KEGG   ENZYME: 1.3.1.71
Entry
EC 1.3.1.71                 Enzyme                                 
Name
Delta24(241)-sterol reductase;
sterol Delta24(28)-methylene reductase;
sterol Delta24(28)-reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
ergosterol:NADP+ Delta24(241)-oxidoreductase
Reaction(IUBMB)
ergosterol + NADP+ = ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+ [RN:R05641]
Reaction(KEGG)
R05641
Substrate
ergosterol [CPD:C01694];
NADP+ [CPD:C00006]
Product
ergosta-5,7,22,24(241)-tetraen-3beta-ol;
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Acts on a range of steroids with a 24(241)-double bond.
History
EC 1.3.1.71 created 2001, modified 2002
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00223  Delta24(24(1))-sterol reductase
Genes
MIS: MICPUN_75586
MPP: MICPUCDRAFT_45028
SCE: YGL012W(ERG4)
SEUB: DI49_1955
SPAO: SPAR_G02220
AGO: AGOS_AGL087C
KLA: KLLA0_A05071g
KMX: KLMA_40436(ERG4)
LTH: KLTH0E07832g
VPO: Kpol_1061p43
ZRO: ZYRO0G10208g
CGR: 2886295(ERG4)
NCS: NCAS_0A03520(NCAS0A03520)
NDI: NDAI_0A03360(NDAI0A03360)
TPF: TPHA_0F00690(TPHA0F00690)
TBL: TBLA_0C04060(TBLA0C04060)
TGB: HG536_0D04420
TDL: TDEL_0F02340(TDEL0F02340)
KAF: KAFR_0A06700(KAFR0A06700) KAFR_0F03420(KAFR0F03420)
KNG: KNAG_0D03530(KNAG0D03530)
ZMK: HG535_0E03920
SLUD: SCDLUD_001495
DHA: DEHA2A08756g
PIC: PICST_29811
PGU: PGUG_03519
SPAA: SPAPADRAFT_61883
LEL: PVL30_002240(ERG4)
LBG: 92207413(LODBEIA_P22170)
CAL: CAALFM_C300760WA(ERG4)
CTP: CTRG_05501
COT: CORT_0D06470
CDU: CD36_80690
CTEN: 18247433(ERG4)
CLU: CLUG_01341
CLUS: A9F13_06g01507
CAUR: CJI96_0000691
ASAU: 88171619(PUMCH_000550)
PPA: PAS_chr4_0063
PKZ: C5L36_0E04860
BNN: FOA43_002797(ERG4)
BBRX: BRETT_002677(ERG4)
OPA: HPODL_04197
YLI: 2911155(YALI2_D00754g)
SLB: AWJ20_5335(ERG4)
NCR: NCU01333
NTE: NEUTE1DRAFT57468(NEUTE1DRAFT_57468)
SMP: 90947739(SMAC4_12855)
PAN: PODANSg8084
PBEL: QC761_202990(ERG4)
PPSD: QC762_202990(ERG4)
PPSP: QC763_202990(ERG4)
PPSA: QC764_202990(ERG4)
TTT: THITE_112329
MTM: MYCTH_111214
CTHR: CTHT_0066940
RTHE: 98126901(VTJ83DRAFT_5635)
MGR: MGG_02465
PPEI: PpBr36_07054
PGRI: PgNI_05615
TMN: UCRPA7_2614 UCRPA7_3454
SSCK: SPSK_05103
FGR: FGSG_10003
FPU: FPSE_03901
FPOA: FPOAC1_003083
FVN: FVRRES_03414
FVR: FVEG_02775
FOX: FOXG_05355 FOXG_16547
NHE: NECHADRAFT_104411
FFC: NCS54_00351300 NCS54_00681100
FKR: NCS57_00721000
FMU: J7337_005690
TRE: TRIREDRAFT_71655
TRR: M419DRAFT_25295
TATV: 25776106(TrAtP1_003432)
TASP: 36616905(TrAFT101_007106) 90967051(TrAFT101_009469)
MAW: 19245460(ERG4_1) 19251281(ERG4_3)
MAJ: MAA_05585 MAA_06762
MBRN: 26238855(sts1_0) 26246237(sts1_1)
PCHM: VFPPC_03148 VFPPC_04032
UVI: 66068524(UV8b_07747)
CMT: CCM_00528
AMUS: LMH87_000843
PLJ: 28891503(PLICBS_010429) 90643512(PLICBS_010091)
PTKZ: JDV02_002319(ERG4)
DCON: 63718009(DCS_05366)
VAL: VDBG_00632 VDBG_07313
VDA: VDAG_00245 VDAG_06020
CFJ: CFIO01_02390
CLUP: CLUP02_11139
CHIG: CH63R_03797 CH63R_08737
CDET: 87940830(CDEST_04327) 87949916(CDEST_13416)
SAPO: SAPIO_CDS10820 SAPIO_CDS4611
ELA: UCREL1_6997
PFY: PFICI_00050 PFICI_07263
SSL: SS1G_04854
BFU: BCIN_09g00250 BCIN_11g04530
MBE: MBM_00042
PSCO: LY89DRAFT_685926
GLZ: GLAREA_11045 GLAREA_12838
ANI: ANIA_02684 ANIA_10648
AFM: AFUA_1G07140 AFUA_5G14350
ACT: ACLA_017250 ACLA_027450
NFI: NFIA_017580 NFIA_072530
AOR: AO090005000559 AO090012000966 AO090026000130
ANG: An07g09690 An14g05780
AFV: AFLA_002693 AFLA_003367 AFLA_006174
ALUC: AKAW2_11325S(ERG4_1) AKAW2_41204S(ERG4_2)
ACHE: ACHE_11303S(ERG4_1) ACHE_80094A(ERG4_2)
APUU: APUU_41300A(ERG4_1) APUU_71128S(ERG4_2)
PCS: N7525_002753 N7525_005173 N7525_009694
PDP: PDIP_25850 PDIP_26810
POU: POX_c04371 POX_e06448
PPSF: 300791921(PFLUO_LOCUS5922) 300792675(PFLUO_LOCUS6600)
TMF: EYB26_006886
TRG: TRUGW13939_11455
CIM: CIMG_02468 CIMG_02803
CPW: 9696465(ERG4_2) 9696565(ERG4_1)
URE: UREG_03241
ABE: ARB_04196 ARB_05318
TVE: TRV_06009 TRV_06893
PBL: PAAG_07980
PBN: PADG_02082
AJE: HCAG_01378 HCAG_01705
BGH: BDBG_03553 BDBG_06155
PNO: SNOG_00937
PTE: PTT_20197
PTRR: 6345762(PtrM4_038610)
BZE: COCCADRAFT_30688
BSC: COCSADRAFT_159355
BOR: COCMIDRAFT_4741
AALT: CC77DRAFT_910557 CC77DRAFT_979736
ADAC: 96085163(ACET3X_004841)
ARAB: EKO05_0002955 EKO05_0004090
ZTR: MYCGRDRAFT_77785(ERG4)
PFJ: MYCFIDRAFT_30104
FFU: CLAFUR5_14230
CBET: CB0940_05508
BCOM: BAUCODRAFT_31753
NPA: UCRNP2_1275
TML: GSTUM_00002482001
SPO: 2541740(erg4)
SOM: SOMG_03817(erg4)
CNE: CNC04470
CNB: CNBC2700
CNG: CNAG_02830
CGI: CGB_C6580C
CDEU: CNBG_3483
CDEC: 89987860(IAS62_001085)
CTEG: 91988989(I308_102131)
CBAS: 91982182(I312_102134)
CDEP: 91089700(L203_105491)
KMG: 30167466(I203_106376)
KNE: 92178219(IAR55_000960)
KDJ: 28964684(I303_100981)
KBI: 30207244(I302_104137)
KPIN: 30169260(I206_100436)
KSH: 87953053(IL334_000922)
KER: 91106173(V865_007372)
KSN: 43588529(CI109_102450)
KEP: 91091625(L201_000953)
TMS: TREMEDRAFT_45737
TASA: A1Q1_07922
CCAC: CcaHIS019_0303720(ERG4)
TVS: TRAVEDRAFT_168609
DSQ: DICSQDRAFT_100750
PCO: PHACADRAFT_129697
SHS: STEHIDRAFT_79157
HIR: HETIRDRAFT_445714
PSQ: PUNSTDRAFT_136760
ADL: AURDEDRAFT_113235
FME: FOMMEDRAFT_16309
GTR: GLOTRDRAFT_110752
LBC: LACBIDRAFT_171141
CCI: CC1G_00893
ABP: AGABI1DRAFT112024(AGABI1DRAFT_112024)
ABV: AGABI2DRAFT193266(AGABI2DRAFT_193266)
PCUB: JR316_0007953
MPR: MPER_11639
MRR: Moror_7029
MORE: E1B28_007330
SCM: SCHCO_01121912(SCHCODRAFT_01121912) SCHCO_02619321(SCHCODRAFT_02619321)
CPUT: CONPUDRAFT_138512
SLA: SERLADRAFT_416883
WSE: WALSEDRAFT_61402(sts1)
WIC: J056_001933
UMA: UMAG_01498
PFP: PFL1_05816
SGRA: EX895_004294
MGL: MGL_2410
MRT: MRET_3238
MSYM: MSY001_1748
PGR: PGTG_05048 PGTG_17808
PTRC: PtA15_10A546
PSTR: Pst134EA_019507
MLR: MELLADRAFT_73573
RIE: OCT59_010747
MBR: MONBRDRAFT_37477
AAF: AURANDRAFT_59487
TCR: 506577.120 507709.90
LMA: LMJF_33_0680
LIF: LINJ_33_0730
LDO: LDBPK_330730
LMI: LMXM_32_0680
LMAT: 92512651(LSCM1_02556)
LBZ: LBRM_33_0720
LPAN: LPMP_330730
LOI: 92358347(LSCM4_02382)
LEIS: 94177784(GH5_02245)
LENR: 94169103(CUR178_01826)
LEIN: 94185594(JIQ42_01860)
PHET: 94288202(JKF63_02082)
NGR: NAEGRDRAFT_29477 NAEGRDRAFT_81757
CBU: CBU_1206
CBS: COXBURSA331_A1354
CBD: CBUD_1293
CBG: CbuG_0804
CBC: CbuK_1070
 » show all
Reference
1  [PMID:14922]
  Authors
Neal WD, Parks LW.
  Title
Sterol 24(28) methylene reductase in Saccharomyces cerevisiae.
  Journal
J Bacteriol 129:1375-8 (1977)
DOI:10.1128/JB.129.3.1375-1378.1977
Reference
2  [PMID:10722850]
  Authors
Zweytick D, Hrastnik C, Kohlwein SD, Daum G.
  Title
Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast saccharomyces cerevisiae.
  Journal
FEBS Lett 470:83-7 (2000)
DOI:10.1016/S0014-5793(00)01290-4
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.71
IUBMB Enzyme Nomenclature: 1.3.1.71
ExPASy - ENZYME nomenclature database: 1.3.1.71
BRENDA, the Enzyme Database: 1.3.1.71
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