KEGG ENZYME: 1.14.20.5

ENZYME: 1.14.20.5

Entry

EC 1.14.20.5                Enzyme

Name

flavone synthase I;
FNSI (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and the other dehydrogenated

Sysname

flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating)

Reaction(IUBMB)

a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O [RN:R07367]

Reaction(KEGG)

R07367 > R02445 R03590 R06551 R07712 R08081

Substrate

flavanone [CPD:C00766];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]

Product

flavone [CPD:C15608];
succinate [CPD:C00042];
CO2 [CPD:C00011];
H2O [CPD:C00001]

Comment

The enzyme, which has been found in rice and in members of the Apiaceae (a plant family), is a member of the 2-oxoglutarate-dependent dioxygenases, and requires ascorbate and Fe2+ for full activity.

History

EC 1.14.20.5 created 2004 as EC 1.14.11.22, transferred 2018 to EC 1.14.20.5

Pathway

ec00941

Flavonoid biosynthesis

ec00943

Isoflavonoid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology