KEGG ENZYME: 1.3.99.6

ENZYME: 1.3.99.6

Entry

EC 1.3.99.6                 Enzyme

Name

3-oxo-5beta-steroid 4-dehydrogenase;
3-oxo-5beta-steroid:(acceptor) Delta4-oxidoreductase

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors

Sysname

3-oxo-5beta-steroid:acceptor Delta4-oxidoreductase

Reaction(IUBMB)

a 3-oxo-5beta-steroid + acceptor = a 3-oxo-Delta4-steroid + reduced acceptor [RN:R02642]

Reaction(KEGG)

R02642 > R02215;
(other) R02219

Substrate

3-oxo-5beta-steroid [CPD:C02797];
acceptor [CPD:C00028]

Product

3-oxo-Delta4-steroid [CPD:C00619];
reduced acceptor [CPD:C00030]

History

EC 1.3.99.6 created 1972

Pathway

ec00140

Steroid hormone biosynthesis

ec01100

Metabolic pathways

Reference

1 [PMID:5907467]

Authors

Davidson SJ, Talalay P.

Title

Purification and mechanism of action of a steroid delta-4-5-beta-dehydrogenase.

Journal

J Biol Chem 241:906-15 (1966)

Other DBs

ExplorEnz - The Enzyme Database:

1.3.99.6

IUBMB Enzyme Nomenclature:

1.3.99.6

ExPASy - ENZYME nomenclature database:

1.3.99.6

BRENDA, the Enzyme Database:

1.3.99.6

CAS:

9067-97-4

LinkDB

REACTION: R02215

Entry

R02215                      Reaction

Name

5beta-pregnane-3,20-dione:(acceptor) delta4-oxidoreductase

Definition

5beta-Pregnane-3,20-dione + Acceptor <=> Progesterone + Reduced acceptor

Equation

C05479 + C00028 <=> C00410 + C00030

Reaction class

RC00145

C00410_C05479

Enzyme

1.3.99.6

Pathway

rn00140

Steroid hormone biosynthesis

rn01100

Metabolic pathways

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.99  With unknown physiological acceptors
    1.3.99.6
     R02215  5beta-Pregnane-3,20-dione + Acceptor <=> Progesterone + Reduced acceptor
IUBMB reaction hierarchy [BR:br08202]
1. Oxidoreductase reactions
  1.3.99.6
   R02642  3-Oxo-5beta-steroid <=> Acceptor
    R02215  5beta-Pregnane-3,20-dione <=> Progesterone

Orthology

K00251

3-oxo-5-beta-steroid 4-dehydrogenase [EC:1.3.1.3]

LinkDB

REACTION: R02219

Entry

R02219                      Reaction

Name

3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase;
3-oxo-5beta-steroid: (acceptor) delta4-oxidoreductase

Definition

Progesterone + NADPH + H+ <=> 5beta-Pregnane-3,20-dione + NADP+

Equation

C00410 + C00005 + C00080 <=> C05479 + C00006

Reaction class

RC00001

C00005_C00006

RC00145

C00410_C05479

Enzyme

1.3.1.3 1.3.99.6

Pathway

rn00140

Steroid hormone biosynthesis

rn01100

Metabolic pathways

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.3
     R02219  Progesterone + NADPH + H+ <=> 5beta-Pregnane-3,20-dione + NADP+
   1.3.99  With unknown physiological acceptors
    1.3.99.6
     R02219  Progesterone + NADPH + H+ <=> 5beta-Pregnane-3,20-dione + NADP+
IUBMB reaction hierarchy [BR:br08202]
1. Oxidoreductase reactions
  1.3.1.3
   R13168  3-Oxo-5beta-steroid <=> 3-Oxo-Delta4-steroid
    R02219  5beta-Pregnane-3,20-dione <=> Progesterone

Orthology

K00251

3-oxo-5-beta-steroid 4-dehydrogenase [EC:1.3.1.3]

LinkDB

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