KEGG   ENZYME: 1.2.1.61
Entry
EC 1.2.1.61                 Enzyme                                 
Name
4-hydroxymuconic-semialdehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase
Reaction(IUBMB)
4-hydroxymuconic semialdehyde + NAD+ + H2O = maleylacetate + NADH + 2 H+ [RN:R05236]
Reaction(KEGG)
R05236
Substrate
4-hydroxymuconic semialdehyde [CPD:C06603];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
maleylacetate [CPD:C02222];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Involved in the 4-nitrophenol degradation pathway.
History
EC 1.2.1.61 created 2000
Pathway
ec00361  Chlorocyclohexane and chlorobenzene degradation
ec01120  Microbial metabolism in diverse environments
Reference
1  [PMID:16348446]
  Authors
Spain JC, Gibson DT.
  Title
Pathway for Biodegradation of p-Nitrophenol in a Moraxella sp.
  Journal
Appl Environ Microbiol 57:812-819 (1991)
DOI:10.1128/AEM.57.3.812-819.1991
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.61
IUBMB Enzyme Nomenclature: 1.2.1.61
ExPASy - ENZYME nomenclature database: 1.2.1.61
UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.61
BRENDA, the Enzyme Database: 1.2.1.61
LinkDB

KEGG   REACTION: R05236
Entry
R05236                      Reaction                               
Name
4-Hydroxymuconic-semialdehyde:NAD+ oxidoreductase
Definition
cis,cis-4-Hydroxymuconic semialdehyde + NAD+ + H2O <=> 2-Maleylacetate + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC02451  C02222_C06603
Enzyme
Pathway
rn00361  Chlorocyclohexane and chlorobenzene degradation
rn01120  Microbial metabolism in diverse environments
Other DBs
RHEA: 22423
LinkDB

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