KEGG   ENZYME: 1.14.13.40
Entry
EC 1.14.13.40               Enzyme                                 
Name
anthraniloyl-CoA monooxygenase;
anthraniloyl coenzyme A reductase;
2-aminobenzoyl-CoA monooxygenase/reductase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
anthraniloyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing)
Reaction(IUBMB)
anthraniloyl-CoA + 2 NAD(P)H + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NAD(P)+ [RN:R03998 R03999]
Reaction(KEGG)
R03998 R03999
Substrate
anthraniloyl-CoA [CPD:C02247];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2-amino-5-oxocyclohex-1-enecarboxyl-CoA [CPD:C05165];
H2O [CPD:C00001];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Comment
A flavoprotein (FAD). The non-aromatic product is unstable and releases CO2 and NH3, forming 1,4-cyclohexanedione.
History
EC 1.14.13.40 created 1992
Pathway
ec00627  Aminobenzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K09461  anthraniloyl-CoA monooxygenase
Genes
KLWDA718_25970
EBTEBL_c27870
XDOXDD1_0582
XHOA9255_13140
XBUHGO23_11080
PRGRB151_004980(namA_1)
PALACO695_02395
PHEINCTC12003_00494(namA_1)
PRQCYG50_13605
PRJNCTC6933_00562(namA_1)
PMAGJI723_02595
PFNHZ99_07200
PTRTHU722_0014830
KIMG3T16_02990
GAIIMCC3135_14605(sdgC)
HAMHALO3237
HCOLOKO_00703(namA)
HOLHORIV_22300
HTTHZS52_20700
HCAMI4484_15180
HSXHNO51_15100
HSVHNO53_15610
HPROLMS44_07350
RSORSc1826 RSp0032
RSLRPSI07_mp0048
RSNRSPO_m00049(namA)
RSMCMR15_11833 CMR15_mp10034
RSEF504_1563 F504_3538
RSYRSUY_32540
RPIRpic_3831
RPFRpic12D_3944
RPJN234_03100 N234_14090
RMNTK49_19400
RINACS15_5519
RPUCDC45_09390 CDC45_17745
RSGJK151_22770
REHH16_A2461(abmA)
CNCCNE_1c23700(abmA) CNE_2c20790(namA2)
CUHBJN34_13195
REUReut_A2184
RMERmet_2202(abmA)
CTIRALTA_A1992
CBWRR42_m2751
CGDCR3_1773
CCUPBKK81_14255
CUPBKK80_15190
CUUBKK79_17815
CPAUEHF44_11750
COXE0W60_21755
CCAMM5D45_10790
BUGBC1001_4662
BGFBC1003_4836
BYIBYI23_D000330
BUEBRPE67_DCDS02360
BUQAC233_26715
BUMAXG89_31275
BXEBxe_B0282
BXBDR64_5623
BPHBphy_4068
BGEBC1002_4971
BPXBUPH_01237
BPYBphyt_7168
BUZAYM40_34325
BFNOI25_5793
BCAIK788_0001059
PSPWBJG93_22160
PARBCJU94_27875
PHSC2L64_18765
PTERC2L65_16600
PGPCUJ91_29520
PCJCUJ87_28565
PTSCUJ90_23170
PCAFDSC91_003278
PMEGFNZ07_03630
PTROG5S35_15795
PGISI6I06_27410
PACPFAZ97_19885
PACSFAZ98_15560
PDIOPDMSB3_3182.1
PPKU875_07390 U875_07770
PPNODA70_00035 DA70_00465
PPNMLV28_05850 LV28_06240
PRBX636_01865 X636_02190
PPULRO07_00230
PSPUNA29_11405
PAPISG18_00525 SG18_23390
PVEUC34_16590
POXMB84_21375
PTXABW99_11420
PFGAB870_03420
PNRAT302_15590 AT302_16715
PANDDRB87_14095 DRB87_15270
PFIBPI93_011445
PCOMNTU39_18180
CABASBC2_47130(namA_2)
BUOBRPE64_DCDS01970
BPABPP3944
BBHBN112_4005
BBRBB4417
BBMBN115_4093
BBXBBS798_4194
BPTBpet0549
BAVBAV3024
BHOD560_1950
BHMD558_1936
BHZACR54_04143(namA_2)
BTRMSAMEA390648700754(namA)
BBROBAU06_22805
BFZBAU07_22945
BPDZBBN53_02380
BOHAKI39_02710
BGMCAL15_21120
BOJCBF45_09680
AXYAXYL_00584 AXYL_02927
AXONH44784_015951
AXNAX27061_0595
AXXERS451415_00587(namA_1)
ADTAPT56_03060
AISBUW96_04720 BUW96_22925
ASWCVS48_03430
ACHRC2U31_07665
ACHBDVB37_02390
ADYHLG70_19170
PUTPT7_3490
PUSCKA81_11030
PUDG9Q38_05920
AMIMMIM_c27580 MIM_c32190
CDNBN940_15406
AFAUZ73_10390
AFQAFA_00270
AAQUD3M96_00255
AAMMFE795_00230
PHNPAEH1_09405
PIGEGT29_10025 EGT29_22805
PACRFXN63_07930
KGYEHF36_09775
PARKLSG25_12045
RSBRS694_10250
RHYRD110_19995
RHFEUB48_19320
RHGEXZ61_19410
RHOAHZ993_20415
POLBpro_0593
PNAPnap_3617
POSDT070_04435
POOF7R28_05015
AAVAave_3180
AAAAcav_2075 Acav_3342
ACKC380_02660
ACRABSY15_1915
AMONH9L24_13485
ARADKI609_02675
VEIVeis_2872
DACDaci_4472
DELDelCs14_2332
DTSBI380_01265
DHKBO996_20235
DLAI6G47_02005
VAPVapar_0656 Vapar_5038
VPEVarpa_5748
VPDVAPA_1c52290
VAAAX767_08035
VBOCKY39_31185
VAMC4F17_20510
CTTCtCNB1_0390
CTESO987_02010
CODOLAD35_21525
RTARta_18140
OTDJ1M35_18055
LIML103DPR2_00573(namA)
LIHL63ED372_00049(namA_1)
HYRBSY239_232
HYBQ5W_17685
HYLLPB072_12030
HYCE5678_19585
HPSEHPF_03110(namA2)
HYNF9K07_03685
HTNKI616_23960
DIHG7047_27110
DRGH9K76_22535
SIMPC6571_08240
KIAG8A07_17990
STHMIS481_10745
PBHAAW51_4168
MIUABE85_02375
ATERMW290_07545
JAGGJA_4016
JAZYQ44_19915
JALBZG29_08040
JSVCNX70_08495
JASFJQ89_24980
JLVG3257_08195
HRBHrubri_4427
MNRACZ75_11815
MASWAM586_12355
MASSCR152_31485
MTIMDIR46_23665
MASYDPH57_12375
MANCIV454_16830
MASZC9I28_09620
MALIEYF70_20945
MUMFCL38_28075
MFLAGO485_23725
MPLIE1742_23305
DUGHH213_19360
UPVEJN92_18660
UPIEJG51_001925
GLCJQN73_16675
PKTAT984_10505
SHDSUTH_01524
EBAebA2164(abmA)
ABREpbN1_14100
APETToN1_50530
AZOazo1934(abmA)
AOAdqs_2089
AZAAZKH_1863(abmA)
ACOMCEW83_03845
AZRCJ010_12640
TCLTchl_1894
TAKTharo_2558
DDZDSYM_08600
CCXCOCOR_07215(vioD)
VINAKJ08_2554
SCLsce8661
SCUSCE1572_46245
CCROCMC5_036610
PAUUE8A73_022700
SAMYDB32_005280
LLUAKJ09_02802
MRMA7982_12512
HOHHoch_4888
MLOmll5434
MLNA9174_00500
MCIMesci_0105
MOPMesop_0103
MAMMesau_00103
MAMOA6B35_07170 A6B35_32745
MESWA9K65_000500
MESMEJ066_10640
MESPC1M53_03370
MHUAMCHK_6460
MJREB229_00505
MERDEB233_00625
MESRFGU64_15785
MESOBSQ44_12055
HOEIMCC20628_01395
AAKAA2016_5731
AMIHCO731_05561(namA_2)
PHYLHB779_00205
NIYFQ775_10870
NKIKW403_07860
KMNHW532_11115
SIXBSY16_4352
EADOV14_a0976
EAHFA04_32430
ARUIG6M88_19300
AVQHRR99_19095
RTRRTCIAT899_CH14260
RHRCKA34_17165
NGLRG1141_CH38250
NGGRG540_CH38900
NEOCYG48_14425
RHTNT26_3993
RFVRFYW14_00020
ABAWD5400_21140
OANOant_4014
OAHDR92_4241
OCRHGK82_22825
OCLGTN27_15080
PSCQKHQ08_01215
BJAblr3436(blr3436)
BJUBJ6T_62050
BJPRN69_30060
BRABRADO2322
BBTBBta_2683
BRSS23_21950
AOLS58_52750
BRCBCCGELA001_25815
BRADBF49_5553
BICLMTR13_30000
BROBRAD285_5020
BRKCWS35_19380
BOTCIT37_23880
BRQCIT40_22380
BGQX265_12380
BGZXH91_22250
BSYMCIT39_21575
BBETF8237_26050
BARHWN72_33965
BVZBRAD3257_3049
BELBE61_67980
BDGLPJ38_32220
BSEPHAP48_0032135
BQBJ4P68_0033380
RPERPE_3229
RBKE0H22_08275
TRBHB776_01660
BOPAXW83_05495
BOSBSY19_2588
BVVBHK69_17925
BOIBLM15_06820
BOFFQV39_07695
AZCAZC_3190
MEAMex_1p1008
MDIMETDI1807
MEXMext_1224
MCHMchl_1385
MPOMpop_1109
MZAB2G69_13395
MNOMnod_1202
METAY590_05165
MAQUMaq22A_c15065(nemA)
MEEDA075_24280
METIDK427_23570
MTEADK419_08565
MINDmvi_06550
MOCBB934_20025
MIVC4E04_10995
MICOGDR74_09810
RHZRHPLAN_46660
DEQXM25_21640
MMYRMXMO3_02961
YTIFNA67_03090
PLEOOHA_1_04299(namA_3)
MMEDMame_00669(namA)
PSINCAK95_01005 CAK95_09885
NOHG5V57_08260
RBMTEF_16560
PSFPSE_3147
PPHRAPZ00_22290
LAPACP90_18595
LABRCHH27_01620
LABPFJ695_03050
LABTFIU93_25255(namA)
LAGGB0E33_02365
SIWGH266_21585
PHRC6569_02045
PSTGE8M01_20635
ACUTMRB58_19490
BNEDA69_02050
TSVDSM104635_00129(namA_1)
SILSPOA0407
SITTM1040_2243
JANJann_1323
RPONG3256_00160
PGAPGA1_c23490
PGLPGA2_c21440
PGDGal_01043
PHPPhaeoP97_02218
PPICPhaeoP14_02133
PHQD1820_06635
LMDMETH_05730
LEJETW24_06930
LAQUR2C4_11705
CEHCEW89_04070
MALGMALG_04450
YPACCEW88_22155
SUAMBOO69_10935
SULZC1J03_14420
SULIC1J05_03665
SULDB5M07_07395
SMEDJNX03_02570
SINLDSM14862_01907(sdgC)
SPSESULPSESMR1_00933(sdgC)
TOMBWR18_13895
RIDRIdsm_02003(namA_2)
THAACFI11_17600
ROTFIV09_19070(namA)
RMHLVO79_13050
PDEPden_5087
PZHCX676_10720
PAROCUV01_00630
PARUCYR75_13990
PARSDRW48_06080
PARREOJ32_00465
PKDF8A10_20305
PPANESD82_10190
PSANHGN31_04540
PMAUCP157_00372(sdgC)
RMBK529_002645
GEHHYN69_07200
GFUKM031_16650
TAWEI545_11375
SEDIEBB79_22690
BOOE2K80_00510
PSEBEOK75_00210
PPRUFDP22_18985
PALWPSAL_021510(namA)
PGVSL003B_1855
THASC6Y53_04945
HDHG5B40_19665
GCEKYE46_05225
NSMJO391_13090
MMRMmar10_2695
HYTHXX25_09895
CBOTATE48_08925
NREBES08_24470
NOVTQ38_007530
SPHPLH20_14085
SGISGRAN_0827(namA)
SPHOC3E99_00525
SPHXE5675_18040
SWISwit_0827
SPHDHY78_22560
SPHITS85_01655 TS85_07550
SSANNX02_11385
SPLKAV944_07730
SPKCKC8_08260
SPAUDRN02_014160
SLUTH9L13_03120
SDHH9L15_04485
SSEDH9L14_00510
SPAPH3Z74_18295
SXAFMM02_04855
SPAIFPZ24_12970
SSING7078_02910
SSAUH8M03_09595
SCLOSCLO_1005700
BLASBSY18_666
BFWB5J99_12515
SMICSmB9_25110
SPHSETR14_04590
AMXAM2010_2430
ELQGa0102493_112845
ERKCD351_08150
KSCCD178_02459(namA_2)
SRFLHU95_07280
AZZDEW08_29430
MAGXXM1_3864(yqjM)
MAGNWV31_20535
FERFNB15_12285
TXITH3_14060
THACCSC3H3_21280
TIIDY252_07805
THAIIT893_13455
NACINUH88_16255
ECOGFIV45_00640
THEFE1B22_00650
MIDMIP_00169
MMMW7S_08110
MFJMFLOJ_23650
MGORH0P51_02485 H0P51_20665
CCYCSCMU_02030
NFANFA_12450 NFA_21970
NFRERS450000_01901(vioD) ERS450000_02865(namA)
NBRO3I_025330
NNONONO_c51160
NSRNS506_05931
NTPCRH09_09700 CRH09_29850
NOZDMB37_35745
NAHF5544_00285
NIEKV110_14390
RHARHA1_ro00482
REBXU06_29655
ROPROP_34330
ROAPd630_LPD03775 Pd630_LPD04581
RHBNY08_2116
RHUA3Q40_02700(namA_2)
RKOJWS14_19400
RGOKYT97_17395
ROZCBI38_04655
GOQACH46_09975
GTABCM27_24985
GJIH1R19_22835
TSMASU32_08740
TOYFO059_01115
SCOSCO5980(StBAC16H6.15)
SMASAVERM_2315
SGRSGR_1568
SGBWQO_27505
SCBSCAB_87841
SVLStrvi_6041
SHYSHJG_7042
SHOSHJGH_6802
SRCM271_00735
SMALSMALA_0965
SSOII1A49_08315
SCTSCAT_p1531
SCYSCATT_p01930
SFASfla_1378
SBHSBI_03207
SVESVEN_5801
SDVBN159_2447 BN159_4425
SALSSLNWT_4232
STRPF750_5505
SFISFUL_5891
SCIB446_27820
SALUDC74_5977
SALLSAZ_30965
SLVSLIV_08715
SGUSGLAU_25615
SVTSVTN_29015
STREGZL_02816
SCWTU94_25300
SLDT261_2068
SLCSL103_26355
STRMM444_26250
STRCAA958_27705
SAMBSAM23877_5695
SPRISPRI_1837
SCZABE83_06710
SCXAS200_12520
SRWTUE45_06576(namA_2)
STRFASR50_27040
SLEsle_17320(sle_17320)
SPAVSpa2297_25130
STRTA8713_24940
SCLFBB341_04830
SGSAVL59_11215
STSIA4E84_30565
SALWCP975_27795
SGMGCM10017557_09750 GCM10017557_77670
SCADDN051_11015
SLSSLINC_6362
SNRSNOUR_12100
SPLULK06_026010
STRDNI25_09500
SNWBBN63_06925
SAUOBV401_08620
SSIAA7J05_09105
SVUB1H20_28090
SPUNBFF78_11530 BFF78_26745
SGVB1H19_30360
SLAUSLA_5838
SALFSMD44_06589 SMD44_08700
SALJSMD11_1628
SLXSLAV_10190(namA1)
STROSTRMOE7_29280
SFKKY5_6122
SNZDC008_26830
SGEDWG14_02132(sdgC_1)
SRJSRO_1862
SLKSLUN_30210
SDXC4B68_09730
SGDELQ87_09985
SCYAEJ357_35050
SASTCD934_06875
SNQCP978_25905
STIRDDW44_24135
SKACP970_10325
SGZC0216_08420
SVNCP980_07920 CP980_30475
SHAWCEB94_31155
SRKFGW37_25090
SFICEIZ62_06960
SGALCP966_27700
SSPODDQ41_25815
SVRCP971_04045
SFYGFH48_03050 GFH48_11320
SAQUEJC51_35675
SGFHEP81_02110
SCAVCVT27_27055
SBYH7H31_06645 H7H31_25330
SRIMCP984_08940
SSUBCP968_08540
SPHVF9278_37185
SCINCP977_26310
SFUGCNQ36_25180
SPACB1H29_08970
STSUB7R87_27220
SCHACP983_10710
SGXH4W23_30110
SCOECP976_32715
SBATG4Z16_06360
SSPBCP982_05280 CP982_31380
SNFJYK04_01135(sdgC_1) JYK04_06347(sdgC_2)
SPLACP981_29460
SBROGQF42_17440 GQF42_32395
STUIGCM10017668_54480
SATAC5746_31700
SCHFIPT68_28080
SHUNDWB77_01873(sdgC)
SCYGS1361_29680(namA2)
SFEUIM697_33340
SDWK7C20_28245
SVDCP969_28655
SCALI6J39_27955
SAUHSU9_026865
SMOBJ7W19_24805
SPEUCGZ69_28460
SROIIAG44_09430
SXNIAG42_08195
SGJIAG43_25330
SHKJ2N69_28725
SANUK7396_08775
SDDD9753_08230
SACTDMT42_29470
SGOBtest1122_10870 test1122_21895
SINEKI385_03695 KI385_33605
SLFJEQ17_43140
SDECL3078_34840
SAOVG3H79_08040
KABB7C62_29180
KAUB6264_27660
KITCFP65_1370
MLVCVS47_00321(sdgC)
LDNH9L06_07565
LVIG7068_12760
LLUTK1X41_12260
ARRARUE_113p00230 ARUE_c41720
ARLAFL94_05000
AREAL755_03290 AL755_04025
AAQAOC05_11115
ARHAHiyo8_40740
ARZAUT26_09955
ARNCGK93_22610
ARXARZXY2_1966
PUEFV140_10230
PNVJMY29_19335
PSULAU252_00125
PSEYGU243_00255
GLUF0M17_05305
GPRJQN66_05435
GMYXH9_03370
XCEXcel_0307
XYLET495_15630
TEHGKE56_05415
SERWFY030_15410
ORNDV701_11150
NAROCFH99_00740
PSIMKR76_15920
THAONI17_008270
NALB005_0467
NGVCDO52_13245
NEXNE857_25345
SAIUJ4H86_05725
AGRAAGRA3207_002245
SROSros_4320
NOABKM31_06735
NOWGBF35_30685
FRAFrancci3_2043
FREFranean1_4331
FRIFraEuI1c_0315
FALFRAAL4320
BSDBLASA_2567
SENSACE_0057 SACE_3134
SACGFDZ84_32065 FDZ84_32895
AMDAMED_8366
AMNRAM_42960
AMMAMES_8237
AMZB737_8238
AOIAORI_7153
AJAAJAP_03220
AMQAMETH_3667
AMYCCU254_34630
AMYBBKN51_29135
AABA4R43_37965
AMYYYIM_40080(vioD)
AORISD37_04700 SD37_10755
AACDLWP59_26770
APRTMUY14_41945
PDXPsed_4248 Psed_6338 Psed_6449
PSEAWY02_28410 WY02_28415
PSEEFRP1_10355 FRP1_14245 FRP1_14250 FRP1_17295
PSEHXF36_14550 XF36_14555 XF36_18085
PSEQAD006_20600 AD006_21910 AD006_21915 AD006_24750
PECQAD017_00180 AD017_01495 AD017_01500 AD017_04340
PHHAFB00_23340 AFB00_23345
PAUTPdca_21640 Pdca_28500 Pdca_28510 Pdca_55320 Pdca_69140
PBROHOP40_00505 HOP40_01080 HOP40_09935 HOP40_15160 HOP40_29240
SESPBN6_40630
KALKALB_3438
KPHYAOZ06_10945
LEDBBK82_33835
ALOCRK57982
SACEGIY23_11615
ACTUActkin_02086(vioD_1)
ASEACPL_5644
AMSAMIS_58160
AFSAFR_11680
ACTSACWT_5514
AIHAiant_15700
ATLAthai_10150
ASERAsera_63120
CAICaci_5522
SNASnas_0297
EKEEK0264_06030
RXYRxyl_2274
RMARGBA65_17970
CWOCwoe_2161 Cwoe_2817
SBAEDSM104329_00242(namA)
ERZER308_09900
EUZDVS28_a0076
KBSEPA93_18310
DPHEHF33_18975
MRBMrub_2111
MREK649_11980
GAUGAU_3276
GPHGEMMAAP_16760
GGRHKW67_13035
GBAJ421_2011 J421_6370
FPSZAMR72_01560
FINKQS_01615
FATDVK85_10675
FPALHYN49_11405
FMGHYN48_11310
FALBHYN59_11925
FSNGS03_02243(namA)
FAKFUA48_13805
FSDLXD69_15365
FLOK1I41_09600
FCCLOS86_07875
HNOLT974_08360
HALUHUG12_05750
HRUHalru_2531
HLRHALLA_02160
 » show all
Reference
1  [PMID:2591379]
  Authors
Buder R, Fuchs G.
  Title
2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Purification and some properties of the enzyme.
  Journal
Eur J Biochem 185:629-35 (1989)
DOI:10.1111/j.1432-1033.1989.tb15159.x
Reference
2  [PMID:2591380]
  Authors
Buder R, Ziegler K, Fuchs G, Langkau B, Ghisla S.
  Title
2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Studies on the stoichiometry and the course of the reaction.
  Journal
Eur J Biochem 185:637-43 (1989)
DOI:10.1111/j.1432-1033.1989.tb15160.x
Reference
3  [PMID:2384085]
  Authors
Langkau B, Ghisla S, Buder R, Ziegler K, Fuchs G.
  Title
2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Identification of the reaction products.
  Journal
Eur J Biochem 191:365-71 (1990)
DOI:10.1111/j.1432-1033.1990.tb19131.x
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.40
IUBMB Enzyme Nomenclature: 1.14.13.40
ExPASy - ENZYME nomenclature database: 1.14.13.40
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.40
BRENDA, the Enzyme Database: 1.14.13.40
CAS: 112692-57-6
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