KEGG   ENZYME: 1.14.17.1
Entry
EC 1.14.17.1                Enzyme                                 
Name
dopamine beta-monooxygenase;
dopamine beta-hydroxylase;
MDBH (membrane-associated dopamine beta-monooxygenase);
SDBH (soluble dopamine beta-monooxygenase);
dopamine-B-hydroxylase;
3,4-dihydroxyphenethylamine beta-oxidase;
4-(2-aminoethyl)pyrocatechol beta-oxidase;
dopa beta-hydroxylase;
dopamine beta-oxidase;
dopamine hydroxylase;
phenylamine beta-hydroxylase;
(3,4-dihydroxyphenethylamine)beta-mono-oxygenase;
DbetaM (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
Reaction(IUBMB)
dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O [RN:R02535]
Reaction(KEGG)
R02535
Substrate
dopamine [CPD:C03758];
ascorbate [CPD:C00072];
O2 [CPD:C00007]
Product
noradrenaline [CPD:C00547];
monodehydroascorbate [CPD:C01041];
H2O [CPD:C00001]
Comment
A copper protein. The enzyme, found in animals, binds two copper ions with distinct roles during catalysis. Stimulated by fumarate.
History
EC 1.14.17.1 created 1965 as EC 1.14.2.1, transferred 1972 to EC 1.14.17.1, modified 2020
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K00503  dopamine beta-monooxygenase
Genes
HSA1621(DBH)
PTR464827(DBH)
PPS100985587(DBH)
GGO101154486(DBH)
PON100461514(DBH)
NLE100597609(DBH)
MCC574105(DBH)
MCF102139527(DBH)
MTHB126937138
CSAB103239676(DBH)
CATY105580523(DBH)
PANU101016746
TGE112608503(DBH)
RRO104669786(DBH)
RBB108513277(DBH)
TFN117099202(DBH)
PTEH111523984(DBH)
CJC100406041(DBH)
SBQ101046079(DBH)
CSYR103273377(DBH)
MMUR105880739(DBH)
LCAT123646086(DBH)
OGA100961448(DBH)
MMU13166(Dbh)
MCAL110290214(Dbh)
MPAH110319201(Dbh)
RNO25699(Dbh)
MCOC116089882(Dbh)
MUN110557516(Dbh)
CGE100761411(Dbh)
MAUA101829122(Dbh)
PLEU114684222(Dbh)
MORG121462939(Dbh)
MFOT126509477
AAMP119819746(Dbh)
NGI103742818(Dbh)
HGL101724312(Dbh)
CPOC100727873(Dbh)
CCAN109677868(Dbh)
DORD105995609(Dbh)
DSP122108906(Dbh)
NCAR124964227
OCU103347199(DBH)
OPI101531833(DBH)
TUP102468703(DBH)
CFA448806(DBH)
CLUD112677400(DBH)
VVP112906947(DBH)
VLG121473853(DBH)
AML100480347(DBH)
UMR103679922(DBH)
UAH113266575(DBH)
UAR123775689(DBH)
ELK111146214
LLV125083193
MPUF101687995(DBH)
ORO101362871(DBH)
EJU114201020(DBH)
ZCA113934884(DBH)
MLX118018100(DBH)
NSU110581632(DBH)
FCA101082957(DBH)
PYU121021226(DBH)
PBG122474494(DBH)
LRUF124522415
PTG102961078(DBH)
PPAD109258287(DBH)
AJU106988258(DBH)
HHV120247318(DBH)
BTA280758(DBH)
BOM102286194(DBH)
BIU109566610(DBH)
BBUB102409301(DBH)
CHX102176244(DBH)
OAS114113851(DBH)
ODA120852173(DBH)
CCAD122442339(DBH)
SSC733609(DBH)
CFR102523816(DBH)
CBAI105068611(DBH)
CDK105106327(DBH)
VPC102534249
BACU103001548(DBH)
LVE103082302(DBH)
OOR101269198(DBH)
DLE111177039(DBH)
PCAD102990638(DBH)
PSIU116755116(DBH)
ECB791247(DBH)
EPZ103564043(DBH)
EAI106845350(DBH)
MYB102264141(DBH)
MYD102763656(DBH)
MMYO118666900(DBH)
MNA107524669(DBH)
PKL118708909(DBH)
HAI109381156(DBH)
DRO112306436(DBH)
SHON118980160(DBH)
AJM119036119(DBH)
PDIC114508649(DBH)
PHAS123823386(DBH)
MMF118629977(DBH)
RFQ117031624(DBH)
PALE102882740(DBH)
PGIG120618872(DBH)
PVP105308213(DBH)
RAY107506265(DBH)
MJV108398386(DBH)
TOD119231230(DBH)
SARA101549744(DBH)
LAV100675803(DBH)
TMU101344432
DNM101445626(DBH)
MDO100018814(DBH)
GAS123235192(DBH)
SHR100925655(DBH)
PCW110205374(DBH)
OAA100073905(DBH)
GGA395549(DBH)
PCOC116234079(DBH)
MGP100544779(DBH)
CJO107321868(DBH)
NMEL110406867(DBH)
APLA101793381(DBH)
ACYG106044068(DBH)
AFUL116497023(DBH)
TGU100224356(DBH)
LSR110477727(DBH)
SCAN103818963(DBH)
PMOA120512423(DBH)
OTC121337041(DBH)
PRUF121362449(DBH)
GFR102038113(DBH)
FAB101810825(DBH)
PHI102100810(DBH)
PMAJ107211985(DBH)
CCAE111937045(DBH)
CCW104688340(DBH)
CBRC103623244(DBH)
ETL114059130(DBH)
ZAB102067155(DBH)
ACHL103807315(DBH)
FPG101923335(DBH)
FCH102048380(DBH)
CLV102097674(DBH)
EGZ104129357(DBH)
NNI104023198(DBH)
PLET104623396(DBH)
PCRI104028747(DBH)
PCAO104050609(DBH)
ACUN113486646(DBH)
TALA104360329(DBH)
PADL103915345(DBH)
AFOR103905336(DBH)
ACHC115335026(DBH)
HALD104321603(DBH)
CCRI104163012(DBH)
CSTI104554872(DBH)
EHS104510808(DBH)
CMAC104487171(DBH)
MUI104541274(DBH)
FGA104080547(DBH)
GSTE104264786(DBH)
LDI104353407(DBH)
MNB103770274(DBH)
OHA104329486(DBH)
NNT104413882(DBH)
DPUB104296410(DBH)
PGUU104462249(DBH)
ACAR104517771(DBH)
AVIT104275314(DBH)
CVF104292827(DBH)
CUCA104066832(DBH)
AAM106484479(DBH)
AROW112964327(DBH)
NPD112956064(DBH)
TGT104568108(DBH)
DNE112979868(DBH)
SCAM104138237(DBH)
ASN102377750(DBH)
AMJ102562465(DBH)
CPOO109313992(DBH)
GGN109293013(DBH)
PSS102455557(DBH)
CMY102935981(DBH)
CPIC101944381(DBH)
TST117867238(DBH)
CABI116817450(DBH)
MRV120386832(DBH)
ACS100566843(dbh)
PVT110089291(DBH)
SUND121936462(DBH)
PBI103050577(DBH)
PMUR107291028(DBH)
CTIG120314624(DBH)
TSR106552853(DBH)
PGUT117671327(DBH)
VKO123035174(DBH)
PMUA114588914(DBH)
ZVI118084255(DBH)
GJA107106563(DBH)
STOW125441929(DBH)
XLA108698178(dbh.L) 108699900(dbh.S)
XTR100492247(dbh)
NPR108792841(DBH)
RTEM120913857(DBH)
BBUF121009593(DBH)
BGAR122919306(DBH)
DRE30505(dbh)
SRX107713263 107744238
SANH107658656 107685164
SGH107595570(dbh) 107597665
CCAR109052532 109080215
CAUA113109649 113109662
PPRM120482193(dbh)
MAMB125257707(dbh)
IPU108276829(dbh)
PHYP113544042(dbh)
SMEO124393247(dbh)
TFD113653083(dbh)
AMEX103038160(dbh)
EEE113576331(dbh)
TRU101066621(dbh)
TNGGSTEN00024729G001
LCO104923914(dbh)
NCC104968179(dbh)
CGOB115016923(dbh)
ELY117269510(dbh)
EFO125905776(dbh)
PLEP121960296(dbh)
SLUC116034955
ECRA117959052(dbh)
ESP116703934
PFLV114571332
GAT120832241(dbh)
PPUG119226520(dbh)
MSAM119882201 119914708(dbh)
CUD121525273(dbh)
ALAT119030408(dbh)
MZE101464817(dbh)
ONL100708156(dbh)
OAU116335170(dbh)
OLA101157870(dbh)
OML112162907(dbh)
XMA102218690(dbh)
XCO114149436(dbh)
XHE116724091(dbh)
PRET103473626(dbh)
PFOR103147866(dbh)
PLAI106948318(dbh)
PMEI106921879(dbh)
GAF122847123(dbh)
CVG107088692(dbh)
CTUL119782614(dbh)
GMU124872393(dbh)
NFU107372400(dbh)
KMR108232649(dbh)
ALIM106514559(dbh)
NWH119424449(dbh) 119429221
AOCE111567020(dbh)
MCEP124996693(dbh)
CSEM103389065(dbh)
POV109626136(dbh)
SSEN122758000(dbh)
HHIP117771598(dbh)
HSP118125929(dbh)
LCF108879254
SDU111238762(dbh)
SLAL111666075(dbh)
XGL120806361(dbh)
HCQ109517071(dbh)
BPEC110174164(dbh)
MALB109963454(dbh)
BSPL114866790(dbh)
SASA106568424(dbh)
STRU115149420(dbh)
OTW112257386
OMY110536983(dbh)
OGO124000827
ONE115105985(dbh)
SALP111980057
SNH120025633(dbh)
CCLU121573457
ELS105014776(dbh)
SFM108934136(dbh)
PKI111854168(dbh)
AANG118212852(dbh)
LOC102682868(dbh)
PSPA121303526 121307068
ARUT117422501(dbh)
LCM102359119(DBH)
CMK103182970(dbh)
BFO118421819
BBEL109482305
CIN100176680
SCLV120339920 120342663
SPU586320 752850
APLC110976390
SKO102804261
DMEDmel_CG1543(Tbh)
DER6551562
DSE6620197
DSIDsimw501_GD16874(Dsim_Tbh)
DYADyak_GE15754
DAN6503980
DSR110178084
DPO6901962
DPE6600415
DMN108165110
DWI6641182
DGR6566217
DMODmoj_GI11219
DAZ108620140
DNV115564952
DHE111598821
DVI6633815
CCAT101458576
BOD106623892
RZE108360686
MDE101897009
SCAC106088619
LCQ111684501
LSQ119606407
HIS119656744
AGAAgaP_AGAP010485
ACOZ120959168
AARA120903805
ASTE118512559
AAG5574019
AALB109427529 115256503
CQUCpipJ_CPIJ019622
CPII120420172
CNS116347605
BCOO119067204
AME751102(Tbh)
ACER107998169
ALAB122712346
BIM100743458
BBIF117209243
BVK117239749
BVAN117165944
BTER100649446
BPYO122566323
CCAL108629262
OBB114880623
MGEN117217919
NMEA116432070
CGIG122398220
SOC105201088
MPHA105837371
AEC105145835
ACEP105618961
PBAR105434118
VEM105570585
HST105182135
DQU106743489
CFO105258572
FEX115236740
LHU105668349
PGC109857916
OBO105277857
PCF106792493
PFUC122513420
VPS122636967
NVI100119029
CSOL105359023
TPRE106655741
MDL103579714
CGLO123265238
FAS105269041
DAM107036592
AGIF122857242
LHT122504037
CCIN107268727
TCA663011(TcTBH)
DPA109541252 109541259
SOY115889971
ATD109600593
CSET123322741
AGB108905603
LDC111509121
NVL108563606
APLN108737152
PPYR116179966
OTU111417408
BMOR100862766(Tbh)
BMAN114239450
MSEX115439887
DPLKGM_207724
BANY112048211
NIQ126773918
PMAC106717834
PPOT106108479
PXU106116017
PRAP110994553
ZCE119838682
HAW110383622
TNL113501985
SLIU111365092
OFU114350246
PXY105395691 105397436
CFEL113385824 113385829
API100166363
DNX107169334
AGS114121829
RMD113558464
BTAB109037049
DCI103510050 103516417
CLEC106667484
NLU111053896
PHUPhum_PHUM211140
FOC113209640
TPAL117640257
ZNE110838985
CSEC111873648
FCD110851639
DPXDAPPUDRAFT_1839
DMK116927591
PJA122245099
PCHN125039833
HAME121860904
PCLA123774002
PTRU123512862
HAZT108669948
EAF111710478
LSM121131025
PPOI119101094
ISCIscW_ISCW000229
DSV119437209
RSAN119400178
RMP119161520
VDE111253578
VJA111272129
TUT107360804
DPTE113793264
DFR124491814
CSCU111615103
PTEP107447331
SDM118182174
CELCELE_H13N06.6(tbh-1)
CBRCBG_07714(Cbr-tbh-1)
HROHELRODRAFT_64253
LGILOTGIDRAFT_120180 LOTGIDRAFT_162200 LOTGIDRAFT_191156 LOTGIDRAFT_233457 LOTGIDRAFT_233458 LOTGIDRAFT_234237
PCAN112557427 112561909 112563147 112570227 112570228 112570230 112570414 112570415 112575465 112576338
BGT106051127 106059217 106066921 106068157 106068158 106077242 106078399 106078772
GAE121383804 121384141
HRF124114394 124121445 124138380 124142782 124142798 124148606 124151079
HRJ124253288 124257823 124266189 124270276 124275898 124284219 124284488 124289238
CRG105321753 105329831 105337151 105342404 105344230 105348387
MYI110442054 110447535 110447536 110450515 110452901 110454243 110454251 110455641 110456098 110456174 110467057 110467403
PMAX117316542 117316561 117316569 117316585 117317248 117319629 117321720 117321721 117321920 117321941 117334297 117334351 117334793 117335029
MMER123533077 123533930 123538847 123545778 123546293 123546596 123555574 123561327
OBI106875923
OSN115219340
LAK106150741 106165088 106173926 106180620 106181793
SMMSmp_163900
OVIT265_00912
AQU100635830 105315872
 » show all
Reference
1  [PMID:14416204]
  Authors
LEVIN EY, LEVENBERG B, KAUFMAN S.
  Title
The enzymatic conversion of 3,4-dihydroxyphenylethylamine to norepinephrine.
  Journal
J Biol Chem 235:2080-6 (1960)
Reference
2  [PMID:5846992]
  Authors
Friedman S, Kaufman S.
  Title
3,4-dihydroxyphenylethylamine beta-hydroxylase. Physical properties, copper content, and role of copper in the catalytic acttivity.
  Journal
J Biol Chem 240:4763-73 (1965)
Reference
3  [PMID:7388045]
  Authors
Skotland T, Ljones T
  Title
Direct spectrophotometric detection of ascorbate free radical formed by dopamine  beta-monooxygenase and by ascorbate oxidase.
  Journal
Biochim Biophys Acta 630:30-5 (1980)
DOI:10.1016/0304-4165(80)90134-8
Reference
4  [PMID:12966104]
  Authors
Evans JP, Ahn K, Klinman JP
  Title
Evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase. Implications for the reactive oxygen species.
  Journal
J Biol Chem 278:49691-8 (2003)
DOI:10.1074/jbc.M300797200
Other DBs
ExplorEnz - The Enzyme Database: 1.14.17.1
IUBMB Enzyme Nomenclature: 1.14.17.1
ExPASy - ENZYME nomenclature database: 1.14.17.1
BRENDA, the Enzyme Database: 1.14.17.1
CAS: 9013-38-1
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