Entry
Name
trans-cinnamate 4-monooxygenase;
cinnamic acid 4-hydroxylase;
CA4H;
cytochrome P450 cinnamate 4-hydroxylase;
cinnamate 4-hydroxylase;
cinnamate 4-monooxygenase;
cinnamate hydroxylase;
cinnamic 4-hydroxylase;
cinnamic acid 4-monooxygenase;
cinnamic acid p-hydroxylase;
t-cinnamic acid hydroxylase;
trans-cinnamate 4-hydroxylase;
trans-cinnamic acid 4-hydroxylase;
CYP73A1 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
trans-cinnamate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
Reaction(IUBMB)
trans-cinnamate + [reduced NADPH---hemoprotein reductase] + O2 = 4-hydroxycinnamate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:
R02253 ]
Reaction(KEGG)
Substrate
trans-cinnamate [CPD:
C00423 ];
[reduced NADPH---hemoprotein reductase] [CPD:
C03024 ];
O2 [CPD:
C00007 ]
Product
4-hydroxycinnamate [CPD:
C00811 ];
[oxidized NADPH---hemoprotein reductase] [CPD:
C03161 ];
H2O [CPD:
C00001 ]
Comment
A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in flavonoid biosynthesis.
History
EC 1.14.14.91 created 1976 as EC 1.14.13.11, transferred 2018 to EC 1.14.14.91
Pathway
ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
ec00940 Phenylpropanoid biosynthesis
ec00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K00487 trans-cinnamate 4-monooxygenase
Genes
CSAT : 104700439 104749839 104786614
EUS : EUTSA_v10016544mg EUTSA_v10016545mg
BRP : 103857322 103857323 103865042 103865043 103867954
BNA : 106348398 106348399 106387868 106387869 106437590 106437591 106446415 111205796 125574765 125608065
BOE : 106295375 106329505 106336023 106337156 106342634
RSZ : 108812700 108847879 108848885 108849675
THJ : 104800793 104808912 104815827
CPAP : 110809815 110823746
CIT : 102577934(C4H1) 102578013(C4H2)
CIC : CICLE_v10000921mg CICLE_v10008125mg
MINC : 123200117 123211848
TCC : 18587499 18589488 18591096
GHI : 107896573 107913579 107916264 107936045 107957678
GAB : 108486152 108486612 108489327
HSYR : 120125666 120127373 120186174 120213114
DZI : 111285045 111285451 111301778 111310044
GMX : 100499623(C4H) 100812188(C4H1) 100818985
GSJ : 114385043 114397278 114401755
PVU : 137823724 137828645 137831574
VRA : 106764845 106771868 106775017
VAR : 108325108 108338193 108341749
VUN : 114187493 114189889 114193905
VUM : 124828697 124830235 124843217
CCAJ : 109797995 109806951 109814569
APRC : 113846441 113848901 113872659
TPRA : 123887997 123900153 123920662 123920941
CAM : 101492721(CYP73) 101503511 101507607
PSAT : 127091226 127118437
LJA : 130717028 130717495 130722603 130733867
ADU : 107458104 107467573 107474042
AIP : 107608857 107616560 107635198
AHF : 112712108 112719871 112764966 112777310 112794230
LANG : 109330369 109339369 109354385
PCIN : 129313475 129318156
QSA : O6P43_003884 O6P43_007804 O6P43_020454 O6P43_020455
AANS : 126786811 126790767
PMUM : 103323718 103339178
PAVI : 110750787 110766184
PDUL : 117613815 117629821
MDM : 103418731 103418775 103427139 103447265
MSYL : 126589351 126614664 126614665 126614666 126614668
PXB : 103945990 103945999 103963306
ZJU : 107406287 107411586 107417662
MNT : 21391595 21394524 21401756
CSAV : 115709609 115719463
CSV : 101204747 101205537 101205775 101208511 101221846 105434566
CMO : 103492214 103492222 103492250 103496249 103497013
BHJ : 120079060 120079601 120080215 120083555 120088389
MCHA : 111017984 111018232 111018233 111024917
CMAX : 111484465 111491732 111492592 111499735
CMOS : 111436256 111448702 111451474 111452469
CPEP : 111777471 111784863 111787467 111795542 111805108 111805109
HBR : 110637148 110653493 110665143
MESC : 110606554 110608744
POP : 112325022 7464737 7498118
PEU : 105118872 105120907 105123239 105137660
PALZ : 118042637 118044218 118054034
PNZ : 133669123 133674605 133706363
JRE : 108993196 108996947 108996955 109002391
CILL : 122290831 122292276 122294360 122298692
CAVE : 132163882 132184522 132185446 132189081
QLO : 115957238 115967336 115984444
TWL : 119991267 119997446 120001790
VVI : 100251539 100253493 100267215
VRI : 117916090 117924864 117925208
SLY : 101244196 101244496 101262919
SPEN : 107020510 107022866 114073827
SSTN : 125866849 125875133
SDUL : 129880679 129898545 129898546
LBB : 132606622 132606633 132640606
NTA : 107781854(CYP73A27) 107791262(CYP73A47v3) 107812882 107820794(CYP73A28) 107823514(C4H) 107826530(CYP73A47v1)
NSY : 104217798 104228366 104244410
NTO : 104097044 104101351 104110622
NAU : 109215399 109225492 109229405
INI : 109146796 109156362 109162834
ITR : 116011928 116016607 116025306 116025383
SIND : 105163854 105170463 105170464 105170465 105170466 105170468 110011256
OEU : 111372687 111377181 111393218
EGT : 105958605 105958637 105958638 105958639 105962128
SSPL : 121746400 121746402 121762481 121765928 121787542 121787848
SMIL : 130992099 130992100
SHIS : 125200968 125214377
APAN : 127251732 127253696
HAN : 110865806 110867747 110873368
ECAD : 122592523 122609569
CCAV : 112506479 112517960
CSIN : 114260674 114288944
AEW : 130769778 130782095 130795822
CQI : 110683790 110684225 110684642 110710327
ATRI : 130797825 130812560 130812562 130827118 130827238
NNU : 104593756 104594470 104601639
MING : 122069001 122079373
PSOM : 113310740 113322609
OSA : 4329324 4329329 4338409 9270590
OBR : 102710874 102720399 102720675
OGL : 127759864 127763525 127763584 127773908
BDI : 100832881 100833073 100839986
ATS : 109751434 109754216 109762639 109770341 109771714 109777191
TDC : 119267500 119269412 119275330 119277409 119292174 119304265 119332146 119335496 119364280 119367479
TAES : 123040936 123048956 123053304 123060617 123062435 123069147 123071222 123077675 123079573 123089637 123099110 123108467 123148431 123159216 123166406 123191571
TUA : 125511525 125521274 125535269 125543167 125543192 125545152
LPER : 127308266 127333043 127341127 127344797
LRD : 124665103 124665217 124667733 124667951 124668244 124668519 124674080 124674244 124685924 124689715
SBI : 8059757 8084483 8085395
ZMA : 100272756 100272801 100284998 103636555
MFLO : 136450501 136456745 136473569 136473597 136514903 136530452 136541715
SITA : 101768416 101773281
SVS : 117848910 117850934 117855309
PVIR : 120655693 120665912 120676246 120699130 120701233 120708487
PHAI : 112885850 112894071 112895823
PDA : 103702142 103702256 103706246 103708914 103713131 103722165 120110174
EGU : 105044830 105045995 105049276 105050451 105052309 105057212
MUS : 103992160 103997903 135606971 135606973 135614565 135622527 135624745
ZOF : 121967555 121988665 121997591 122016214 122031866 122034341 122041523 122046034 122047857 122052786
MSIN : 131217570 131217571 131223866 131253618
NCOL : 116254902 116262247 116267900
CJF : 131031141 131049134 131049136 131049138 131049140 131049141 131049159 131074951 131873612
SMO : SELMODRAFT_450569(C4H1-1) SELMODRAFT_450570(C4H1-2)
PPP : 112277388 112279424 112281483 112290352
» show all
Taxonomy
Reference
Authors
Potts JR, Weklych R, Conn EE, Rowell J.
Title
The 4-hydroxylation of cinnamic acid by sorghum microsomes and the requirement for cytochrome P-450.
Journal
J Biol Chem 249:5019-26 (1974)
Reference
Authors
Russell DW, Conn EE.
Title
The cinnamic acid 4-hydroxylase of pea seedlings.
Journal
Reference
Authors
Pierrel MA, Batard Y, Kazmaier M, Mignotte-Vieux C, Durst F, Werck-Reichhart D
Title
Catalytic properties of the plant cytochrome P450 CYP73 expressed in yeast. Substrate specificity of a cinnamate hydroxylase.
Journal
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