CYP82N2 (gene name)
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
protopine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6-hydroxylating)
protopine + [reduced NADPH---hemoprotein reductase] + O2 = 6-hydroxyprotopine + [oxidized NADPH---hemoprotein reductase] + H2O [RN:
[reduced NADPH---hemoprotein reductase] [CPD:
[oxidized NADPH---hemoprotein reductase] [CPD:
A cytochrome P-450 (heme-thiolate) protein involved in benzophenanthridine alkaloid synthesis in higher plants.
EC 18.104.22.168 created 1999 as EC 22.214.171.124, transferred 2018 to EC 126.96.36.199
ec00950 Isoquinoline alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
K21693 protopine 6-monooxygenase
PSOM: 113330723 113357146 Taxonomy
Tanahashi, T. and Zenk, M.H.
Elicitor induction and characterization of microsomal protopine-6-hydroxylase, the central enzyme in benzophenanthridine alkaloid biosynthesis.
Phytochemistry 29:1113-1122 (1990)
Takemura T, Ikezawa N, Iwasa K, Sato F
Molecular cloning and characterization of a cytochrome P450 in sanguinarine biosynthesis from Eschscholzia californica cells.
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