KEGG ENZYME: 1.14.17.1

ENZYME: 1.14.17.1

Entry

EC 1.14.17.1                Enzyme

Name

dopamine beta-monooxygenase;
dopamine beta-hydroxylase;
MDBH (membrane-associated dopamine beta-monooxygenase);
SDBH (soluble dopamine beta-monooxygenase);
dopamine-B-hydroxylase;
3,4-dihydroxyphenethylamine beta-oxidase;
4-(2-aminoethyl)pyrocatechol beta-oxidase;
dopa beta-hydroxylase;
dopamine beta-oxidase;
dopamine hydroxylase;
phenylamine beta-hydroxylase;
(3,4-dihydroxyphenethylamine)beta-mono-oxygenase;
DbetaM (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)

Reaction(IUBMB)

dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O [RN:R02535]

Reaction(KEGG)

R02535

Substrate

dopamine [CPD:C03758];
ascorbate [CPD:C00072];
O2 [CPD:C00007]

Product

noradrenaline [CPD:C00547];
monodehydroascorbate [CPD:C01041];
H2O [CPD:C00001]

Comment

A copper protein. The enzyme, found in animals, binds two copper ions with distinct roles during catalysis. Stimulated by fumarate.

History

EC 1.14.17.1 created 1965 as EC 1.14.2.1, transferred 1972 to EC 1.14.17.1, modified 2020

Pathway

ec00350

Tyrosine metabolism

ec01100

Metabolic pathways

Orthology

K00503

dopamine beta-monooxygenase

Genes

HSA:

1621(DBH)

PTR:	464827(DBH)

PPS:	100985587(DBH)

GGO:	101154486(DBH)

PON:	100461514(DBH)

PPYG:

129044136(DBH)

NLE:	100597609(DBH)

HMH:	116475831(DBH)

SSYN:

129478715(DBH)

MCC:	574105(DBH)

MCF:	102139527(DBH)

MTHB:

126937138

MNI:	105471876(DBH)

CSAB:

103239676(DBH)

CATY:

105580523(DBH)

PANU:

101016746

TGE:	112608503(DBH)

MLEU:

105547818(DBH)

RRO:	104669786(DBH)

RBB:	108513277(DBH)

TFN:	117099202(DBH)

PTEH:

111523984(DBH)

CANG:

105503972(DBH)

CJC:	100406041(DBH)

SBQ:	101046079(DBH)

CIMI:

108292306(DBH)

ANAN:

105712191(DBH)

CSYR:

103273377(DBH)

MMUR:

105880739(DBH)

LCAT:

123646086(DBH)

PCOQ:

105826696(DBH)

OGA:	100961448(DBH)

MMU:	13166(Dbh)

MCAL:

110290214(Dbh)

MPAH:

110319201(Dbh)

RNO:	25699(Dbh)

MCOC:

116089882(Dbh)

ANU:	117704073(Dbh)

MUN:	110557516(Dbh)

CGE:	100761411(Dbh)

MAUA:

101829122(Dbh)

PROB:

127221930(Dbh)

PLEU:

114684222(Dbh)

MORG:

121462939(Dbh)

MFOT:

126509477

AAMP:

119819746(Dbh)

NGI:	103742818(Dbh)

HGL:	101724312(Dbh)

CPOC:

100727873(Dbh)

CCAN:

109677868(Dbh)

DORD:

105995609(Dbh)

DSP:	122108906(Dbh)

PLOP:

125353283(Dbh)

NCAR:

124964227

MMMA:

107159145(Dbh)

OPI:	101531833(DBH)

TUP:	102468703(DBH)

GVR:	103596907(DBH)

CFA:	448806(DBH)

CLUD:

112677400(DBH)

VVP:	112906947(DBH)

VLG:	121473853(DBH)

NPO:	129517647(DBH)

AML:	100480347(DBH)

UMR:	103679922(DBH)

UAH:	113266575(DBH)

UAR:	123775689(DBH)

ELK:

111146214

LLV:

125083193

MPUF:

101687995(DBH)

MNP:	132024938(DBH)

MLK:	131812941(DBH)

NVS:	122916823(DBH)

ORO:	101362871(DBH)

EJU:	114201020(DBH)

ZCA:	113934884(DBH)

MLX:	118018100(DBH)

NSU:	110581632(DBH)

FCA:	101082957(DBH)

PYU:	121021226(DBH)

PCOO:

112860343(DBH)

PBG:	122474494(DBH)

PVIV:

125150068(DBH)

LRUF:

124522415

PTG:	102961078(DBH)

PPAD:

109258287(DBH)

PUC:

125923040

AJU:

106988258

HHV:	120247318(DBH)

BTA:	280758(DBH)

BOM:	102286194(DBH)

BIU:	109566610(DBH)

BBUB:

102409301(DBH)

BBIS:

104983329(DBH)

CHX:	102176244(DBH)

OAS:	114113851(DBH)

BTAX:

128056614(DBH)

ODA:	120852173(DBH)

CCAD:

122442339(DBH)

MBEZ:

129539725(DBH)

SSC:	733609(DBH)

CFR:	102523816(DBH)

CBAI:

105068611(DBH)

CDK:	105106327(DBH)

VPC:

102534249

BACU:

103001548(DBH)

BMUS:

118897084(DBH)

LVE:	103082302(DBH)

OOR:	101269198(DBH)

DLE:	111177039(DBH)

PCAD:

102990638(DBH)

PSIU:

116755116(DBH)

NASI:

112411311(DBH)

ECB:	791247(DBH)

EPZ:	103564043(DBH)

EAI:	106845350(DBH)

MYB:	102264141(DBH)

MYD:	102763656(DBH)

MMYO:

118666900(DBH)

MDT:	132212532(DBH)

PKL:	118708909(DBH)

EFUS:

103295991(DBH)

MNA:	107524669(DBH)

DRO:	112306436(DBH)

SHON:

118980160(DBH)

AJM:	119036119(DBH)

PDIC:

114508649(DBH)

PHAS:

123823386(DBH)

MMF:	118629977(DBH)

PPAM:

129079166(DBH)

HAI:	109381156(DBH)

RFQ:	117031624(DBH)

PALE:

102882740(DBH)

PGIG:

120618872(DBH)

PVP:	105308213(DBH)

RAY:	107506265(DBH)

MJV:	108398386(DBH)

TOD:	119231230(DBH)

SARA:

101549744(DBH)

SETR:

126009332(DBH)

LAV:	100675803(DBH)

TMU:

101344432

ETF:	101657053(DBH)

DNM:	101445626(DBH)

MDO:	100018814(DBH)

GAS:	123235192(DBH)

SHR:	100925655(DBH)

AFZ:

127547077

PCW:	110205374(DBH)

TVP:	118844572(DBH)

OAA:	100073905(DBH)

GGA:	395549(DBH)

PCOC:

116234079(DBH)

MGP:	100544779(DBH)

CJO:	107321868(DBH)

TPAI:

128073402(DBH)

LMUT:

125702511(DBH)

NMEL:

110406867(DBH)

APLA:

101793381(DBH)

ACYG:

106044068(DBH)

CATA:

118252230(DBH)

AFUL:

116497023(DBH)

TGU:	100224356(DBH)

LSR:	110477727(DBH)

SCAN:

103818963(DBH)

PMOA:

120512423(DBH)

OTC:	121337041(DBH)

PRUF:

121362449(DBH)

GFR:	102038113(DBH)

FAB:	101810825(DBH)

OMA:	130260260(DBH)

PHI:	102100810(DBH)

PMAJ:

107211985(DBH)

CCAE:

111937045(DBH)

CCW:	104688340(DBH)

CBRC:

103623244(DBH)

ETL:	114059130(DBH)

ZAB:	102067155(DBH)

ZLE:	135454926(DBH)

ACHL:

103807315(DBH)

SVG:	106851290(DBH)

MMEA:

130576690(DBH)

HRT:	120761618(DBH)

SATI:

136369786(DBH)

FPG:	101923335(DBH)

FCH:	102048380(DBH)

CCRI:

104163012(DBH)

NNT:	104413882(DBH)

SHAB:

115617137(DBH)

ACUN:

113486646(DBH)

TALA:

104360329(DBH)

ACHC:

115335026(DBH)

HALD:

104321603(DBH)

HLE:	104833860(DBH)

AGEN:

126052377

GCL:

127023841

CSTI:

104554872(DBH)

LDI:	104353407(DBH)

MNB:	103770274(DBH)

DPUB:

104296410(DBH)

AVIT:

104275314(DBH)

BRHI:

104496129(DBH)

EGZ:	104129357(DBH)

NNI:	104023198(DBH)

PCRI:

104028747(DBH)

PCAO:

104050609(DBH)

PADL:

103915345(DBH)

AFOR:

103905336(DBH)

FGA:	104080547(DBH)

GSTE:

104264786(DBH)

CLV:	102097674(DBH)

MUI:	104541274(DBH)

PGUU:

104462249(DBH)

PLET:

104623396(DBH)

EHS:	104510808(DBH)

CMAC:

104487171(DBH)

CUCA:

104066832(DBH)

TEO:	104375628(DBH)

BREG:

104638501(DBH)

OHA:	104329486(DBH)

ACAR:

104517771(DBH)

CPEA:

104389814(DBH)

CVF:	104292827(DBH)

RTD:	128917489(DBH)

AAM:	106484479(DBH)

AROW:

112964327(DBH)

NPD:	112956064(DBH)

TGT:	104568108(DBH)

DNE:	112979868(DBH)

SCAM:

104138237(DBH)

ASN:	102377750(DBH)

AMJ:	102562465(DBH)

CPOO:

109313992(DBH)

GGN:	109293013(DBH)

PSS:	102455557(DBH)

CMY:	102935981(DBH)

CCAY:

125623615(DBH)

DCC:	119844211(DBH)

CPIC:

101944381(DBH)

TST:	117867238(DBH)

CABI:

116817450(DBH)

MRV:	120386832(DBH)

ACS:	100566843(dbh)

ASAO:

132763872(DBH)

PVT:	110089291(DBH)

SUND:

121936462(DBH)

PBI:	103050577(DBH)

PMUR:

107291028(DBH)

CTIG:

120314624(DBH)

TSR:	106552853(DBH)

PGUT:

117671327(DBH)

APRI:

131186228(DBH)

PTEX:

113448480(DBH)

NSS:	113426294(DBH)

VKO:	123035174(DBH)

PMUA:

114588914(DBH)

PRAF:

128406237(DBH)

ZVI:	118084255(DBH)

HCG:	128338782(DBH)

GJA:	107106563(DBH)

STOW:

125441929(DBH)

EMC:	129341924(DBH)

XLA:	108698178(dbh.L) 108699900(dbh.S)

XTR:	100492247(dbh)

NPR:	108792841(DBH)

RTEM:

120913857(DBH)

BBUF:

121009593(DBH)

BGAR:

122919306(DBH)

MUO:	115472054(DBH)

GSH:	117368390(DBH)

DRE:	30505(dbh)

SRX:	107713263 107744238

SANH:

107658656 107685164

SGH:	107595570(dbh) 107597665

CCAR:

109052532 109080215

CAUA:

113109649 113109662

CGIB:

127966274

PTET:

122352743(dbh)

LROH:

127171928(dbh)

OMC:	131548322(dbh)

PPRM:

120482193(dbh)

RKG:	130073531(dbh)

MAMB:

125257707(dbh)

CIDE:

127520887

CERY:

137027501(dbh)

MASI:

127433690

TROS:

130546436(dbh)

TDW:	130412074(dbh)

MANU:

129447255(dbh)

IPU:

108276829

IFU:	128620171 128620707(dbh)

PHYP:

113544042(dbh)

SMEO:

124393247(dbh)

TFD:	113653083(dbh)

TVC:	132863268(dbh)

TRN:	134332182(dbh)

AMEX:

103038160(dbh)

CMAO:

118824922(dbh)

EEE:	113576331(dbh)

CHAR:

105906021(dbh)

TRU:	101066621(dbh)

TFS:	130517645(dbh)

TNG:	GSTEN00024729G001

LCO:	104923914(dbh)

NCC:	104968179(dbh)

TBEN:

117476401(dbh)

CGOB:

115016923(dbh)

PGEO:

117455785(dbh)

GACU:

117534087(dbh)

EMAC:

134868709(dbh)

ELY:	117269510(dbh)

EFO:	125905776(dbh)

PLEP:

121960296(dbh)

SLUC:

116034955

ECRA:

117959052(dbh)

ESP:

116703934

PFLV:

114571332

GAT:	120832241(dbh)

PPUG:

119226520(dbh)

AFB:	129102695(dbh)

CLUM:

117740726(dbh)

PSWI:

130205805(dbh)

MSAM:

119882201 119914708(dbh)

SCHU:

122865195(dbh)

CUD:	121525273(dbh)

ALAT:

119030408(dbh)

ASTR:

137608326(dbh)

MZE:	101464817(dbh)

ONL:	100708156(dbh)

OAU:	116335170(dbh)

OLA:	101157870(dbh)

OML:	112162907(dbh)

CSAI:

133455328(dbh)

XMA:	102218690(dbh)

XCO:	114149436(dbh)

XHE:	116724091(dbh)

PRET:

103473626(dbh)

PFOR:

103147866(dbh)

PLAI:

106948318(dbh)

PMEI:

106921879(dbh)

GAF:	122847123(dbh)

PPRL:

129366448(dbh)

CVG:	107088692(dbh)

CTUL:

119782614(dbh)

GMU:	124872393(dbh)

NFU:	107372400(dbh)

KMR:	108232649(dbh)

ALIM:

106514559(dbh)

NWH:	119424449(dbh) 119429221

AOCE:

111567020(dbh)

MCEP:

124996693(dbh)

CSEM:

103389065(dbh)

POV:	109626136(dbh)

SSEN:

122758000(dbh)

HHIP:

117771598(dbh)

HSP:	118125929(dbh)

PPLT:

128424550(dbh)

SMAU:

118284738(dbh)

LCF:

108879254

SDU:	111238762(dbh)

SLAL:

111666075(dbh)

XGL:	120806361(dbh)

HCQ:	109517071(dbh)

SSCV:

125980063

SBIA:

133490565(dbh)

PEE:	133414113(dbh)

PTAO:

133489895(dbh)

BPEC:

110174164(dbh)

MALB:

109963454(dbh)

BSPL:

114866790(dbh)

SJO:	128380399(dbh)

SASA:

106568424(dbh)

STRU:

115149420(dbh)

OTW:

112257386

OMY:	110536983(dbh)

OGO:

124000827

ONE:	115105985(dbh)

OKI:	109893630(dbh)

OKE:

118391620

SALP:

111980057

SNH:	120025633(dbh)

CCLU:

121573457

ELS:	105014776(dbh)

SFM:	108934136(dbh)

PKI:	111854168(dbh)

AANG:

118212852(dbh)

LOC:	102682868(dbh)

PSPA:

121303526 121307068

ARUT:

117422501(dbh)

PSEX:

120535438(dbh)

LCM:	102359119(DBH)

CMK:	103182970(dbh)

RTP:	109911276(dbh)

HOC:	132825774(dbh)

LERI:

129712113(dbh)

PMRN:

116955387(DBH)

BFO:

118421819

BBEL:

109482305

CIN:

100176680

SCLV:

120339920 120342663

SPU:	586320 752850

LPIC:

129278135 129278136

APLC:

110976390

ARUN:

117303158

SKO:

102804261

DME:	Dmel_CG1543(Tbh)

DER:

6551562

DSE:

6620197

DSI:	Dsimw501_GD16874(Dsim_Tbh)

DYA:	Dyak_GE15754

DAN:

6503980

DSR:

110178084

DPO:

6901962

DPE:

6600415

DMN:

108165110

DWI:

6641182

DGR:

6566217

DMO:	Dmoj_GI11219

DAZ:

108620140

DNV:

115564952

DHE:

111598821

DVI:

6633815

CCAT:

101458576

BOD:

106623892

BDR:

105225692

RZE:

108360686

AOQ:

129248525

TDA:

119669832

MDE:

101897009

SCAC:

106088619

LCQ:

111684501

LSQ:

119606407

GFS:

119635517

ECOE:

129946934

CLON:

129618760

HIS:

119656744

AGA:

1269192

ACOZ:

120959168

AARA:

120903805

AMER:

121600202

ASTE:

118512559

AFUN:

125772739

AMOU:

128307018

AALI:

118465293

AAG:

5574019

AALB:

109427529 115256503

ASUA:

134204518 134207195

CQU:	CpipJ_CPIJ019622

CPII:

120420172

CNS:

116347605

BCOO:

119067204

LLL:

129793618

AME:	751102(Tbh)

ACER:

107998169

ALAB:

122712346

ADR:

102679996

AFLR:

100866754

BIM:

100743458

BBIF:

117209243

BVK:

117239749

BVAN:

117165944

BTER:

100649446

BAFF:

126916315

BPYO:

122566323

BPAS:

132905448

FVI:

122532975

CCAL:

108629262

OBB:

114880623

OLG:

117608063

MGEN:

117217919

NMEA:

116432070

CGIG:

122398220

SOC:

105201088

MPHA:

105837371

AEC:

105145835

ACEP:

105618961

PBAR:

105434118

VEM:

105570585

HST:

105182135

DQU:

106743489

CFO:

105258572

FEX:

115236740

LHU:	105668349(Tbh)

PGC:

109857916

OBO:

105277857

PCF:

106792493

PFUC:

122513420

VPS:

122636967

VCRB:

124431097

VVE:

124957048

NVI:

100119029

CSOL:

105359023

TPRE:

106655741

LHT:

122504037

LBD:

127277593

MDL:

103579714

CGLO:

123265238

FAS:

105269041

DAM:

107036592

AGIF:

122857242

CINS:

118068481

VCAN:

122410233

CCIN:

107268727

DSM:

124410556

NPT:

124218584

NFB:

124182105

NLO:

107217355

NVG:

124304850

AROA:

105685648

TCA:	663011(TcTBH)

DPA:	109541252 109541259

SOY:

115889971

AGRG:

126739089

ATD:

109600593

CSET:

123322741

AGB:

108905603

LDC:

111509121

DVV:

114339812

NVL:

108563606

APLN:

108737152

PPYR:

116179966

OTU:

111417408

BMOR:

100862766(Tbh)

BMAN:

114239450

MSEX:

115439887

DPL:	KGM_207724

BANY:

112048211

MJU:

123872275

NIQ:

126773918

VCD:

124534328

MCIX:

123656568

PMAC:

106717834

PPOT:

106108479

PXU:

106116017

PRAP:

110994553

PBX:

123709853

PNAP:

125049218

ZCE:

119838682

CCRC:

123696187

LSIN:

126979368

AAGE:

121733157

HAW:

110383622

TNL:

113501985

SLIU:

111365092

OFU:

114350246

ATRA:

106138267

GMW:

113520813

PXY:

105397436

PGW:

126371832

LGLY:

125230654

CFEL:

113385824 113385829

CCRN:

123292104

API:

100166363

DNX:

107169334

AGS:

114121829

RMD:

113558464

ACOO:

126838348

DVT:	126908822 126909213

BTAB:

109037049

DCI:	103510050 103516417

CLEC:

106667484

NLU:

111053896

HVI:

124360002

MQU:

128991988

PHU:	Phum_PHUM211140

FOC:

113209640

TPAL:

117640257

ZNE:

110838985

CSEC:

111873648

SGRE:

126298490

BROR:

134530734

IEL:

124169473

FCD:

110851639

DPX:	DAPPUDRAFT_1839

DMK:

116927591

DPZ:

124315187

PJA:

122245099

PCHN:

125039833

PMOO:

119597333

HAME:

121860904

PCLA:

123774002

CQD:

128704643

PTRU:

123512862

ESN:

126985262

MNZ:

135203622

MRJ:	136852989(Tbh)

HAZT:

108669948

EAF:

111710478

LSM:

121131025

TCF:

131888776

PPOI:

119101094

DSV:

119437209

RSAN:

119400178

RMP:

119161520

VDE:

111253578

VJA:

111272129

TUT:

107360804

DPTE:

113793264

DFR:

124491814

CSCU:

111615103

CVS:	136986377(Tbh)

PTEP:

107447331

ABRU:

129960344

UDV:

129231372

SDM:

118182174

LPOL:

106476351

PMEO:

129599633

CEL:	CELE_H13N06.6(tbh-1)

CBR:	CBG_07714(Cbr-tbh-1)

CRQ:	GCK72_025527

HRO:	HELRODRAFT_64253

LGI:	LOTGIDRAFT_120180 LOTGIDRAFT_162200 LOTGIDRAFT_191156 LOTGIDRAFT_233457 LOTGIDRAFT_234237

PVUL:

126812196 126832242

PCAN:

112557427 112561909 112563147 112570230 112570414 112575465 112576338

BGT:	106066921 106077242 106078772

GAE:	121383804 121384141

HRF:	124114394 124138380 124142782 124142798 124148606 124151079

HRJ:	124253288 124257823 124266189 124270276 124275898 124284219 124284488 124289238

CRG:	105321753 105329831 105337151 105344230

CANU:

128155514

CVN:	111125361 111127321 111133921

OED:

125679743

MYI:	110442054 110447535 110447536 110450515 110452901 110454243 110454251 110455641 110456098 110456174 110467057 110467403

PMAX:

117316542 117316561 117316569 117316585 117319629 117321720 117321721 117321920 117321941 117334297 117334351 117334793 117335029

MCAF:

127728851

MMER:

123533077 123533930 123538847 123545778 123546293 123555574 123561327

RPHI:

132749255

DPOL:

127839781

MAEA:

128223274

OBI:

106875923

OSN:

115219340

LJP:

135480993

LAK:	106150741 106165088 106173926 106180620 106181793

SMM:	Smp_163900

OVI:	T265_00912

LLON:

135501443

» show all

Reference

1 [PMID:14416204]

Authors

LEVIN EY, LEVENBERG B, KAUFMAN S.

Title

The enzymatic conversion of 3,4-dihydroxyphenylethylamine to norepinephrine.

Journal

J Biol Chem 235:2080-6 (1960)

Reference

2 [PMID:5846992]

Authors

Friedman S, Kaufman S.

Title

3,4-dihydroxyphenylethylamine beta-hydroxylase. Physical properties, copper content, and role of copper in the catalytic acttivity.

Journal

J Biol Chem 240:4763-73 (1965)

Reference

3 [PMID:7388045]

Authors

Skotland T, Ljones T

Title

Direct spectrophotometric detection of ascorbate free radical formed by dopamine beta-monooxygenase and by ascorbate oxidase.

Journal

Biochim Biophys Acta 630:30-5 (1980)
DOI:10.1016/0304-4165(80)90134-8

Reference

4 [PMID:12966104]

Authors

Evans JP, Ahn K, Klinman JP

Title

Evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase. Implications for the reactive oxygen species.

Journal

J Biol Chem 278:49691-8 (2003)
DOI:10.1074/jbc.M300797200

Other DBs

ExplorEnz - The Enzyme Database:

1.14.17.1

IUBMB Enzyme Nomenclature:

1.14.17.1

ExPASy - ENZYME nomenclature database:

1.14.17.1

BRENDA, the Enzyme Database:

1.14.17.1

CAS:

9013-38-1

LinkDB

DBGET integrated database retrieval system