogalonate monooxygenase;
SnoaB (gene name);
12-deoxynogalonic acid oxidoreductase;
[4,5-dihydroxy-10-oxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate oxidase;
[4,5-dihydroxy-10-oxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate monooxygenase;
deoxynogalonate oxidoreductase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
Sysname
deoxynogalonate:oxygen oxidoreductase
Reaction(IUBMB)
deoxynogalonate + O2 = nogalonate + H2O [RN:R09327]
Reaction(KEGG)
R09327
Substrate
deoxynogalonate [CPD:C18629];
O2 [CPD:C00007]
Product
nogalonate [CPD:C12416];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the bacterium Streptomyces nogalater, is involved in the biosynthesis of the aromatic polyketide nogalamycin.
History
EC 1.13.12.22 created 2015
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K15941  deoxynogalonate / 12-deoxyaklanonic acid monooxygenase
Genes
SRW: TUE45_01321
STIR: DDW44_27785
SKA: CP970_39835
SGAL: CP966_29065
SCIN: CP977_28060
STSU: B7R87_22030
SCOE: CP976_32920
SLIA: HA039_05630
SPEU: CGZ69_24320
SXN: IAG42_36425 IAG42_36735
SDD: D9753_08545
SINE: KI385_25230
SNIG: HEK616_47560
TALX: FOF52_07550
PMAD: BAY61_07690
MAU: Micau_3995
MIL: ML5_4426
CCAZ: COUCH_15935
 » show all
Reference
1  [PMID:19255477]
  Authors
Koskiniemi H, Grocholski T, Schneider G, Niemi J
  Title
Expression, purification and crystallization of the cofactor-independent monooxygenase SnoaB from the nogalamycin biosynthetic pathway.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 65:256-9 (2009)
DOI:10.1107/S1744309109001389
  Sequence
[ag:CAA12015]
Reference
2  [PMID:20052967]
  Authors
Grocholski T, Koskiniemi H, Lindqvist Y, Mantsala P, Niemi J, Schneider G
  Title
Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism.
  Journal
Biochemistry 49:934-44 (2010)
DOI:10.1021/bi901985b
  Sequence
[ag:CAA12015]
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.22
IUBMB Enzyme Nomenclature: 1.13.12.22
ExPASy - ENZYME nomenclature database: 1.13.12.22
BRENDA, the Enzyme Database: 1.13.12.22
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