KEGG   ENZYME: 1.14.14.51
Entry
EC 1.14.14.51               Enzyme                                 
Name
(S)-limonene 6-monooxygenase;
(-)-limonene 6-hydroxylase;
(-)-limonene 6-monooxygenase;
(-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
(S)-limonene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6-hydroxylating)
Reaction(IUBMB)
(S)-limonene + [reduced NADPH---hemoprotein reductase] + O2 = (-)-trans-carveol + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R02468]
Reaction(KEGG)
R02468
Substrate
(S)-limonene [CPD:C00521];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
(-)-trans-carveol [CPD:C00964];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme thiolate) enzyme. The enzyme participates in the biosynthesis of (-)-carvone, which is responsible for the aroma of spearmint.
History
EC 1.14.14.51 created 1992 as EC 1.14.13.48, modified 2003, transferred 2017 to EC 1.14.14.51
Pathway
ec00902  Monoterpenoid biosynthesis
ec00903  Limonene and pinene degradation
ec01110  Biosynthesis of secondary metabolites
Orthology
K07381  (S)-limonene 6-monooxygenase
K14732  limonene hydroxylase
K17719  cytochrome P450 family 2 subfamily C9
K17721  cytochrome P450 family 2 subfamily C19
Genes
HSA1557(CYP2C19) 1559(CYP2C9)
PTR100616515(CYP2C9) 740956(CYP2C19)
PPS100995695(CYP2C19) 100996034(CYP2C9)
GGO101126456 101151965
PON100439483 100450749
NLE100591471 100601437
MCC678686(CYP2C75) 678695(CYP2C9)
MCF102115450(CYP2C9) 102147103(CYP2C19)
CSAB103216299(CYP2C19) 103216301(CYP2C9)
CATY105575618 105581138 105586929 105586938
PANU100997824 101012978
TGE112631549 112631550
RRO104665355 104666123
TFN117083900 117092015
PTEH111531037 111552212
CJC100389947(CYP2C19)
SBQ101041912
CSYR103277060
OGA100950266
DORD106001520
NCAR124985776
GAS123236335 123238232
 » show all
Reference
1  [PMID:2297225]
  Authors
Karp F, Mihaliak CA, Harris JL, Croteau R
  Title
Monoterpene biosynthesis: specificity of the hydroxylations of (-)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata), and perilla (Perilla frutescens) leaves.
  Journal
Arch Biochem Biophys 276:219-26 (1990)
DOI:10.1016/0003-9861(90)90029-X
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.51
IUBMB Enzyme Nomenclature: 1.14.14.51
ExPASy - ENZYME nomenclature database: 1.14.14.51
BRENDA, the Enzyme Database: 1.14.14.51
CAS: 138066-93-0
LinkDB

DBGET integrated database retrieval system