KEGG   ENZYME: 1.3.1.104
Entry
EC 1.3.1.104                Enzyme                                 
Name
enoyl-[acyl-carrier-protein] reductase (NADPH);
acyl-ACP dehydrogenase (ambiguous);
enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase;
NADPH 2-enoyl Co A reductase;
enoyl-ACP reductase (ambiguous);
fabL (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
acyl-[acyl-carrier protein]:NADP+ oxidoreductase
Reaction(IUBMB)
an acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+ [RN:R01404]
Reaction(KEGG)
R01404 > R04430 R04725 R04956 R04959 R04962 R04967 R04970
Substrate
acyl-[acyl-carrier protein] [CPD:C00173];
NADP+ [CPD:C00006]
Product
trans-2,3-dehydroacyl-[acyl-carrier protein] [CPD:C00693];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme completes each cycle of fatty acid elongation by catalysing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl-carrier protein, in an NADPH-dependent manner. This entry stands for enzymes whose stereo-specificity with respect to NADP+ is not known. [cf. EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific), EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.3.1.9, enoyl-[acyl-carrier-protein] reductase (NADH)].
History
EC 1.3.1.104 created 2013
Pathway
ec00061  Fatty acid biosynthesis
ec01100  Metabolic pathways
Orthology
K10780  enoyl-[acyl-carrier protein] reductase III
Genes
SMAF: D781_2232
SFW: WN53_21285
SFG: AV650_17030
SRZ: AXX16_2910
SERM: CLM71_11550
SRHZ: FO014_22215
PALC: A0T30_17150
PCAM: HNE05_12885
LPH: LPV_0452
LPO: LPO_0408
LPU: LPE509_02876
LPM: LP6_0350(fabL)
LPA: lpa_00572
LPE: lp12_0359
LLO: LLO_0519
LFA: LFA_2780(fabL)
LHA: LHA_0370(fabL)
LOK: Loa_00420
LCD: clem_13305(fabL)
LSH: CAB17_06780(fabL)
LLG: 44548918_00264(fabL)
LIB: E4T55_06160(fabL)
LGT: E4T54_04805(fabL)
LJR: NCTC11533_00288(fabL)
LCJ: NCTC11976_01126(fabL) NCTC11976_02509(phaB_4)
LWA: SAMEA4504053_0677(fabL)
LSS: NCTC12082_02402(fabL)
TMC: LMI_0465(fabL)
BMAR: HF888_13400
GBI: PG2T_08100
PPAI: E1956_04250
BOZ: DBV39_18780(fabL)
VEI: Veis_2543
RBS: RHODOSMS8_02171(fabL)
RDI: CMV14_20020
DLM: DPPLL_21860(fabL)
DPR: Despr_0937
DDU: GF1_05560(fabL)
ECOM: QTN59_07475(fabL)
EAJ: Q3M24_19255(fabL)
ELAX: KKHLCK_04545(fabL)
EAQ: LDFHOB_13215(fabL)
MSD: MYSTI_06026
CCX: COCOR_02185(fabG9)
MFU: LILAB_25050
SUR: STAUR_4694 STAUR_7038
AGE: AA314_01964 AA314_07156
AVM: JQX13_22655
MBD: MEBOL_004393
CFUS: CYFUS_001265
CCRO: CMC5_023740
MRM: A7982_00886 A7982_02081
SAMY: DB32_005294
LLU: AKJ09_02466
TRO: trd_0268
STI: Sthe_0993
RBA: RB10454(chcA)
LCRE: Pla8534_03000(fabL_1) Pla8534_16180(fabL_2)
AAGG: ETAA8_31190(fabL)
BVO: Pan97_33970(fabL_2)
BREM: PSR63_21170
SMAM: Mal15_43370(fabL_1)
SNEP: Enr13x_06110(fabL_1)
BGOK: Pr1d_23790(fabL_1)
PLM: Plim_1674
PEH: Spb1_25250(fabL)
MRI: Mal4_48560(fabL_2)
PLON: Pla110_25280(fabL)
CCOP: Mal65_35400(fabL)
ORP: MOP44_06185
SUS: Acid_2156
CPI: Cpin_5032
CHIH: GWR21_30980
SGN: SGRA_1403(fabI)
MUP: A0256_07540
MUC: MuYL_2694
MGOT: MgSA37_02494(fabL)
MGIN: FRZ54_06410
MGK: FSB76_12515
MMAB: HQ865_23795
MGIK: GO620_015025
SLI: Slin_3188
SRD: SD10_17175
SPIR: CWM47_06615
SPIK: EXU85_33670
SFOL: H3H32_29190
GFO: GFO_1609(fabI)
GRL: LPB144_03625
GRS: C7S20_14460
RBI: RB2501_14724
CAT: CA2559_10903
MARM: YQ22_18190
MART: BTR34_17885
MARB: CJ263_18640
MARE: EJ994_04390
CAO: Celal_3842
CBAL: M667_15700
KDI: Krodi_2526
DOK: MED134_04719
DDO: I597_1946(fabL)
DOD: DCS32_14685
LACI: CW733_13200
LNU: N7U66_12060
ZGA: ZOBELLIA_4386
ASL: Aeqsu_2711
PTQ: P700755_000481
NDO: DDD_3154
NOM: AAT17_01000
NSD: BST91_04905
NOB: CW736_10875
NOJ: EJ995_09005
POM: MED152_08610
WIJ: BWZ20_08860
SYI: SB49_03770
TJE: TJEJU_0277
SALT: AO058_12230
SMIS: LDL76_14585
OLL: CW732_02590
AUE: C5O00_12550
KAN: IMCC3317_45070(fabL)
AQD: D1816_03765
EMAR: D1013_12460
MUR: EQY75_06045
PPON: MUN68_017095
AFLA: FHG64_01250
ANP: FK178_04090
OCI: FEZ18_06955
GAA: HX109_13950
CAGG: HYG79_16880
ALTI: ALE3EI_2232
MUT: GVT53_13935
SPON: HME9304_03191(fabI)
FLD: ABNE31_17075
FBE: FF125_04625
MGEL: G5B37_02090
CSAL: NBC122_00026(fabL)
CHRC: QGN23_05500
CJG: NCTC13459_00416(fabL)
CCAS: EIB73_04505
CANT: NCTC13489_01022(fabL)
KDA: EIB71_08845
KFA: Q73A0000_01465
KAQ: L0B70_11685
OHO: Oweho_0671
CPH: Cpha266_1101
PROW: OO006_13155
PROI: OO005_12130
CTS: Ctha_2098
IAL: IALB_0753
MRO: MROS_0289
CABY: Cabys_861
BSU: BSU08650(fabL)
BSR: I33_0968
BSL: A7A1_0300
BSH: BSU6051_08650(fabL)
BSY: I653_04335
BSUT: BSUB_00939(fabL)
BSUL: BSUA_00939(fabL)
BSUS: Q433_04825
BSO: BSNT_07250(fabL)
BSN: BSn5_16190
BSQ: B657_08650(fabL)
BSX: C663_0887(fabL)
BSP: U712_04400
BSS: BSUW23_04355(fabL)
BST: GYO_1133
BIT: BIS30_14905
BLI: BL03039(fabL)
BLD: BLi00887(fabL)
BLH: BaLi_c09910(fabL)
BAY: RBAM_008740(fabL)
BAQ: BACAU_0849(fabL)
BYA: BANAU_0792(fabL)
BQY: MUS_0887(fabL)
BAMP: B938_04215
BAML: BAM5036_0783(fabL)
BAMA: RBAU_0847(fabL)
BAMN: BASU_0823(fabL)
BAMB: BAPNAU_0805(fabL)
BAMT: AJ82_04870
BAMY: V529_08190(fabL)
BMP: NG74_00869(fabL)
BAO: BAMF_0873(fabL)
BAZ: BAMTA208_03980(fabL)
BQL: LL3_00935(fabL)
BXH: BAXH7_00830(fabL)
BAMI: KSO_015445
BAMC: U471_08640
BAMF: U722_04360
BSIA: CWD84_17480
BAE: BATR1942_01895
BVM: B9C48_04330
BSON: S101395_01084(phbB)
BHT: DIC78_05445(fabL)
BMOJ: HC660_08980(fabL)
BTEQ: G4P54_04520(fabL)
BIQ: AN935_04495
BSTR: QI003_04650(fabL)
BPU: BPUM_0812
BPUM: BW16_04360
BPUS: UP12_04370
BIF: N288_05665
BMET: BMMGA3_03445(fabL)
BSM: BSM4216_0820
BGY: BGLY_0909(fabL)
BWH: A9C19_16770
BXI: BK049_03945
BALT: CFN77_04250(fabL)
BAER: BAE_11815
BSAF: BSL056_04215
BFD: NCTC4823_02971(fabL)
BSHI: LGQ02_04825(fabL)
BBAD: K7T73_03305(fabL)
BCAB: EFK13_04855(fabL)
BRY: M0696_04835(fabL)
BJS: MY9_0954
BACI: B1NLA3E_03370
GST: HW35_14250
BACW: QR42_04160
BACP: SB24_05545
BACB: OY17_07015
BACY: QF06_03160
BACL: BS34A_09630(fabL)
BALM: BsLM_0900
BACS: AUL54_06290
BACQ: DOE78_05160(fabL)
BACA: FAY30_06395(fabL)
BAQU: K6959_02525(fabL)
BZH: NF868_03600(fabL)
BHAI: KJK41_06355(fabL)
BAEI: RE735_15245(fabL)
BACF: AM500_21830
BAFC: K3G25_18415(fabL)
BCO: Bcell_0978
BHK: B4U37_05220
BCIR: C2I06_23175
NTX: NQZ71_18495(fabL)
NIL: L8T27_003105(fabL)
BMQ: BMQ_0404
BMD: BMD_0405
BMH: BMWSH_4822(fabL)
BMEG: BG04_2695(fabL)
BEO: BEH_02810
BFX: BC359_18390
PKS: IE339_02595(fabL)
BHA: BH0938
BCL: ABC1313(fabL)
BLE: BleG1_1207
SHUA: PQ477_14510(fabL)
BGI: BGM20_19495
BPF: BpOF4_10865
BON: A361_06105
BKO: CKF48_03275
CGOT: J1899_04845(fabL)
CSUA: IM538_02670(fabL)
CFIR: NAF01_05770(fabL)
CSOA: LIS82_05480(fabL)
CSPG: LS684_03950(fabL)
CPSS: M5V91_15660(fabL)
BDA: FSZ17_06550(fabL)
FEC: QNH15_12635(fabL)
APAK: AP3564_02345
ACOP: RI196_15135(fabL)
BSJ: UP17_03800
BMUR: ABE28_003640
PBUT: DTO10_15160(fabL)
PASA: BAOM_0748(fabL)
PPSR: I6J18_10860(fabL)
PFRI: L8956_03850(fabL)
PERI: RE409_03550(fabL)
BTHV: CQJ30_05400
PSYH: D0S48_17065(fabL)
PSYO: PB01_15925(fabL)
PSYB: KD050_06060(fabL)
RUE: DT065_17745(fabL)
SALE: EPH95_17465(fabL)
SCIB: HUG20_05875(fabL)
SCIA: HUG15_08260(fabL)
NMK: CHR53_06670
NDT: L1999_05165(fabL)
NCM: QNK12_05235(fabL)
NNV: QNH39_06795(fabL)
MEKU: HUW50_12015(fabL)
MSEM: GMB29_02775(fabL)
MDG: K8L98_03440(fabL)
MLIT: KDJ21_001880(fabL)
MENL: MVE64_16440(fabL)
MEBZ: LPC09_02930(fabL)
AIA: AWH56_003345(fabL)
BLEN: NCTC4824_03129(fabL)
BVQ: FHE72_06720(fabL)
RMF: D5E69_07415(fabL)
RAZ: U9J35_06720(fabL)
ROD: P8596_06920(fabL)
ROSS: V2W31_06645(fabL)
BCK: BCO26_2328
BAG: Bcoa_2111
BCOA: BF29_1474(fabL)
BVJ: I5776_16130(fabL)
BOU: I5818_19755(fabL)
HSPO: JGZ69_01715(fabL)
MCUI: G8O30_01735(fabL)
PSUA: FLK61_28145(fabL)
SLMS: MM221_15895(fabL)
MJO: FOF60_05100(fabL)
MSUT: LC048_16725(fabL)
SFOR: QNH23_10385(fabL)
ECTO: MUG87_03860(fabL)
ALKL: MM271_04935(fabL)
DOM: RRU94_21925(fabL)
AHAL: FTX54_005865(fabL)
GKA: GK0465
GTE: GTCCBUS3UF5_5810
GTK: GT3570_02290
GTM: GT3921_16915
GLI: GLN3_12750
BCAL: CWI35_07755
GTN: GTNG_0470(fabI)
GWC: GWCH70_0470
GYC: GYMC61_1347
GYA: GYMC52_0468
GCT: GC56T3_3006
GMC: GY4MC1_3310
GGH: GHH_c04870(fabL)
GJF: M493_02735
GEA: GARCT_00511(fabL)
GEL: IB49_12935
GSE: GT50_12145
GSR: GS3922_13360
GEJ: A0V43_18130
GZA: IC807_16070(fabL)
GTH: Geoth_3364
PTL: AOT13_05915
PTB: DER53_06955(fabL)
PARG: PspKH34_32790(fabL)
PCAL: BV455_01279(fabL)
ANM: GFC28_2058(fabL)
ANL: GFC29_3376(fabL)
AND: GRQ40_02945(fabL)
ACAI: ISX45_18400(fabL)
AAMY: GFC30_882(fabL)
STEA: C0679_05560
PUK: PU629_11165 PU629_12465(fabL) PU629_17860(fabL)
LMO: lmo1688
LMN: LM5578_1835
LMY: LM5923_1787
LMT: LMRG_02762
LMOC: LMOSLCC5850_1751(fabL)
LMOE: BN418_2021
LMOB: BN419_2025
LMOD: LMON_1755
LMOW: AX10_02655
LMOQ: LM6179_02444(fabL)
LMR: LMR479A_1790(fabL)
LMOM: IJ09_01415
LMF: LMOf2365_1712
LMC: Lm4b_01702
LMOG: BN389_17160(fabL)
LMP: MUO_08685
LMOL: LMOL312_1695(fabL)
LMOJ: LM220_01906
LMOZ: LM1816_07017(fabL)
LMOX: AX24_06135
LMH: LMHCC_0876
LMQ: LMM7_1777(fabL)
LML: lmo4a_1745(fabL)
LMG: LMKG_02669
LMS: LMLG_1553
LMJ: LMOG_02840
LMW: LMOSLCC2755_1700(fabL)
LMX: LMOSLCC2372_1754(fabL)
LMZ: LMOSLCC2482_1752(fabL)
LMON: LMOSLCC2376_1647(fabL)
LMOS: LMOSLCC7179_1662(fabL)
LMOO: LMOSLCC2378_1709(fabL)
LMOY: LMOSLCC2479_1752(fabL)
LMOT: LMOSLCC2540_1771(fabL)
LMOA: LMOATCC19117_1703(fabL)
LMOK: CQ02_08775
LMV: Y193_07125(fabL)
LIN: lin1796
LWE: lwe1706
LSG: lse_1656
LIV: LIV_1663
LII: JL52_08810
LIW: AX25_08970
LIA: JL58_08955
LIO: JL53_09420
LWI: UE46_10530
LGZ: NCTC10812_01163(fabL)
LMAR: LAX80_008225(fabL)
LNW: OTR81_11055(fabL)
BTHS: CNY62_10305
BBE: BBR47_10320(fabL)
BLR: BRLA_c007290(fabL)
BFM: BP422_00280
BAGR: BA6348_23750
BRW: GOP56_19540(fabL)
BCOP: JD108_18300(fabL)
BPAB: PSE45_05150(fabL)
BHUI: LOK74_01630(fabL)
BAYD: BSPP4475_16895(fabL)
BBOR: RFB14_20965(fabL)
BRUM: NDK47_21850(fabL)
BREH: HP435_05225(fabL)
ASED: IRT44_09025(fabL)
PBJ: VN24_23250
ASOC: CB4_03899(fabL_1)
AUD: PO771_16375(fabL)
AAC: Aaci_2398 Aaci_2412
AAD: TC41_2687(fabG) TC41_2700(fabL)
AFX: JZ786_19250(fabL) JZ786_19315
AACO: K1I37_18445 K1I37_18565(fabL)
ADAU: NZD86_04905(fabL) NZD86_04985
AFAS: NZD89_04880(fabL) NZD89_04935
ACYC: JI721_14715 JI721_16895(fabL)
ALIC: GI364_00850 GI364_05075 GI364_12615(fabL)
BTS: Btus_2604
KYR: CVV65_13045
TUM: CBW65_01130
TAB: CIG75_05115
EFF: skT53_19840(fabL)
FFE: LSG31_00875(fabL)
PLN: Plano_0800
PKU: AUO94_12280
PRT: AUC31_05130
PLL: I858_003125
PANA: BBH88_16255
PDG: BCM40_11645
PHC: BBI08_00375
PMAR: B0X71_04815
PPLA: BBI15_00615
PFAE: AJGP001_04920
PLX: CW734_06355
PMAT: BBI11_05800
PDEC: H1Q58_04960(fabL)
PGQ: FK545_12995(fabL)
PLAY: DNR44_015760(fabL)
PLIQ: QWY22_05360(fabL)
PSHE: QWY16_05380(fabL)
PSHX: QWY21_05445(fabL)
JEO: JMA_12600
SPSY: AZE41_03675
SPAE: E2C16_00445(fabL)
SURL: BI350_04045
PAEK: D3873_10330(fabL)
PANC: E2636_04035(fabL)
SAY: TPY_3095 TPY_3240(fabL)
SAP: Sulac_0799 Sulac_1673
HFV: R50_2604
LXA: OW255_06910
LPIL: LIP_1119
MMOR: MMOR_36050(fabL)
NBR: O3I_026240
NSL: BOX37_17080
NOZ: DMB37_02610
ROA: Pd630_LPD04497
DIZ: CT688_13190
SGB: WQO_30010
SVL: Strvi_8195
SHY: SHJG_1192
SHO: SHJGH_1027
SRC: M271_30645
SMAL: SMALA_2908
SSOI: I1A49_18470
SFA: Sfla_5328
SBH: SBI_06749 SBI_06855
STRP: F750_1295
SLE: sle_01250(sle_01250)
SGS: AVL59_46205
SAUO: BV401_18195
SVU: B1H20_30845
SALF: SMD44_08690
SKA: CP970_38055
SSPO: DDQ41_16075
SSEO: D0Z67_12220
SSPB: CP982_05330
SPLA: CP981_34470
SCAL: I6J39_30650
SGJ: IAG43_17255
STUB: MMF93_28535
SANT: QR300_26900
SHAU: K9S39_12925
SLUO: PS467_16365
SCHE: QRN89_14820
SGLY: P8A20_31045
LXL: KDY119_01212
MPRT: ET475_01045
MHOT: PU630_04780
CUB: BJK06_01395
CPOI: OE229_13280
FSB: GCM10025867_34250
CPHY: B5808_12155
HUM: DVJ78_08790
HUW: FPZ11_10075
GRY: D7I44_00415
HEA: HL652_11045
CELZ: E5225_00720
CCHE: NP064_11490
PSEI: GCE65_03975
MIK: FOE78_00275
MICG: GJV80_19840
NDK: I601_1166(fabL)
AWN: NQV15_07675 NQV15_14330
AGRA: AGRA3207_002235
NOA: BKM31_45865
ACE: Acel_1197
BMON: ABDB74_10125
AMYY: YIM_26855(fabL)
PDX: Psed_2586
KAL: KALB_7822
KUT: JJ691_15740 JJ691_19750
MICH: FJK98_15115
MCAB: HXZ27_30090
PLAB: C6361_09525
PLAT: C6W10_06020
ATL: Athai_27180
ASER: Asera_47540
CATI: CS0771_54770(fabL)
AFO: Afer_1057
AQZ: KSP35_11145
NON: NOS3756_03710
LMAJ: GKN94_10640
ATM: ANT_17280
PSUB: Pelsub_P1998
CAP: CLDAP_22810
TTR: Tter_0966
MOX: DAMO_2491
 » show all
Reference
1  [PMID:11007778]
  Authors
Heath RJ, Su N, Murphy CK, Rock CO
  Title
The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis.
  Journal
J Biol Chem 275:40128-33 (2000)
DOI:10.1074/jbc.M005611200
  Sequence
[bsu:BSU08650]
Reference
2  [PMID:17329825]
  Authors
Kim KH, Park JK, Ha BH, Moon JH, Kim EE
  Title
Crystallization and preliminary X-ray crystallographic analysis of enoyl-ACP reductase III (FabL) from Bacillus subtilis.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 63:246-8 (2007)
DOI:10.1107/S1744309107008469
Reference
3  [PMID:21185310]
  Authors
Kim KH, Ha BH, Kim SJ, Hong SK, Hwang KY, Kim EE
  Title
Crystal structures of Enoyl-ACP reductases I (FabI) and III (FabL) from B. subtilis.
  Journal
J Mol Biol 406:403-15 (2011)
DOI:10.1016/j.jmb.2010.12.003
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.104
IUBMB Enzyme Nomenclature: 1.3.1.104
ExPASy - ENZYME nomenclature database: 1.3.1.104
BRENDA, the Enzyme Database: 1.3.1.104
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