KEGG ENZYME: 1.3.1.87

ENZYME: 1.3.1.87

Entry

EC 1.3.1.87                 Enzyme

Name

3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase;
hcaB (gene name);
cis-dihydrodiol dehydrogenase;
2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase

Reaction(IUBMB)

(1) 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ = 3-(2,3-dihydroxyphenyl)propanoate + NADH + H+ [RN:R06784];
(2) (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD+ = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NADH + H+ [RN:R06785]

Reaction(KEGG)

R06784 R06785

Substrate

3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate [CPD:C11588];
NAD+ [CPD:C00003];
(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate [CPD:C12622]

Product

3-(2,3-dihydroxyphenyl)propanoate [CPD:C04044];
NADH [CPD:C00004];
H+ [CPD:C00080];
(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate [CPD:C12623]

Comment

This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation.

History

EC 1.3.1.87 created 2011

Pathway

ec00360

Phenylalanine metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K05711

2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase

Genes

ECO:	b2541(hcaB)

ECJ:	JW2525(hcaB)

ECD:	ECDH10B_2708(hcaB)

EBW:	BWG_2305(hcaB)

ECOK:

ECMDS42_2085(hcaB)

ECOC:

C3026_14075

ECE:	Z3813(hcaB)

ECS:	ECs_3407(hcaB)

ECF:	ECH74115_3773(hcaB)

ETW:	ECSP_3485(hcaB)

ELX:	CDCO157_3174

EOI:	ECO111_3265(hcaB)

EOJ:	ECO26_3588(hcaB)

EOH:	ECO103_3061(hcaB)

ESL:

O3K_06710

ESO:

O3O_18940

ESM:

O3M_06755

ECK:	EC55989_2827(hcaB)

EOK:	G2583_3071(hcaB)

ELR:	ECO55CA74_15200

ELH:

ETEC_2698

ECW:	EcE24377A_2826(hcaB)

EUN:	UMNK88_3194

ECOA:

APECO78_16435

ECX:	EcHS_A2693(hcaB)

ECM:	EcSMS35_2694(hcaB)

ECY:

ECSE_2828

ECR:	ECIAI1_2593(hcaB)

EUM:	ECUMN_2861(hcaB)

ECT:	ECIAI39_2742(hcaB)

EOC:	CE10_2973(hcaB)

EBR:	ECB_02433(hcaB)

ECOB:

C3029_16795

EBL:	ECD_02433(hcaB)

EBE:	B21_02397(hcaB)

EBD:

ECBD_1143

ELO:	EC042_2745(hcaB)

ECL:	EcolC_1136

EKF:	KO11_10115(hcaB)

EDH:	EcDH1_1127

EDJ:	ECDH1ME8569_2468(hcaB)

ELW:	ECW_m2767(hcaB)

ELL:	WFL_13550(hcaB)

ELP:	P12B_c2641(hcaB)

ECOL:

LY180_13035

ESZ:	FEM44_02695(hcaB)

ESF:	ACK8NJ_06110(hcaB)

SFL:	SF2588(hcaB)

SFX:	S2760(hcaB)

SFV:	SFV_2589(hcaB)

SFE:	SFxv_2844(hcaB)

SFN:

SFy_3675

SFS:

SFyv_3752

SFT:	NCTC1_02844(hcaB)

SSN:	SSON_2623(hcaB)

SBO:	SBO_2565(hcaB)

SHQ:	A0259_16430

SHIG:

LXH19_06105(hcaB)

KPV:	KPNIH29_19735

REE:	electrica_01230(hcaB)

CFD:	CFNIH1_24140

CWE:	CO701_05125

CYO:	CD187_06580

CPOT:

FOB25_17725(hcaB)

CFQ:	C2U38_18475

CIF:	AL515_17225

CIE:	AN232_10840

CPAR:

CUC49_13150

CITZ:

E4Z61_23080(hcaB)

CARS:

E1B03_19725(hcaB)

CIX:	M4I31_06390(hcaB)

CIB:	HF677_006310(hcaB)

CITR:

GUC46_06295(hcaB)

KAS:	KATP_11280(hcaB)

KLU:	K7B04_23375(hcaB)

KCY:	RIN60_06195(hcaB)

KGN:	GY169_05930(hcaB)

PSGC:

G163CM_01180(hcaB)

EBF:

D782_1128

SFW:	WN53_15155

SFG:	AV650_10695

PLU:	plu2207(hcaB)

PLUM:

A4R40_11065

PAY:	PAU_02354(hcaB)

PTT:	VY86_20025

PAKH:

B0X70_11380

PLUI:

CE143_11295

LRI:	NCTC12151_03200(hcaB)

VNA:	PN96_06455

VEJ:	VEJY3_06595

VFU:	vfu_A01968

VID:	DBX26_06760

PKM:	PZ739_18220(hcaB)

ALC:	OTEC02_08855

AEI:	AOY20_01935

ASJ:	AsACE_CH00361(hcaB)

ADV:	DJ533_16915(hcaB)

ARJ:	DOM24_01620

ATN:	FM020_13940(hcaB)

ACHI:

CDG60_03005

ALJ:	G8D99_13365(hcaB)

AWG:	GFH30_01750(hcaB)

ASHA:

G8E00_02290(hcaB)

ATG:	J4G44_04430(hcaB)

AVB:	RYU24_27060(hcaB)

ABOU:

ACBO_27660(hcaB)

ACIU:

A3K93_01305

APOT:

MZO21_10805(hcaB)

ATZ:	M5E07_14150(hcaB)

ACIE:

KIP84_08225(hcaB)

ACIG:

BS636_03560

ATV:	ABEF79_01900(hcaB)

APIS:

ACDW34_15715(hcaB)

ACAZ:

ABJ384_12905(hcaB)

ZOB:	ACEVBK_16190(hcaB)

GBI:	PG2T_08585

AQL:	BXU06_16220

BDF:	WI26_30265

BANN:

JFN94_26745(hcaB)

PACP:

FAZ97_23030(hcaB)

PPAI:

E1956_24370(hcaB)

PHUN:

U0042_13195(hcaB)

BOJ:	CBF45_10080

AALN:

Q3V95_01605(hcaB)

AFA:	UZ73_04225

AFQ:

AFA_13930

AAQU:

D3M96_14790

AAMM:

FE795_12885(hcaB)

ALCN:

MID00_13025(hcaB)

KGY:	EHF36_10480

DIH:	G7047_02075(hcaB)

RBU:	PG1C_04295

NHUM:

PQ457_20565(hcaB)

SYB:	TZ53_25060

SPHT:

K426_22019

TRO:

trd_A0926

MSA:	Mycsm_01916 Mycsm_01932 Mycsm_01993

MGOR:

H0P51_21145

MYW:	BVC93_18890

MVA:

Mvan_4412

MAB:

MAB_4365c

CDR:	CDHC03_1955(hcaB)

CAZ:	CARG_03230

CII:	CIMIT_11750

CMV:	CMUST_15100(hcaB)

CRF:	FRC0190_02113

CLIZ:

G7Y31_11570

COK:	COCCU_04445(bphB)

CPSL:

KBP54_01730

CHIN:

J5O04_05680

CFG:	CFREI_11775(bphB)

CCAW:

CCANI_11875(bphB)

CFEU:

CFELI_14035(bphB)

CORN:

BJP05_09125

NNO:	NONO_c29070

RHWQ:

HUN07_20115(hcaB)

REQ:

REQ_35110

PSOW:

ABI214_20515(hcaB)

SGRF:

SGFS_032160

SCB:	SCAB_2141(hcaB)

STSI:

A4E84_36405

SGM:	GCM10017557_80200(hcaB)

SPHV:

F9278_45570

SAKB:

K1J60_43925

SSEC:

ABZO29_43100(hcaB)

MIO:	AOA12_18575

ASUN:

KG104_01765

NAE:	BHE16_09205

BLAP:

MVA48_02345

» show all

Reference

1 [PMID:9603882]

Authors

Diaz E, Ferrandez A, Garcia JL.

Title

Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.

Journal

J Bacteriol 180:2915-23 (1998)
DOI:10.1128/JB.180.11.2915-2923.1998

Sequence

[eco:b2541]

Other DBs

ExplorEnz - The Enzyme Database:

1.3.1.87

IUBMB Enzyme Nomenclature:

1.3.1.87

ExPASy - ENZYME nomenclature database:

1.3.1.87

UM-BBD (Biocatalysis/Biodegradation Database):

1.3.1.87

BRENDA, the Enzyme Database:

1.3.1.87

LinkDB

DBGET integrated database retrieval system