KEGG   ENZYME: 1.5.8.2
Entry
EC 1.5.8.2                  Enzyme                                 
Name
trimethylamine dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With a flavin or flavoprotein as acceptor
Sysname
trimethylamine:electron-transfer flavoprotein oxidoreductase (demethylating)
Reaction(IUBMB)
trimethylamine + H2O + electron-transfer flavoprotein = dimethylamine + formaldehyde + reduced electron-transfer flavoprotein [RN:R02511]
Reaction(KEGG)
R02511
Substrate
trimethylamine [CPD:C00565];
H2O [CPD:C00001];
electron-transfer flavoprotein [CPD:C04253]
Product
dimethylamine [CPD:C00543];
formaldehyde [CPD:C00067];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
A number of alkyl-substituted derivatives of trimethylamine can also act as electron donors; phenazine methosulfate and 2,6-dichloroindophenol can act as electron acceptors. Contains FAD and a [4Fe-4S] cluster.
History
EC 1.5.8.2 created 1976 as EC 1.5.99.7, transferred 2002 to EC 1.5.8.2
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00317  dimethylamine/trimethylamine dehydrogenase
Genes
PMEX: H4W19_11290
RHD: R2APBS1_0788
RTH: LRK53_05475
DJI: CH75_07125
DTX: ATSB10_15590
XBA: C7S18_14515
PRE: PCA10_47330
PFC: PflA506_4693(tmd)
POI: BOP93_22725
PSHH: HU773_024440
PHYG: JTY93_23165
PTRL: OU419_05970
PHEF: PSH57_11310
TPSY: RGQ13_17920
HPIS: P1P91_05060
TSN: W908_00015
THIN: CRN91_01375
RSO: RSp0682
RSE: F504_4539
RPU: CDC45_21030
RNC: GO999_17495
RSL: RPSI07_mp0583
RSN: RSPO_m01017(stcD)
RSM: CMR15_mp10652
RSY: RSUY_38890(tmd)
RSG: JK151_04710
COX: E0W60_31885
BPH: Bphy_5960
BCAI: K788_0001542
PHS: C2L64_21885
PTER: C2L65_26085
PSAA: QEN71_34155
PPAI: E1956_20380
PSPU: NA29_08505
CDN: BN940_13011
ALCN: MID00_10605
RHOA: HZ993_23385
IDC: LRM40_18490
CFU: CFU_2684
CPRA: CPter91_1920(tmd)
MEH: M301_1400
MEI: Msip34_2459
MEP: MPQ_2403
AZA: AZKH_p0217
AZI: AzCIB_2375
MCI: Mesci_2636
MCIC: A4R28_14440
MOP: Mesop_5984
MAM: Mesau_02601
MESW: A9K65_014455
MESP: C1M53_02585
MERD: EB233_12920 EB233_26910
MESR: FGU64_14490
MMEI: LRP31_28040
MESJ: MJ8_10490 MJ8_44860
AAK: AA2016_5993
PHT: BLM14_27655
KMN: HW532_16390
SME: SMa0257
SMK: Sinme_5357
SMX: SM11_pC1602
SMI: BN406_04939(tmd)
SMEG: C770_GR4pC1294
SMEL: SM2011_a0257
SMER: DU99_24725
SMD: Smed_1285
SIX: BSY16_2386(hdh) BSY16_277
SKM: PZL22_005785
ATA: AWN88_01220
RHID: FFM81_027465
SHZ: shn_10745 shn_30205
SZO: K8M09_09840 K8M09_20940
OIN: IAR37_22770
OAN: Oant_3262
OAH: DR92_3227(hdh)
OPS: A8A54_15775
BPSN: NIK97_15890
OCR: HGK82_18870
OCL: GTN27_18995
OCC: KMS41_16940
OCH: CES85_4558(tmd)
XAU: Xaut_0917
STAR: G3545_26390
LNE: FZC33_09600 FZC33_21465
HDN: Hden_0194 Hden_0535
HDT: HYPDE_25228 HYPDE_25748 HYPDE_34963
HMC: HYPMC_3962 HYPMC_3963
MCG: GL4_2663
BLAG: BLTE_16710
PLEO: OHA_1_00468(tmd_1) OHA_1_00478(tmd_2)
NOH: G5V57_02665 G5V57_05590 G5V57_06430 G5V57_31675
CAUL: KCG34_05695 KCG34_22905
RUA: D1823_18085
RCON: K3740_03325
RDE: RD1_4141(tmd)
RLI: RLO149_c003340(tmd)
RPON: G3256_12605 G3256_12610 G3256_12615
RFU: ROLI_013800(tmd_1) ROLI_013810(tmd_2)
OAT: OAN307_c42970(tmd)
OAR: OA238_c47830(tmd1) OA238_c47840(tmd2) OA238_c47850(tmd3)
OTM: OSB_15670(tmd)
LMD: METH_21805
LEJ: ETW24_01555 ETW24_05525
LCAE: K3721_20240 K3721_20805
YAN: AYJ57_15570
SUAM: BOO69_07220
SULI: C1J05_06740 C1J05_19580
SINL: DSM14862_03441(tmd_1) DSM14862_03666(tmd_2)
RMM: ROSMUCSMR3_03636(tmd)
ROK: RAK1035_2462
RID: RIdsm_00662(tmd_1) RIdsm_04243(tmd_2) RIdsm_04244(tmd_3)
ROM: EI983_01485 EI983_01490 EI983_01495 EI983_09835 EI983_12585
ROH: FIU89_18495(tmd)
RPEL: N7U68_06485 N7U68_11895
AHT: ANTHELSMS3_00564
THAA: CFI11_03135
MALU: KU6B_04850
RHP: LPB142_07370
RBL: B6K69_00080
FYT: QF092_00980 QF092_17580 QF092_18440 QF092_19300
PAMN: pAMV3p0110(dmd) pAMV3p0194(tmd)
PSEW: JHW44_16105
PSAP: JHX88_10600
PFIS: JHX87_13990
DON: BSK21_05955
RBZ: B9057_07560
GEH: HYN69_03530 HYN69_12980
GFU: KM031_01850 KM031_19465
TAW: EI545_11145 EI545_19315
SEDI: EBB79_22970 EBB79_23890
PPSO: QPJ95_18105 QPJ95_18110 QPJ95_19445
HML: HmaOT1_18870
PPRU: FDP22_03105
PAED: G5B38_12110 G5B38_17400 G5B38_20470
NSM: JO391_00855 JO391_09270 JO391_14010
AALK: LGT41_0005560
AMYL: QBD29_02340 QBD29_12395
SNJ: A7E77_04570
SMY: BJP26_14925
SCH: Sphch_1857
SLAA: EUU25_06940 EUU25_06985(ndpC)
SMIC: SmB9_20160
HTQ: FRZ44_06770 FRZ44_10820 FRZ44_23470 FRZ44_47380
HADH: FRZ61_06860 FRZ61_11050 FRZ61_23740
GSO: PH603_02775
MDX: BTO20_01230
MVQ: MYVA_5919
MMAT: MMAGJ_23260
MSEI: MSEDJ_15750
MGO: AFA91_30545
MRF: MJO55_07995
MDF: K0O62_08600
NYA: LTV02_09175
RHA: RHA1_ro01789
ROP: ROP_14630 ROP_27330
ROA: Pd630_LPD05948 Pd630_LPD07456
RKO: JWS14_09075
RPSK: JWS13_36935
RHOJ: JVH1_28390
GOI: LK459_16700
GMG: NWF22_14920
TPR: Tpau_0381
SPHV: F9278_41870
SANU: K7396_16130
LDN: H9L06_06465
NCA: Noca_0579 Noca_0618
NARO: CFH99_14995
PSIM: KR76_16005
AGRA: AGRA3207_001949
PHH: AFB00_19150
KUT: JJ691_53080(tmd)
PLK: CIK06_05545
SBAE: DSM104329_00584(tmd_1) DSM104329_02421(tmd_2) DSM104329_02427(tmd_3) DSM104329_03741(tmd_4)
RRS: RoseRS_2964
RCA: Rcas_1934
 » show all
Reference
1  [PMID:5116569]
  Authors
Colby J, Zatman LJ.
  Title
The purification and properties of a bacterial trimethylamine dehydrogenase.
  Journal
Biochem J 121:9P-10P (1971)
DOI:10.1042/bj1210009p
Reference
2  [PMID:204297]
  Authors
Steenkamp DJ, Singer TP.
  Title
Participation of the iron-sulphur cluster and of the covalently bound coenzyme of trimethylamine dehydrogenase in catalysis.
  Journal
Biochem J 169:361-9 (1978)
DOI:10.1042/bj1690361
Reference
3  [PMID:7592591]
  Authors
Huang L, Rohlfs RJ, Hille R.
  Title
The reaction of trimethylamine dehydrogenase with electron transferring flavoprotein.
  Journal
J Biol Chem 270:23958-65 (1995)
DOI:10.1074/jbc.270.41.23958
Reference
4  [PMID:11756429]
  Authors
Jones M, Talfournier F, Bobrov A, Grossmann JG, Vekshin N, Sutcliffe MJ, Scrutton NS
  Title
Electron transfer and conformational change in complexes of trimethylamine dehydrogenase and electron transferring flavoprotein.
  Journal
J Biol Chem 277:8457-65 (2002)
DOI:10.1074/jbc.M111105200
Reference
5  [PMID:11192721]
  Authors
Scrutton NS, Sutcliffe MJ.
  Title
Trimethylamine dehydrogenase and electron transferring flavoprotein.
  Journal
Subcell Biochem 35:145-81 (2000)
DOI:10.1007/0-306-46828-x_5
Other DBs
ExplorEnz - The Enzyme Database: 1.5.8.2
IUBMB Enzyme Nomenclature: 1.5.8.2
ExPASy - ENZYME nomenclature database: 1.5.8.2
UM-BBD (Biocatalysis/Biodegradation Database): 1.5.8.2
BRENDA, the Enzyme Database: 1.5.8.2
CAS: 39307-09-0
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