KEGG   ENZYME: 1.5.98.1
Entry
EC 1.5.98.1                 Enzyme                                 
Name
methylenetetrahydromethanopterin dehydrogenase;
N5,N10-methylenetetrahydromethanopterin dehydrogenase;
5,10-methylenetetrahydromethanopterin dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With other, known, physiological acceptors
Sysname
5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase
Reaction(IUBMB)
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420 [RN:R04456]
Reaction(KEGG)
R04456
Substrate
5,10-methylenetetrahydromethanopterin [CPD:C04377];
oxidized coenzyme F420 [CPD:C00876]
Product
5,10-methenyltetrahydromethanopterin [CPD:C04330];
reduced coenzyme F420 [CPD:C01080]
Comment
Coenzyme F420 is a 7,8-didemethyl-8-hydroxy-5-deazariboflavin derivative; methanopterin is a pterin analogue. The enzyme is involved in the formation of methane from CO2 in the methanogen Methanothermobacter thermautotrophicus.
History
EC 1.5.98.1 created 1989 as EC 1.5.99.9, modified 2004, transferred 2014 to EC 1.5.98.1
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00319  methylenetetrahydromethanopterin dehydrogenase
Genes
MJA: MJ_1035
MFE: Mefer_1257
MVU: Metvu_0302
MFS: MFS40622_1652
MIF: Metin_0918
MJH: JH146_0907
MESG: MLAUSG7_1174(mtd)
MESA: MLASG1_0617(mtd)
MMP: MMP0372(mtd)
MMQ: MmarC5_1303
MMX: MmarC6_0579
MMZ: MmarC7_1368
MMD: GYY_01920
MMAK: MMKA1_03910(mtd)
MMAO: MMOS7_03850(mtd)
MMAD: MMJJ_07050
MAE: Maeo_1367
MVN: Mevan_1360
MVO: Mvol_1675
MOK: Metok_0668
METF: CFE53_05635
MTH: MTH_1464
MMG: MTBMA_c00500(mtd)
MWO: MWSIV6_0005(mtd)
MTEE: MTTB_00390
METC: MTCT_1331
METE: tca_01413
METZ: METMT2_1375
METK: FVF72_04285
MTHM: FZP57_09025
METJ: FZP68_01710
MST: Msp_0163(mtd)
METB: AW729_06295
MEIS: PXD04_04700
MRU: mru_2142(mtd)
MSI: Msm_1204
MEB: Abm4_0039(mtd)
MMIL: sm9_0086(mtd1) sm9_1352(mtd2)
MEYE: TL18_10280
MOL: YLM1_1676
MARO: MarbSA_11530
METV: K4897_05370
MEL: Metbo_0080
MEW: MSWAN_0008
METH: MBMB1_0003(mtd)
MFC: BRM9_0042(mtd)
MFI: DSM1535_1363(mtd)
MCUB: MCBB_0002(mtd)
MSUB: BK009_09725
METN: BK008_05395
METT: CIT01_05640
METO: CIT02_07115
MEME: HYG87_06515
MFEG: GCM10025860_07640
MEER: NKF70_06660
MFV: Mfer_0811
MKA: MK0011(mtd)
AFU: AF_0714
AFG: AFULGI_00007960
APO: Arcpr_1586
AVE: Arcve_1338
AST: Asulf_02280
FPL: Ferp_1018
GAC: GACE_0596
GAH: GAH_01690
MBA: Mbar_A1095
MBY: MSBRM_3350
MBW: MSBRW_3627
MBAR: MSBR2_3303
MBAK: MSBR3_3304
MAC: MA_4430(mtd)
MMA: MM_1108
MMAZ: MmTuc01_1147
MMJ: MSMAS_0195
MMAC: MSMAC_0200
MVC: MSVAZ_0176
MEK: MSKOL_0171
MLS: MSLAZ_2924
METM: MSMTP_0225
MEF: MSWH1_0494
MEQ: MSWHS_0504
MSJ: MSSAC_4111
MSZ: MSSIH_3647
MSW: MSSIT_3702
MTHR: MSTHT_1723
MTHE: MSTHC_1565
MHOR: MSHOH_0247
MFZ: AOB57_007795
MBU: Mbur_0929(mtd)
MMET: MCMEM_1436
MELO: J7W08_05895
MMH: Mmah_0679
MHAZ: BHR79_10205
MPOT: BKM01_09905
MEV: Metev_1727
MZH: Mzhil_0239
MPY: Mpsy_1459
MZI: HWN40_01520
MMAV: RE476_08770
MSEB: RE474_05330
MHZ: Metho_0243
MTP: Mthe_0809
MCJ: MCON_1052(mtd)
MHI: Mhar_1470
MHU: Mhun_2255
MRTJ: KHC33_15685
MLA: Mlab_0079
MEM: Memar_0562
MBG: BN140_1676(mtd)
MEMA: MMAB1_2159(mtd)
MCHK: MchiMG62_06880
MSUM: OH143_09530
MRC: R6Y96_09835
MPI: Mpet_2185
MEND: L6E24_10145
MEFW: F1737_01875
MAQE: RJ40_06365
MFK: E2N92_06500
MOU: OU421_03220
MESB: L1S32_06805
MANQ: L1994_02955
MBN: Mboo_0530
MFO: Metfor_2657
MESK: METHP_00437
MPL: Mpal_0329
MPD: MCP_1313(mtd)
MEZ: Mtc_1592(mtd)
RCI: RCIX2230(mtd)
MJK: N2V74_00125 N2V74_05725
MEAM: MU439_04045
MEAE: QEN48_06140
 » show all
Reference
1  [PMID:4084309]
  Authors
Hartzell PL, Zvilius G, Escalante-Semerena JC, Donnelly MI.
  Title
Coenzyme F420 dependence of the methylenetetrahydromethanopterin dehydrogenase of Methanobacterium thermoautotrophicum.
  Journal
Biochem Biophys Res Commun 133:884-90 (1985)
DOI:10.1016/0006-291X(85)91218-5
Reference
2  [PMID:1911853]
  Authors
te Brommelstroet BW, Geerts WJ, Keltjens JT, van der Drift C, Vogels GD
  Title
Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri.
  Journal
Biochim Biophys Acta 1079:293-302 (1991)
DOI:10.1016/0167-4838(91)90072-8
Other DBs
ExplorEnz - The Enzyme Database: 1.5.98.1
IUBMB Enzyme Nomenclature: 1.5.98.1
ExPASy - ENZYME nomenclature database: 1.5.98.1
BRENDA, the Enzyme Database: 1.5.98.1
CAS: 100357-01-5
LinkDB

DBGET integrated database retrieval system