KEGG   ENZYME: 1.14.14.84
Entry
EC 1.14.14.84               Enzyme                                 
Name
linalool 8-monooxygenase;
P-450lin;
CYP111
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
linalool,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (8-hydroxylating)
Reaction(IUBMB)
linalool + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = (6E)-8-oxolinalool + 2 [oxidized NADPH---hemoprotein reductase] + 3 H2O (overall reaction) [RN:R09925];
(1a) linalool + [reduced NADPH---hemoprotein reductase] + O2 = (6E)-8-hydroxylinalool + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R04366];
(1b) (6E)-8-hydroxylinalool + [reduced NADPH---hemoprotein reductase] + O2 = (6E)-8-oxolinalool + [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:R09924]
Reaction(KEGG)
R04366 > R09922 R09923;
R09924 R09925
Substrate
linalool [CPD:C03985];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007];
(6E)-8-hydroxylinalool [CPD:C04433]
Product
(6E)-8-oxolinalool [CPD:C20221];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001];
(6E)-8-hydroxylinalool [CPD:C04433]
Comment
A cytochrome P-450 (heme-thiolate) protein found in plants. The secondary electron donor is a specific [2Fe-2S] ferredoxin from the same bacterial strain.
History
EC 1.14.14.84 created 1989 as EC 1.14.99.28, transferred 2012 to EC 1.14.13.151, transferred 2018 to EC 1.14.14.84
Pathway
ec00902  Monoterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K05525  linalool 8-monooxygenase
Genes
ACI: ACIAD1575(linC)
ASOL: BEN76_16475
SNAN: I6N98_04895
STAW: NCG89_15635
PLA: Plav_0029
CAUL: KCG34_08930
NAR: Saro_0759
NRE: BES08_22970
NOV: TQ38_024465
NOR: FA702_04225
NOL: NSDW_21660
NCP: U0041_19265
SMY: BJP26_16325
SARI: H5J25_00655
SBIN: SBA_ch2_1840
SRAD: LLW23_13450
SYA: A6768_11830
SPYG: YGS_C1P1370
SUR: STAUR_6105(linC)
 » show all
Reference
1  [PMID:2295633]
  Authors
Ullah AJ, Murray RI, Bhattacharyya PK, Wagner GC, Gunsalus IC
  Title
Protein components of a cytochrome P-450 linalool 8-methyl hydroxylase.
  Journal
J Biol Chem 265:1345-51 (1990)
Reference
2  [PMID:8376348]
  Authors
Ropp JD, Gunsalus IC, Sligar SG
  Title
Cloning and expression of a member of a new cytochrome P-450 family: cytochrome P-450lin (CYP111) from Pseudomonas incognita.
  Journal
J Bacteriol 175:6028-37 (1993)
DOI:10.1128/JB.175.18.6028-6037.1993
  Sequence
[ag:AAA25810]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.84
IUBMB Enzyme Nomenclature: 1.14.14.84
ExPASy - ENZYME nomenclature database: 1.14.14.84
BRENDA, the Enzyme Database: 1.14.14.84
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