KEGG   ENZYME: 1.4.1.26
Entry
EC 1.4.1.26                 Enzyme                                 
Name
2,4-diaminopentanoate dehydrogenase (NAD+);
DAPDH (ambiguous)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2R,4S)-2,4-diaminopentanoate:NADP+ oxidoreductase (deaminating)
Reaction(IUBMB)
(2R,4S)-2,4-diaminopentanoate + H2O + NAD+ = (2R)-2-amino-4-oxopentanoate + NH3 + NADH + H+ [RN:R04200]
Reaction(KEGG)
R04200
Substrate
(2R,4S)-2,4-diaminopentanoate [CPD:C03943];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
(2R)-2-amino-4-oxopentanoate [CPD:C03341];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from an unknown bacterium in an environmental sample, has some activity with (2R,4R)-2,4-diaminopentanoate. It has very low activity with NADP+ (cf. EC 1.4.1.12, 2,4-diaminopentanoate dehydrogenase).
History
EC 1.4.1.26 created 2017
Pathway
ec00470  D-Amino acid metabolism
ec01100  Metabolic pathways
Orthology
K21672  2,4-diaminopentanoate dehydrogenase
Genes
CEHCEW89_15600
EAVEH197_05050
VCPH9L18_06400
VHYG7082_14535
CSQCSCA_0127
CACECACET_c17480(dapB2)
CEUA7L45_16560
CFMBJL90_14515
CARGRSJ17_08675
CDRKB9W14_17905
AMTAmet_2367
AOEClos_1699
GFEGferi_26730
CALEFDN13_03020
CRSFQB35_06685
CPRFK7H06_09005
FPLAA4U99_15095
CDFCD630_04420(ord)
PDCCDIF630_00570(ord)
CDCCD196_0399
CDLCDR20291_0385
PDFCD630DERM_04420(ord)
CSTCLOST_1294(ord)
TEMJW646_03950
TEBT8CH_0873(ord)
DAIDesaci_1873
AACXDEACI_0846
VGUHYG85_19050
VPYHZI73_17680
ACAEHYG86_08075
AMIJEQM06_12600
AMICAmi3637_07690
ABUTAmi103574_00595
ETMCE91St48_39740(ord)
EUUADJ67_00765
TTETTE1234
TEXTeth514_1477
THXThet_1426
TPDTeth39_1040
TBOThebr_1067
TWIThewi_1184
TOCToce_1489
NTHNther_1166
NCDACONDI_00602(ord)
HORHore_21120
AFTBBF96_13560
KMEH0A61_00511(ord)
SPOAEQM13_10965
KPARJL105_07140
CAZOG3A45_03845
SEDZJYG23_00910
PFTJBW_01651
MANRMPAN_008560(ord)
MBJKQ51_00248
TBMBK010_05560
TBZBK011_05600
TBKHF295_00050
MPHUMPHO_01310
ARSADJ73_08360
PACPPA2276
PAKHMPREF0675_5353
PAVTIA2EST22_11160
PAXTIA2EST36_11135
PAZTIA2EST2_11080
PAWPAZ_c23740(dapB2)
PADTIIST44_04200
PCNTIB1ST10_11600
PACCPAC1_11610
PACHPAGK_2185
PACNTIA1EST1_11230
CACNRN83_00010
PRLBCB70_06960
CGRN4412665_00379
PAUSNCTC13651_02412
PPCHMPREF9154_0892
ARUBJ5A65_10535
ABATCFX1CAM_0745
TPITREPR_1364
SLRL21SP2_1023
FHWRN87_08680
FPDCTM68_09160
FCII6I83_05765
SBRSY1_03600
TMETmel_0905
TAFTHA_1160
THPBG95_05265
THERY592_05345
TFEJYK00_04200
FNOFnod_1646
FPEFerpe_1990
FIANA23_09975(ord)
OCYOSSY52_03900(ord)
PMOPmob_1166
MPZMarpi_1533
MARNLN42_08170
DTNDTL3_0759
KOLKole_0356
KPFIX53_10190
MPGTheba_1251
MINFMESINF_2284
ASACATHSA_0997
 » show all
Reference
1  [PMID:19251850]
  Authors
Fonknechten N, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J, Salanoubat M
  Title
A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine.
  Journal
J Bacteriol 191:3162-7 (2009)
DOI:10.1128/JB.01777-08
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.26
IUBMB Enzyme Nomenclature: 1.4.1.26
ExPASy - ENZYME nomenclature database: 1.4.1.26
BRENDA, the Enzyme Database: 1.4.1.26
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