KEGG   ENZYME: 1.14.13.14
Entry
EC 1.14.13.14               Enzyme                                 
Name
trans-cinnamate 2-monooxygenase;
cinnamic acid 2-hydroxylase;
cinnamate 2-monooxygenase;
cinnamic 2-hydroxylase;
cinnamate 2-hydroxylase;
trans-cinnamic acid 2-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating)
Reaction(IUBMB)
trans-cinnamate + NADPH + H+ + O2 = 2-hydroxycinnamate + NADP+ + H2O [RN:R02254]
Reaction(KEGG)
R02254
Substrate
trans-cinnamate [CPD:C00423];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2-hydroxycinnamate [CPD:C01772];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
History
EC 1.14.13.14 created 1976
Pathway
ec00360  Phenylalanine metabolism
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Reference
1  [PMID:4153528]
  Authors
Gestetner B, Conn EE.
  Title
The 2-hydroxylation of trans-cinnamic acid by chloroplasts from Melilotus alba Desr.
  Journal
Arch Biochem Biophys 163:617-24 (1974)
DOI:10.1016/0003-9861(74)90522-0
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.14
IUBMB Enzyme Nomenclature: 1.14.13.14
ExPASy - ENZYME nomenclature database: 1.14.13.14
BRENDA, the Enzyme Database: 1.14.13.14
CAS: 53126-56-0
LinkDB

KEGG   REACTION: R02254
Entry
R02254                      Reaction                               
Name
trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating)
Definition
trans-Cinnamate + Oxygen + NADPH + H+ <=> trans-2-Hydroxycinnamate + NADP+ + H2O
Equation
C00423 + C00007 + C00005 + C00080 <=> C01772 + C00006 + C00001
Reaction class
RC00001  C00005_C00006
RC00046  C00423_C01772
Enzyme
1.14.13.14
Pathway
rn00360  Phenylalanine metabolism
rn00999  Biosynthesis of various plant secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.14
     R02254  trans-Cinnamate + Oxygen + NADPH + H+ <=> trans-2-Hydroxycinnamate + NADP+ + H2O
Other DBs
RHEA: 10959
LinkDB

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