KEGG ENZYME: 1.14.13.5

ENZYME: 1.14.13.5

Entry

EC 1.14.13.5                Enzyme

Name

imidazoleacetate 4-monooxygenase;
imidazoleacetic hydroxylase;
imidazoleacetate hydroxylase;
imidazoleacetic monooxygenase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating)

Reaction(IUBMB)

4-imidazoleacetate + NADH + H+ + O2 = 5-hydroxy-4-imidazoleacetate + NAD+ + H2O [RN:R04066]

Reaction(KEGG)

R04066

Substrate

4-imidazoleacetate [CPD:C02835];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]

Product

5-hydroxy-4-imidazoleacetate [CPD:C05133];
NAD+ [CPD:C00003];
H2O [CPD:C00001]

Comment

A flavoprotein (FAD).

History

EC 1.14.13.5 created 1965 as EC 1.14.1.5, transferred 1972 to EC 1.14.13.5

Pathway

ec00340

Histidine metabolism

ec01100

Metabolic pathways

Reference

1 [PMID:5772468]

Authors

Maki Y, Yamamoto S, Nozaki M, Hayaishi O.

Title

Studies on monooxygenases. II. Crystallization and some properties of imidazole acetate monooxygenase.

Journal

J Biol Chem 244:2942-50 (1969)

Other DBs

ExplorEnz - The Enzyme Database:

1.14.13.5

IUBMB Enzyme Nomenclature:

1.14.13.5

ExPASy - ENZYME nomenclature database:

1.14.13.5

BRENDA, the Enzyme Database:

1.14.13.5

CAS:

9029-65-6

LinkDB

DBGET integrated database retrieval system