Entry |
|
Name |
prephenate dehydrogenase;
hydroxyphenylpyruvate synthase;
chorismate mutase---prephenate dehydrogenase
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Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
prephenate:NAD+ oxidoreductase (decarboxylating)
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Reaction(IUBMB) |
prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH [RN: R01728]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
This enzyme in the enteric bacteria also possesses chorismate mutase activity (EC 5.4.99.5 chorismate mutase) and converts chorismate into prephenate.
|
History |
EC 1.3.1.12 created 1972
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Pathway |
ec00400 | Phenylalanine, tyrosine and tryptophan biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K00220 | cyclohexadieny/prephenate dehydrogenase |
K04517 | prephenate dehydrogenase |
K14187 | chorismate mutase / prephenate dehydrogenase |
K24018 | cyclohexadieny/prephenate dehydrogenase / 3-phosphoshikimate 1-carboxyvinyltransferase |
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Genes |
ECOO: | ECRM13514_3426(tyrA) |
ECOH: | ECRM13516_3282(tyrA) |
ELR: | ECO55CA74_15470(tyrA) |
ECW: | EcE24377A_2884(tyrA) |
EDJ: | ECDH1ME8569_2521(tyrA) |
ECOI: | ECOPMV1_02830(tyrA) |
SEM: | STMDT12_C27230(tyrA) |
SETC: | CFSAN001921_03685(tyrA) |
SEEN: | SE451236_19585(tyrA) |
SENH: | CFSAN002069_18700(tyrA) |
SEEH: | SEEH1578_22375(tyrA) |
SENJ: | CFSAN001992_20330(tyrA) |
SEEC: | CFSAN002050_20015(tyrA) |
SEEB: | SEEB0189_006485(tyrA) |
SENC: | SEET0819_20525(tyrA) |
REE: | electrica_01164(tyrA) |
RTG: | NCTC13098_01668(tyrA_1) |
CLAP: | NCTC11466_00876(tyrA) |
KIE: | NCTC12125_00109(tyrA) |
BAGE: | BADSM9389_10100(tyrA) |
AHN: | NCTC12129_03839(tyrA) |
PTF: | PROFFT_A_00350(tyrA) |
PSHI: | SAMEA2665130_2304(tyrA) |
YPG: | YpAngola_A3483(tyrA) |
YPI: | YpsIP31758_3219(tyrA) |
SMW: | SMWW4_v1c08450(tyrA) |
SERS: | SERRSCBI_03935(tyrA) |
SFJ: | SAMEA4384070_0903(tyrA) |
SOF: | NCTC11214_00630(tyrA) |
SSAR: | SSARUM_000793(tyrA) |
SERA: | Ser39006_008400(tyrA) |
PAQU: | DMB82_0005485(tyrA) |
PARL: | PEC302110_29470(tyrA) |
DIC: | Dpoa569_003054(tyrA) |
TPTY: | NCTC11468_02934(tyrA) |
PHEI: | NCTC12003_00920(tyrA) |
PRJ: | NCTC6933_01008(tyrA) |
LRI: | NCTC12151_00923(tyrA) |
HIC: | NTHIC486_01374(tyrA) |
HPIT: | NCTC13334_01563(tyrA) |
HHZ: | NCTC10839_01381(tyrA) |
HAEG: | NCTC8502_01719(tyrA) |
PDAG: | 4362423_00718(tyrA) |
ALIG: | NCTC10568_00212(tyrA) |
ASEG: | NCTC10977_01284(tyrA) |
AVT: | NCTC3438_01407(tyrA) |
RPNE: | NCTC8284_02115(tyrA) |
PAET: | NCTC13378_00867(tyrA) |
XPH: | XppCFBP6546_03810(XppCFBP6546P_03810) |
XHA: | PG878_09130 PG878_10330 |
VAU: | VANGNB10_cI0622(tyrA) |
VPL: | SA104470976_02033(tyrA) |
VOS: | KNV97_06270(tyrA) KNV97_21685(tyrA) |
PPUN: | PP4_40010(tyrA_aroA) |
PPRC: | PFLCHA0_c43820(aroA1) |
PMUD: | NCTC8068_01765(aroA_1) |
PFW: | PF1751_v1c16150(aroA) |
PPUU: | PputUW4_01362(aroA) |
PTW: | TUM18999_16600(aroA) |
PTAE: | NCTC10697_01565(aroA) |
MSHE: | MAALD49_23120(aroA) |
PSYC: | DABAL43B_1618(aroA) |
PKY: | PKHYL_22090 PKHYL_22100 |
MCAT: | MC25239_00892(aroA) |
MCUN: | NCTC10297_01609(aroA) |
SCAA: | TUM17387_11450(tyrA) |
PLZ: | S4054249_15820(tyrA) |
AMC: | MADE_000001021085(tyrA) |
SALH: | HMF8227_01879(pheA) |
LWA: | SAMEA4504053_0509(tyrA) |
TXA: | HQN79_05915 HQN79_05920(aroA) |
TSE: | THMIRHAS_13620 THMIRHAS_13630 |
TZO: | THMIRHAT_13330 THMIRHAT_13340 |
RHEI: | ATY27_11000(tyrA) ATY27_18655(tyrA) |
TFRI: | Thiofri_02517(tyrC) |
TNI: | TVNIR_1809(tyrC_[H]) |
GAI: | IMCC3135_25830(tyrA) |
SEDS: | AAY24_04570 AAY24_13490 |
ALCA: | ASALC70_04154(aroA) |
MPON: | MACH16_20310(aroA_2) |
AEL: | NCTC12917_01509(tyrA) |
CDIZ: | CEDIAZO_00917(tyrA) |
NWE: | SAMEA3174300_0060(tyrC) |
NZO: | SAMEA4504057_1079(tyrC) |
NCI: | NCTC10296_00192(tyrC) |
NCZ: | NCTC10294_01255(tyrC) |
NANI: | NCTC12227_01728(tyrC) |
ECOR: | SAMEA4412678_0558(tyrC) |
PLG: | NCTC10937_03983(aroA_1) |
LMIR: | NCTC12852_01221(tyrC) |
MYCO: | MPB2EB_1207(aroA_2) |
BTRM: | SAMEA390648703848(tyrA) |
AXX: | ERS451415_01608(tyrC) |
PHN: | PAEH1_04565 PAEH1_12400 |
LIM: | L103DPR2_01276(tyrA) |
LIH: | L63ED372_00851(tyrA) |
SMIO: | CATMQ487_45690(tyrA) |
URU: | DSM104443_02638(tyrC) |
UPL: | DSM104440_02367(tyrC) |
THAG: | CKCBHOJB_01308(tyrC) |
FMY: | HO273_02635(aroA) HO273_02640 |
KMN: | HW532_15205 HW532_17190 |
RBS: | RHODOSMS8_02687(tyrA) |
SMEL: | SM2011_c00711(tyrC) |
SFD: | USDA257_c50690(tyrC) |
SAME: | SAMCFNEI73_Ch3031(tyrC) |
AVV: | RvVAT039_13760(tyrC) |
AVF: | RvVAR031_00790(tyrC) |
REC: | RHECIAT_CH0004080(tyrC) |
REL: | REMIM1_CH03894(tyrC) |
REP: | IE4803_CH04183(tyrC) |
REI: | IE4771_CH04125(tyrC) |
RGA: | RGR602_CH03730(tyrC) |
RPHA: | AMC79_CH04014(tyrC) |
NEN: | NCHU2750_33520(tyrC) |
BIO: | BR141012304_10729(tyrC) |
OCR: | HGK82_11120 HGK82_22495 |
OCL: | GTN27_11355 GTN27_15445 |
OCH: | CES85_2441 CES85_4412 |
VGO: | GJW-30_1_00717(tyrA) |
BVV: | BHK69_10220 BHK69_26125 |
BOS: | BSY19_1383 BSY19_3655 |
BOI: | BLM15_00760 BLM15_15740 |
BOF: | FQV39_13005 FQV39_27450 |
BHS: | BM1374165_01676(tyrC) |
BTX: | BM1374166_02242(tyrC) |
BEZ: | NCTC12898_01572(tyrC) |
MAQU: | Maq22A_1p32200(tyrA) Maq22A_c09385(tyrA) |
MEE: | DA075_09520 DA075_13240 |
METI: | DK427_06840 DK427_14780 |
MTEA: | DK419_17270 DK419_22200 |
MIV: | C4E04_02610 C4E04_06765 |
MTUN: | MTUNDRAET4_0586(tyrC) |
PSTG: | E8M01_01820 E8M01_09520 |
BVY: | NCTC9239_02692(tyrA) |
TSV: | DSM104635_02909(tyrC) |
RUA: | D1823_11570 D1823_18245 |
RLI: | RLO149_c027460(tyrC) |
PGA: | PGA1_c06690 PGA1_c25230(tyrC) |
PGL: | PGA2_c06250 PGA2_c23230(tyrC) |
PHP: | PhaeoP97_02393(tyrC) PhaeoP97_02683 |
PPIC: | PhaeoP14_00592 PhaeoP14_02309(tyrC) |
PHQ: | D1820_07510 D1820_16450 |
SINL: | DSM14862_00654(tyrC) |
SPSE: | SULPSESMR1_02431(tyrA) |
RMM: | ROSMUCSMR3_01256(tyrA) |
AHT: | ANTHELSMS3_01141(tyrA) |
THAA: | CFI11_06550 CFI11_12505 |
LALG: | LentiSH36_00258(tyrC) |
PAMI: | JCM7686_0612 JCM7686_0962 |
PYE: | A6J80_17645 A6J80_22410 |
PZH: | CX676_05200 CX676_11240 |
DAA: | AKL17_0923 AKL17_3385 |
LVS: | LOKVESSMR4R_00454(tyrA) |
PPRU: | FDP22_04615 FDP22_09435 |
PSHQ: | F3W81_08530 F3W81_18000 |
SPAG: | sphantq_02194(tyrC) |
SFLA: | SPHFLASMR4Y_02396(tyrA) |
SPHS: | ETR14_24205 ETR14_25105 |
ASZ: | ASN_2215(tyrC) ASN_2736(pdh) |
ATO: | CIW82_01555 CIW82_17625 |
RGI: | RGI145_01295 RGI145_07950 |
ROS: | CTJ15_09395 CTJ15_17285 |
RMUC: | FOB66_11185 FOB66_21245 |
SHUM: | STHU_49340(tyrC_1) STHU_49350(tyrC_2) |
SVC: | STVA_01960 STVA_01970 |
STEL: | STAQ_44560(tyrC_1) STAQ_44570(tyrC_2) |
ABS: | AZOBR_p1130164(tyrC) |
HHM: | BN341_16860 BN341_16900 |
HSH: | NHP194022_11610(tyrA) |
HPUL: | NCTC13154_01533(tyrA) |
CJV: | MTVDSCj20_0127(tyrA) |
CFV: | CFVI03293_1534(tyrA) |
CAMP: | CFT03427_1461(tyrA) |
CCOC: | CCON33237_0474(tyrA) |
CLR: | UPTC16701_0222(tyrA) |
CLM: | UPTC16712_0220(tyrA) |
CAMR: | CAQ16704_0219(tyrA) |
CHV: | CHELV3228_0269(tyrA) |
CAMZ: | CVIC12175_1365(tyrA) |
GBN: | GEOBRER4_09560(tyrA) |
BAZ: | BAMTA208_05660(tyrA) |
BSTR: | QI003_11225 QI003_14655 |
BFD: | NCTC4823_02080(tyrA) |
BMQ: | BMQ_2999(tyrA) BMQ_4316(tyrA) |
BMD: | BMD_3028(tyrA) BMD_4303(tyrA) |
BMH: | BMWSH_0914 BMWSH_2181(tyrA) |
BMEG: | BG04_1235 BG04_5529 |
BFX: | BC359_06155 BC359_09565 |
PKS: | IE339_12460 IE339_17865 |
PARG: | PspKH34_13140(tyrA) |
BLEN: | NCTC4824_01996(tyrA) |
BOU: | I5818_10395 I5818_11810 |
SAX: | USA300HOU_1300(tyrA) |
SAUV: | SAI7S6_1009820(tyrA) |
SAUW: | SAI5S5_1009780(tyrA) |
SAUX: | SAI6T6_1009790(tyrA) |
SAUY: | SAI8T7_1009820(tyrA) |
SDP: | NCTC12225_01615(tyrC) |
SPIC: | SAMEA4384060_1568(tyrA) |
SSH: | NCTC13712_01356(tyrC) |
SSIM: | SAMEA4384339_1262(tyrC) |
SSTE: | SAMEA4384403_1407(tyrC) |
LMOC: | LMOSLCC5850_1986(tyrA) |
LMOB: | BN419_2311 BN419_2312 |
LMW: | LMOSLCC2755_1984(tyrA) |
LMX: | LMOSLCC2372_1990(tyrA) |
LMZ: | LMOSLCC2482_1985(tyrA) |
LMON: | LMOSLCC2376_1886(tyrA) |
LMOS: | LMOSLCC7179_1896(tyrA) |
LMOO: | LMOSLCC2378_1947(tyrA) |
LMOY: | LMOSLCC2479_1987(tyrA) |
LMOT: | LMOSLCC2540_2005(tyrA) |
LMOA: | LMOATCC19117_1942(tyrA) |
LGZ: | NCTC10812_00894(tyrC) |
PPQ: | PPSQR21_028920(tyrA) |
SNV: | SPNINV200_12190(tyrA) |
SPNG: | HMPREF1038_01361(tyrA) |
SPNE: | SPN034156_02920(tyrA) |
SPNU: | SPN034183_12040(tyrA) |
SPNM: | SPN994038_11930(tyrA) |
SPNO: | SPN994039_11940(tyrA) |
SGG: | SGGBAA2069_c13410(tyrA) |
SVB: | NCTC12167_00684(tyrA2) |
SMEN: | SAMEA4412692_0995(tyrC) |
SFER: | NCTC12278_01210(tyrA) |
SAUP: | NCTC3168_01538(tyrC) |
SVF: | NCTC3166_01209(tyrC) |
SMIE: | NCTC11169_01159(tyrC) |
LGS: | LEGAS_1108(aroQ_TyrA) |
EFU: | HMPREF0351_11590(tyrA) |
ECEC: | NCTC12421_01268(tyrC) |
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