EC 220.127.116.11 Enzyme
4-hydroxybenzaldehyde dehydrogenase (NAD+);
p-hydroxybenzaldehyde dehydrogenase (ambiguous);
4-hydroxybenzaldehyde dehydrogenase (ambiguous)
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + 2 H+ [RN:
The bacterial enzyme (characterized from an unidentified denitrifying bacterium) is involved in an anaerobic toluene degradation pathway. The plant enzyme is involved in formation of 4-hydroxybenzoate, a cell wall-bound phenolic acid that plays a major role in plant defense against pathogens. cf. EC
, 4-hydroxybenzaldehyde dehydrogenase (NADP+).
EC 18.104.22.168 created 2000, modified 2015
Microbial metabolism in diverse environments
Bossert ID, Whited G, Gibson DT, Young LY.
Anaerobic oxidation of p-cresol mediated by a partially purified methylhydroxylase from a denitrifying bacterium.
J Bacteriol 171:2956-62 (1989)
Sircar D, Mitra A
Evidence for p-hydroxybenzoate formation involving enzymatic phenylpropanoid side-chain cleavage in hairy roots of Daucus carota.
J Plant Physiol 165:407-14 (2008)
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