KEGG ENZYME: 1.14.13.10

ENZYME: 1.14.13.10

Entry

EC 1.14.13.10               Enzyme

Name

2,6-dihydroxypyridine 3-monooxygenase;
2,6-dihydroxypyridine oxidase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)

Reaction(IUBMB)

2,6-dihydroxypyridine + NADH + H+ + O2 = 2,3,6-trihydroxypyridine + NAD+ + H2O [RN:R04130]

Reaction(KEGG)

R04130

Substrate

2,6-dihydroxypyridine [CPD:C03056];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]

Product

2,3,6-trihydroxypyridine [CPD:C03458];
NAD+ [CPD:C00003];
H2O [CPD:C00001]

Comment

A flavoprotein.

History

EC 1.14.13.10 created 1976

Pathway

ec00760

Nicotinate and nicotinamide metabolism

ec01120

Microbial metabolism in diverse environments

Orthology

K19189

2,6-dihydroxypyridine 3-monooxygenase

Genes

MSA:	Mycsm_00621

MYV:	G155_18735

MADI:

A7U43_14955

MYW:	BVC93_18970

MSM:	MSMEG_6489

MSG:	MSMEI_6317

MSB:	LJ00_32075

MSN:	LI99_32080

MSH:	LI98_32085

MCB:	Mycch_5202

MNE:	D174_16010

MYN:	MyAD_15730

MFT:	XA26_38230

MVQ:

MYVA_5903

MLL:	B1R94_14805

MAUU:

NCTC10437_04697 NCTC10437_05530(xlnD_2)

MTY:	MTOK_02580

MPSC:

MPSYJ_11170

MARZ:

MARA_10670

MHEV:

MHEL_55420

MANY:

MANY_16660

MPOF:

MPOR_03570

MPHU:

MPHO_51930

MMAT:

MMAGJ_48930

MBOK:

MBOE_35660

MFG:	K6L26_12975

MSEI:

MSEDJ_52910

MGO:	AFA91_04745

MSEN:

K3U95_16170

MRF:	MJO55_26550

MGRO:

FZ046_25585

MAUS:

JN090_07460

ROP:

ROP_27430

ROA:	Pd630_LPD07468

RHOP:

D8W71_20465

SGRF:

SGFS_017950

SHY:

SHJG_1751

SHO:	SHJGH_1516

SBH:

SBI_01580

SCOA:

QU709_39100

ARX:	ARZXY2_4564

PUE:	FV140_09350

PNV:	JMY29_20630(dhpH)

PAYJ:

HMI59_00960

TED:	U5C87_22435

NCA:

Noca_0592

NMES:

H9L09_09790

NML:

Namu_4899

BSD:	BLASA_1457

SACG:

FDZ84_24385

AMQ:	AMETH_3752

PPEL:

H6H00_20310 H6H00_25285

STI:

Sthe_2312

» show all

Reference

1 [PMID:4344227]

Authors

Holmes PE, Rittenberg SC.

Title

The bacterial oxidation of nicotine. VII. Partial purification and properties of 2,6-dihydroxypyridine oxidase.

Journal

J Biol Chem 247:7622-7 (1972)

Reference

2 [PMID:4636328]

Authors

Holmes PE, Rittenberg SC, Knackmuss HJ.

Title

The bacterial oxidation of nicotine. 8. Synthesis of 2,3,6-trihydroxypyridine and accumulation and partial characterization of the product of 2,6-dihydroxypyridine oxidation.

Journal

J Biol Chem 247:7628-33 (1972)

Other DBs

ExplorEnz - The Enzyme Database:

1.14.13.10

IUBMB Enzyme Nomenclature:

1.14.13.10

ExPASy - ENZYME nomenclature database:

1.14.13.10

UM-BBD (Biocatalysis/Biodegradation Database):

1.14.13.10

BRENDA, the Enzyme Database:

1.14.13.10

CAS:	39279-38-4

LinkDB

DBGET integrated database retrieval system