KEGG ENZYME: 1.14.14.85

ENZYME: 1.14.14.85

Entry

EC 1.14.14.85               Enzyme

Name

7-deoxyloganate 7-hydroxylase;
CYP72A224 (gene name);
7-deoxyloganin 7-hydroxylase (incorrect);
7-deoxyloganin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating) (incorrect)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

7-deoxyloganate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating)

Reaction(IUBMB)

7-deoxyloganate + [reduced NADPH---hemoprotein reductase] + O2 = loganate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R05832]

Reaction(KEGG)

R05832;
(other) R03556

Substrate

7-deoxyloganate [CPD:C11636];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

loganate [CPD:C01512];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

The enzyme, characterized from the plant Catharanthus roseus, is a cytochrome P-450 (heme-thiolate) enzyme. It catalyses a reaction in the pathway leading to biosynthesis of monoterpenoid indole alkaloids.

History

EC 1.14.14.85 created 2002 as EC 1.14.13.74, transferred 2018 to EC 1.14.14.85, modified 2018

Pathway

ec00902

Monoterpenoid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K23276

7-deoxyloganate 7-hydroxylase

Reference

1 [PMID:11524113]

Authors

Katano N, Yamamoto H, Iio R, Inoue K.

Title

7-Deoxyloganin 7-hydroxylase in Lonicera japonica cell cultures.

Journal

Phytochemistry 58:53-8 (2001)
DOI:10.1016/S0031-9422(01)00181-9

Reference

2 [PMID:24710322]

Authors

Miettinen K, Dong L, Navrot N, Schneider T, Burlat V, Pollier J, Woittiez L, van der Krol S, Lugan R, Ilc T, Verpoorte R, Oksman-Caldentey KM, Martinoia E, Bouwmeester H, Goossens A, Memelink J, Werck-Reichhart D

Title

The seco-iridoid pathway from Catharanthus roseus.

Journal

Nat Commun 5:3606 (2014)
DOI:10.1038/ncomms4606

Sequence

[ag:AHK60834]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.14.85

IUBMB Enzyme Nomenclature:

1.14.14.85

ExPASy - ENZYME nomenclature database:

1.14.14.85

BRENDA, the Enzyme Database:

1.14.14.85

CAS:	335305-40-3

LinkDB

DBGET integrated database retrieval system