KEGG   ENZYME: 1.2.1.33
Entry
EC 1.2.1.33                 Enzyme                                 
Name
(R)-dehydropantoate dehydrogenase;
D-aldopantoate dehydrogenase;
D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine nucleotide (DPN+) oxidoreductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(R)-4-dehydropantoate:NAD+ 4-oxidoreductase
Reaction(IUBMB)
(R)-4-dehydropantoate + NAD+ + H2O = (R)-3,3-dimethylmalate + NADH + 2 H+ [RN:R03198]
Reaction(KEGG)
R03198
Substrate
(R)-4-dehydropantoate [CPD:C01053];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
(R)-3,3-dimethylmalate [CPD:C01088];
NADH [CPD:C00004];
H+ [CPD:C00080]
History
EC 1.2.1.33 created 1972
Pathway
ec00770  Pantothenate and CoA biosynthesis
Reference
1  [PMID:4287371]
  Authors
Magee PT, Snell EE.
  Title
The bacterial degradation of pantothenic acid. IV. Enzymatic conversion of aldopantoate to alpha-ketoisovalerate.
  Journal
Biochemistry 5:409-16 (1966)
DOI:10.1021/bi00866a004
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.33
IUBMB Enzyme Nomenclature: 1.2.1.33
ExPASy - ENZYME nomenclature database: 1.2.1.33
BRENDA, the Enzyme Database: 1.2.1.33
CAS: 37250-96-7
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