KEGG   ENZYME: 1.14.99.2
Entry
EC 1.14.99.2                Enzyme                                 
Name
kynurenine 7,8-hydroxylase;
kynurenic acid hydroxylase;
kynurenic hydroxylase;
kynurenate 7,8-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
Sysname
kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating)
Reaction(IUBMB)
kynurenate + reduced acceptor + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor [RN:R03441]
Reaction(KEGG)
R03441 > R03439 R03440
Substrate
kynurenate [CPD:C01717];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
7,8-dihydro-7,8-dihydroxykynurenate [CPD:C01249];
acceptor [CPD:C00028]
History
EC 1.14.99.2 created 1965 as EC 1.14.1.4, transferred 1972 to EC 1.14.99.2
Pathway
ec00380  Tryptophan metabolism
Reference
1  [PMID:13984873]
  Authors
TANIUCHI H, HAYAISHI O.
  Title
Studies on the metabolism of kynurenic acid. III. Enzymatic formation of 7,8-dihydroxykynurenic acid from kynurenic acid.
  Journal
J Biol Chem 238:283-93 (1963)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.2
IUBMB Enzyme Nomenclature: 1.14.99.2
ExPASy - ENZYME nomenclature database: 1.14.99.2
BRENDA, the Enzyme Database: 1.14.99.2
CAS: 9029-63-4
LinkDB

KEGG   REACTION: R03439
Entry
R03439                      Reaction                               
Name
kynurenate:oxygen oxidoreductase (hydroxylating)
Definition
4-Hydroxy-2-quinolinecarboxylic acid + Oxygen + NADH + H+ <=> 7,8-Dihydro-7,8-dihydroxykynurenate + NAD+
Equation
C01717 + C00007 + C00004 + C00080 <=> C01249 + C00003
Comment
NADPH (see R03440)
Reaction class
RC00001  C00003_C00004
RC00091  C01249_C01717
Enzyme
1.14.99.2
Pathway
rn00380  Tryptophan metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.99  Miscellaneous
    1.14.99.2
     R03439  4-Hydroxy-2-quinolinecarboxylic acid + Oxygen + NADH + H+ <=> 7,8-Dihydro-7,8-dihydroxykynurenate + NAD+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.14.99.2
   R03441  Reduced acceptor <=> Acceptor
    R03439  NADH <=> NAD+
LinkDB

KEGG   REACTION: R03440
Entry
R03440                      Reaction                               
Name
kynurenate:oxygen oxidoreductase (hydroxylating)
Definition
4-Hydroxy-2-quinolinecarboxylic acid + Oxygen + NADPH + H+ <=> 7,8-Dihydro-7,8-dihydroxykynurenate + NADP+
Equation
C01717 + C00007 + C00005 + C00080 <=> C01249 + C00006
Comment
NADH (see R03439)
Reaction class
RC00001  C00005_C00006
RC00091  C01249_C01717
Enzyme
1.14.99.2
Pathway
rn00380  Tryptophan metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.99  Miscellaneous
    1.14.99.2
     R03440  4-Hydroxy-2-quinolinecarboxylic acid + Oxygen + NADPH + H+ <=> 7,8-Dihydro-7,8-dihydroxykynurenate + NADP+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.14.99.2
   R03441  Reduced acceptor <=> Acceptor
    R03440  NADPH <=> NADP+
LinkDB

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