Entry
Name
FAD-dependent urate hydroxylase;
HpxO enzyme;
FAD-dependent urate oxidase;
urate hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
urate,NADH:oxygen oxidoreductase (5-hydroxyisourate-forming)
Reaction(IUBMB)
urate + NADH + H+ + O2 = 5-hydroxyisourate + NAD+ + H2O [RN:
R09514 ]
Reaction(KEGG)
Substrate
Product
Comment
A flavoprotein. The reaction is part of the purine catabolic pathway in the bacterium Klebsiella pneumoniae. The enzyme is different from EC
1.7.3.3 , factor-independent urate hydroxylase, found in most plants, which produces hydrogen peroxide. The product of the enzyme is a substrate for EC
3.5.2.17 , hydroxyisourate hydrolase.
History
EC 1.14.13.113 created 2010
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K16839 FAD-dependent urate hydroxylase
K22879 FAD-dependent urate hydroxylase
Genes
REE : electrica_03279(hpxO)
RTG : NCTC13098_04816(nagX)
KRD : A3780_00565 A3780_08190
KOU : C0557_00815 C0557_08600
SYM : K6K13_09440 K6K13_09480
PDZ : HHA33_13475(hpxO) HHA33_18785
METY : MRY16398_24170 MRY16398_37110
PVJ : LMA04_04810(hpxO) LMA04_17990
MPHG : MPHASIOC01_001306(hpxO)
EBC : C2U52_21450 C2U52_26935
SFJ : SAMEA4384070_2390(xlnD)
RIU : I2123_21930(hpxO) I2123_22295
GQU : AWC35_01895 AWC35_17225 AWC35_23540
RBAD : H2866_18690 H2866_21635(hpxO) H2866_22965
RCB : O1V66_02490 O1V66_05350 O1V66_08555(hpxO)
NIG : C1N62_06590 C1N62_20010
EPE : CI789_02300 CI789_08305
ERWI : GN242_09825(hpxO) GN242_17225
ERP : LJN55_12290(hpxO) LJN55_18955
ERWE : GKQ23_01380(hpxO) GKQ23_04370
PVA : Pvag_1367(kmo) Pvag_pPag30384
PAGG : AL522_01665 AL522_14090
PAO : Pat9b_1955 Pat9b_3298
KLN : LH22_05875 LH22_12690
PANT : PSNIH1_02755 PSNIH1_13525
PANS : FCN45_09790(hpxO) FCN45_15900
PEY : EE896_09535(hpxO) EE896_19960 EE896_21225
PDIS : D8B20_08600(hpxO) D8B20_19870
PER : LAC65_07550(hpxO) LAC65_13310
PJI : KTJ90_09640(hpxO) KTJ90_20135
PANO : OJ965_00910 OJ965_11705(hpxO)
TPTY : NCTC11468_01923(nagX) NCTC11468_02749(xlnD)
XPH : XppCFBP6546_10400(hpyO)
XHD : LMG31886_03210(hpyO)
VSR : Vspart_02715(hpxO_2)
PEZ : HWQ56_11695(hpxO) HWQ56_17430
PSIV : LZ023_18125 LZ023_26170(hpxO)
ACW : A0J50_00575 A0J50_08030 A0J50_18335
HCS : FF32_01200 FF32_13905
HAMS : NF683_01265 NF683_15950
HAXH : J4377_07735 J4377_13310
HALK : CUU95_10960 CUU95_16440
HVN : EI420_08320 EI420_15180
HAA : A5892_01090 A5892_03615
MMW : Mmwyl1_0338 Mmwyl1_2710
MME : Marme_0757 Marme_3806
MPC : Mar181_1373 Mar181_3321
MPRI : MP3633_0234 MP3633_1480
CBW : RR42_m2178 RR42_m2450
CCUP : BKK81_10870 BKK81_11110
CUP : BKK80_11125 BKK80_11365
CUU : BKK79_01470 BKK79_01710
CUPP : CTP10_R13810 CTP10_R53050
BXE : Bxe_A2162 Bxe_C0093 Bxe_C0114
BXB : DR64_4316 DR64_8313 DR64_8334
BCAI : K788_0001411 K788_0001442
PARB : CJU94_14785 CJU94_21780
POX : MB84_23090 MB84_29035
PACR : FXN63_03425 FXN63_12400 FXN63_12795
AANT : HUK68_09455 HUK68_22025
XYK : GT347_19860 GT347_26495
AMIH : CO731_00347 CO731_05352
ALF : CFBP5473_15145 CFBP5473_17280
AVV : RvVAT039_36790(hpyO)
AVF : RvVAR031_39870(hpyO)
RHR : CKA34_31150 CKA34_32630
RRG : J3P73_05880 J3P73_29460 J3P73_32220
RSUL : N2599_05750 N2599_32455
RTU : PR017_24280 PR017_27840
ARA : Arad_14232 Arad_7954 Arad_9888
RBW : RLCC275e_03240 RLCC275e_28970
RHIB : I8E17_26215 I8E17_29060
NGL : RG1141_PA06260 RG1141_PA06550
NGG : RG540_PA06090 RG540_PA06390
NEN : NCHU2750_46400 NCHU2750_56150
NPM : QEO92_06980 QEO92_07030
BJA : blr0238(blr0238) blr3336(blr3336)
BARH : WN72_14485 WN72_19685 WN72_35980
BBAN : J4G43_019000 J4G43_020265 J4G43_027210
BROS : QUH67_13390 QUH67_29035
BOY : LQG66_04470 LQG66_15085
BVV : BHK69_00155 BHK69_03000
BOP : AXW83_05385 AXW83_17940
BOF : FQV39_01835 FQV39_23425
BOSE : RMR04_01420 RMR04_04125
MAQU : Maq22A_1p31745(trkA) Maq22A_c06055(trkA)
MEE : DA075_00240 DA075_21885
MTEA : DK419_05885 DK419_15075
MIND : mvi_08060 mvi_46960
DNP : N8A98_16420 N8A98_18170
PLEO : OHA_1_00486 OHA_1_01086 OHA_1_01485
MAAD : AZF01_00420 AZF01_04370
MMED : Mame_00036(iucD) Mame_00571 Mame_02840 Mame_04367 Mame_04371
MLUT : JET14_01625 JET14_05400
PSTG : E8M01_17965 E8M01_20595
PAQT : E8L99_10475 E8L99_21530
KVL : KVU_1677 KVU_2406 KVU_PB0179
KVU : EIO_0058 EIO_2118 EIO_3146
KRO : BVG79_00076 BVG79_01387 BVG79_01729 BVG79_01910
PABY : Ga0080574_TMP2577 Ga0080574_TMP4529
NPN : JI59_06010 JI59_13860
SPAG : sphantq_04369(hpyO)
GOH : B932_1263 B932_3115 B932_3802
GSP : IGS75_02920 IGS75_03255 IGS75_04870
KNA : B0W47_13570 B0W47_14135 B0W47_16505
APER : A0U91_00670 A0U91_07260
KBA : A0U89_04065 A0U89_13835
RCV : PFY06_07100 PFY06_19930
LCK : HN018_01180 HN018_03430 HN018_19065 HN018_22880
NGU : QN315_01140 QN315_08090
RGI : RGI145_00730 RGI145_12990 RGI145_16835
ROS : CTJ15_15935 CTJ15_19325 CTJ15_23385
RMUC : FOB66_14640 FOB66_19190 FOB66_22505
RMT : IAI58_06535 IAI58_13240
SRF : LHU95_00355 LHU95_00970
ELIO : KO353_02260 KO353_06700
MBAI : MB901379_04332(hpxO_2)
GRU : GCWB2_04395 GCWB2_17135(hpxO1)
GAM : GII34_04955 GII34_15985(hpxO)
GPD : GII33_04415 GII33_15425(hpxO)
MIH : BJP65_07605 BJP65_07865
MICM : CHE218_18370(hpyO) CHE218_19170(hpxO)
LET : O77CONTIG1_04142(hpxO)
PRUN : PCC7821_02342(hpxO)
NED : HUN01_01880 HUN01_02840
SCYT : SAMD_77520 SAMD_81260
» show all
Taxonomy
Reference
Authors
O'Leary SE, Hicks KA, Ealick SE, Begley TP
Title
Biochemical characterization of the HpxO enzyme from Klebsiella pneumoniae, a novel FAD-dependent urate oxidase.
Journal
Sequence
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