KEGG   ENZYME: 1.14.14.146
Entry
EC 1.14.14.146              Enzyme                                 
Name
geranylgeraniol 18-hydroxylase;
GGOH-18-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
geranylgeraniol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (18-hydroxylating)
Reaction(IUBMB)
geranylgeraniol + [reduced NADPH---hemoprotein reductase] + O2 = 18-hydroxygeranylgeraniol + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R09122]
Reaction(KEGG)
R09122
Substrate
geranylgeraniol [CPD:C09094];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
18-hydroxygeranylgeraniol [CPD:C13273];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein isolated from the plant Croton sublyratus.
History
EC 1.14.14.146 created 2009 as EC 1.14.13.110, transferred 2018 to EC 1.14.14.146
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Reference
1
  Authors
Tansakul P, De-Eknamkul W.
  Title
Geranylgeraniol-18-hydroxylase: the last enzyme in the plaunotol biosynthetic pathway in Croton sublyratus.
  Journal
Phytochemistry 47:1241-1246 (1998)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.146
IUBMB Enzyme Nomenclature: 1.14.14.146
ExPASy - ENZYME nomenclature database: 1.14.14.146
BRENDA, the Enzyme Database: 1.14.14.146
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