Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
BRITE hierarchy

acyl-CoA,acceptor:oxygen oxidoreductase (5,6 cis-dehydrogenating)

(1) (11Z,14Z)-icosa-11,14-dienoyl-CoA + reduced acceptor + O2 = (5Z,11Z,14Z)-icosa-5,11,14-trienoyl-CoA + acceptor + 2 H2O [RN:R11057];
(2) (11Z,14Z,17Z)-icosa-11,14,17-trienoyl-CoA + reduced acceptor + O2 = (5Z,11Z,14Z,17Z)-icosa-5,11,14,17-tetraenoyl-CoA + acceptor + 2 H2O [RN:R11058]

R11057 R11058
Reaction

(11Z,14Z)-icosa-11,14-dienoyl-CoA [CPD:C16180];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007];
(11Z,14Z,17Z)-icosa-11,14,17-trienoyl-CoA [CPD:C16179]

The enzyme, characterized from the plant Anemone leveillei, introduces a cis double bond at carbon 5 of acyl-CoAs that do not contain a double bond at position 8. In vivo it forms non-methylene-interrupted polyunsaturated fatty acids such as sciadonate and juniperonate. When expressed in Arabidopsis thaliana the enzyme could also act on unsaturated substrates such as palmitoyl-CoA. cf. EC 1.14.19.44, acyl-CoA (8-3)-desaturase.

EC 1.14.19.37 created 2015

1  [PMID:17384161]