KEGG   ENZYME: 1.2.1.29
Entry
EC 1.2.1.29                 Enzyme                                 
Name
aryl-aldehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
aryl-aldehyde:NAD+ oxidoreductase
Reaction(IUBMB)
an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+ [RN:R01486]
Reaction(KEGG)
R01486 > R02655 R02695 R03300 R05235
Substrate
aromatic aldehyde [CPD:C00193];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
aromatic acid [CPD:C00539];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Oxidizes a number of aromatic aldehydes, but not aliphatic aldehydes.
History
EC 1.2.1.29 created 1972
Pathway
ec00350  Tyrosine metabolism
ec00622  Xylene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Reference
1  [PMID:4289834]
  Authors
Raison JK, Henson G, Rienits KG.
  Title
The oxidation of gentisaldehyde by nicotinamide-adenine dinucleotide-specific, aromatic aldehyde dehydrogenase from rabbit liver.
  Journal
Biochim Biophys Acta 118:285-98 (1966)
DOI:10.1016/s0926-6593(66)80037-1
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.29
IUBMB Enzyme Nomenclature: 1.2.1.29
ExPASy - ENZYME nomenclature database: 1.2.1.29
UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.29
BRENDA, the Enzyme Database: 1.2.1.29
CAS: 37250-94-5
LinkDB

KEGG   REACTION: R02695
Entry
R02695                      Reaction                               
Name
4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase
Definition
4-Hydroxyphenylacetaldehyde + NAD+ + H2O <=> 4-Hydroxyphenylacetate + NADH + H+
Equation
C03765 + C00003 + C00001 <=> C00642 + C00004 + C00080
Comment
see R02697 (NADPH)
Reaction class
RC00001  C00003_C00004
RC00080  C00642_C03765
Enzyme
1.2.1.5         1.2.1.29        1.2.1.39        1.2.1.53
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.5
     R02695  4-Hydroxyphenylacetaldehyde + NAD+ + H2O <=> 4-Hydroxyphenylacetate + NADH + H+
    1.2.1.29
     R02695  4-Hydroxyphenylacetaldehyde + NAD+ + H2O <=> 4-Hydroxyphenylacetate + NADH + H+
    1.2.1.39
     R02695  4-Hydroxyphenylacetaldehyde + NAD+ + H2O <=> 4-Hydroxyphenylacetate + NADH + H+
    1.2.1.53
     R02695  4-Hydroxyphenylacetaldehyde + NAD+ + H2O <=> 4-Hydroxyphenylacetate + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.2.1.5
   R00538  Aldehyde <=> Carboxylate
    R02695  4-Hydroxyphenylacetaldehyde <=> 4-Hydroxyphenylacetate
  1.2.1.29
   R01486  Aromatic aldehyde <=> Aromatic acid
    R02695  4-Hydroxyphenylacetaldehyde <=> 4-Hydroxyphenylacetate
Orthology
K00129  aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
K00146  phenylacetaldehyde dehydrogenase [EC:1.2.1.39]
Other DBs
RHEA: 17276
LinkDB

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