KEGG   ENZYME: 1.14.11.1
Entry
EC 1.14.11.1                Enzyme                                 
Name
gamma-butyrobetaine dioxygenase;
alpha-butyrobetaine hydroxylase;
gamma-butyrobetaine hydroxylase;
butyrobetaine hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2 [RN:R02397]
Reaction(KEGG)
R02397
Substrate
4-trimethylammoniobutanoate [CPD:C01181];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
3-hydroxy-4-trimethylammoniobutanoate [CPD:C00487];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate.
History
EC 1.14.11.1 created 1972
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K00471  gamma-butyrobetaine dioxygenase
Genes
HSA8424(BBOX1)
PTR466474(BBOX1)
PPS100987653(BBOX1)
GGO101131986(BBOX1)
PON100173794(BBOX1)
NLE100592137(BBOX1)
MCC699465(BBOX1)
MCF101864912(BBOX1)
CSAB103238580(BBOX1)
CATY105572788(BBOX1)
PANU101008910(BBOX1)
TGE112607110(BBOX1)
RRO104671120(BBOX1)
RBB108523305(BBOX1)
TFN117080424(BBOX1)
PTEH111554705(BBOX1)
CJC100394422(BBOX1)
SBQ101035393(BBOX1)
CSYR103252126(BBOX1) 110595261
MMUR105860144(BBOX1)
OGA100956318(BBOX1)
MMU170442(Bbox1)
MCAL110283990(Bbox1)
MPAH110319316(Bbox1)
RNO64564(Bbox1)
MCOC116090626(Bbox1)
MUN110563797(Bbox1)
CGE100759730(Bbox1)
PLEU114702106(Bbox1)
NGI103741027(Bbox1)
HGL101702765(Bbox1)
CPOC100724732(Bbox1)
CCAN109680391(Bbox1)
DORD105988092(Bbox1)
DSP122117725(Bbox1)
NCAR124960541
OCU100356171(BBOX1)
OPI101518142(BBOX1)
TUP102477622(BBOX1)
CFA476894(BBOX1)
VVP112935028(BBOX1)
VLG121476468(BBOX1)
AML100467920(BBOX1)
UMR103659370(BBOX1)
UAH113265092(BBOX1)
UAR123799471(BBOX1)
ELK111150087
LLV125110234
MPUF101684619(BBOX1)
ORO101381928(BBOX1)
EJU114220045(BBOX1)
ZCA113913925(BBOX1)
MLX118015710(BBOX1)
FCA101082182(BBOX1)
PYU121043631(BBOX1)
PBG122483639(BBOX1)
PTG102966727(BBOX1)
PPAD109271274(BBOX1)
AJU106970275(BBOX1)
HHV120220101(BBOX1)
BTA507159(BBOX1)
BOM102278682(BBOX1)
BIU109569931(BBOX1)
BBUB102393856(BBOX1)
CHX102179499(BBOX1)
OAS101115823(BBOX1)
ODA120876810(BBOX1)
CCAD122449796(BBOX1)
SSC100519353(BBOX1)
CFR102512431(BBOX1)
CBAI105076554(BBOX1)
CDK105106403(BBOX1)
VPC102533957(BBOX1)
BACU103016705(BBOX1)
LVE103082783(BBOX1)
OOR101280530(BBOX1)
DLE111179826(BBOX1)
PCAD102996220(BBOX1)
PSIU116758835(BBOX1)
ECB100072253(BBOX1)
EPZ103552651(BBOX1)
EAI106824925(BBOX1)
MYB102248153(BBOX1)
MYD102755785(BBOX1)
MMYO118664938(BBOX1)
MLF102439125(BBOX1)
MNA107531939(BBOX1)
PKL118713224(BBOX1)
HAI109373324(BBOX1)
DRO112303456(BBOX1)
SHON118983118(BBOX1)
AJM119040125(BBOX1)
PDIC114500352(BBOX1)
PHAS123810042(BBOX1)
MMF118628859(BBOX1)
RFQ117029600(BBOX1)
PALE102894724(BBOX1)
PGIG120605064(BBOX1)
PVP105293726(BBOX1)
RAY107512174(BBOX1)
MJV108404857(BBOX1)
TOD119254549(BBOX1)
SARA101537986(BBOX1)
LAV100668456(BBOX1)
TMU101348989
DNM101431057(BBOX1)
MDO100030745(BBOX1)
GAS123252554(BBOX1)
SHR100933762(BBOX1)
PCW110201920(BBOX1)
OAA100080259(BBOX1)
GGA426932(BBOX1)
PCOC116237834(BBOX1)
MGP100548089(BBOX1)
CJO107314364(BBOX1)
NMEL110401561(BBOX1)
APLA101793349(BBOX1)
ACYG106033948(BBOX1)
AFUL116490281(BBOX1)
TGU100222550(BBOX1)
LSR110475133(BBOX1)
SCAN103822203(BBOX1)
PMOA120509832(BBOX1)
OTC121340243(BBOX1)
PRUF121363090(BBOX1)
GFR102042420(BBOX1)
FAB101821064(BBOX1)
PHI102106518(BBOX1)
PMAJ107206111(BBOX1)
CCAE111930481(BBOX1)
ETL114066781(BBOX1)
ZAB102073721(BBOX1)
FPG101921157(BBOX1)
FCH102053623(BBOX1)
CLV102092334(BBOX1)
EGZ104125702(BBOX1)
NNI104009421(BBOX1)
ACUN113481296(BBOX1)
TALA104364282(BBOX1)
PADL103925755(BBOX1)
ACHC115351922(BBOX1)
AAM106498227(BBOX1)
AROW112969637(BBOX1)
NPD112948796(BBOX1)
DNE112996337(BBOX1)
ASN102382469(BBOX1)
AMJ102567742(BBOX1)
CPOO109321407(BBOX1)
GGN109299022(BBOX1)
PSS102444784(BBOX1)
CMY102936607(BBOX1)
CPIC101940563(BBOX1)
TST117877077(BBOX1)
CABI116819267(BBOX1)
MRV120402815(BBOX1)
ACS100561261(bbox1)
PVT110077403(BBOX1)
SUND121919604(BBOX1)
PBI103066330(BBOX1)
PMUR107286943(BBOX1)
TSR106544766(BBOX1)
PGUT117665404(BBOX1)
VKO123021193(BBOX1)
PMUA114597153(BBOX1)
ZVI118086241(BBOX1)
GJA107122568(BBOX1)
STOW125427470(BBOX1)
XLA108715211(bbox1.S)
XTR100145728(bbox1)
NPR108793134(BBOX1)
RTEM120917218(BBOX1)
BBUF120980843(BBOX1)
BGAR122945215(BBOX1)
DRE572649(bbox1)
SRX107740450 107755108
SANH107663933 107664378(bbox1)
SGH107553100 107563451
CCAR109063114(bbox1) 109068675
CAUA113051502 113052336 113106019
PPRM120490975 120490980
MAMB125264800(bbox1)
IPU108259295(bbox1)
PHYP113541022(bbox1)
SMEO124380068(bbox1)
TFD113636741(bbox1)
AMEX103030022(bbox1) 111196817
EEE113574097(bbox1)
TRU101071219(bbox1)
TNGGSTEN00018177G001
LCO104920628(bbox1)
NCC104955316(bbox1)
ELY117258981(bbox1)
PLEP121946183(bbox1)
SLUC116043450(bbox1)
ECRA117944883(bbox1)
PFLV114556296(bbox1)
GAT120835828(bbox1)
PPUG119194740(bbox1)
MSAM119890101(bbox1)
CUD121512000(bbox1)
MZE101466552(bbox1)
ONL100695497(bbox1)
OAU116324015(bbox1)
OLA101162990(bbox1)
OML112160651(bbox1)
XMA102227274(bbox1)
XCO114143592(bbox1)
XHE116718297(bbox1)
PRET103462718(bbox1)
PFOR103149706(bbox1)
PLAI106955015(bbox1)
PMEI106912080(bbox1)
GAF122845874(bbox1)
CVG107095289(bbox1)
CTUL119773581(bbox1)
GMU124866732(bbox1)
NFU107381956(bbox1)
KMR108234810(bbox1)
ALIM106523551(bbox1)
NWH119430237(bbox1)
AOCE111571263(bbox1)
CSEM103378801(bbox1)
POV109637182(bbox1)
SSEN122772235(bbox1)
HHIP117759196(bbox1)
LCF108887814(bbox1)
SDU111223802(bbox1)
SLAL111644317(bbox1)
XGL120793338(bbox1)
HCQ109525776(bbox1)
BPEC110162466(bbox1)
MALB109965062(bbox1)
SASA106561934 106587091
OTW112248992 112263489
OMY110506302(bbox1) 110526182
OGO124033931 124035903
ONE115112061 115113476
SALP111969205 111974271
SNH120024944 120045561
ELS105025966(bbox1)
SFM108942260(bbox1)
PKI111858129(bbox1)
AANG118228037(bbox1)
LOC102686305(bbox1)
PSPA121294993(bbox1)
ARUT117432186(bbox1)
LCM102355837(BBOX1)
CMK103174979(bbox1)
RTP109915986(bbox1)
BFO118406318 118406880 118413080 118414311 118415037
BBEL109464228 109464368 109465590 109467348 109467591 109470077 109471674 109475641 109480214
CIN100177042 100180618 100182414 100186683
SPU100889965 575977 577138 577198 579623 583892 585058 587148 589740
APLC110974962 110974969 110974990 110975081 110975086 110975110 110975114 110977463 110977489 110977490 110978498 110978503 110978522 110978525 110979659 110983900 110983902
SKO100369969 100370368 100372811 100373291 100375284 100375436
DMEDmel_CG10814(CG10814) Dmel_CG4335(CG4335) Dmel_CG5321(CG5321)
DER6549465 6550626 6555792
DSE6608987 6619610
DSIDsimw501_GD16541(Dsim_GD16541) Dsimw501_GD17176(Dsim_GD17176) Dsimw501_GD25765(Dsim_GD25765)
DYADyak_GE13368 Dyak_GE16657 Dyak_GE17150
DAN6494056
DSR110179632 110180797 110181902
DPODpse_GA10576 Dpse_GA18803 Dpse_GA22704
DPE6590266 6596658 6598191
DMN108152659 108157945 108165313 117191682
DWI6644779 6646280 6652911
DGR6559209 6565424 6569571
DMODmoj_GI14867 Dmoj_GI15613 Dmoj_GI19441
DAZ108617584 108619147 108619371
DNV108655202 108657295 108657477
DHE111595753 111600219 111601890
DVI6626970 6631921 6635597
CCAT101451345 101452432 101454364
BOD106614399 106615580 106618321 118681510 118683030
MDE101891259 101893754 101894750
SCAC106086134 106086193 106086424 106088752
LCQ111682797 111686389 111690369
AGAAgaP_AGAP008246 AgaP_AGAP012477
ACOZ120954899
AARA120896309 120900684
AAG5572067
AALB109402345
CQUCpipJ_CPIJ017090 CpipJ_CPIJ017091
CPII120432450
CNS116336704 116345422 116352378
CCIN107264740 107272779
NVL108561612 108564914
APLN108734955 108741047
PPYR116167504 116167505
OTU111416947 111423507
BMOR101743493
BMAN114247484
MSEX115442174 115448305
DPLKGM_202962
BANY112047972 112056982
PMAC106716042
PPOT106099310
PXU106124687
PRAP110993693 110994511 110994526
ZCE119838813
HAW110380306
TNL113501998
SLIU111353505 111358694
OFU114350724 114359123
PXY105390519
API100568468
DNX107168661
AGS114129356
RMD113556599
BTAB109044249
DCI103519988
NLU111046390
PHUPhum_PHUM477100
FOC113209597
ZNE110833534
CSEC111864633
FCD110852279
DPXDAPPUDRAFT_207173 DAPPUDRAFT_226211
DMK116919038 116923410
PVM113805135 113805144 113810030 113814498 113815222 113825853 113827416 113828032 113828035
PJA122246670 122254394 122257250 122257399 122259157 122259158 122262247 122262250
PCHN125030738 125035789 125036116 125038177 125038190 125042433 125045149 125045150 125046264 125046914
HAME121854913 121855918 121864667 121865395 121865979 121877065 121877068 121877069
PCLA123758441 123762277 123766850 123768337 123769803
PTRU123499459 123502521 123504064 123504153 123504657 123509641 123513856 123514360
HAZT108665978 108673585 108679774
ISCIscW_ISCW024731
DSV119450837
RSAN119383983
RMP119169816
VDE111245933
VJA111259346
TUT107372282
CSCU111633481
PTEP107439896
SDM118190047 118201062
CELCELE_D2089.5(gbh-1) CELE_M05D6.7(gbh-2)
CBRCBG_00615(Cbr-gbh-2) CBG_03032(Cbr-gbh-1)
LGILOTGIDRAFT_237554
HRF124119266 124124252 124124259 124125027 124148499
HRJ124272863 124272870 124272871 124283682
CRG105341351
MYI110458262
PMAX117323167 117327120 117327668 117328112
LAK106151224 106152800 106161769 106171134
NVE5502526 5505091 5508199 5508203 5508209 5508786 5512084 5512115
EPA110233932 110238609 110242440 110247248 110247300
ATEN116288368 116301523 116301528 116304158
ADF107327306 107327319 107327320 107331124
AMIL114962821 114969251 114969252 114969267 114972035
PDAM113669897 113670005 113681509 113682405 113682406
SPIS111324369 111329098 111332334
DGT114524405 114524406 114526928 114533500 114533542 114535633 114535646 114541915
XEN124433681 124433682 124445566 124445567 124445568 124445569 124446777 124446848 124446854 124447000
HMG101238208
TADTRIADDRAFT_13890 TRIADDRAFT_25346 TRIADDRAFT_25731 TRIADDRAFT_26039 TRIADDRAFT_33849 TRIADDRAFT_34256 TRIADDRAFT_34259 TRIADDRAFT_38529 TRIADDRAFT_61648 TRIADDRAFT_62652
QSU112023428
PANPODANSg1370
TTTTHITE_2117990
MTMMYCTH_2315436
MGRMGG_09250
TMNUCRPA7_3519
FGRFGSG_05953
FPUFPSE_03026
FVRFVEG_15504
FOXFOXG_07653
NHENECHADRAFT_45388 NECHADRAFT_48822
TRETRIREDRAFT_59838
MAJMAA_01451
PLJVFPFJ_08274
ELAUCREL1_8612
PFYPFICI_01909
SSLSS1G_07756
BFUBCIN_15g01670
MBEMBM_05571
PSCOLY89DRAFT_599673
GLZGLAREA_03074
PNOSNOG_04594
PTEPTT_17370
BZECOCCADRAFT_2320
BORCOCMIDRAFT_86558
AALTCC77DRAFT_1019507
ZTRMYCGRDRAFT_34825
PFJMYCFIDRAFT_98155
BCOMBAUCODRAFT_141887
NPAUCRNP2_7647
CNECNA03910
CNBCNBA3720
CNGCNAG_00403
CGICGB_A3650W
TMSTREMEDRAFT_59346
TASAA1Q1_00176
TVSTRAVEDRAFT_67522
DSQDICSQDRAFT_156869
PCOPHACADRAFT_63017
SHSSTEHIDRAFT_87639
HIRHETIRDRAFT_327285
ADLAURDEDRAFT_140056 AURDEDRAFT_184813
FMEFOMMEDRAFT_79643
LBCLACBIDRAFT_184002
MRRMoror_3187
MOREE1B28_005669
CCICC1G_15552
SCMSCHCODRAFT_85827
SLASERLADRAFT_447901
WSEWALSEDRAFT_36328
WICJ056_000177
ACANACA1_155090
SMINv1.2.010310.t1(symbB.v1.2.010310.t1) v1.2.029451.t1(symbB.v1.2.029451.t1) v1.2.041171.t1(symbB.v1.2.041171.t1)
NGDNGA_0602100
SPARSPRG_07932
EHXEMIHUDRAFT_313257 EMIHUDRAFT_357110
GTTGUITHDRAFT_164324
VTAB1462
PMYPmen_0503
PFLPFL_5756
PPRCPFLCHA0_c57090
PPROPPC_5702
PFEPSF113_5458
PFNHZ99_05555
PFOPfl01_5234
PFSPFLU_4654
PMANOU5_3943
PCGAXG94_13180
PAZOAYR47_04540 AYR47_20405
PFWPF1751_v1c51000
PFFPFLUOLIPICF710490
PFXA7318_25085
PBAPSEBR_a5239
PBCCD58_27505
PPUUPputUW4_05037
PSVPVLB_12435
PSKU771_29385
PCHEY04_31840
PCZPCL1606_05050
PCPJM49_02635
PSEMTO66_29120
PSOSPOS17_5690
PKRAYO71_28035
PFKPFAS1_13510
PANRA7J50_5402
PPSLBJP27_13695
PSILPMA3_28055
PYMAK972_0255
PKEDLD99_26680
PUMHGP31_28945
PGYAWU82_08710
PVKEPZ47_27605
PBZGN234_20605
PMAOPMYSY11_3768 PMYSY11_3769
PATAJWU58_02880
PZEHU754_027970
PMOEHV782_027010
PSEPC4K39_3910
PVWHU752_030305
PTZHU718_028205
PHVHU739_020055
PAZEKSS91_26735
PALVKSS97_26910
PZAHU749_027700
PIEHU724_026115
PGFJ0G10_28555
ALTambt_12790
ASPAOR13_2361
ASQAVL57_10495
AAWAVL56_09635
ALEAV939_09510
ALZAV940_09285
MMAAFR932_13000
GAIIMCC3135_18480
CSACsal_0540 Csal_2770 Csal_3171
HELHELO_1569 HELO_2757 HELO_2759
HAKKO116_01623
HAMHALO1690
HHUAR456_09255 AR456_09265
HSIBOX17_04605 BOX17_07480 BOX17_10405
HALOBWR19_14955
HBEBEI_0652 BEI_1556 BEI_1559 BEI_3127
HAFC8233_03150 C8233_10025 C8233_14370 C8233_17355
HSRHSBAA_44230
HMDCTT34_12855
HTTHZS52_13005
HPIZGYM47_12140
CMAIBFX80_03010 BFX80_06240 BFX80_09875 BFX80_16080
CAMHLCW13_01220 LCW13_08145 LCW13_11270 LCW13_14205
KUYFY550_03780
PAURFGL86_03530 FGL86_03565 FGL86_07300
MARSA8C75_16655 A8C75_21935
NJPNEJAP_1806
RFOREIFOR_01840
SALNSALB1_1515
BPSBPSS1110
BPMBURPS1710b_A0070
BPLBURPS1106A_A1481
BPDBURPS668_A1569
BPSEBDL_4396
BPSMBBQ_5061
BPSUBBN_4535
BPSDBBX_3561
BPZBP1026B_II1173
BPQBPC006_II1485
BPKBBK_6001
BPSHDR55_4217
BPSABBU_4952
BPSOX996_4311
BUTX994_6047
BOKDM82_5272 DM82_5369
BOCBG90_5239 BG90_5337
BUUWS70_23100
BSAVWS86_24095
BVIBcep1808_3389
BVEAK36_3372
BURBcep18194_B0616
BCNBcen_3320
BCHBcen2424_5047
BCMBcenmc03_5237
BCJBCAM2290
BCEWDM40_4990
BCEOI35_6181
BAMBamb_4455
BACBamMC406_4975
BCTGEM_3400 GEM_4721
BCEDDM42_5701
BCEPAPZ15_27665
BDLAK34_3509
BPYRABD05_24135
BCONNL30_01110
BUBBW23_3453
BDFWI26_24135
BLATWK25_27430
BTEIWS51_08470
BSEMWJ12_31340
BMECWJ16_29790
BSTGWT74_30165
BSTLBBJ41_25200
BGLbglu_2g17560
BGUKS03_4173
BGDbgla_2g05780
BGOBM43_4216
BUKMYA_3007
BGPBGL_2c23480
BPLAbpln_2g23760
BURKDM992_22875
PMEGFNZ07_10570
CABASBC2_45160
PVACHC248_01441
HYCE5678_13285
HPOHMPREF4655_21349
ALPLPB137_05315
MYMA176_001848
SURSTAUR_2090
MBDMEBOL_007418
SCLsce1889
SCUSCE1572_11510
CCROCMC5_014140
SAMYDB32_002785
MRMA7982_09697
HOHHoch_4369
MERDEB233_11895
HOEIMCC20628_01439
NIYFQ775_20650
KMNHW532_16515
AVIAvi_3411
AGCBSY240_950
RLBRLEG3_03455
RBMTEF_17550
LAPACP90_09620 ACP90_19975
LABRCHH27_00295 CHH27_10980
LABPFJ695_23520
LABTFIU93_15180 FIU93_26520
LAGGB0E33_03695 B0E33_21555
CAULKCG34_00120
SITTM1040_0052 TM1040_2006
PGDGal_00639
OATOAN307_c19610
OAROA238_c21470
TPROGa0080559_TMP3867
SULIC1J05_04130
RIDRIdsm_02193
SAGUCDO87_14345
ROTFIV09_00930
TGLHFZ77_10825
HATRC74_16275
RMBK529_000315
DONBSK21_10315
SEDIEBB79_19545
PALWPSAL_036380
RBZB9057_03290
FAQG5B39_15310 G5B39_15515
ANHA6F65_00135
HTQFRZ44_32130 FRZ44_47990
HADHFRZ61_09040 FRZ61_15530 FRZ61_45660
APCHIMB59_00001420
SNEANBZ79_09335 NBZ79_14355
MMIMMAR_0692(tauD_1)
MMAEMMARE11_06410(tauD_1)
MLIMULP_00691(tauD_1)
MSHOMSHO_24200
RCRNCTC10994_03391
SGSAVL59_28950
SALJSMD11_6780
SLXSLAV_33440
SVRCP971_09120
SFYGFH48_05035
KSKKSE_56020
KAUB6264_04180
KITCFP65_5525
LMOIVV02_08475
NOABKM31_14220
FRIFraEuI1c_0586
PSEAWY02_15675
PSEEFRP1_27130
PSEHXF36_26945
PSEQAD006_06310
PECQAD017_14125
PAUTPdca_66260
KALKALB_3391
TERTery_0693 Tery_2451
MPROBJP34_15525 BJP34_27290 BJP34_30050 BJP34_34645
KANIMCC3317_28310
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Reference
1  [PMID:4396068]
  Authors
Lindstedt G, Lindstedt S.
  Title
Cofactor requirements of gamma-butyrobetaine hydroxylase from rat liver.
  Journal
J Biol Chem 245:4178-86 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.1
IUBMB Enzyme Nomenclature: 1.14.11.1
ExPASy - ENZYME nomenclature database: 1.14.11.1
BRENDA, the Enzyme Database: 1.14.11.1
CAS: 9045-31-2
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