KEGG ENZYME: 1.5.1.51

ENZYME: 1.5.1.51

Entry

EC 1.5.1.51                 Enzyme

Name

N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase;
SbnB

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate:NAD+ dehydrogenase (L-2,3-diaminopropanoate-forming)

Reaction(IUBMB)

N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD+ + H2O = 2-oxoglutarate + L-2,3-diaminopropanoate + NADH + H+ [RN:R11655]

Reaction(KEGG)

R11655

Substrate

N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate [CPD:C21559];
NAD+ [CPD:C00003];
H2O [CPD:C00001]

Product

2-oxoglutarate [CPD:C00026];
L-2,3-diaminopropanoate [CPD:C03401];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B.

History

EC 1.5.1.51 created 2017

Pathway

ec00997

Biosynthesis of various other secondary metabolites

ec00998

Biosynthesis of various antibiotics

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K21721

N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase

Genes

ACC:	BDGL_001498(ocd2)

ANO:	RR32_07480

ACAL:

BUM88_11500

ASEI:

I8T81_07365(sbnB)

ACD:	AOLE_07115

ACW:	A0J50_07100

AGU:

AS4_16160

SDN:

Sden_0589

TACT:

SG35_003595(sbnB)

CEK:	D0B88_14055(sbnB)

CEG:	D0C16_05385(sbnB)

RSO:

RSp0418

RSE:

F504_3906

RPU:	CDC45_19720

RNC:	GO999_24060(sbnB)

RSL:	RPSI07_mp0379

RSN:	RSPO_m01410

RSM:	CMR15_mp10431

RSY:	RSUY_34860(rapL_2)

RSG:	JK151_14180(sbnB)

CNC:	CNE_2c14840(ocd)

CUH:	BJN34_08320

RME:	Rmet_1116(ocd)

CUK:	KB879_12560(sbnB)

BPLA:

bpln_2g05020

NLC:	EBAPG3_006455

NIZ:	NNRS527_01549

ALEG:

CFBP4996_27385(sbnB)

MNO:

Mnod_6949

MAQU:

Maq22A_c25430

MIWA:

SS37A_35540(ocd2_1) SS37A_39060(ocd2_2)

SBD:	ATN00_04615

DBK:	DGMP_24730

BTHT:

H175_328p223

BBAD:

K7T73_21445(sbnB)

BARD:

QRY57_07110 QRY57_11940(sbnB)

PCAL:

BV455_03923

LMAC:

I6G82_02105(sbnB)

SCIA:

HUG15_04755

SAU:	SA0113(sbnB)

SAV:

SAV0117

SAW:

SAHV_0116

SAH:	SaurJH1_0108

SAJ:	SaurJH9_0104

SAM:	MW0090(sbnB)

SAS:

SAS0091

SAR:

SAR0120

SAC:

SACOL0101

SAX:	USA300HOU_0128(ocd)

SAA:	SAUSA300_0119

SAO:	SAOUHSC_00076

SAE:	NWMN_0061(sbnB)

SAD:

SAAV_0085

SUU:	M013TW_0107(sbnB)

SUV:	SAVC_00325

SUE:

SAOV_0064

SUJ:	SAA6159_00100(sbnB)

SUK:	SAA6008_00095

SUC:

ECTR2_73

SUT:	SAT0131_00103

SUQ:	HMPREF0772_10380

SUZ:

MS7_0109

SUD:	ST398NM01_0128

SUX:	SAEMRSA15_00830(sbnB)

SUW:	SATW20_01290(sbnB)

SUG:

SAPIG0128

SUF:	SARLGA251_00920(sbnB)

SAUA:

SAAG_00601

SAUE:

RSAU_000071

SAUN:

SAKOR_00091

SAUS:

SA40_0084(sbnB)

SAUU:

SA957_0099(sbnB)

SAUG:

SA268_0096(sbnB)

SAUZ:

SAZ172_0128(sbnB)

SAUT:

SAI1T1_2000730

SAUJ:

SAI2T2_1000730

SAUK:

SAI3T3_1000730

SAUQ:

SAI4T8_1000730

SAUV:

SAI7S6_1000730

SAUW:

SAI5S5_1000730

SAUX:

SAI6T6_1000730

SAUY:

SAI8T7_1000730

SAUF:

X998_0096

SAB:

SAB0056

SUY:	SA2981_0118(sbnB)

SAUB:

C248_0105

SAUM:

BN843_1190

SAUC:

CA347_128

SAUR:

SABB_01723(sbnB)

SAUI:

AZ30_00610

SAUD:

CH52_05135

SAMS:

NI36_00505

SUH:	SAMSHR1132_00930

SSD:	SPSINT_0335

SDT:	SPSE_2123(sbnB)

SDP:	NCTC12225_02340(sbnB)

SHU:	SHYC_00360(sbnB)

SSCH:

LH95_00360

SSCZ:

RN70_00580

SAGQ:

EP23_09765(sbnB)

SEQO:

SE1039_25100

SLZ:	B5P37_07595

SARL:

SAP2_02040

SSH:	NCTC13712_00070

SRAI:

LN051_00235(sbnB)

SFF:	FOB90_07430(sbnB)

BLR:	BRLA_c008320

BAGR:

BA6348_15350

BRW:	GOP56_19910(sbnB)

PMAH:

PTQ21_17790(sbnB)

ANX:	ACH33_02520

ATHE:

K3F53_05635 K3F53_16430(sbnB)

SACA:

FFV09_03655(sbnB)

TUM:	CBW65_11390

TAB:	CIG75_16790

LFB:	C1X05_04235

KPUL:

GXN76_14220(sbnB)

PABS:

JIR001_05100(sbnB)

SACG:

FDZ84_26435(sbnB)

PMAD:

BAY61_28575

AFLO:

HEQ12_15470(sbnB)

PPIO:

CE91St28_22640(ocd2)

» show all

Reference

1 [PMID:21906287]

Authors

Beasley FC, Cheung J, Heinrichs DE

Title

Mutation of L-2,3-diaminopropionic acid synthase genes blocks staphyloferrin B synthesis in Staphylococcus aureus.

Journal

BMC Microbiol 11:199 (2011)
DOI:10.1186/1471-2180-11-199

Reference

2 [PMID:24485762]

Authors

Kobylarz MJ, Grigg JC, Takayama SJ, Rai DK, Heinrichs DE, Murphy ME

Title

Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor.

Journal

Chem Biol 21:379-88 (2014)
DOI:10.1016/j.chembiol.2013.12.011

Sequence

[sae:NWMN_0061]

Other DBs

ExplorEnz - The Enzyme Database:

1.5.1.51

IUBMB Enzyme Nomenclature:

1.5.1.51

ExPASy - ENZYME nomenclature database:

1.5.1.51

BRENDA, the Enzyme Database:

1.5.1.51

LinkDB

DBGET integrated database retrieval system