KEGG   ENZYME: 1.14.14.51
Entry
EC 1.14.14.51               Enzyme                                 
Name
(S)-limonene 6-monooxygenase;
(-)-limonene 6-hydroxylase;
(-)-limonene 6-monooxygenase;
(-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
(S)-limonene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6-hydroxylating)
Reaction(IUBMB)
(S)-limonene + [reduced NADPH---hemoprotein reductase] + O2 = (-)-trans-carveol + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R02468]
Reaction(KEGG)
R02468
Substrate
(S)-limonene [CPD:C00521];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
(-)-trans-carveol [CPD:C00964];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme thiolate) enzyme. The enzyme participates in the biosynthesis of (-)-carvone, which is responsible for the aroma of spearmint.
History
EC 1.14.14.51 created 1992 as EC 1.14.13.48, modified 2003, transferred 2017 to EC 1.14.14.51
Pathway
ec00902  Monoterpenoid biosynthesis
ec00903  Limonene degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K07381  (S)-limonene 6-monooxygenase
K14732  limonene hydroxylase
K17719  cytochrome P450 family 2 subfamily C9
K17721  cytochrome P450 family 2 subfamily C19
Genes
HSA: 1557(CYP2C19) 1559(CYP2C9)
PTR: 100616515(CYP2C9) 740956(CYP2C19)
PPS: 100995695(CYP2C19) 100996034(CYP2C9)
GGO: 101126456 101151965
PON: 100439483(CYP2C19) 100450749(CYP2C9)
PPYG: 129006337 129006530
NLE: 100591471 100601437
HMH: 116457268 116457271
SSYN: 129468897 129468985
MCC: 678686(CYP2C75) 678695(CYP2C9)
MCF: 102115450(CYP2C9) 102147103(CYP2C19)
MTHB: 126962028 126962032
MNI: 105479916 105479949
CSAB: 103216299(CYP2C19) 103216301(CYP2C9)
CATY: 105575618 105581138 105586929 105586938
PANU: 100997824 101012978
TGE: 112631549 112631550
MLEU: 105534699 105534700 105535382 105536626
RRO: 104665355 104666123
TFN: 117083900 117092015
PTEH: 111531037 111552212
CANG: 105501587 105504516 105504517
CJC: 100389947(CYP2C19)
SBQ: 101041912
CIMI: 108281686(CYP2C19)
ANAN: 110568730 135273997
CSYR: 103277060
PCOQ: 105822723
OGA: 100950266
DORD: 106001520
NCAR: 124985776
MMMA: 107149734
GAS: 123236335 123238232
TVP: 118828297 118828298 118828299 118828301 118828302
 » show all
Reference
1  [PMID:2297225]
  Authors
Karp F, Mihaliak CA, Harris JL, Croteau R
  Title
Monoterpene biosynthesis: specificity of the hydroxylations of (-)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata), and perilla (Perilla frutescens) leaves.
  Journal
Arch Biochem Biophys 276:219-26 (1990)
DOI:10.1016/0003-9861(90)90029-X
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.51
IUBMB Enzyme Nomenclature: 1.14.14.51
ExPASy - ENZYME nomenclature database: 1.14.14.51
BRENDA, the Enzyme Database: 1.14.14.51
CAS: 138066-93-0
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