KEGG   ENZYME: 1.5.8.1
Entry
EC 1.5.8.1                  Enzyme                                 
Name
dimethylamine dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With a flavin or flavoprotein as acceptor
Sysname
dimethylamine:electron-transfer flavoprotein oxidoreductase
Reaction(IUBMB)
dimethylamine + H2O + electron-transfer flavoprotein = methylamine + formaldehyde + reduced electron-transfer flavoprotein [RN:R01588]
Reaction(KEGG)
R01588
Substrate
dimethylamine [CPD:C00543];
H2O [CPD:C00001];
electron-transfer flavoprotein [CPD:C04253]
Product
methylamine [CPD:C00218];
formaldehyde [CPD:C00067];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Contains FAD and a [4Fe-4S] cluster.
History
EC 1.5.8.1 created 1999 as EC 1.5.99.10, transferred 2002 to EC 1.5.8.1
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00317  dimethylamine/trimethylamine dehydrogenase
Genes
PMEX: H4W19_11290
RHD: R2APBS1_0788
RTH: LRK53_05475
DJI: CH75_07125
DTX: ATSB10_15590
XBA: C7S18_14515
PRE: PCA10_47330
PFC: PflA506_4693(tmd)
POI: BOP93_22725
PSHH: HU773_024440
PHYG: JTY93_23165
PTRL: OU419_05970
PHEF: PSH57_11310
TPSY: RGQ13_17920
HPIS: P1P91_05060
TSN: W908_00015
THIN: CRN91_01375
RSO: RSp0682
RSE: F504_4539
RPU: CDC45_21030
RNC: GO999_17495
RSL: RPSI07_mp0583
RSN: RSPO_m01017(stcD)
RSM: CMR15_mp10652
RSY: RSUY_38890(tmd)
RSG: JK151_04710
COX: E0W60_31885
BPH: Bphy_5960
BCAI: K788_0001542
PHS: C2L64_21885
PTER: C2L65_26085
PSAA: QEN71_34155
PPAI: E1956_20380
PSPU: NA29_08505
CDN: BN940_13011
ALCN: MID00_10605
RHOA: HZ993_23385
IDC: LRM40_18490
CFU: CFU_2684
CPRA: CPter91_1920(tmd)
MEH: M301_1400
MEI: Msip34_2459
MEP: MPQ_2403
AZA: AZKH_p0217
AZI: AzCIB_2375
MCI: Mesci_2636
MCIC: A4R28_14440
MOP: Mesop_5984
MAM: Mesau_02601
MESW: A9K65_014455
MESP: C1M53_02585
MERD: EB233_12920 EB233_26910
MESR: FGU64_14490
MMEI: LRP31_28040
MESJ: MJ8_10490 MJ8_44860
AAK: AA2016_5993
PHT: BLM14_27655
KMN: HW532_16390
SME: SMa0257
SMK: Sinme_5357
SMX: SM11_pC1602
SMI: BN406_04939(tmd)
SMEG: C770_GR4pC1294
SMEL: SM2011_a0257
SMER: DU99_24725
SMD: Smed_1285
SIX: BSY16_2386(hdh) BSY16_277
SKM: PZL22_005785
ATA: AWN88_01220
RHID: FFM81_027465
SHZ: shn_10745 shn_30205
SZO: K8M09_09840 K8M09_20940
OIN: IAR37_22770
OAN: Oant_3262
OAH: DR92_3227(hdh)
OPS: A8A54_15775
BPSN: NIK97_15890
OCR: HGK82_18870
OCL: GTN27_18995
OCC: KMS41_16940
OCH: CES85_4558(tmd)
XAU: Xaut_0917
STAR: G3545_26390
LNE: FZC33_09600 FZC33_21465
HDN: Hden_0194 Hden_0535
HDT: HYPDE_25228 HYPDE_25748 HYPDE_34963
HMC: HYPMC_3962 HYPMC_3963
MCG: GL4_2663
BLAG: BLTE_16710
PLEO: OHA_1_00468(tmd_1) OHA_1_00478(tmd_2)
NOH: G5V57_02665 G5V57_05590 G5V57_06430 G5V57_31675
CAUL: KCG34_05695 KCG34_22905
RUA: D1823_18085
RCON: K3740_03325
RDE: RD1_4141(tmd)
RLI: RLO149_c003340(tmd)
RPON: G3256_12605 G3256_12610 G3256_12615
RFU: ROLI_013800(tmd_1) ROLI_013810(tmd_2)
OAT: OAN307_c42970(tmd)
OAR: OA238_c47830(tmd1) OA238_c47840(tmd2) OA238_c47850(tmd3)
OTM: OSB_15670(tmd)
LMD: METH_21805
LEJ: ETW24_01555 ETW24_05525
LCAE: K3721_20240 K3721_20805
YAN: AYJ57_15570
SUAM: BOO69_07220
SULI: C1J05_06740 C1J05_19580
SINL: DSM14862_03441(tmd_1) DSM14862_03666(tmd_2)
RMM: ROSMUCSMR3_03636(tmd)
ROK: RAK1035_2462
RID: RIdsm_00662(tmd_1) RIdsm_04243(tmd_2) RIdsm_04244(tmd_3)
ROM: EI983_01485 EI983_01490 EI983_01495 EI983_09835 EI983_12585
ROH: FIU89_18495(tmd)
RPEL: N7U68_06485 N7U68_11895
AHT: ANTHELSMS3_00564
THAA: CFI11_03135
MALU: KU6B_04850
RHP: LPB142_07370
RBL: B6K69_00080
FYT: QF092_00980 QF092_17580 QF092_18440 QF092_19300
PAMN: pAMV3p0110(dmd) pAMV3p0194(tmd)
PSEW: JHW44_16105
PSAP: JHX88_10600
PFIS: JHX87_13990
DON: BSK21_05955
RBZ: B9057_07560
GEH: HYN69_03530 HYN69_12980
GFU: KM031_01850 KM031_19465
TAW: EI545_11145 EI545_19315
SEDI: EBB79_22970 EBB79_23890
PPSO: QPJ95_18105 QPJ95_18110 QPJ95_19445
HML: HmaOT1_18870
PPRU: FDP22_03105
PAED: G5B38_12110 G5B38_17400 G5B38_20470
NSM: JO391_00855 JO391_09270 JO391_14010
AALK: LGT41_0005560
AMYL: QBD29_02340 QBD29_12395
SNJ: A7E77_04570
SMY: BJP26_14925
SCH: Sphch_1857
SLAA: EUU25_06940 EUU25_06985(ndpC)
SMIC: SmB9_20160
HTQ: FRZ44_06770 FRZ44_10820 FRZ44_23470 FRZ44_47380
HADH: FRZ61_06860 FRZ61_11050 FRZ61_23740
GSO: PH603_02775
MDX: BTO20_01230
MVQ: MYVA_5919
MMAT: MMAGJ_23260
MSEI: MSEDJ_15750
MGO: AFA91_30545
MRF: MJO55_07995
MDF: K0O62_08600
NYA: LTV02_09175
RHA: RHA1_ro01789
ROP: ROP_14630 ROP_27330
ROA: Pd630_LPD05948 Pd630_LPD07456
RKO: JWS14_09075
RPSK: JWS13_36935
RHOJ: JVH1_28390
GOI: LK459_16700
GMG: NWF22_14920
TPR: Tpau_0381
SPHV: F9278_41870
SANU: K7396_16130
LDN: H9L06_06465
NCA: Noca_0579 Noca_0618
NARO: CFH99_14995
PSIM: KR76_16005
AGRA: AGRA3207_001949
PHH: AFB00_19150
KUT: JJ691_53080(tmd)
PLK: CIK06_05545
SBAE: DSM104329_00584(tmd_1) DSM104329_02421(tmd_2) DSM104329_02427(tmd_3) DSM104329_03741(tmd_4)
RRS: RoseRS_2964
RCA: Rcas_1934
 » show all
Reference
1  [PMID:7556160]
  Authors
Yang CC, Packman LC, Scrutton NS
  Title
The primary structure of Hyphomicrobium X dimethylamine dehydrogenase. Relationship to trimethylamine dehydrogenase and implications for substrate recognition.
  Journal
Eur J Biochem 232:264-71 (1995)
DOI:10.1111/j.1432-1033.1995.tb20808.x
  Sequence
[hdn:Hden_0194]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.8.1
IUBMB Enzyme Nomenclature: 1.5.8.1
ExPASy - ENZYME nomenclature database: 1.5.8.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.5.8.1
BRENDA, the Enzyme Database: 1.5.8.1
CAS: 68247-64-3
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