KEGG   ENZYME: 1.14.18.5
Entry
EC 1.14.18.5                Enzyme                                 
Name
sphingolipid C4-monooxygenase;
sphinganine C4-monooxygenase;
sphingolipid C4-hydroxylase;
SUR2 (gene name);
SBH1 (gene name);
SBH2 (gene name);
DEGS2 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With another compound as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)
Reaction(IUBMB)
a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4R)-4-hydroxysphinganine ceramide + 2 ferricytochrome b5 + H2O [RN:R06526]
Reaction(KEGG)
R06526;
(other) R06525
Substrate
dihydroceramide [CPD:C12126];
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
(4R)-4-hydroxysphinganine ceramide [CPD:C12145];
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001]
Comment
The enzyme, which belongs to the familiy of endoplasmic reticular cytochrome b5-dependent enzymes, is involved in the biosynthesis of sphingolipids in eukaryotes. Some enzymes are bifunctional and also catalyse EC 1.14.19.17, sphingolipid 4-desaturase [4].
History
EC 1.14.18.5 created 2012 as EC 1.14.13.169, transferred 2015 to EC 1.14.18.5
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K04712  sphingolipid 4-desaturase/C4-monooxygenase
K04713  sphinganine C4-monooxygenase
Genes
HSA123099(DEGS2) 8560(DEGS1)
PTR453157(DEGS2) 457770(DEGS1)
PPS100979702(DEGS2) 100990486(DEGS1)
GGO101143812(DEGS2) 101151016(DEGS1)
PON100171788(DEGS1) 100444414(DEGS2)
NLE100591022(DEGS1) 100606261(DEGS2)
MCC702128(DEGS1) 717222(DEGS2)
MCF102125533(DEGS1) 102146231(DEGS2)
CSAB103229686(DEGS2) 103230017(DEGS1)
CATY105576957(DEGS1) 105596688(DEGS2)
PANU101020274(DEGS1) 101026219(DEGS2)
TGE112622488(DEGS1) 112628461(DEGS2)
RRO104654459(DEGS2) 104677277(DEGS1)
RBB108528244(DEGS1) 108542338(DEGS2)
TFN117071393(DEGS2) 117076319(DEGS1)
PTEH111537091(DEGS1) 111538297(DEGS2)
CJC100404123(DEGS1) 100409287(DEGS2)
SBQ101029219(DEGS2) 101034740(DEGS1)
CSYR103249512(DEGS1) 103251231(DEGS2)
MMUR105861545(DEGS2) 105863773(DEGS1)
LCAT123627508(DEGS1) 123644603(DEGS2)
OGA100942178(DEGS2) 100947778(DEGS1)
MMU13244(Degs1) 619326(9130409I23Rik) 70059(Degs2)
MCAL110292749(Degs1) 110307385(Degs2)
MPAH110321736(Degs1) 110322299 110324835(Degs2)
RNO289322(RGD1564463) 314438(Degs2) 498300 58970(Degs1)
MCOC116068055 116080334(Degs2) 116096990
MUN110546668(Degs1) 110551777(Degs2) 110559919
CGE100753569(Degs1) 100758876 100760423 100771298(Degs2)
MAUA101834205(Degs1) 101835052(Degs2) 101835264 101836958
PLEU114684427(Degs1) 114686407 114690600 114690713 114701910(Degs2)
MORG121434274(Degs2) 121435904 121435931(Degs1)
AAMP119819440(Degs2) 119827584 119827714 119827894
NGI103726249 103726263(Degs1) 103727650(Degs2)
HGL101706415(Degs2) 101722992(Degs1)
CPOC100717671(Degs1) 100725617(Degs2)
CCAN109677085(Degs1) 109694353(Degs2)
DORD105984343(Degs2) 105984962(Degs1)
DSP122109514(Degs1) 122118729(Degs2)
NCAR124961704 124961857 124976771
OCU100342774 100345221(DEGS2) 100355393(DEGS1)
OPI101520988(DEGS2) 101532189(DEGS1)
TUP102484126(DEGS2) 106734250(DEGS1)
CFA490395(DEGS1) 490854(DEGS2)
VVP112923572(DEGS1) 112930235(DEGS2)
VLG121493384(DEGS2) 121501590(DEGS1)
AML100472421(DEGS2) 100478672(DEGS1)
UMR103667253(DEGS1) 103673578(DEGS2)
UAH113262903(DEGS1) 113267276(DEGS2)
UAR123778194(DEGS2) 123791928(DEGS1)
ELK111148688 111150825
LLV125086061 125103727
MPUF101677134(DEGS1) 101687134(DEGS2)
ORO101365656(DEGS1) 101366847(DEGS2)
EJU114208490(DEGS2) 114215576(DEGS1)
ZCA113908873(DEGS2) 113930429 113933334(DEGS1)
MLX118002416(DEGS2) 118012997(DEGS1)
FCA101080546(DEGS2) 101083993(DEGS1)
PYU121015185(DEGS1) 121032275(DEGS2)
PBG122469530(DEGS2) 122476225(DEGS1)
PTG102972723(DEGS1)
PPAD109258915(DEGS1) 109274554(DEGS2)
AJU106983185(DEGS1) 113601448(DEGS2)
HHV120234158(DEGS1) 120245742(DEGS2)
BTA507290(DEGS1) 540994(DEGS2)
BOM102267014(DEGS2) 102270794(DEGS1)
BIU109570649(DEGS1) 109575437(DEGS2)
BBUB102395639(DEGS2) 102405878(DEGS1)
CHX102179052(DEGS2) 102181802(DEGS1)
OAS100192315(DEGS1) 101118389(DEGS2) 101120481
ODA120875202(DEGS2) 120880367(DEGS1)
CCAD122419687(DEGS2) 122452210(DEGS1)
SSC100135677(DEGS1) 100739329(DEGS2)
CFR102511645(DEGS1) 102514149(DEGS2)
CBAI105079924(DEGS2) 105083946(DEGS1)
CDK105095393(DEGS2) 105099817(DEGS1)
VPC102525949(DEGS2) 102546011(DEGS1)
BACU103009449(DEGS1) 103012505(DEGS2)
LVE103077083(DEGS1) 103083645 103091108(DEGS2)
OOR101269383(DEGS1) 101281613(DEGS2)
DLE111176088(DEGS2) 111177510(DEGS1)
PCAD102973359(DEGS2) 102974202(DEGS1)
PSIU116748468(DEGS2) 116757512(DEGS1)
ECB100049834(DEGS2) 100055442(DEGS1)
EPZ103556478(DEGS1) 103564051(DEGS2)
EAI106833179(DEGS1) 106839663(DEGS2)
MYB102251258(DEGS2) 102260316(DEGS1)
MYD102761894(DEGS2) 102768904(DEGS1)
MMYO118660135(DEGS2) 118678810(DEGS1)
MLF102421059(DEGS1) 102441468(DEGS2)
MNA107541612(DEGS2) 107543612(DEGS1)
PKL118704263(DEGS2) 118727624(DEGS1)
HAI109381071(DEGS2) 109381186(DEGS1)
DRO112311909(DEGS2) 112318898(DEGS1)
SHON118976942(DEGS2) 119003264(DEGS1)
AJM119037996(DEGS2) 119044429(DEGS1)
PDIC114492698(DEGS2) 114512331(DEGS1)
PHAS123807862(DEGS2) 123832264(DEGS1)
MMF118624642(DEGS2) 118640781(DEGS1)
RFQ117018533(DEGS1) 117023512(DEGS2)
PALE102877713(DEGS2) 102884338(DEGS1)
PGIG120619140(DEGS1) 120619781(DEGS2)
PVP105292590(DEGS1) 105302285(DEGS2)
RAY107497563(DEGS2) 107521085(DEGS1)
MJV108400774(DEGS2) 108405657(DEGS1)
TOD119239398(DEGS2) 119244393(DEGS1)
SARA101543104(DEGS1) 101546437(DEGS2)
LAV100663518(DEGS1) 100677351(DEGS2)
TMU101340709 101353051
DNM101420853(DEGS1) 101423036(DEGS2)
MDO100018776(DEGS1) 100022759(DEGS2)
GAS123235677(DEGS2) 123244148(DEGS1)
SHR100924041(DEGS1) 100933090(DEGS2)
PCW110205533(DEGS1) 110222390(DEGS2)
OAA100079563(DEGS2) 100081682(DEGS1) 100088407
GGA421327(DEGS1) 423454(DEGS2)
PCOC116228852(DEGS2) 116230921(DEGS1)
MGP100545871(DEGS1) 100547168(DEGS2)
CJO107311009(DEGS1) 107315308(DEGS2)
NMEL110396071(DEGS1) 110401292(DEGS2)
APLA101791732(DEGS2) 101803108(DEGS1)
ACYG106031546(DEGS1) 106033723(DEGS2)
AFUL116487408(DEGS1) 116490205(DEGS2)
TGU100219126(DEGS1) 100225864(DEGS2)
LSR110481160(DEGS2) 110483217(DEGS1)
SCAN103819278(DEGS1) 103826431(DEGS2)
PMOA120503802(DEGS2) 120505907(DEGS1)
OTC121332031(DEGS2) 121346950(DEGS1)
PRUF121357002(DEGS1) 121358254(DEGS2)
GFR102044700(DEGS1) 102044947(DEGS2)
FAB101817336(DEGS2) 101820925(DEGS1)
PHI102110893(DEGS1) 102114412(DEGS2)
PMAJ107201542(DEGS1) 107205859(DEGS2)
CCAE111926254(DEGS1) 111929821(DEGS2)
CCW104685558(DEGS1) 104686450(DEGS2)
ETL114064453(DEGS2) 114073706(DEGS1)
ZAB102072480(DEGS1) 102073053(DEGS2)
FPG101918839(DEGS2) 101919611(DEGS1)
FCH102048090(DEGS1) 102059577(DEGS2)
CLV102084187(DEGS1) 102086116(DEGS2)
EGZ104124506(DEGS2) 104124691(DEGS1)
NNI104014818(DEGS2) 104019281(DEGS1)
PLET104621624(DEGS1) 104627313(DEGS2)
PCRI104026019(DEGS2) 104037434(DEGS1)
ACUN113477792(DEGS1) 113480655(DEGS2)
TALA104360506(DEGS1) 104369004(DEGS2)
PADL103920395(DEGS2) 103925021(DEGS1)
ACHC115349823(DEGS1) 115352643(DEGS2)
CCRI104164939(DEGS2) 104168857(DEGS1)
AAM106482702(DEGS1) 106482961(DEGS2)
AROW112963436(DEGS1) 112972658(DEGS2)
NPD112954812(DEGS1) 112956950(DEGS2)
DNE112980024(DEGS1) 112989895(DEGS2)
ASN102372084 102373680(DEGS2) 102374259(DEGS1)
AMJ102559976(DEGS1) 102573648 106737226(DEGS2)
CPOO109319767(DEGS1) 109321753(DEGS2)
GGN109296892(DEGS1) 109298458(DEGS2)
PSS102455413 102456288(DEGS2) 102457738(DEGS1)
CMY102936544(DEGS1) 102939815 102941197(DEGS2)
CPIC101933091 101934087(DEGS2) 101944949
TST117874499(DEGS1) 117877123(DEGS2) 117888931
CABI116815279(DEGS2) 116822368 116825592(DEGS1)
MRV120388689 120400955(DEGS1) 120404407(DEGS2)
ACS100551621(degs2) 100551856(degs1) 100560415
PVT110070304(DEGS2) 110075366(DEGS1) 110075723
SUND121915806 121919321(DEGS1) 121921479(DEGS2)
PBI103057812(DEGS1) 103058861(DEGS2) 103062400
PMUR107291367(DEGS2) 107292031(DEGS1)
TSR106543356(DEGS2) 106549644(DEGS1)
PGUT117665980(DEGS2) 117671754(DEGS1)
VKO123024925(DEGS1) 123026139 123026626(DEGS2)
PMUA114587345(DEGS2) 114594625 114594627 114603001
ZVI118080578(DEGS2) 118083211 118083213 118086943
GJA107116946 107121524(DEGS2) 107121631(DEGS1)
STOW125425759(DEGS2) 125437190(DEGS1)
XLA108700206(degs3.S) 108716481(degs1.L) 108717695(degs1.S) 380539(degs3.L) 446989(degs2.L)
XTR100495063(degs2) 394549(degs3) 493214(degs1)
NPR108787065(DEGS1) 108791127 108801754(DEGS2)
RTEM120913571 120937864(DEGS1)
BBUF120977424 120982487(DEGS2) 120999617(DEGS1)
BGAR122921878(DEGS2) 122934460(DEGS1) 122946522
DRE327075(degs1) 402799(degs2)
SRX107719492 107719493 107733197 107742811 107753721
SANH107674056 107697737 107699139 107705009
SGH107565896 107578558 107594812(degs2)
CCAR109058180 109108390
CAUA113057445 113060590 113069079 113113113 113117474
PPRM120477336(degs2) 120492311(degs1)
MAMB125268914(degs2) 125277539(degs1)
IPU100528134(degs2) 108260864(degs1)
PHYP113538582 113544443(degs1)
SMEO124381509(degs1) 124389950(degs2)
TFD113659546(degs2) 113660740(degs1)
AMEX103035033(degs1) 103039355(degs2)
EEE113576663(degs2) 113585484(degs1)
TRU101071715(degs2) 101072518 115249571
TNGGSTEN00032208G001
LCO104921571(degs2) 104938997(degs1)
NCC104957390(degs1) 104960358(degs2)
CGOB115020237 115027476(degs2)
ELY117248731(degs1) 117266726(degs2)
PLEP121953714(degs2) 121954976(degs1)
SLUC116035890(degs2) 116065930(degs1)
ECRA117936069(degs2) 117960955(degs1)
PFLV114546765(degs2) 114571717(degs1)
GAT120820591(degs1) 120832625(degs2)
PPUG119214004(degs1) 119228118(degs2)
MSAM119910467(degs2) 119917119(degs1)
CUD121511109(degs1) 121526347(degs2)
ALAT119004673(degs2) 119033881(degs1)
MZE101475928(degs1) 101481400(degs2)
ONL100703192(degs2) 100711880(degs1)
OAU116333034(degs1) 116334843(degs2)
OLA101158246(degs2) 101175288(degs1)
OML112138714(degs1) 112152958(degs2)
XMA102226056(degs2) 102230059(degs1)
XCO114134747(degs2) 114137810(degs1)
XHE116708982(degs2) 116712798(degs1)
PRET103458891(degs2) 103476669(degs1)
PFOR103144262 103154293
PLAI106959557 106963706
PMEI106918269 106920215
GAF122842694(degs1) 122846506(degs2)
CVG107087559(degs2) 107088921(degs1)
CTUL119784289(degs2) 119792659(degs1)
GMU124859446(degs1) 124885058(degs2)
NFU107376444 107392298(degs2)
KMR108234807(degs2) 108242396(degs1)
ALIM106521433(degs2) 106535193
NWH119420729(degs1) 119427322(degs2)
AOCE111563648(degs1) 111588537(degs2)
MCEP125018714(degs1) 125023384(degs2)
CSEM103376871(degs2) 103387773(degs1)
POV109628141(degs2) 109639876(degs1)
SSEN122781641(degs1) 122783066(degs2)
HHIP117756365(degs2) 117775913(degs1)
HSP118116309(degs2) 118119451(degs1)
LCF108888113 108894847(degs1)
SDU111225737(degs2) 111239209(degs1)
SLAL111644804(degs2) 111649244 111669504
XGL120795314(degs2) 120796348(degs1)
HCQ109517137(degs1) 109526113(degs2)
BPEC110155422(degs2) 110156995(degs1)
MALB109955044(degs2) 109964347(degs1)
BSPL114848173(degs2) 114870463(degs1)
SASA106576957 106603795 106606739 106610341(degs2)
OTW112228330 112252974 112254228 112262107(degs2)
OMY110498198(degs2) 110502434 110528376 110533418
OGO124001742(degs2) 124013426 124038233 124041288
ONE115113246 115135148 115136129 115146459(degs2)
SALP111951039 111951910 111968952(degs2) 111977799
SNH120017624 120046548 120056467 120059789(degs2)
ELS105011018 105015975(degs2) 105023239(degs1)
SFM108941515(degs2) 108942606
PKI111849028(degs1) 111852425(degs2)
AANG118218129(degs1) 118235192 118237027(degs2)
LOC102682570(degs2) 102683140(degs1) 102687742
PSPA121315679 121316759 121324274 121329567
ARUT117403287 117410644 117418134 117422154
LCM102355762 102357565(DEGS1) 102358925(DEGS2)
CMK103175334(degs2) 103181614(degs1)
RTP109913156 109920265 109937856
BFO118407735 118408386 118427793 118427795
BBEL109474924 109474925 109487723
CIN100175607 100178733
SCLV120335568 120346097
SPU587766
APLC110981957
SKO100367170 100378209
DMEDmel_CG9078(ifc)
DER6540675
DSE6613556
DSIDsimw501_GD23376(Dsim_GD23376)
DYADyak_GE25800(Dyak_ifc)
DAN6498402
DSR110185704
DPODpse_GA21524
DPE6588729
DMN108162838
DWI6642236
DGR6562452
DMODmoj_GI17538
DAZ108610628
DNV115562528
DHE111602344
DVI6628916
CCAT101455374
BOD106623531
MDE101900309
SCAC106091278
LCQ111679645
LSQ119607018
HIS119650653
AGAAgaP_AGAP011402 AgaP_AGAP012111
ACOZ120955101 120957684
AARA120900745 120901324
ASTE118503983 118507303
AAG5577178
AALB109424709
CQUCpipJ_CPIJ016440 CpipJ_CPIJ019193
CPII120428239 120429989
CNS116336945
BCOO119072757 119081977
AME100578035
ACER108000422
ALAB122711752
BIM100746260
BBIF117211140
BVK117238525
BVAN117160384
BTER100644949
BPYO122577208
CCAL108623330
OBB114875777
MGEN117227408
NMEA116424622
CGIG122395663
SOC105197389 105202448
MPHA105834843
AEC105146118
ACEP105624284
PBAR105430648
VEM105569807
HST105188033 112588947
DQU106749129
CFO105254886
FEX115236578 115236582
LHU105669721
PGC109860326
OBO105285916
PCF106789465
PFUC122524693
VPS122627648
NVI100116927
CSOL105365921
TPRE106657947
MDL103580004
CGLO123261320
FAS105268761
DAM107044829
AGIF122858801
CCIN107270686
TCA660778
DPA109543045
SOY115881467
ATD109597916 109605776
CSET123319990
AGB108915225
NVL108569904
APLN108739976
PPYR116161110
OTU111414128
BMOR101744040
BMAN114249776
MSEX115456248
BANY112052030
PMAC106721272
PPOT106107431
PXU106124790
PRAP110997933
ZCE119838223
HAW110378518
TNL113498537
SLIU111354736
OFU114359022
PXY105389100
API100162405
DNX107165376
AGS114125028
RMD113556684
BTAB109036809
DCI103514090
CLEC106668058
HHAL106679904
NLU120355393 120355562
PHUPhum_PHUM423600
FOC113215019
TPAL117641342
ZNE110832977
CSEC111873095
FCD110853896
DPXDAPPUDRAFT_48184
DMK116928473
PVM113806775
PJA122243721
PCHN125029512
HAME121856263
PCLA123773128
PTRU123510305
HAZT108668576
LSM121129202
PPOI119096560 119103214 119104664 119108010 119108013 119111646
ISCIscW_ISCW010259
RSAN119375589
RMP119167415
VDE111247391
VJA111262501
TUT107366821
DPTE113789969
DFR124494009
CSCU111625553
PTEP107449875
SDM118191868
CELCELE_F33D4.4(F33D4.4) CELE_Y54E5A.1(ttm-5)
CBRCBG_05940 CBG_08757(Cbr-ttm-5)
BMYBM_BM3789(Bm3789)
LOALOAG_10890
NAINECAME_07602 NECAME_10036
TSPTsp_03742
HROHELRODRAFT_188309 HELRODRAFT_66489
LGILOTGIDRAFT_124615 LOTGIDRAFT_150030
PCAN112564085
BGT106069456 106079203
GAE121370634 121384771
HRF124116566 124130636 124140687
HRJ124258333 124279420
CRG105320205 105325194
MYI110463500
PMAX117322873 117339260
MMER123545044 123546795
OBI106875542 106877162
OSN115216999 115219091
LAK106160143 106161831
OVIT265_03568 T265_07974
NVE5504168 5504170
EPA110231299 110240339
ATEN116300858
ADF107349940 107349957 107352497 107353118
AMIL114953604 114953605 114966289 114966290 114966351
PDAM113678608
SPIS111319356 111324911
DGT114520058 114520302
XEN124441487 124441997
HMG100209713
TADTRIADDRAFT_50675
AQU100633266 100639553
ATHAT1G14290(SBH2) AT1G69640(SBH1) AT4G04930(DES-1-LIKE)
ALY9308788 9324790 9326110 9326691
CRB17881667 17894998 17897638
CSAT104701603 104707649 104740092 104741160 104750811 104755724 104756847 104774626 104776592 104788032 109129885
EUSEUTSA_v10008529mg EUTSA_v10019024mg EUTSA_v10028789mg
BRP103831367 103839798 103852599 103872122 108869092
BNA106346482 106357210 106362103 106364469 106372048 106372740 106374594 106380268 106394013 106400431 106400950 106402640 106430975
BOE106296817 106299657 106308044 106317439 106319770 106343316
RSZ108823585 108823662 108824540 108824973 108826951 108842671
THJ104805155 104806290 104806773 104809744 104812890 104816141 104822119 104822918
CPAP110809182 110817954 110817995 110818246
CIT102607890 102615791 102619229 107177550 107177764
CICCICLE_v10002220mg CICLE_v10015896mg CICLE_v10027564mg CICLE_v10032432mg CICLE_v10033335mg CICLE_v10033828mg
PVY116105130 116119720 116126785 116134041
MINC123192429 123203502 123212868 123217624 123229785
TCC18593089 18596872 18610411 18610412 18610413 18610417
GRA105764517 105771585 105773387 105776712 105794188 105794190 105794191 105794193
GHI107886264 107886265 107889713 107900374 107908451 107908453 107908454 107908455 107920200 107925278 107937759 107940654 107952288 107962168 107963502 121223137
GAB108465539 108466907 108474720 108478644 108479565 108484750 108486385 108487423
DZI111278185 111280753 111282648 111288707 111311186 111317614 111317617 111317618 111317619 111317620 111317621 111317759 111317760 111317762 111317763
EGR104433626 104445178 104449566
GMX100778076 100786675 100792937(DES1.2) 100795462 100796655 100810780(DES1.1)
GSJ114372396 114376352 114385700 114386440 114403525 114411208
PVUPHAVU_002G086100g PHAVU_006G187100g PHAVU_007G085500g
VRA106772704 106775237 106778037
VAR108326593 108334608 108341878
VUN114173611 114187027 114192168
CCAJ109801001 109803659 109812182
APRC113852898 113868942 113872748
MTRMTR_1g097310 MTR_1g097320 MTR_2g013070 MTR_5g040320
CAM101489150 101502547 101512972
LJALj2g3v1280020.1(Lj2g3v1280020.1) Lj5g3v1889400.1(Lj5g3v1889400.1) Lj6g3v2043190.1(Lj6g3v2043190.1)
ADU107468729 107489386
AIP107618853 107623981 107643627
AHF112712501 112714605 112750359 112776107 112785025 112801607
LANG109330235 109340230 109346735 109354594 109356666
FVE101301836 101306226 101307465 101310321
RCN112167101 112174497 112177742 112179499 112197410
PPER18766179 18769317 18780571 18790374
PMUM103321587 103324743 103336183 103341153
PAVI110751387 110759987 110761565 110766790
PDUL117614180 117625786 117634585 117638209
MDM103431850 103443947 103446428 103448177 103451822 114827516
PXB103929689 103931957 103936723 103950829 103953953
ZJU107421380 107423895 107428983
MNT21384805 21384806 21386731 21386735 21386736 21386737 21386739 21389946 21395327
CSV101203795 101206018 101207762
CMO103485785 103486276 103489111
BHJ120079365 120081486 120082725
MCHA111010944 111019225 111025684
CMAX111467426 111471367 111485096 111490149 111493180 111495782
CMOS111433967 111449337 111450547 111452712 111457308 111458865
CPEP111782589 111787781 111802313 111802540 111805695 111810354
RCU8260622 8279484 8281414
JCU105630430 105635528 105649524
HBR110635114 110635189 110638775 110640540 110645469 110649157
MESC110603435 110604036 110605395 110605868 110608482 110616289
POP18103006 7464789 7480734 7492502
PEU105126940 105128054 105138848 105139883
PALZ118031327 118043081 118061771
JRE108988804 108990634 109000394 109009244 109011372 109011517
QSU111984469 111989675 111993167 111994826 112001532 112031613 112033980 112034477 112036900
QLO115963771 115975449 115975482 115982828 115992778
TWL119988126 119993658 120015891 120017034
VVI100253403 100254529 100854247
VRI117907347 117924324 117924603
SLY101248229 101259740 101265235 543709
SPEN107001981 107002661 107015659 107018663
SOT102583804 102583924 102594844 102602428 102605411 102606075
CANN107845766 107847749 107867609 107877639
NTA107767458 107793600 107795812 107802324 107806069 107807159 107808948 107810197 107830309
NSY104211339 104214898 104234121 104235146 104240023 104249538
NTO104086050 104092306 104099634 104110948 104116808
NAU109212085 109215199 109215481 109215909 109230914
INI109149487 109158823 109161005 109161813 109166227
ITR116005301 116022156 116023995 116028795 116031063
SIND105156541 105158913 105159960 105167910 105175640
OEU111370571 111397402 111406199 111408777
EGT105959387 105967689 105968934 105974689
SSPL121744418 121755058 121755478 121757533 121767232 121770850 121788616 121802247 121802495 121806359 121808183
HAN110889085 110891584 110894348
ECAD122606308 122609413
LSV111896054 111905532 111919543
CCAV112509290 112519183 112523189 112524282
DCR108197019 108200667 108206957 108228062
CSIN114263554 114265307 114287006 114288185 114305159 114318032
BVG104885845 104897930 104900720
SOE110802441 110806258
CQI110690397 110693600 110706890 110712391
NNU104586429 104587162 104587417 104597426 104598149 104599998
MING122071561 122071858 122080155 122093777
TSS122638781 122648593 122655706 122667247
PSOM113275954 113281639 113282725 113287030 113292972 113293050 113316844 113318623 113324783 113325147 113326140 113335619 113344356 113348835
NCOL116248475 116248508 116249731
OSA107276244 4330104 4330718 4340921 4343979 9268279
DOSAOs02t0639600-01(Os02g0639600) Os02t0745700-01(Os02g0745700) Os06t0226950-01(Os06g0226950) Os06t0330400-00(Os06g0330400) Os07t0627700-01(Os07g0627700)
OBR102699692 102704594 102705693 102720892
BDI100824012 100830033 100834457 100834617 100835386 100837450 100843649
ATS109732110 109736566 109740771 109752027 109754174 109754190 109760276 109768799 109770401 109775925 109778107 109783086
TDC119271626 119281373 119284030 119289035 119289650 119289652 119293421 119293696 119314825 119317860 119323465 119327426 119329743 119333045 119338180 119340528 119353710 119355776 119362894 119364917
TAES123044118 123046042 123051999 123053923 123058421 123065493 123074596 123082207 123082947 123082952 123084208 123084209 123094575 123099651 123099994 123128378 123130294 123138233 123140739 123142876 123145493 123150885 123152471 123152975 123154624 123160354 123160900 123164209 123169355 123169898 123170742 123187864 123189815
TUA125521640 125523583 125524644 125525532 125525590 125530002 125536142 125539059 125539063 125548458 125550311 125553614
SBI8058601 8060125 8062134 8066433 8066506 8066507 8066509 8071750 8079358 8081286 8082875 8085187
ZMA100273604 100273655 100277100 100282881 100283399 103636134 103646156 103651403 103652928 103655903 107436073
SITA101752771 101759312 101765094 101768829 101781523
SVS117838005 117846451 117851391 117858627 117862492
PVIR120640027 120641689 120642503 120657239 120661905 120669173 120670934 120674252 120683091 120685124 120694564 120703086 120710052
PHAI112879503 112879911 112889520 112890096 112890228 112895923 112899109
PDA103698206 103700454 103701531 103703428 103703673 103703686 103703695 103703704 103703713 103704997 103707796 103713482 103719205 103722705 120107336 120107343 120109385 120111018 120111217
EGU105032082 105032706 105035561 105039671 105041694 105041725 105041726 105056537 105056572 105056573 105056574 105056739 105059001
MUS103970361 103972020 103976103 103977198 103981062 103982846 103987749 103988205 103992129 103992418 103992750 103994110
DCT110104929 110107881 110108769 110108770 110108771 110108772 110110402 110114549 110114559
PEQ110021500 110025042 110026593 110026594 110026595 110030739 110031458 110034662 110036865 110037301 110037669
AOF109820323 109831018 109832009 109832014 109832016 109832018 109832019 109832020 109832465 109832475 109832482 109832580 109832581 109832604 109836119 109836120 109839596 109839696 109843333
ATR18422301 18422395 18423108
SMOSELMODRAFT_74254 SELMODRAFT_77748 SELMODRAFT_87013 SELMODRAFT_94775
PPP112275635 112276102
CRECHLRE_02g103500v5
VCNVOLCADRAFT_57952
MNGMNEG_11081 MNEG_2991
CSLCOCSUDRAFT_12493
CVRCHLNCDRAFT_57665
APROF751_5185
MISMICPUN_95334
MPPMICPUCDRAFT_49081
CMECYME_CMP318C
GSLGasu_65890
CCPCHC_T00009094001 CHC_T00009401001
SCEYDR297W(SUR2)
SEUBDI49_0474
SPAOSPAR_D04880
AGOAGOS_AAL066W AGOS_AGR025W
ERCEcym_2648 Ecym_3191
KLAKLLA0_C10406g KLLA0_F18656g
KMXKLMA_30430(SUR2) KLMA_40111(dsd1)
LTHKLTH0C07282g KLTH0G06094g
VPOKpol_1023p47
ZROZYRO0E06798g ZYRO0G17006g
CGRCAGL0H01375g
NCSNCAS_0A01360(NCAS0A01360)
NDINDAI_0C02160(NDAI0C02160)
TPFTPHA_0E01350(TPHA0E01350)
TBLTBLA_0A02900(TBLA0A02900)
TDLTDEL_0E03130(TDEL0E03130)
TGBHG536_0E03250
KAFKAFR_0D04510(KAFR0D04510)
KNGKNAG_0B04760(KNAG0B04760)
ZMKHG535_0A04250
PPAPAS_chr3_0425 PAS_chr3_0939
DHADEHA2E06996g DEHA2G12232g
PICPICST_54788(FAD3) PICST_77904(SUR2)
PGUPGUG_04311 PGUG_05540
SPAASPAPADRAFT_52340 SPAPADRAFT_60777
LELLELG_00720 LELG_04077
CALCAALFM_C202860WA(SUR2) CAALFM_C505480WA(DES1)
CTPCTRG_01360 CTRG_06153
COTCORT_0A09960 CORT_0F00160
CDUCD36_17510 CD36_55070
CTENCANTEDRAFT_110367 CANTEDRAFT_116396
YLIYALI0D06237g YALI0E17347g
CLUCLUG_01158 CLUG_05542
CLUSA9F13_09g02200 A9F13_16g00396
CAURCJI97_000788 CJI97_002081
SLBAWJ20_3453(SUR2) AWJ20_4618(DES1)
PKZC5L36_0B01370 C5L36_0B07030
BNNFOA43_001703 FOA43_001747
BBRXBRETT_004758 BRETT_004805
OPAHPODL_03217 HPODL_04362
SLUDSCDLUD_000005 SCDLUD_004618
NCRNCU06465 NCU08927
NTENEUTE1DRAFT41476(NEUTE1DRAFT_41476) NEUTE1DRAFT56362(NEUTE1DRAFT_56362)
SMPSMAC_05550 SMAC_08886
PANPODANSg5411 PODANSg9178
TTTTHITE_2109119 THITE_2151508
MTMMYCTH_2092086 MYCTH_2314931
CTHRCTHT_0063770 CTHT_0070010
MGRMGG_06250 MGG_13187
PPEIPpBr36_06733
TMNUCRPA7_2219 UCRPA7_2597
SSCKSPSK_06354 SPSK_09301
FGRFGSG_02522 FGSG_10374
FPUFPSE_01195 FPSE_08642
FVRFVEG_03105 FVEG_09197
FOXFOXG_05028 FOXG_10550
NHENECHADRAFT_70420 NECHADRAFT_93811
TRETRIREDRAFT_61750 TRIREDRAFT_69122
TRRM419DRAFT_133692 M419DRAFT_139366
MAWMAC_04942 MAC_06691
MAJMAA_03210 MAA_08955
CMTCCM_01623 CCM_09611
PLJVFPFJ_04463 VFPFJ_04829
VALVDBG_00624 VDBG_02819
VDAVDAG_00237 VDAG_03739
CFJCFIO01_02349 CFIO01_10059
CHIGCH63R_02974 CH63R_08694
SAPOSAPIO_CDS10789 SAPIO_CDS5739
ELAUCREL1_3594 UCREL1_5684 UCREL1_5727
PFYPFICI_04340 PFICI_06719 PFICI_12121
SSLSS1G_10567 SS1G_10642 SS1G_12521
BFUBCIN_04g01340 BCIN_04g01350 BCIN_04g04440 BCIN_10g04230
MBEMBM_04946 MBM_08292
PSCOLY89DRAFT_592377 LY89DRAFT_688598
GLZGLAREA_04417 GLAREA_08957
ANIAN0640.2 AN4405.2
AFMAFUA_1G16850 AFUA_4G06940
ACTACLA_018630 ACLA_032380 ACLA_046230
NFINFIA_008510 NFIA_109300
AORAO090005000995 AO090023000893
ANGANI_1_1368014(An01g10030) ANI_1_294184(An04g01320)
AFVAFLA_003820 AFLA_007245
ALUCAKAW2_21046A AKAW2_51161A
ACHEACHE_20592S ACHE_30074A
APUUAPUU_11387S APUU_70588S
PCSPc21g23490 Pc22g18020
PDPPDIP_11690 PDIP_13190
TMFPMAA_027370 PMAA_075400
TRGTRUGW13939_08735
CIMCIMG_01209 CIMG_02985 CIMG_13770(CIMG04127)
CPWCPC735_000400 CPC735_002840 CPC735_051790
UREUREG_02944 UREG_05566
PBLPAAG_07567 PAAG_09079
PBNPADG_06550 PADG_08266
ABEARB_01623 ARB_02243
TVETRV_03635 TRV_07677
AJEHCAG_02142 HCAG_05618
BGHBDBG_06830 BDBG_07631
PNOSNOG_01984 SNOG_05241
PTEPTT_07390 PTT_10469
BZECOCCADRAFT_38072 COCCADRAFT_84816
BSCCOCSADRAFT_108938 COCSADRAFT_176504
BORCOCMIDRAFT_105277 COCMIDRAFT_36785
AALTCC77DRAFT_1063500 CC77DRAFT_929543
ZTRMYCGRDRAFT_111474 MYCGRDRAFT_99123
PFJMYCFIDRAFT_152489 MYCFIDRAFT_161054 MYCFIDRAFT_34324 MYCFIDRAFT_35897
FFUCLAFUR5_02572 CLAFUR5_13459
BCOMBAUCODRAFT_38034 BAUCODRAFT_69097
NPAUCRNP2_2799 UCRNP2_4889
TMLGSTUM_00003900001 GSTUM_00008990001
SPOSPBC3B8.07c(dsd1) SPBC887.15c(sur2)
CNECNA06240 CNB03230
CNBCNBA6050 CNBB2450
CNGCNAG_00644 CNAG_03834
CGICGB_A3120W CGB_A7030C
TMSTREMEDRAFT_38594 TREMEDRAFT_39015
TASAA1Q1_00267 A1Q1_00456
TVSTRAVEDRAFT_126587 TRAVEDRAFT_42773 TRAVEDRAFT_59866 TRAVEDRAFT_75620
DSQDICSQDRAFT_153709 DICSQDRAFT_53575
PCOPHACADRAFT_253646 PHACADRAFT_263621
SHSSTEHIDRAFT_142325
HIRHETIRDRAFT_324650 HETIRDRAFT_477043
PSQPUNSTDRAFT_106171 PUNSTDRAFT_120449
ADLAURDEDRAFT_116234 AURDEDRAFT_88980
FMEFOMMEDRAFT_17099 FOMMEDRAFT_17835
GTRGLOTRDRAFT_130935 GLOTRDRAFT_39950
LBCLACBIDRAFT_245369 LACBIDRAFT_302799
MPRMPER_08444
MRRMoror_14190 Moror_6907
MOREE1B28_006544 E1B28_007498
CCICC1G_05513 CC1G_11555
SCMSCHCODRAFT_234069 SCHCODRAFT_84967
ABPAGABI1DRAFT118992(AGABI1DRAFT_118992) AGABI1DRAFT122617(AGABI1DRAFT_122617)
ABVAGABI2DRAFT187203(AGABI2DRAFT_187203) AGABI2DRAFT206283(AGABI2DRAFT_206283)
PCUBJR316_0008209 JR316_0009700
CPUTCONPUDRAFT_109539 CONPUDRAFT_83448
SLASERLADRAFT_457090 SERLADRAFT_472811
WSEWALSEDRAFT_31605 WALSEDRAFT_40171
WICJ056_001356 J056_004289
UMAUMAG_02651 UMAG_11819
PFPPFL1_01128 PFL1_04007
MGLMGL_0601 MGL_0733
MRTMRET_0088 MRET_1301
MSYMMSY001_2780
PGRPGTG_07554 PGTG_13207
MLRMELLADRAFT_77012 MELLADRAFT_94954
MBRMONBRDRAFT_38045
DDIDDB_G0269738(desA)
DPPDICPUDRAFT_155619
DFADFA_06927(desA)
ACANACA1_400540
TGOTGME49_237200
TETTTHERM_00334320 TTHERM_00765110
PTMGSPATT00017857001 GSPATT00020602001 GSPATT00022121001 GSPATT00027264001
SMINv1.2.004853.t1(symbB.v1.2.004853.t1)
PTIPHATRDRAFT_22677
FCYFRACYDRAFT_269456
TPSTHAPSDRAFT_32145
NGDNGA_0463000 NGA_0673910(DEGS) NGA_0673920(DEGS)
AAFAURANDRAFT_59180
PIFPITG_13403
PSOJPHYSODRAFT_543976
SPARSPRG_06401 SPRG_06402
EHXEMIHUDRAFT_223714 EMIHUDRAFT_420157(DCDS) EMIHUDRAFT_54601(DEGS2)
GTTGUITHDRAFT_83878
TBRTb927.6.3000
TBGTbgDal_VI2790
TCR510565.20
LMALMJF_26_1670 LMJF_26_1680 LMJF_26_1690 LMJF_26_1700
LIFLINJ_26_1680
LDOLDBPK_261680
LMILMXM_26_1670 LMXM_26_1700 LmxM_26_1690_1
LBZLBRM_23_1980
LPANLPMP_261660
NGRNAEGRDRAFT_33242 NAEGRDRAFT_83266
CHROCXB49_03525
SURSTAUR_8007
AGEAA314_02017 AA314_07675
AVMJQX13_29560
CFUSCYFUS_005548 CYFUS_007513
SCLsce3478
MRMA7982_06815
BIDBind_0284
MSLMsil_1351
MTUNMTUNDRAET4_3996
MLGCWB41_00255
BBARRHAL1_02690
MSCBN69_0791
MBRYB1812_10565
MROSEHO51_09965
MHEYH2LOC_006045
MPARF7D14_02780
MTWCQW49_11820
SIWGH266_01175
PHRC6569_13045
PSTGE8M01_06340
ALHG6N82_12570
ADOA6F68_01478
PORLBG023_111685
BMXBMS_0949
BSTOC0V70_05345
PLPPle7327_0968
RULUC8_47960
TPXTurpa_0657
CPICpin_5868
CHIHGWR21_09525
CFILMYF79_25335
FGGFSB75_00900
ARBA9P82_08610
AGIFSB73_01950
ARACE0W69_015550
ATEEK9M52_02635
FLNFLA_1786
SHGSph21_3689
MUPA0256_02420
MUCMuYL_1054
MGOTMgSA37_00742(desA)
MUHHYN43_001880
MGINFRZ54_11735
MGKFSB76_26790 FSB76_30360
MRUBDEO27_016485
MGOSDIU38_001030
MMABHQ865_07400
MGIKGO620_016605
OLIFKG96_15690
SLISlin_4982
SRDSD10_00345
SMONAWR27_18615
SPIRCWM47_26170
SPIKEXU85_32840
SPIBG8759_04750
STAEHNV11_20475
SRHOHH216_07800
PSEZHME7025_01475(degS)
FAEFAES_4403
FIBA6C57_09985
HYGAUC43_02620
HYPA0257_02900
HYZAXW84_01985
HNVDDQ68_17725
HYJFHG12_10855
HMTMTP16_08445
HTBMTX78_20340
CHKD4L85_10360
IALIALB_0269
 » show all
Reference
1  [PMID:9368039]
  Authors
Haak D, Gable K, Beeler T, Dunn T
  Title
Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p.
  Journal
J Biol Chem 272:29704-10 (1997)
DOI:10.1074/jbc.272.47.29704
  Sequence
[sce:YDR297W]
Reference
2  [PMID:9556590]
  Authors
Grilley MM, Stock SD, Dickson RC, Lester RL, Takemoto JY
  Title
Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae.
  Journal
J Biol Chem 273:11062-8 (1998)
DOI:10.1074/jbc.273.18.11062
  Sequence
[sce:YDR297W]
Reference
3  [PMID:11297741]
  Authors
Sperling P, Ternes P, Moll H, Franke S, Zahringer U, Heinz E
  Title
Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana.
  Journal
FEBS Lett 494:90-4 (2001)
DOI:10.1016/S0014-5793(01)02332-8
  Sequence
Reference
4  [PMID:11937514]
  Authors
Ternes P, Franke S, Zahringer U, Sperling P, Heinz E
  Title
Identification and characterization of a sphingolipid delta 4-desaturase family.
  Journal
J Biol Chem 277:25512-8 (2002)
DOI:10.1074/jbc.M202947200
  Sequence
[mmu:70059]
Reference
5  [PMID:15063729]
  Authors
Mizutani Y, Kihara A, Igarashi Y
  Title
Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation.
  Journal
FEBS Lett 563:93-7 (2004)
DOI:10.1016/S0014-5793(04)00274-1
  Sequence
[hsa:123099]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.18.5
IUBMB Enzyme Nomenclature: 1.14.18.5
ExPASy - ENZYME nomenclature database: 1.14.18.5
BRENDA, the Enzyme Database: 1.14.18.5
LinkDB

DBGET integrated database retrieval system