KEGG   ENZYME: 1.3.1.79
Entry
EC 1.3.1.79                 Enzyme                                 
Name
arogenate dehydrogenase [NAD(P)+];
arogenic dehydrogenase (ambiguous);
cyclohexadienyl dehydrogenase;
pretyrosine dehydrogenase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-arogenate:NAD(P)+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2 [RN:R00732 R00733]
Reaction(KEGG)
R00732 R00733
Substrate
L-arogenate [CPD:C00826];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
L-tyrosine [CPD:C00082];
NADH [CPD:C00004];
NADPH [CPD:C00005];
CO2 [CPD:C00011]
Comment
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). Enzymes that can utilize both cofactors have been reported from some Proteobacteria, including Burkholderia caryophylli, Burkholderia cepacia, Pseudomonas marginata and Delftia acidovorans.
History
EC 1.3.1.79 created 2005
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
Reference
1  [PMID:7419490]
  Authors
Byng GS, Whitaker RJ, Gherna RL, Jensen RA
  Title
Variable enzymological patterning in tyrosine biosynthesis as a means of determining natural relatedness among the Pseudomonadaceae.
  Journal
J Bacteriol 144:247-57 (1980)
DOI:10.1128/JB.144.1.247-257.1980
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.79
IUBMB Enzyme Nomenclature: 1.3.1.79
ExPASy - ENZYME nomenclature database: 1.3.1.79
BRENDA, the Enzyme Database: 1.3.1.79
CAS: 64295-75-6
LinkDB

KEGG   REACTION: R00732
Entry
R00732                      Reaction                               
Name
L-arogenate:NAD+ oxidoreductase
Definition
L-Arogenate + NAD+ <=> L-Tyrosine + CO2 + NADH + H+
Equation
Comment
NADP+ (ec 1.3.1.79, see R00733)
Reaction class
RC00001  C00003_C00004
RC00125  C00082_C00826
Enzyme
1.3.1.43        1.3.1.79
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01230  Biosynthesis of amino acids
Module
M00040  Tyrosine biosynthesis, chorismate => arogenate => tyrosine
Orthology
K00220  cyclohexadieny/prephenate dehydrogenase [EC:1.3.1.43 1.3.1.12]
K24018  cyclohexadieny/prephenate dehydrogenase / 3-phosphoshikimate 1-carboxyvinyltransferase [EC:1.3.1.43 1.3.1.12 2.5.1.19]
Other DBs
RHEA: 12259
LinkDB

KEGG   REACTION: R00733
Entry
R00733                      Reaction                               
Name
L-arogenate:NADP+ oxidoreductase
Definition
L-Arogenate + NADP+ <=> L-Tyrosine + CO2 + NADPH + H+
Equation
Comment
NAD+ (ec 1.3.1.79, see R00732)
Reaction class
RC00001  C00005_C00006
RC00125  C00082_C00826
Enzyme
1.3.1.78        1.3.1.79
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01230  Biosynthesis of amino acids
Module
M00040  Tyrosine biosynthesis, chorismate => arogenate => tyrosine
Orthology
K15226  arogenate dehydrogenase (NADP+) [EC:1.3.1.78]
K15227  arogenate dehydrogenase (NADP+), plant [EC:1.3.1.78]
Other DBs
RHEA: 15420
LinkDB

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