(19E)-geissoschizine oxidase;
GO (gene name);
CYP71D1V1 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
A cytochrome P-450 (heme-thiolate) enzyme characterized from the plant Catharanthus roseus (Madagascar periwinkle), that participates in the biosynthesis of a number of monoterpene alkaloids, as well as the bisindole alkaloids vinblastine and vincristine. The enzyme generates a nine-carbon ring that contains a nitrogen atom. The direct product of the enzyme, 3,17-didehydrostemmadenine, is unstable, and in the absence of other enzymes becomes akuammicine non-enzymically. However, in the presence of two dehydrogenases it is converted to stemmadenine via 17-dehydrostemmadenine.
Tatsis EC, Carqueijeiro I, Duge de Bernonville T, Franke J, Dang TT, Oudin A, Lanoue A, Lafontaine F, Stavrinides AK, Clastre M, Courdavault V, O'Connor SE
Title
A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate.
Qu Y, Easson MEAM, Simionescu R, Hajicek J, Thamm AMK, Salim V, De Luca V
Title
Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine.
