KEGG   ENZYME: 1.5.3.12
Entry
EC 1.5.3.12                 Enzyme                                 
Name
dihydrobenzophenanthridine oxidase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
Sysname
dihydrobenzophenanthridine:oxygen oxidoreductase
Reaction(IUBMB)
(1) dihydrosanguinarine + O2 = sanguinarine + H2O2 [RN:R04703];
(2) dihydrochelirubine + O2 = chelirubine + H2O2 [RN:R04706];
(3) dihydromacarpine + O2 = macarpine + H2O2 [RN:R04768]
Reaction(KEGG)
R04703 R04706 R04768
Substrate
dihydrosanguinarine [CPD:C05191];
O2 [CPD:C00007];
dihydrochelirubine [CPD:C05194];
dihydromacarpine [CPD:C05316]
Product
sanguinarine [CPD:C06162];
H2O2 [CPD:C00027];
chelirubine [CPD:C06327];
macarpine [CPD:C06165]
Comment
A CuII enzyme found in higher plants that produces oxidized forms of the benzophenanthridine alkaloids
History
EC 1.5.3.12 created 1999
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Reference
1  [PMID:24241413]
  Authors
Schumacher HM, Zenk MH
  Title
Partial purification and characterization of dihydrobenzophenanthridine oxidase from Eschscholtzia californica cell suspension cultures.
  Journal
Plant Cell Rep 7:43-6 (1988)
DOI:10.1007/BF00272975
Reference
2  [PMID:1444440]
  Authors
Arakawa H, Clark WG, Psenak M, Coscia CJ.
  Title
Purification and characterization of dihydrobenzophenanthridine oxidase from elicited Sanguinaria canadensis cell cultures.
  Journal
Arch Biochem Biophys 299:1-7 (1992)
DOI:10.1016/0003-9861(92)90236-P
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.12
IUBMB Enzyme Nomenclature: 1.5.3.12
ExPASy - ENZYME nomenclature database: 1.5.3.12
BRENDA, the Enzyme Database: 1.5.3.12
CAS: 114051-83-1
LinkDB

KEGG   REACTION: R04703
Entry
R04703                      Reaction                               
Name
dihydrosanguinarine:oxygen oxidoreductase
Definition
Dihydrosanguinarine + Oxygen + H+ <=> Sanguinarine + Hydrogen peroxide
Equation
C05191 + C00007 + C00080 <=> C06162 + C00027
Reaction class
RC01204  C05191_C06162
RC02755  C00007_C00027
Enzyme
1.3.3.8         1.5.3.12
Pathway
rn00950  Isoquinoline alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00945  Sanguinarine biosynthesis, (S)-reticuline => sanguinarine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.3  With oxygen as acceptor
    1.3.3.8
     R04703  Dihydrosanguinarine + Oxygen + H+ <=> Sanguinarine + Hydrogen peroxide
  1.5  Acting on the CH-NH group of donors
   1.5.3  With oxygen as acceptor
    1.5.3.12
     R04703  Dihydrosanguinarine + Oxygen + H+ <=> Sanguinarine + Hydrogen peroxide
Orthology
K22089  tetrahydroprotoberberine oxidase [EC:1.3.3.8]
Other DBs
RHEA: 16624
LinkDB

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