KEGG   ENZYME: 1.17.1.10
Entry
EC 1.17.1.10                Enzyme                                 
Name
formate dehydrogenase (NADP+);
NADP+-dependent formate dehydrogenase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With NAD+ or NADP+ as acceptor
Sysname
formate:NADP+ oxidoreductase
Reaction(IUBMB)
formate + NADP+ = CO2 + NADPH [RN:R00134]
Reaction(KEGG)
R00134
Substrate
formate [CPD:C00058];
NADP+ [CPD:C00006]
Product
CO2 [CPD:C00011];
NADPH [CPD:C00005]
Comment
A tungsten-selenium-iron protein characterized from the bacterium Moorella thermoacetica. It is extremely sensitive to oxygen.
History
EC 1.17.1.10 created 1978 as EC 1.2.1.43, transferred 2017 to EC 1.17.1.10
Pathway
ec00680  Methane metabolism
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05299  formate dehydrogenase (NADP+) alpha subunit
K15022  formate dehydrogenase (NADP+) beta subunit
Genes
XBAC7S18_01025
VFUvfu_A02711
VGABSQ33_17050
VSRVspart_03926(gltD_2)
MARAD0851_18400
THTE2K93_16355
THAPFNC98_07420
SPOIIMCC21906_01458
SNANI6N98_13510
STAWNCG89_14460
ZALAZF00_11880
OSGBST96_15830
HALCEY643_10615
AFUSEYZ66_05555
MCAMCA0770
METUGNH96_04330
MMAIsS8_1217
MOZMoryE10_08010
MISZMishRS11D_26240
TIGTHII_3690
TNITVNIR_2014
TTITHITH_06945
WOCBA177_02470
SDFACG33_14960
ATYA9R16_007295
REVHUE57_15930
EPSL0Y14_07115
GPBHDN1F_09540(korC)
LHKLHK_02330
CCAXKZ686_11545(fdhF)
RFRRfer_2800
RHFEUB48_11830
VAMC4F17_30485
SUTTSUTMEG_16550
SUTKFG381_03580
SWSI6J16_02780
BBAYA4V04_04855
DOEDENOEST_3558(korC)
URUDSM104443_02000(sfrB)
UPLDSM104440_01845(sfrB)
ABREpbN1_08280(korC)
APETToN1_43220(korC)
AZIAzCIB_1254
APPCAP2UW1_2582
DDZDSYM_19100
BEBABWI17_16695
HBLXJ32_06675
WSUWS0477(FDHB)
TDNSuden_1824
SUASaut_1830
SULNFJR47_08390
SULGFJR48_10415
SULCCVO_01175
SPALFM071_08755
SSEIFJR45_10385
SBALHUE88_01240
SMASHUE87_10880
SMAXFJR03_09560
SKUSulku_0269
SULRB649_01165
HYONNO_1954
NSANitsa_0162
SUNSUN_2227
SLHYH65_00465
SINUIMZ28_01145
NISNIS_0293
GSUGSU0509(sfrA) GSU0510(sfrB)
GSKKN400_0498(sfrA) KN400_0499(sfrB)
GMEGmet_3022(sfrA) Gmet_3023(sfrB)
GPIGPICK_13835 GPICK_13840
GBZJZM60_03195 JZM60_03200
GEMGM21_0672 GM21_0673
GEBGM18_3695 GM18_3696
GEFFO488_01565
GURGura_3639 Gura_3640
GEOGeob_1607(sfrB) Geob_1608(sfrA)
GLOGlov_0660 Glov_0661
GBMGbem_0659(sfrB) Gbem_0660(sfrA)
GBNGEOBRER4_06660(sfrB) GEOBRER4_06670(sfrA) GEOBRER4_30170
GSBGSUB_01595 GSUB_01600
GERKP004_02570 KP004_02575
GSUBKP001_12875 KP001_12880
GNTKP003_02205 KP003_02210
GPLM1B72_18390 M1B72_18395
PCAPcar_2503(sfrB)
DESDSOUD_3426 DSOUD_3427
DEUDBW_0666 DBW_0667
DVEDESUT3_04340(sfrB) DESUT3_04350(sfrA)
DEPAOP6_2711(sfrA) AOP6_2712(sfrB)
DVUDVU_1772
DVLDvul_1383
DVGDeval_1526
DDSDdes_1543
DPGDESPIGER_0723
DEFCNY67_05260
DSADesal_0925 Desal_1735
DHYDESAM_22464 DESAM_23223
DAFDesaf_1699
DASDaes_1334
DPIBN4_10151 BN4_10592
DEJAWY79_10930 AWY79_17585
PPRFDPRO_0175 DPRO_0998
PSELGM415_12865
DDNDND132_0178 DND132_0691 DND132_2868
PSEFPSDVSF_06760
PPORJCM14722_04400 JCM14722_09200
PSYFN1030_00160(fdhF)
DBADbac_0167
DPSDP0682
DPRDespr_0054
DOGHP555_01030
DBKDGMP_17720
DDUGF1_09750
DOLDole_2825
DMLDmul_27610(rnfB2)
DALDalk_0215 Dalk_2557 Dalk_2596 Dalk_2597
DATHRM2_16890(fdhA6) HRM2_26590(gltD1) HRM2_32120
DTOTOL2_C10170(rnfB) TOL2_C28850(fdhA2)
DOVDSCO28_46070 DSCO28_50930(sfrB) DSCO28_53000 DSCO28_60770
DWDDSCW_19530 DSCW_24100 DSCW_39410
DALKDSCA_31580 DSCA_39350 DSCA_49620 DSCA_51850 DSCA_56540
DMMdnm_034450 dnm_072420(rnfB2) dnm_095740
DEKDSLASN_10670
ADEAdeh_2406
DAODesac_1071 Desac_2111
DTIDesti_0863 Desti_2930 Desti_2931
SFUSfum_1181
DAXFDQ92_14530 FDQ92_14660
DBRDeba_0487 Deba_0488 Deba_1743
DHRLGS26_01895(fdhF)
BJUBJ6T_26780
BJPRN69_13060
BRSS23_15710
AOLS58_18190
BRCBCCGELA001_09365
BRADBF49_4910
BICLMTR13_06695
BROBRAD285_1508
BRKCWS35_34360
BOTCIT37_20920
BRQCIT40_25555
BGQX265_09525
BGZXH91_08400
BSYMCIT39_24540
BBETF8237_23020
BARHWN72_38585
BVZBRAD3257_2513
BELBE61_34720
BDGLPJ38_13750
BSEPHAP48_0003660
BQBJ4P68_0009390
BSEIKMZ68_06510
BBANJ4G43_041520
RPARPA0135
RPERPE_3861
RPTRpal_0138
RPXRpdx1_0129
VGOGJW-30_1_03563(gltD)
MSLMsil_2986
RHJHZY79_09490
RHZRHPLAN_41330
BVRBVIR_2956
BLAGBLTE_01210
PSINCAK95_21475
NOHG5V57_01550
LABRCHH27_22930
LABPFJ695_09980
PSTGE8M01_18385
CMBCSW64_17740
CAULKCG34_19100
PZUPHZ_c1698
PHBHYN04_01865
TSVDSM104635_00264(gltD_1)
RCPRCAP_rcc01729
RHCRGUI_3847
MMRMmar10_0350
HYTHXX25_05400
CBOTATE48_11810
SWISwit_3235
SPHDHY78_09380
RDICMV14_00345
RAPRHOA_1103
SHUMSTHU_46680
SVCSTVA_49780
STELSTAQ_01940
DEXHWD60_06710
DVNHQ394_06325
MAGQMGMAQ_1747
MFNGa0123462_0191
BDAFSZ17_13590
NMKCHR53_17840
AIAAWH56_024275
CLJCLJU_c08690
CAHCAETHG_2963
CDRKB9W14_11420
CMICcaldi_03270
DSYDSY3968(fdhF)
DHDDhaf_1398
DDHDesde_1318
DDLDesdi_1184
SGYSgly_2685
DORDesor_0661 Desor_4477
DAIDesaci_0777
DMIDesmer_0214 Desmer_0713
DEDDHBDCA_p1614
DECDCF50_p1622
DRSDEHRE_11885
DCADesca_2053
DAEDtox_3503 Dtox_3507
DAUDaud_0104
FWADCMF_14065
AACXDEACI_1377
TJRTherJR_0670 TherJR_0942
DGIDesgi_2136 Desgi_3847
HMOHM1_1745(fdhA)
AWOAwo_c11780
AWICHL1_000121(fdhF)
CTHMCFE_2215
CHYCHY_0733(fdhA)
MTAMoth_2312(fdhA) Moth_2314
MTHOMOTHE_c23870(fdhF3) MOTHE_c23890(sfrB2)
MTHZMOTHA_c24590(fdhF3) MOTHA_c24610(sfrB2)
ADGAdeg_0156 Adeg_0334
TOCToce_0785
NTHNther_0100
AARAcear_2299
CADCuri_c16640(fdhB)
KPARJL105_10655(fdhF)
MMONEWR22_26295
PBOPACID_05180
AACIASQ49_02230
ACIJJS278_02794(sfrB)
TEJKDB89_02590
DETDET0123
DEVDhcVS_131
DMGGY50_0154
DMXX792_00790
DMYX793_00645
DUCUCH007_01080
DLYDehly_0151 Dehly_0227 Dehly_1357
DEWDGWBC_1766
DFODform_02183
DETHHX448_07080(fdhF)
NPYNPRO_12980
ULIETAA1_06170
KSTKSMBR1_3796
BROCIPI25_00230 IPI25_04935 IPI25_07710(fdhF) IPI25_08630(fdhF) IPI25_10400
BPITBPIT_05580 BPIT_26950
JETL3J17_07505 L3J17_14530(fdhF)
ADINH7849_06915(nuoG)
SUSAcid_3510
PFERIRI77_15560
GBAJ421_1491
FLPLK994_03895 LK994_09320
HHYHalhy_3670
MGOTMgSA37_01366(gltD_1)
CMRCycma_0108
CAMUCA2015_0079
RHOZGXP67_33000
RSIRunsl_4914
RUNDR864_05545
RUPDTQ70_06190
EOLEmtol_2383
ASACATHSA_0203
DDFDEFDS_1613
DAPDacet_2494
GTLEP073_00480
CNICalni_1870
FSIFlexsi_0433
MSCHN508_001026(sfrA) N508_001027(sfrB)
DTPJZK55_05530(nuoG-1_1) JZK55_11790 JZK55_19460(fdhA)
NKFNkreftii_003503 Nkreftii_004097
TAVG4V39_01635
TMAIFVE67_00210
NLIG3M70_15040
MOXDAMO_0766
MTHMTH_1552
MMGMTBMA_c01380(fdhA1)
MTEEMTTB_15350
METCMTCT_1417
METEtca_01501(fdhF_2)
METZMETMT2_0015
METKFVF72_03860
METJFZP68_05395
MELMetbo_2515
METTCIT01_06250
MEMEHYG87_07080(fdhF)
MTPMthe_0915
BARBAOA66_1514(sudA_1)
 » show all
Reference
1  [PMID:4154039]
  Authors
Andreesen JR, Ljungdahl LG.
  Title
Nicotinamide adenine dinucleotide phosphate-dependent formate dehydrogenase from Clostridium thermoaceticum: purification and properties.
  Journal
J Bacteriol 120:6-14 (1974)
DOI:10.1128/JB.120.1.6-14.1974
Reference
2  [PMID:6822536]
  Authors
Yamamoto I, Saiki T, Liu SM, Ljungdahl LG
  Title
Purification and properties of NADP-dependent formate dehydrogenase from Clostridium thermoaceticum, a tungsten-selenium-iron protein.
  Journal
J Biol Chem 258:1826-32 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 1.17.1.10
IUBMB Enzyme Nomenclature: 1.17.1.10
ExPASy - ENZYME nomenclature database: 1.17.1.10
BRENDA, the Enzyme Database: 1.17.1.10
CAS: 51377-43-6
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