KEGG   ENZYME: 1.17.1.10
Entry
EC 1.17.1.10                Enzyme                                 
Name
formate dehydrogenase (NADP+);
NADP+-dependent formate dehydrogenase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With NAD+ or NADP+ as acceptor
Sysname
formate:NADP+ oxidoreductase
Reaction(IUBMB)
formate + NADP+ = CO2 + NADPH [RN:R00134]
Reaction(KEGG)
R00134
Substrate
formate [CPD:C00058];
NADP+ [CPD:C00006]
Product
CO2 [CPD:C00011];
NADPH [CPD:C00005]
Comment
A tungsten-selenium-iron protein characterized from the bacterium Moorella thermoacetica. It is extremely sensitive to oxygen.
History
EC 1.17.1.10 created 1978 as EC 1.2.1.43, transferred 2017 to EC 1.17.1.10
Pathway
ec00680  Methane metabolism
ec00720  Other carbon fixation pathways
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05299  formate dehydrogenase (NADP+) alpha subunit
K15022  formate dehydrogenase (NADP+) beta subunit
Genes
VFU: vfu_A02711
VGA: BSQ33_17050
VSR: Vspart_03926(gltD_2)
TIG: THII_3690
TNI: TVNIR_2014
TTI: THITH_06945
ATY: A9R16_007295
LHK: LHK_02330
CCAX: KZ686_11545(fdhF)
SUTT: SUTMEG_16550
SUTK: FG381_03580
SWS: I6J16_02780
BBAY: A4V04_04855
DDZ: DSYM_19100
RPA: TX73_000695
RPE: RPE_3861
RPT: Rpal_0138
RPX: Rpdx1_0129
BVR: BVIR_2956
BLAG: BLTE_01210
RHC: RGUI_3847
RAP: RHOA_1103
MAGQ: MGMAQ_1747
HBL: XJ32_06675
WSU: WS0477(FDHB)
TDN: Suden_1824
SUA: Saut_1830
SULN: FJR47_08390
SULG: FJR48_10415
SULC: CVO_01175
SPAL: FM071_08755
SSEI: FJR45_10385
SBAL: HUE88_01240
SMAS: HUE87_10880
SMAX: FJR03_09560
SKU: Sulku_0269
SULR: B649_01165
HYO: NNO_1954
HTM: RZR91_01580
HCJ: HCR_15980(sfrB)
NSA: Nitsa_0162
SUN: SUN_2227
SLH: YH65_00465
SINU: IMZ28_01145
SMAB: LN246_12055
NIS: NIS_0293
GSU: GSU0509(sfrA) GSU0510(sfrB)
GSK: KN400_0498(sfrA) KN400_0499(sfrB)
GME: Gmet_3022(sfrA) Gmet_3023(sfrB)
GPI: GPICK_13835 GPICK_13840
GBZ: JZM60_03195 JZM60_03200
GEM: GM21_0672 GM21_0673
GEB: GM18_3695 GM18_3696
GEF: FO488_01565
GEV: GSVR_06160(sfrA) GSVR_06170(sfrB)
GEC: GEO60473_34020 GEO60473_34030
GUR: Gura_3639 Gura_3640
GEO: Geob_1607(sfrB) Geob_1608(sfrA)
GLO: Glov_0660 Glov_0661
TAMM: GEAMG1_0198(sfrA) GEAMG1_0199(sfrB)
GBM: Gbem_0659(sfrB) Gbem_0660(sfrA)
GBN: GEOBRER4_06660(sfrB) GEOBRER4_06670(sfrA) GEOBRER4_30170
GER: KP004_02570 KP004_02575
GSUB: KP001_12875 KP001_12880
GNT: KP003_02205 KP003_02210
GPL: M1B72_18390 M1B72_18395
GSB: GSUB_01595 GSUB_01600
GHC: L9S41_11600 L9S41_11605
PCA: Pcar_2503(sfrB)
DEU: DBW_0666 DBW_0667
DVE: DESUT3_04340(sfrB) DESUT3_04350(sfrA)
DEP: AOP6_2711(sfrA) AOP6_2712(sfrB)
DES: DSOUD_3426 DSOUD_3427
DDS: Ddes_1543
DEF: CNY67_05260
PSYF: N1030_00160(fdhF)
DSA: Desal_0925 Desal_1735
DHY: DESAM_22464 DESAM_23223
DAF: Desaf_1699
DAS: Daes_1334
DPI: BN4_10151 BN4_10592
DEJ: AWY79_10930 AWY79_17585
PPRF: DPRO_0175 DPRO_0998
PSEL: GM415_12865
DDN: DND132_0178 DND132_0691 DND132_2868
PSEF: PSDVSF_06760
PPOR: JCM14722_04400 JCM14722_09200
PNW: SYK_05490 SYK_08600 SYK_15590
PTHE: LF599_02925 LF599_10600
DVU: DVU_1772
DVL: Dvul_1383
DVG: Deval_1526
DBA: Dbac_0167
DESU: NLA06_12110(fdhF)
DPS: DP0682
DBK: DGMP_17720
DDU: GF1_09750
DOL: Dole_2825
DAL: Dalk_0215 Dalk_2557 Dalk_2596 Dalk_2597
DAT: HRM2_16890(fdhA6) HRM2_26590(gltD1) HRM2_32120
DTO: TOL2_C10170(rnfB) TOL2_C28850(fdhA2)
DOV: DSCO28_46070 DSCO28_50930(sfrB) DSCO28_53000 DSCO28_60770
DWD: DSCW_19530 DSCW_24100 DSCW_39410
DALK: DSCA_31580 DSCA_39350 DSCA_49620 DSCA_51850 DSCA_56540
DML: Dmul_27610(rnfB2)
DMM: dnm_034450 dnm_072420(rnfB2) dnm_095740
DEK: DSLASN_10670
DAO: Desac_1071 Desac_2111
DTI: Desti_0863 Desti_2930 Desti_2931
SFU: Sfum_1181
DAX: FDQ92_14530 FDQ92_14660
DBR: Deba_0487 Deba_0488 Deba_1743
DMP: FAK_07840 FAK_16570
TAV: G4V39_01635
TMAI: FVE67_00210
ADE: Adeh_2406
DHR: LGS26_01895(fdhF)
CLJ: CLJU_c08690
CAH: CAETHG_2963
CDRK: B9W14_11420
CMIC: caldi_03270
DSY: DSY3968(fdhF)
DHD: Dhaf_1398
DDH: Desde_1318
DDL: Desdi_1184
SGY: Sgly_2685
DOR: Desor_0661 Desor_4477
DAI: Desaci_0777
DMI: Desmer_0214 Desmer_0713
DED: DHBDCA_p1614
DEC: DCF50_p1622
DRS: DEHRE_11885
DCA: Desca_2053
DAE: Dtox_3503 Dtox_3507
DAU: Daud_0104
FWA: DCMF_14065
AACX: DEACI_1377
TJR: TherJR_0670 TherJR_0942
DGI: Desgi_2136 Desgi_3847
HMO: HM1_1745(fdhA)
AWI: CHL1_000121(fdhF)
CTHM: CFE_2215
CHY: CHY_0733(fdhA)
ADG: Adeg_0156 Adeg_0334
MTA: Moth_2312(fdhA) Moth_2314
MTHO: MOTHE_c23870(fdhF3) MOTHE_c23890(sfrB2)
MTHZ: MOTHA_c24590(fdhF3) MOTHA_c24610(sfrB2)
TOC: Toce_0785
NTH: Nther_0100
AAR: Acear_2299
CAD: Curi_c16640(fdhB)
KPAR: JL105_10655(fdhF)
SSPH: SPSPH_014220(fdhF_5)
SOVA: SOV_14460(fdhF_1) SOV_46170
SSID: SPSIL_050700(napA_4)
DET: DET0123
DEV: DhcVS_131
DMG: GY50_0154
DMX: X792_00790
DMY: X793_00645
DUC: UCH007_01080
DLY: Dehly_0151 Dehly_0227 Dehly_1357
DEW: DGWBC_1766
DFO: Dform_02183
DETH: HX448_07080(fdhF)
LMAJ: GKN94_07055
CALL: OZ401_003579
KBB: ccbrp13_10910
ULI: ETAA1_06170
KST: KSMBR1_3796
BROC: IPI25_00230 IPI25_04935 IPI25_07710(fdhF) IPI25_08630(fdhF) IPI25_10400
BPIT: BPIT_05580 BPIT_26950
JET: L3J17_07505 L3J17_14530(fdhF)
ADIN: H7849_06915(nuoG)
SUS: Acid_3510
PFER: IRI77_15560
ARAM: KAR29_00265(fdhF)
ASAC: ATHSA_0203
DDF: DEFDS_1613
DAP: Dacet_2494
GTL: EP073_00480
CNI: Calni_1870
FSI: Flexsi_0433
MSCH: N508_001026(sfrA) N508_001027(sfrB)
DTP: JZK55_05530(nuoG-1_1) JZK55_11790 JZK55_19460(fdhA)
NKF: Nkreftii_003503 Nkreftii_004097
NTI: DNFV4_00402 DNFV4_00911
NALL: PP769_05445 PP769_08770(nuoG)
NNEO: PQG83_16650 PQG83_19995(nuoG)
NLI: G3M70_15040
NVA: G3M78_09375
MOX: DAMO_0766
MTH: MTH_1552
MMG: MTBMA_c01380(fdhA1)
MTEE: MTTB_15350
METC: MTCT_1417
METE: tca_01501(fdhF_2)
METZ: METMT2_0015
METK: FVF72_03860
METJ: FZP68_05395
MEL: Metbo_2515
METT: CIT01_06250
MEME: HYG87_07080(fdhF)
MFEG: GCM10025860_09010
MEER: NKF70_07300(fdhF)
MTP: Mthe_0915
BARB: AOA66_1514(sudA_1)
LOB: NEF87_003197
 » show all
Reference
1  [PMID:4154039]
  Authors
Andreesen JR, Ljungdahl LG.
  Title
Nicotinamide adenine dinucleotide phosphate-dependent formate dehydrogenase from Clostridium thermoaceticum: purification and properties.
  Journal
J Bacteriol 120:6-14 (1974)
DOI:10.1128/JB.120.1.6-14.1974
Reference
2  [PMID:6822536]
  Authors
Yamamoto I, Saiki T, Liu SM, Ljungdahl LG
  Title
Purification and properties of NADP-dependent formate dehydrogenase from Clostridium thermoaceticum, a tungsten-selenium-iron protein.
  Journal
J Biol Chem 258:1826-32 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 1.17.1.10
IUBMB Enzyme Nomenclature: 1.17.1.10
ExPASy - ENZYME nomenclature database: 1.17.1.10
BRENDA, the Enzyme Database: 1.17.1.10
CAS: 51377-43-6
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