Entry
Name
kynurenine 3-monooxygenase;
kynurenine 3-hydroxylase;
kynurenine hydroxylase;
L-kynurenine-3-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O [RN:
R01960 ]
Reaction(KEGG)
Substrate
Product
Comment
A flavoprotein (FAD).
History
EC 1.14.13.9 created 1961 as EC 1.99.1.5, transferred 1965 to EC 1.14.1.2, transferred 1972 to EC 1.14.13.9
Pathway
Orthology
K00486 kynurenine 3-monooxygenase
Genes
PTG : 102960651 102971760(KMO)
CAUA : 113069966 113092360
MASI : 127412275 127414414
NGRA : 132888902 132889594
TNG : GSTEN00003719G001 GSTEN00003720G001
SASA : 106576798 106604861
STRU : 115153038 115193973
OKI : 109888749 109899611(kmo)
OCLA : 139381087 139416748
SALP : 111951680 111977827
SFON : 129836140 129853248
SCLV : 120338396 120340721
LPIC : 129269172 129270240
PFLL : 139144302 139145352 139149871 139149873
DSI : Dsimw501_GD15302(Dsim_GD15302)
DPL : KGM_202125A KGM_202125B
CFEL : 113385157 113386676 113386677
SGRE : 126267269 126267271
AFRA : 136026374 136027491 136027500
PCLA : 123764542 138372420
ABRU : 129965725 129966778
PCAN : 112570761 112571116
LSAX : 138947404 138952929
BARL : 143293385 143295914 143296645
CANU : 128176676 128177088
MMER : 123543449 123543466
MAEA : 128207426 128207618
NVE : 5515907 5517226 5517230
ATEN : 116304775 116304778
SPIS : 111333321 111333343
AQU : 100633691 100635488 100635740 100642063
PPP : 112274524 112285606 112289138
CSL : COCSUDRAFT_62855 COCSUDRAFT_64116
TPF : TPHA_0K00610(TPHA0K00610)
TDL : TDEL_0C02920(TDEL0C02920)
LBG : 92207336(LODBEIA_P21400)
CAL : CAALFM_C300260CA(BNA4)
ASAU : 88174138(PUMCH_003074)
YLI : 2910925(YALI2_D00195g)
NTE : NEUTE1DRAFT66569(NEUTE1DRAFT_66569)
SMP : 10803065(SMAC4_05864)
RTHE : 98124293(VTJ83DRAFT_3288)
PPEI : PpBr36_03214 PpBr36_08333
PGRI : PgNI_01484 PgNI_08485
FPOA : FPOAC1_001501(NIC3)
TATV : 25776194(TrAtP1_006081)
UVI : 66068699(UV8b_07922)
PLJ : 28891052(PLICBS_004633)
CDET : 87949282(CDEST_12782)
BFU : BCIN_01g01500(Bcbna4)
ANG : An01g08540 An07g02080 An07g09110
ALUC : AKAW2_11381S(BNA4_1) AKAW2_11947A(BNA4_2) AKAW2_20907A(BNA4_3)
PPSF : 300790089(PFLUO_LOCUS4272)
TRG : TRUGW13939_00810 TRUGW13939_06229
PTRR : 6345570(PtrM4_040690) 6347390(PtrM4_035890)
ADAC : 96085713(ACET3X_005391)
CDEC : 89987896(IAS62_001121)
CTEG : 91988953(I308_102095)
CBAS : 91982146(I312_102098)
CDEP : 91085228(L203_101014)
KMG : 30167447(I203_106357)
KNE : 92178247(IAR55_000988)
KDJ : 28964676(I303_100973)
KBI : 30207226(I302_104119)
KPIN : 30169245(I206_100453)
KSH : 87953047(IL334_000916)
KER : 91106154(V865_007353)
KSN : 43588559(CI109_102420)
KEP : 91091632(L201_000960)
CCAC : CcaHIS019_0601720(BNA4)
GTR : GLOTRDRAFT_104124 GLOTRDRAFT_112580
ABP : AGABI1DRAFT125224(AGABI1DRAFT_125224)
ABV : AGABI2DRAFT64309(AGABI2DRAFT_64309)
MRR : Moror_6444 Moror_6465
SCM : SCHCO_02606041(SCHCODRAFT_02606041)
DFA : DFA_02548(kmo) DFA_03351
TPS : THAPSDRAFT_10093 THAPSDRAFT_8420
GTT : GUITHDRAFT_164107 GUITHDRAFT_68158
XPH : XppCFBP6546_18285(XppCFBP6546P_18285)
XHD : LMG31886_27260(kmo_1)
LCP : LC55x_2802(kmo) LC55x_4981
LGU : LG3211_2673(kmo) LG3211_4388
LEZ : GLE_0549(kmo) GLE_2679(kmo)
LYA : RDV84_03685 RDV84_18975
LSH : CAB17_01625 CAB17_15340
LJR : NCTC11533_01089(kmo)
LCJ : NCTC11976_00128(kmo)
LWA : SAMEA4504053_1221(kmo)
LSS : NCTC12082_00150(kmo)
LANT : TUM19329_23210(kmo)
WOC : BA177_04335 BA177_12690
FOK : KK2020170_10880(kmo)
PHG : KCTC32516_00169(kmo)
AALG : AREALGSMS7_00100(kmo)
AANR : KCTC52924_02235(kmo_1)
KOS : KORDIASMS9_02203(kmo)
PTAN : CRYO30217_00115(kmo)
DCO : SAMEA4475696_2017(kmo)
ACIR : OG979_02770 OG979_37515
AWS : ACN3XK_32165 ACN3XK_33310
STP : Strop_3529 Strop_4419
MSAG : GCM10017556_50320(kmo)
PRY : Prubr_41060(kmo_1) Prubr_59210(kmo_2)
NHY : JQS43_06595 JQS43_08480
AMR : AM1_0975(kmo) AM1_2357(kmo) AM1_3387
ACAM : HRE53_02080 HRE53_09450
NSPH : BDGGKGIB_04365(kmo_2)
CALS : NIES3974_07330(kmo)
NCN : BZZ01_13115 BZZ01_22510
» show all
Taxonomy
Reference
1
Authors
de Castro FT, Price JM, Brown RR.
Title
Reduced triphosphopyridinenucleotide requirement for the enzymatic formation of 3-hydroxykynurenine from L-kynurenine.
Journal
J Am Chem Soc 78:2904-2905 (1956)
Reference
Authors
Okamoto H, Hayaishi O.
Title
Flavin adenine dinucleotide requirement for kynurenine hydroxylase of rat liver mitochondria.
Journal
Reference
Authors
SAITO Y, HAYAISHI O, ROTHBERG S.
Title
Studies on oxygenases; enzymatic formation of 3-hydroxy-L-kynurenine from L-kynurenine.
Journal
J Biol Chem 229:921-34 (1957)
Other DBs
ExPASy - ENZYME nomenclature database: 1.14.13.9
LinkDB
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