KEGG   ENZYME: 1.14.14.146
Entry
EC 1.14.14.146              Enzyme                                 
Name
geranylgeraniol 18-hydroxylase;
GGOH-18-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
geranylgeraniol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (18-hydroxylating)
Reaction(IUBMB)
geranylgeraniol + [reduced NADPH---hemoprotein reductase] + O2 = 18-hydroxygeranylgeraniol + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R09122]
Reaction(KEGG)
R09122
Substrate
geranylgeraniol [CPD:C09094];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
18-hydroxygeranylgeraniol [CPD:C13273];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein isolated from the plant Croton sublyratus.
History
EC 1.14.14.146 created 2009 as EC 1.14.13.110, transferred 2018 to EC 1.14.14.146
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Reference
1
  Authors
Tansakul P, De-Eknamkul W.
  Title
Geranylgeraniol-18-hydroxylase: the last enzyme in the plaunotol biosynthetic pathway in Croton sublyratus.
  Journal
Phytochemistry 47:1241-1246 (1998)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.146
IUBMB Enzyme Nomenclature: 1.14.14.146
ExPASy - ENZYME nomenclature database: 1.14.14.146
BRENDA, the Enzyme Database: 1.14.14.146
LinkDB

KEGG   REACTION: R09122
Entry
R09122                      Reaction                               
Name
geranylgeraniol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (18-hydroxylating)
Definition
Geranylgeraniol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Plaunotol + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C09094 + C03024 + C00007 <=> C13273 + C03161 + C00001
Reaction class
RC01137  C09094_C13273
Enzyme
1.14.14.146
Pathway
rn00904  Diterpenoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.146
     R09122  Geranylgeraniol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Plaunotol + [Oxidized NADPH---hemoprotein reductase] + H2O
Other DBs
RHEA: 26236
LinkDB

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