KEGG   ENZYME: 1.3.1.104
Entry
EC 1.3.1.104                Enzyme                                 
Name
enoyl-[acyl-carrier-protein] reductase (NADPH);
acyl-ACP dehydrogenase (ambiguous);
enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase;
NADPH 2-enoyl Co A reductase;
enoyl-ACP reductase (ambiguous);
fabL (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
acyl-[acyl-carrier protein]:NADP+ oxidoreductase
Reaction(IUBMB)
an acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+ [RN:R01404]
Reaction(KEGG)
Substrate
acyl-[acyl-carrier protein] [CPD:C00173];
NADP+ [CPD:C00006]
Product
trans-2,3-dehydroacyl-[acyl-carrier protein] [CPD:C00693];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme completes each cycle of fatty acid elongation by catalysing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl-carrier protein, in an NADPH-dependent manner. This entry stands for enzymes whose stereo-specificity with respect to NADP+ is not known. [cf. EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific), EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.3.1.9, enoyl-[acyl-carrier-protein] reductase (NADH)].
History
EC 1.3.1.104 created 2013
Pathway
ec00061  Fatty acid biosynthesis
ec01100  Metabolic pathways
Orthology
K10780  enoyl-[acyl-carrier protein] reductase III
Genes
SMAFD781_2232
SFWWN53_21285
SFGAV650_17030
SRZAXX16_2910
SERMCLM71_11550
SRHZFO014_22215
PALCA0T30_17150
PCAMHNE05_12885
LPHLPV_0452
LPOLPO_0408
LPULPE509_02876
LPMLP6_0350(fabL)
LPAlpa_00572
LPElp12_0359
LLOLLO_0519
LFALFA_2780(fabL)
LHALHA_0370(fabL)
LOKLoa_00420
LCDclem_13305(fabL)
LSHCAB17_06780(fabL)
LLG44548918_00264(fabL)
LIBE4T55_06160(fabL)
LGTE4T54_04805(fabL)
LJRNCTC11533_00288(fabL)
LCJNCTC11976_01126(fabL) NCTC11976_02509(phaB_4)
LWASAMEA4504053_0677(fabL)
LSSNCTC12082_02402(fabL)
TMCLMI_0465(fabL)
BMARHF888_13400
GBIPG2T_08100
BOZDBV39_18780(fabL)
VEIVeis_2543
DPRDespr_0937
MSDMYSTI_06026
CCXCOCOR_02185(fabG9)
MFULILAB_25050
SURSTAUR_4694 STAUR_7038
AGEAA314_01964 AA314_07156
AVMJQX13_22655
MBDMEBOL_004393
CFUSCYFUS_001265
CCROCMC5_023740
SAMYDB32_005294
LLUAKJ09_02466
MRMA7982_00886 A7982_02081
RBSRHODOSMS8_02171(fabL)
RDICMV14_20020
BSUBSU08650(fabL)
BSRI33_0968
BSLA7A1_0300
BSHBSU6051_08650(fabL)
BSYI653_04335
BSUTBSUB_00939(fabL)
BSULBSUA_00939(fabL)
BSUSQ433_04825
BSOBSNT_07250(fabL)
BSNBSn5_16190
BSQB657_08650(fabL)
BSXC663_0887(fabL)
BSPU712_04400
BSSBSUW23_04355(fabL)
BSTGYO_1133
BLIBL03039(fabL)
BLDBLi00887(fabL)
BLHBaLi_c09910(fabL)
BAYRBAM_008740(fabL)
BAQBACAU_0849(fabL)
BYABANAU_0792(fabL)
BAMPB938_04215
BQYMUS_0887(fabL)
BAMLBAM5036_0783(fabL)
BAMARBAU_0847(fabL)
BAMNBASU_0823(fabL)
BAMBBAPNAU_0805(fabL)
BAMTAJ82_04870
BAMYV529_08190(fabL)
BMPNG74_00869(fabL)
BAOBAMF_0873(fabL)
BAZBAMTA208_03980(fabL)
BQLLL3_00935(fabL)
BXHBAXH7_00830(fabL)
BAMIKSO_015445
BAMCU471_08640
BAMFU722_04360
BSIACWD84_17480
BAEBATR1942_01895
BVMB9C48_04330
BSONS101395_01084(phbB)
BHTDIC78_05445(fabL)
BMOJHC660_08980(fabL)
BTEQG4P54_04520(fabL)
BIQAN935_04495
BPUBPUM_0812
BPUMBW16_04360
BPUSUP12_04370
BJSMY9_0954
BACIB1NLA3E_03370
BIFN288_05665
BMETBMMGA3_03445(fabL)
GSTHW35_14250
BACWQR42_04160
BACPSB24_05545
BACBOY17_07015
BACYQF06_03160
BACLBS34A_09630(fabL)
BALMBsLM_0900
BSMBSM4216_0820
BGYBGLY_0909(fabL)
BWHA9C19_16770
BXIBK049_03945
BALTCFN77_04250(fabL)
BACSAUL54_06290
BSAFBSL056_04215
BITBIS30_14905
BACQDOE78_05160(fabL)
BFDNCTC4823_02971(fabL)
BDAFSZ17_06550(fabL)
BSHILGQ02_04825(fabL)
BBADK7T73_03305(fabL)
BCABEFK13_04855(fabL)
BCOBcell_0978
BHKB4U37_05220
BCIRC2I06_23175
BMQBMQ_0404
BMDBMD_0405
BMHBMWSH_4822(fabL)
BMEGBG04_2695(fabL)
BEOBEH_02810
BFXBC359_18390
PKSIE339_02595(fabL)
BCKBCO26_2328
BAGBcoa_2111
BCOABF29_1474(fabL)
BHABH0938
BCLABC1313(fabL)
BLEBleG1_1207
BGIBGM20_19495
BPFBpOF4_10865
BONA361_06105
BKOCKF48_03275
CGOTJ1899_04845(fabL)
CSUAIM538_02670(fabL)
GKAGK0465
GTEGTCCBUS3UF5_5810
GTKGT3570_02290
GTMGT3921_16915
GLIGLN3_12750
GTNGTNG_0470(fabI)
GWCGWCH70_0470
GYCGYMC61_1347
GYAGYMC52_0468
GCTGC56T3_3006
GMCGY4MC1_3310
GGHGHH_c04870(fabL)
GJFM493_02735
GEAGARCT_00511(fabL)
GELIB49_12935
GSEGT50_12145
GSRGS3922_13360
GEJA0V43_18130
GZAIC807_16070(fabL)
GTHGeoth_3364
PTLAOT13_05915
PTBDER53_06955(fabL)
PCALBV455_01279(fabL)
ANMGFC28_2058(fabL)
AAMYGFC30_882(fabL)
ANLGFC29_3376(fabL)
ANDGRQ40_02945(fabL)
ACAIISX45_18400(fabL)
ASEDIRT44_09025(fabL)
APAKAP3564_02345
BSJUP17_03800
BMURABE28_003640
PBUTDTO10_15160(fabL)
PASABAOM_0748(fabL)
PPSRI6J18_10860(fabL)
PFRIL8956_03850(fabL)
BTHVCQJ30_05400
PSYHD0S48_17065(fabL)
PSYOPB01_15925(fabL)
RUEDT065_17745(fabL)
SALEEPH95_17465(fabL)
SCIBHUG20_05875(fabL)
SCIAHUG15_08260(fabL)
NMKCHR53_06670
MEKUHUW50_12015(fabL)
MSEMGMB29_02775(fabL)
MDGK8L98_03440(fabL)
AIAAWH56_003345(fabL)
BLENNCTC4824_03129(fabL)
BVQFHE72_06720(fabL)
RMFD5E69_07415(fabL)
BVJI5776_16130(fabL)
BOUI5818_19755(fabL)
MCUIG8O30_01735(fabL)
PSUAFLK61_28145(fabL)
STEAC0679_05560
LMOlmo1688
LMNLM5578_1835
LMYLM5923_1787
LMTLMRG_02762
LMOCLMOSLCC5850_1751(fabL)
LMOEBN418_2021
LMOBBN419_2025
LMODLMON_1755
LMOWAX10_02655
LMOQLM6179_2444(fabL)
LMRLMR479A_1790(fabL)
LMOMIJ09_01415
LMFLMOf2365_1712
LMCLm4b_01702
LMOGBN389_17160(fabL)
LMPMUO_08685
LMOLLMOL312_1695(fabL)
LMOJLM220_01906
LMOZLM1816_07017(fabL)
LMOXAX24_06135
LMHLMHCC_0876
LMQLMM7_1777(fabL)
LMLlmo4a_1745(fabL)
LMGLMKG_02669
LMSLMLG_1553
LMJLMOG_02840
LMWLMOSLCC2755_1700(fabL)
LMXLMOSLCC2372_1754(fabL)
LMZLMOSLCC2482_1752(fabL)
LMONLMOSLCC2376_1647(fabL)
LMOSLMOSLCC7179_1662(fabL)
LMOOLMOSLCC2378_1709(fabL)
LMOYLMOSLCC2479_1752(fabL)
LMOTLMOSLCC2540_1771(fabL)
LMOALMOATCC19117_1703(fabL)
LMOKCQ02_08775
LMVY193_07125(fabL)
LINlin1796
LWElwe1706
LSGlse_1656
LIVLIV_1663
LIIJL52_08810
LIWAX25_08970
LIAJL58_08955
LIOJL53_09420
LWIUE46_10530
LGZNCTC10812_01163(fabL)
LMARLAX80_008225(fabL)
BTHSCNY62_10305
BBEBBR47_10320(fabL)
BLRBRLA_c007290(fabL)
BFMBP422_00280
BAGRBA6348_23750
BRWGOP56_19540(fabL)
BCOPJD108_18300(fabL)
PBJVN24_23250
ASOCCB4_03899(fabL_1)
AACAaci_2398 Aaci_2412
AADTC41_2687(fabG) TC41_2700(fabL)
AFXJZ786_19250(fabL) JZ786_19315
AACOK1I37_18565(fabL)
BTSBtus_2604
KYRCVV65_13045
TUMCBW65_01130
TABCIG75_05115
EFFskT53_19840(fabL)
PLNPlano_0800
PKUAUO94_12280
PRTAUC31_05130
PLLI858_003125
PANABBH88_16255
PDGBCM40_11645
PHCBBI08_00375
PMARB0X71_04815
PPLABBI15_00615
PFAEAJGP001_04920
PLXCW734_06355
PMATBBI11_05800
PDECH1Q58_04960(fabL)
PGQFK545_12995(fabL)
JEOJMA_12600
SPSYAZE41_03675
SPAEE2C16_00445(fabL)
PAEKD3873_10330(fabL)
PANCE2636_04035(fabL)
PLAYDNR44_015760(fabL)
SAYTPY_3095 TPY_3240(fabL)
SAPSulac_0799 Sulac_1673
LPILLIP_1119
MMORMMOR_36050(fabL)
NBRO3I_026240
NSLBOX37_17080
NOZDMB37_02610
ROAPd630_LPD04497
DIZCT688_13190
SGBWQO_30010
SVLStrvi_8195
SHYSHJG_1192
SHOSHJGH_1027
SRCM271_30645
SMALSMALA_2908
SSOII1A49_18470
SFASfla_5328
SBHSBI_06749 SBI_06855
STRPF750_1295
SLEsle_01250(sle_01250)
SGSAVL59_46205
SAUOBV401_18195
SVUB1H20_30845
SALFSMD44_08690
SKACP970_38055
SSPODDQ41_16075
SSEOD0Z67_12220
SSPBCP982_05330
SPLACP981_34470
SCALI6J39_30650
SGJIAG43_17255
LXLKDY119_01212
MIOAOA12_09960
MPALBO218_02695
MIHBJP65_01770
MAURBOH66_10360
MOOBWL13_01459(fabL)
MPRTET475_01045
CUBBJK06_01395
CPHYB5808_12155
HUMDVJ78_08790
HUWFPZ11_10075
GRYD7I44_00415
HEAHL652_11045
CELZE5225_00720
PSEIGCE65_03975
MIKFOE78_00275
MICGGJV80_19840
NDKI601_1166(fabL)
AGRAAGRA3207_002235
NOABKM31_45865
ACEAcel_1197
AMYYYIM_26855(fabL)
PDXPsed_2586
KALKALB_7822
MICHFJK98_15115
MCABHXZ27_30090
PLABC6361_09525
PLATC6W10_06020
ATLAthai_27180
ASERAsera_47540
CATICS0771_54770(fabL)
AFOAfer_1057
AQZKSP35_11145
NONNOS3756_03710
TROtrd_0268
STISthe_0993
ATMANT_17280
PSUBPelsub_P1998
CAPCLDAP_22810
KBSEPA93_26395
TTRTter_0966
RBARB10454(chcA)
LCREPla8534_03000(fabL_1) Pla8534_16180(fabL_2)
AAGGETAA8_31190(fabL)
BVOPan97_33970(fabL_2)
PLMPlim_1674
PEHSpb1_25250(fabL)
MRIMal4_48560(fabL_2)
PLONPla110_25280(fabL)
SUSAcid_2156
CPICpin_5032
CHIHGWR21_30980
SGNSGRA_1403(fabI)
MUPA0256_07540
MUCMuYL_2694
MGOTMgSA37_02494(fabL)
MGINFRZ54_06410
MGKFSB76_12515
MMABHQ865_23795
MGIKGO620_015025
SLISlin_3188
SRDSD10_17175
SPIRCWM47_06615
SPIKEXU85_33670
GFOGFO_1609(fabI)
GRLLPB144_03625
GRSC7S20_14460
RBIRB2501_14724
CATCA2559_10903
MARMYQ22_18190
MARTBTR34_17885
MARBCJ263_18640
MAREEJ994_04390
CAOCelal_3842
CBALM667_15700
KDIKrodi_2526
DOKMED134_04719
DDOI597_1946(fabL)
DODDCS32_14685
LACICW733_13200
ZGAZOBELLIA_4386
MUTGVT53_13935
SPONHME9304_03191(fabI)
ASLAeqsu_2711
PTQP700755_000481
NDODDD_3154
NOMAAT17_01000
NSDBST91_04905
NOBCW736_10875
NOJEJ995_09005
POMMED152_08610
WIJBWZ20_08860
SYISB49_03770
TJETJEJU_0277
SALTAO058_12230
SMISLDL76_14585
OLLCW732_02590
AUEC5O00_12550
KANIMCC3317_45070(fabL)
AQDD1816_03765
EMARD1013_12460
MUREQY75_06045
AFLAFHG64_01250
ANPFK178_04090
OCIFEZ18_06955
MGELG5B37_02090
GAAHX109_13950
CAGGHYG79_16880
ALTIALE3EI_2232
FBEFF125_04625
CSALNBC122_00026(fabL)
CJGNCTC13459_00416(fabL)
CCASEIB73_04505
CANTNCTC13489_01022(fabL)
KDAEIB71_08845
OHOOweho_0671
CPHCpha266_1101
CTSCtha_2098
IALIALB_0753
MROMROS_0289
CABYCabys_861
MOXDAMO_2491
 » show all
Reference
1  [PMID:11007778]
  Authors
Heath RJ, Su N, Murphy CK, Rock CO
  Title
The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis.
  Journal
J Biol Chem 275:40128-33 (2000)
DOI:10.1074/jbc.M005611200
  Sequence
[bsu:BSU08650]
Reference
2  [PMID:17329825]
  Authors
Kim KH, Park JK, Ha BH, Moon JH, Kim EE
  Title
Crystallization and preliminary X-ray crystallographic analysis of enoyl-ACP reductase III (FabL) from Bacillus subtilis.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 63:246-8 (2007)
DOI:10.1107/S1744309107008469
Reference
3  [PMID:21185310]
  Authors
Kim KH, Ha BH, Kim SJ, Hong SK, Hwang KY, Kim EE
  Title
Crystal structures of Enoyl-ACP reductases I (FabI) and III (FabL) from B. subtilis.
  Journal
J Mol Biol 406:403-15 (2011)
DOI:10.1016/j.jmb.2010.12.003
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.104
IUBMB Enzyme Nomenclature: 1.3.1.104
ExPASy - ENZYME nomenclature database: 1.3.1.104
BRENDA, the Enzyme Database: 1.3.1.104
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